LOCUS       NM_172596               4446 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus SEC24 homolog C, COPII coat complex component
            (Sec24c), transcript variant 1, mRNA.
ACCESSION   NM_172596
VERSION     NM_172596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4446)
  AUTHORS   Adams EJ, Khoriaty R, Kiseleva A, Cleuren ACA, Tomberg K, van der
            Ent MA, Gergics P, Tang VT, Zhu G, Hoenerhoff MJ, O'Shea KS,
            Saunders TL and Ginsburg D.
  TITLE     Murine SEC24D can substitute functionally for SEC24C during
            embryonic development
  JOURNAL   Sci Rep 11 (1), 21100 (2021)
   PUBMED   34702932
  REMARK    GeneRIF: Murine SEC24D can substitute functionally for SEC24C
            during embryonic development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4446)
  AUTHORS   Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL,
            Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM,
            Zakharenko SS, Ginsburg D and Kundu M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
  REMARK    GeneRIF: These data suggest that SEC24C is a major cargo adapter
            for COPII-dependent transport in postmitotic neurons in developing
            and adult brains and that its functions overlap at least partially
            with those of SEC24D in mammals.
REFERENCE   3  (bases 1 to 4446)
  AUTHORS   Adams,E.J., Chen,X.W., O'Shea,K.S. and Ginsburg,D.
  TITLE     Mammalian COPII coat component SEC24C is required for embryonic
            development in mice
  JOURNAL   J Biol Chem 289 (30), 20858-20870 (2014)
   PUBMED   24876386
  REMARK    GeneRIF: Thus, SEC24C is required in early mammalian development
            but is dispensable in a number of tissues, likely as a result of
            compensation by other Sec24 paralogs.
REFERENCE   4  (bases 1 to 4446)
  AUTHORS   Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P and
            Freissmuth M.
  TITLE     The serotonin transporter is an exclusive client of the coat
            protein complex II (COPII) component SEC24C
  JOURNAL   J Biol Chem 286 (18), 16482-16490 (2011)
   PUBMED   21454670
  REMARK    GeneRIF: The serotonin transporter is an exclusive client of the
            coat protein complex II (COPII) component SEC24C
REFERENCE   5  (bases 1 to 4446)
  AUTHORS   Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E and
            Meijlink F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   6  (bases 1 to 4446)
  AUTHORS   Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H and Yaginuma H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   7  (bases 1 to 4446)
  AUTHORS   Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M,
            Freissmuth M, Millan MJ, Bockaert J and Marin P.
  TITLE     Physical interaction between the serotonin transporter and neuronal
            nitric oxide synthase underlies reciprocal modulation of their
            activity
  JOURNAL   Proc Natl Acad Sci U S A 104 (19), 8119-8124 (2007)
   PUBMED   17452640
REFERENCE   8  (bases 1 to 4446)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4446)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036519.1 and AK122199.1.
            
            On Nov 26, 2009 this sequence version replaced NM_172596.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040370.1, AK036519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2648              AK036519.1         1-2648
            2649-4446           AK122199.1         2399-4196
FEATURES             Location/Qualifiers
     source          1..4446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..4446
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /note="SEC24 homolog C, COPII coat complex component"
                     /db_xref="GeneID:218811"
                     /db_xref="MGI:MGI:1919746"
     exon            1..68
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            69..268
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3387
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /note="isoform 1 is encoded by transcript variant 1; Sec24
                     related gene family, member C"
                     /codon_start=1
                     /product="protein transport protein Sec24C isoform 1"
                     /protein_id="NP_766184.2"
                     /db_xref="CCDS:CCDS26850.1"
                     /db_xref="GeneID:218811"
                     /db_xref="MGI:MGI:1919746"
                     /translation="MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAY
                     NGPVPGYQQAPPQGVPRAPPSSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMQ
                     RVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAGMQISGAVAQAPPPSGLGY
                     GPPTSLASASGNFPNSGPYGSYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPAS
                     GGPQMPSMTGLLPPGQGFGSLPVNQANHVSSPPAPALPPGTQMTGPPVPPPPPMHSPQ
                     QPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGSQPGPPQPLPPKRLDPDAIPSPIQV
                     IEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQ
                     AQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCS
                     FCSCVNDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIF
                     MIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSS
                     LAQPQMMVVSDVADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPV
                     IQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTY
                     QTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSD
                     LRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHD
                     DRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKF
                     AYRAVLNSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVL
                     KSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTAEPPAVRA
                     SEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPL
                     SKKVRGLIDSLRAQRMRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMH
                     KEIRQLLS"
     exon            269..404
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            405..577
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            578..952
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1089
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1201
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1329
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1468
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1584
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1709
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1901
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1995
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2112
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2283
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2380
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2526
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2665
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2784
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2964
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3156
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3246
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..4446
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggaaccgg aagttgagcc tgggagcctt gacgttagga acgaagtcga acctggatct
       61 ggagccgggt gagatcaaat cggggatgct ctcataatga atgtcaacca gtcagctcca
      121 cctgttccac catatgggca gaaccagccc atctacccag ggtatcatca gtcgagttat
      181 ggtgggcaac caggacctgc agcccctgct actccctatg gagcctacaa tggcccagtg
      241 ccaggttatc agcaggcacc tcctcaaggt gtgccaagag ccccaccttc ctcaggggca
      301 cctccagcct ctgcagcaca ggtcccttgt ggtcagacta catatggcca gtttggccaa
      361 ggtgatatac agaatgggcc gagttccaca gctcagatgc aaagggtccc tggttctcag
      421 cagtttggtc ctccattggc ccctgtggtc agccagccag ctgtgcttca gccctatggc
      481 cctcccccca caagtacaca ggtgactgca cagctggccg gaatgcagat cagtggtgct
      541 gtggcccagg cccctccccc ttctgggttg ggctatggtc caccaacatc attggcctca
      601 gcctcaggaa atttccctaa ttctggtcca tacggctcct atcctcagag ccaggctcct
      661 ccccttagcc aggctcaagg tcatcctgga gtccagcctc cccttcgatc tgccccacct
      721 ctggcttcca gcttcacgtc cccagcttca ggtggtcctc agatgccttc catgactgga
      781 ctactcccgc ctggacaggg ctttgggagt cttccagtga accaggctaa ccacgtgtcc
      841 tcacctcctg ctcctgctct gcccccgggc acccagatga ctgggccccc agtaccaccg
      901 ccaccaccta tgcactcccc tcagcagcct ggttatcagc tgcagcaaaa tggttccttt
      961 ggaccagctc gaggccctca acctaattat gagagcccat accctggagc acctaccttt
     1021 ggcagtcagc ctgggcctcc ccagccattg cctcctaagc gtctggaccc tgatgccatc
     1081 cccagcccta ttcaggttat tgaagatgat agaaacaacc ggggttcaga gccatttgtt
     1141 actggtgtac ggggacaggt gccaccttta gtcaccacca atttcctggt gaaagaccaa
     1201 gggaatgcaa gtccccgcta cattcgatgc acatcctata atatcccttg tacttctgac
     1261 atggctaaac aggctcaggt gcctctggcc gctgtcatta aaccactggc aaggctgcct
     1321 ccagaggagg cttcaccgta tgttgtggat catggagaat ctggccccct gcgctgtaat
     1381 cgctgcaaag catacatgtg ccctctcatg acattcatcg agggagggag gcgcttccag
     1441 tgctccttct gcagttgtgt caatgatgtt cccccccagt attttcaaca tctggatcat
     1501 accggcaaac gtgtggatgc ttatgaccgt cctgagctgt ctctgggatc ttatgaattc
     1561 ttggctactg tagattactg taagaacaat aaattcccta gtcctcctgc cttcatcttt
     1621 atgattgatg tctcctacaa tgccatcaga actggtcttg ttcggctcct ctgtgaggag
     1681 ctcaagtcac tcttagacta cctacctagg gagggtggag cagaagagtc agcaatccga
     1741 gttggctttg tcacctataa taaagtgctc cacttctaca atgtgaaaag ctccttggct
     1801 cagccacaga tgatggttgt atctgatgta gctgacatgt ttgtgccact gctggatggc
     1861 ttcctagtca atgtcagtga gtctcgggct gttatcacca gcttattgga tcagattcca
     1921 gaaatgtttg cagatacaag agagacagag acagtgtttg ctccagttat ccaggccggg
     1981 atggaagctc tgaaggctgc tgagtgtgca ggaaagctgt ttctgttcca cacatccttg
     2041 cccattgcag aggccccagg gaagctgaag aatagagatg ataggaagtt gatcaacaca
     2101 gacaaggaga agactctgtt tcagcctcag acaggtacct atcagactct ggccaaagag
     2161 tgtgtggccc aaggctgctg tgtggacctc ttcctcttcc ctaaccaata tgtcgatgtg
     2221 gccacactct ctgttgttcc ccagctcact ggaggctctg tctacaaata tgcctgcttc
     2281 caggtggaaa atgaccagga acggttcttg agtgacctgc gtcgggatgt acagaaggtg
     2341 gttggctttg atgctgttat gcgggttcgg acaagtactg gtatccgtgc tgtagatttc
     2401 tttggcgctt tctatatgag caatacaaca gatgtggagt tggctggatt ggatggagac
     2461 aagacagtga ctgtggaatt caagcatgat gaccggctca atgaagagaa tggagcccta
     2521 ctgcagtgtg ccctgcttta taccagctgt gcagggcagc gtcggctccg catccacaac
     2581 ttggccctaa actgctgcac ccagctggct gatctgtatc gaaactgtga gactgacacg
     2641 ctcatcaact acatggccaa gtttgcatac cgggctgttc tgaatagtcc tgtgaagact
     2701 gtccgtgaca ctctcatcac ccagtgtgcc cagatcctgg cctgttatag aaagaactgt
     2761 gccagccctt cttctgcagg acagttgatt cttcctgagt gcatgaagct cctcccagtt
     2821 tacctgaact gtgtgttgaa gagtgatgtt ctgcagcctg gagctgaggt cactactgat
     2881 gatcgtgcct atgttcggca gctggtttcc tccatggatg tggctgagac caatgtcttc
     2941 ttctaccctc ggctcctacc actgacaaag tctccccttg atagtaccgc tgaaccacca
     3001 gcagttcgag cctctgaaga gcgcctaagc agtggcgata tatatttgct ggaaaatggg
     3061 ctcaacctct ttgtctgggt gggagcaagc gtccaacaag gtgttgtcca gagccttttc
     3121 aacgtgtcct ccttcagtca gatcaccagc ggcttgagtg ttctgccagt tctggataat
     3181 ccactgtcta agaaagttcg aggtctcatc gatagcttac gggcacagag aatgcggtac
     3241 atgaagctta tcgtggtcaa gcaggaagac aagctggaga tgctgttcaa gcacttcctg
     3301 gtggaagaca agagcctaag tggaggtgca tcctatgtgg actttctctg tcatatgcac
     3361 aaggagatcc ggcagctact gagctaaagc aagtgggtaa atggcatagg gtcccaggcc
     3421 agcttccagg aagaacccca ggatgacaga gaaattggga cagttccata tcgtataagt
     3481 catgtaagct gacctcagtt gacttctttt ggggggaggg cgagatataa ggagacaccg
     3541 tctttctggg ctcaaataca ctaccactct gtcatgtcct gctgatcgaa ggtgcctcag
     3601 gccccttact ctaccctttc tcctgctaat cctcttgtaa tgaatgtagt ttctcagttc
     3661 actgtatatg attcggtgtt gggggtttgg aggcagctgg gccctggcaa cagtgtgtcc
     3721 ctttggatga gcctccaaga ggaagggcag gcaggaagaa gtgggaatcc cagggttatt
     3781 acaggaggtg gcaaattcag ctccgtgtca tcaacaactt cctatattag ggacaaaata
     3841 tacaggtgca caagagctgg ggtacaggcc gtaggtggtg gagagtaaaa tagttggtcc
     3901 tttgggtgcc tgatggtcag tagcaaagtc atagttaccg aggatggatg actaatctct
     3961 ctacttccac tgcgcgtgct ctctctcccc tgcaatgatt ggtgagcact tcgtggatga
     4021 atgagcctgg ggtaagaatt gcaaaacata ttaacacctt ggggaagtag cagcctcctt
     4081 tccagatgga gaagccccaa tcctggatgg ttctgtagag cgcctgatgg tcaacttgca
     4141 atacctcaca gagccagccc acatcccact cagcttccac cagaaacgtt gttggggaga
     4201 ggcagatatg gctggagccc tgtcttccgg tgccaggacg ttactgggct ttggtattga
     4261 ctgagtggct gacaagttat cttccaactc cagttggctg ggcaggacaa gggctaggaa
     4321 tgaccgtggt caggcctgcc tgctcccagc ccaggatgcc cctgctatgg acctttcatt
     4381 tcttttcatt ggtttatttt tcaatgcatc tttaatttgt aaagaaataa aataagatgt
     4441 aaccag
//
