LOCUS       NM_001168273            4218 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus SEC24 homolog C, COPII coat complex component
            (Sec24c), transcript variant 2, mRNA.
ACCESSION   NM_001168273
VERSION     NM_001168273.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4218)
  AUTHORS   Adams EJ, Khoriaty R, Kiseleva A, Cleuren ACA, Tomberg K, van der
            Ent MA, Gergics P, Tang VT, Zhu G, Hoenerhoff MJ, O'Shea KS,
            Saunders TL and Ginsburg D.
  TITLE     Murine SEC24D can substitute functionally for SEC24C during
            embryonic development
  JOURNAL   Sci Rep 11 (1), 21100 (2021)
   PUBMED   34702932
  REMARK    GeneRIF: Murine SEC24D can substitute functionally for SEC24C
            during embryonic development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4218)
  AUTHORS   Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL,
            Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM,
            Zakharenko SS, Ginsburg D and Kundu M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
  REMARK    GeneRIF: These data suggest that SEC24C is a major cargo adapter
            for COPII-dependent transport in postmitotic neurons in developing
            and adult brains and that its functions overlap at least partially
            with those of SEC24D in mammals.
REFERENCE   3  (bases 1 to 4218)
  AUTHORS   Adams,E.J., Chen,X.W., O'Shea,K.S. and Ginsburg,D.
  TITLE     Mammalian COPII coat component SEC24C is required for embryonic
            development in mice
  JOURNAL   J Biol Chem 289 (30), 20858-20870 (2014)
   PUBMED   24876386
  REMARK    GeneRIF: Thus, SEC24C is required in early mammalian development
            but is dispensable in a number of tissues, likely as a result of
            compensation by other Sec24 paralogs.
REFERENCE   4  (bases 1 to 4218)
  AUTHORS   Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P and
            Freissmuth M.
  TITLE     The serotonin transporter is an exclusive client of the coat
            protein complex II (COPII) component SEC24C
  JOURNAL   J Biol Chem 286 (18), 16482-16490 (2011)
   PUBMED   21454670
  REMARK    GeneRIF: The serotonin transporter is an exclusive client of the
            coat protein complex II (COPII) component SEC24C
REFERENCE   5  (bases 1 to 4218)
  AUTHORS   Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E and
            Meijlink F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   6  (bases 1 to 4218)
  AUTHORS   Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H and Yaginuma H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   7  (bases 1 to 4218)
  AUTHORS   Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M,
            Freissmuth M, Millan MJ, Bockaert J and Marin P.
  TITLE     Physical interaction between the serotonin transporter and neuronal
            nitric oxide synthase underlies reciprocal modulation of their
            activity
  JOURNAL   Proc Natl Acad Sci U S A 104 (19), 8119-8124 (2007)
   PUBMED   17452640
REFERENCE   8  (bases 1 to 4218)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4218)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036519.1 and AK122199.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment and contains an alternate in-frame exon compared to variant
            1. The resulting isoform (2) has the same N- and C-termini but is
            shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK036519.1         1-22
            23-4218             AK122199.1         1-4196
FEATURES             Location/Qualifiers
     source          1..4218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..4218
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /note="SEC24 homolog C, COPII coat complex component"
                     /db_xref="GeneID:218811"
                     /db_xref="MGI:MGI:1919746"
     exon            1..68
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            69..268
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3159
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /note="isoform 2 is encoded by transcript variant 2; Sec24
                     related gene family, member C"
                     /codon_start=1
                     /product="protein transport protein Sec24C isoform 2"
                     /protein_id="NP_001161745.1"
                     /db_xref="CCDS:CCDS88586.1"
                     /db_xref="GeneID:218811"
                     /db_xref="MGI:MGI:1919746"
                     /translation="MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAY
                     NGPVPGYQQAPPQGVPRAPPSSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMQ
                     RVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQGFGSLPVNQANHVSSPPAPALPPGT
                     QMTGPPVPPPPPMHSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGSQPGPPQP
                     LPPKRLDPDAIPSPQLNELPPQQKTRHRIDPDAIPSPIQVIEDDRNNRGSEPFVTGVR
                     GQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPE
                     EASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCVNDVPPQYFQHLDH
                     TGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLC
                     EELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVP
                     LLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLF
                     LFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFL
                     FPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVR
                     TSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYT
                     SCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVLNSPVKTVRDTLI
                     TQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAY
                     VRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTAEPPAVRASEERLSSGDIYLLENGLN
                     LFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRMRY
                     MKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS"
     exon            269..404
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            405..501
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            502..655
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            656..792
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            793..861
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            862..973
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1101
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1240
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1356
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1481
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1673
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1767
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1884
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2055
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2152
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2298
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2437
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2556
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2736
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2928
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3018
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..4218
                     /gene="Sec24c"
                     /gene_synonym="2610204K03Rik; mKIAA0079"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggaaccgg aagttgagcc tgggagcctt gacgttagga acgaagtcga acctggatct
       61 ggagccgggt gagatcaaat cggggatgct ctcataatga atgtcaacca gtcagctcca
      121 cctgttccac catatgggca gaaccagccc atctacccag ggtatcatca gtcgagttat
      181 ggtgggcaac caggacctgc agcccctgct actccctatg gagcctacaa tggcccagtg
      241 ccaggttatc agcaggcacc tcctcaaggt gtgccaagag ccccaccttc ctcaggggca
      301 cctccagcct ctgcagcaca ggtcccttgt ggtcagacta catatggcca gtttggccaa
      361 ggtgatatac agaatgggcc gagttccaca gctcagatgc aaagggtccc tggttctcag
      421 cagtttggtc ctccattggc ccctgtggtc agccagccag ctgtgcttca gccctatggc
      481 cctcccccca caagtacaca gggctttggg agtcttccag tgaaccaggc taaccacgtg
      541 tcctcacctc ctgctcctgc tctgcccccg ggcacccaga tgactgggcc cccagtacca
      601 ccgccaccac ctatgcactc ccctcagcag cctggttatc agctgcagca aaatggttcc
      661 tttggaccag ctcgaggccc tcaacctaat tatgagagcc cataccctgg agcacctacc
      721 tttggcagtc agcctgggcc tccccagcca ttgcctccta agcgtctgga ccctgatgcc
      781 atccccagcc ctcaacttaa tgagctgcct cctcagcaga aaaccaggca cagaatagat
      841 cctgatgcca ttcctagtcc aattcaggtt attgaagatg atagaaacaa ccggggttca
      901 gagccatttg ttactggtgt acggggacag gtgccacctt tagtcaccac caatttcctg
      961 gtgaaagacc aagggaatgc aagtccccgc tacattcgat gcacatccta taatatccct
     1021 tgtacttctg acatggctaa acaggctcag gtgcctctgg ccgctgtcat taaaccactg
     1081 gcaaggctgc ctccagagga ggcttcaccg tatgttgtgg atcatggaga atctggcccc
     1141 ctgcgctgta atcgctgcaa agcatacatg tgccctctca tgacattcat cgagggaggg
     1201 aggcgcttcc agtgctcctt ctgcagttgt gtcaatgatg ttccccccca gtattttcaa
     1261 catctggatc ataccggcaa acgtgtggat gcttatgacc gtcctgagct gtctctggga
     1321 tcttatgaat tcttggctac tgtagattac tgtaagaaca ataaattccc tagtcctcct
     1381 gccttcatct ttatgattga tgtctcctac aatgccatca gaactggtct tgttcggctc
     1441 ctctgtgagg agctcaagtc actcttagac tacctaccta gggagggtgg agcagaagag
     1501 tcagcaatcc gagttggctt tgtcacctat aataaagtgc tccacttcta caatgtgaaa
     1561 agctccttgg ctcagccaca gatgatggtt gtatctgatg tagctgacat gtttgtgcca
     1621 ctgctggatg gcttcctagt caatgtcagt gagtctcggg ctgttatcac cagcttattg
     1681 gatcagattc cagaaatgtt tgcagataca agagagacag agacagtgtt tgctccagtt
     1741 atccaggccg ggatggaagc tctgaaggct gctgagtgtg caggaaagct gtttctgttc
     1801 cacacatcct tgcccattgc agaggcccca gggaagctga agaatagaga tgataggaag
     1861 ttgatcaaca cagacaagga gaagactctg tttcagcctc agacaggtac ctatcagact
     1921 ctggccaaag agtgtgtggc ccaaggctgc tgtgtggacc tcttcctctt ccctaaccaa
     1981 tatgtcgatg tggccacact ctctgttgtt ccccagctca ctggaggctc tgtctacaaa
     2041 tatgcctgct tccaggtgga aaatgaccag gaacggttct tgagtgacct gcgtcgggat
     2101 gtacagaagg tggttggctt tgatgctgtt atgcgggttc ggacaagtac tggtatccgt
     2161 gctgtagatt tctttggcgc tttctatatg agcaatacaa cagatgtgga gttggctgga
     2221 ttggatggag acaagacagt gactgtggaa ttcaagcatg atgaccggct caatgaagag
     2281 aatggagccc tactgcagtg tgccctgctt tataccagct gtgcagggca gcgtcggctc
     2341 cgcatccaca acttggccct aaactgctgc acccagctgg ctgatctgta tcgaaactgt
     2401 gagactgaca cgctcatcaa ctacatggcc aagtttgcat accgggctgt tctgaatagt
     2461 cctgtgaaga ctgtccgtga cactctcatc acccagtgtg cccagatcct ggcctgttat
     2521 agaaagaact gtgccagccc ttcttctgca ggacagttga ttcttcctga gtgcatgaag
     2581 ctcctcccag tttacctgaa ctgtgtgttg aagagtgatg ttctgcagcc tggagctgag
     2641 gtcactactg atgatcgtgc ctatgttcgg cagctggttt cctccatgga tgtggctgag
     2701 accaatgtct tcttctaccc tcggctccta ccactgacaa agtctcccct tgatagtacc
     2761 gctgaaccac cagcagttcg agcctctgaa gagcgcctaa gcagtggcga tatatatttg
     2821 ctggaaaatg ggctcaacct ctttgtctgg gtgggagcaa gcgtccaaca aggtgttgtc
     2881 cagagccttt tcaacgtgtc ctccttcagt cagatcacca gcggcttgag tgttctgcca
     2941 gttctggata atccactgtc taagaaagtt cgaggtctca tcgatagctt acgggcacag
     3001 agaatgcggt acatgaagct tatcgtggtc aagcaggaag acaagctgga gatgctgttc
     3061 aagcacttcc tggtggaaga caagagccta agtggaggtg catcctatgt ggactttctc
     3121 tgtcatatgc acaaggagat ccggcagcta ctgagctaaa gcaagtgggt aaatggcata
     3181 gggtcccagg ccagcttcca ggaagaaccc caggatgaca gagaaattgg gacagttcca
     3241 tatcgtataa gtcatgtaag ctgacctcag ttgacttctt ttggggggag ggcgagatat
     3301 aaggagacac cgtctttctg ggctcaaata cactaccact ctgtcatgtc ctgctgatcg
     3361 aaggtgcctc aggcccctta ctctaccctt tctcctgcta atcctcttgt aatgaatgta
     3421 gtttctcagt tcactgtata tgattcggtg ttgggggttt ggaggcagct gggccctggc
     3481 aacagtgtgt ccctttggat gagcctccaa gaggaagggc aggcaggaag aagtgggaat
     3541 cccagggtta ttacaggagg tggcaaattc agctccgtgt catcaacaac ttcctatatt
     3601 agggacaaaa tatacaggtg cacaagagct ggggtacagg ccgtaggtgg tggagagtaa
     3661 aatagttggt cctttgggtg cctgatggtc agtagcaaag tcatagttac cgaggatgga
     3721 tgactaatct ctctacttcc actgcgcgtg ctctctctcc cctgcaatga ttggtgagca
     3781 cttcgtggat gaatgagcct ggggtaagaa ttgcaaaaca tattaacacc ttggggaagt
     3841 agcagcctcc tttccagatg gagaagcccc aatcctggat ggttctgtag agcgcctgat
     3901 ggtcaacttg caatacctca cagagccagc ccacatccca ctcagcttcc accagaaacg
     3961 ttgttgggga gaggcagata tggctggagc cctgtcttcc ggtgccagga cgttactggg
     4021 ctttggtatt gactgagtgg ctgacaagtt atcttccaac tccagttggc tgggcaggac
     4081 aagggctagg aatgaccgtg gtcaggcctg cctgctccca gcccaggatg cccctgctat
     4141 ggacctttca tttcttttca ttggtttatt tttcaatgca tctttaattt gtaaagaaat
     4201 aaaataagat gtaaccag
//
