LOCUS       NM_207209               4901 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SEC24 homolog B, COPII coat complex component
            (Sec24b), transcript variant 1, mRNA.
ACCESSION   NM_207209 XM_131192
VERSION     NM_207209.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4901)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4901)
  AUTHORS   Lu,C.L., Ortmeier,S., Brudvig,J., Moretti,T., Cain,J.,
            Boyadjiev,S.A., Weimer,J.M. and Kim,J.
  TITLE     Collagen has a unique SEC24 preference for efficient export from
            the endoplasmic reticulum
  JOURNAL   Traffic 23 (1), 81-93 (2022)
   PUBMED   34761479
  REMARK    GeneRIF: Collagen has a unique SEC24 preference for efficient
            export from the endoplasmic reticulum.
REFERENCE   3  (bases 1 to 4901)
  AUTHORS   Wang,B., Joo,J.H., Mount,R., Teubner,B.J.W., Krenzer,A., Ward,A.L.,
            Ichhaporia,V.P., Adams,E.J., Khoriaty,R., Peters,S.T.,
            Pruett-Miller,S.M., Zakharenko,S.S., Ginsburg,D. and Kundu,M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
REFERENCE   4  (bases 1 to 4901)
  AUTHORS   Ha,S., Stottmann,R.W., Furley,A.J. and Beier,D.R.
  TITLE     A forward genetic screen in mice identifies mutants with abnormal
            cortical patterning
  JOURNAL   Cereb Cortex 25 (1), 167-179 (2015)
   PUBMED   23968836
REFERENCE   5  (bases 1 to 4901)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4901)
  AUTHORS   Wansleeben,C., van Gurp,L., Feitsma,H., Kroon,C., Rieter,E.,
            Verberne,M., Guryev,V., Cuppen,E. and Meijlink,F.
  TITLE     An ENU-mutagenesis screen in the mouse: identification of novel
            developmental gene functions
  JOURNAL   PLoS One 6 (4), e19357 (2011)
   PUBMED   21559415
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4901)
  AUTHORS   Wansleeben,C., Feitsma,H., Montcouquiol,M., Kroon,C., Cuppen,E. and
            Meijlink,F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
  REMARK    GeneRIF: Data present evidence that Sec24b deficiency specifically
            affects transport of the planar cell polarity core protein Vangl2,
            based on experiments in embryos and in cultured primary cells.
REFERENCE   8  (bases 1 to 4901)
  AUTHORS   Merte,J., Jensen,D., Wright,K., Sarsfield,S., Wang,Y., Schekman,R.
            and Ginty,D.D.
  TITLE     Sec24b selectively sorts Vangl2 to regulate planar cell polarity
            during neural tube closure
  JOURNAL   Nat Cell Biol 12 (1), 41-6 (2010)
   PUBMED   19966784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118620.10.
            
            On Aug 25, 2022 this sequence version replaced NM_207209.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046776.1, SRR13861890.115615.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC118620.10        12776-12887
            113-886             AC118620.10        32009-32782
            887-1030            AC118620.10        39482-39625
            1031-1135           AC118620.10        52814-52918
            1136-1216           AC118620.10        61584-61664
            1217-1449           AC118620.10        63562-63794
            1450-1634           AC118620.10        65861-66045
            1635-1737           AC118620.10        68360-68462
            1738-1864           AC118620.10        70390-70516
            1865-1974           AC118620.10        71042-71151
            1975-2087           AC118620.10        73832-73944
            2088-2206           AC118620.10        76657-76775
            2207-2262           AC118620.10        77060-77115
            2263-2469           AC118620.10        77336-77542
            2470-2593           AC118620.10        79064-79187
            2594-2752           AC118620.10        79568-79726
            2753-2926           AC118620.10        80308-80481
            2927-3037           AC118620.10        82015-82125
            3038-3213           AC118620.10        82986-83161
            3214-3351           AC118620.10        83670-83807
            3352-3456           AC118620.10        84456-84560
            3457-3549           AC118620.10        85677-85769
            3550-3653           AC118620.10        89186-89289
            3654-4901           AC118620.10        89450-90697
FEATURES             Location/Qualifiers
     source          1..4901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.87 cM"
     gene            1..4901
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /note="SEC24 homolog B, COPII coat complex component"
                     /db_xref="GeneID:99683"
                     /db_xref="MGI:MGI:2139764"
     exon            1..112
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..3768
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /note="isoform 1 is encoded by transcript variant 1; Sec24
                     related gene family, member B"
                     /codon_start=1
                     /product="protein transport protein Sec24B isoform 1"
                     /protein_id="NP_997092.1"
                     /db_xref="CCDS:CCDS17840.1"
                     /db_xref="GeneID:99683"
                     /db_xref="MGI:MGI:2139764"
                     /translation="MSAPAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSPMQVPS
                     GYGLPHQNYMVPSGHYSQGPGKMTSLPLDSQCDSYYSRPYTVPTQNSGTPSSANQPGA
                     QQMYGRGPSAPHMGGSMPGSFQGIPASASHSYSSASQPYSSLGNRYSSPTTYSANASV
                     ASQGYPSTCSHYPISTVSNVVYPNVSYPSLPASEPYGQMFTSQSAPPPARPVKESYSG
                     PSTALTYPSRPPPPPSQHQQQQQQQQQQQQQQQSHSGYSSLPWSGPALPPAQDSLIRN
                     QMGSLATANSHPTNNENVQPPKSSSVVSTVLPGPSSTRMPPAPSHPVGPVPSAPPPPE
                     QMQTKGMQYGDYGNNQASSTATPLSSASDDEEEQEEDEEAGVDSSSTTSSASPLPNSY
                     DALEGGSYPDMHSSSASSPVPDHALEPSPTLAQALSAAPTPPAAQPAKVAKPFGYGYP
                     ALQPAYQNAAPPPMPAAHPSGPAYTGYPQHYPGVNQLSSGLGGLSLQSSPQPESLRPV
                     NLTQEKNILPPTPIWAPVPNLSAELSKLNCSPDSFRCTLTSIPQTQALLNKAKLPLGL
                     LLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFLY
                     NPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTVL
                     CQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDS
                     LLVNLYESKELIKDLLNALPSMFINTRETHSALGPALQAAFKLMSPTGGRVSVFQTQL
                     PSLGAGLLQSREDPNQRSSTKVVHHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSD
                     LASLACMSKYSAGCIFYYPSFHSTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKG
                     LSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTALVCFQTALLYTSSKG
                     ERRIRVHTLCLPVVSSLADVYAGVDVQAAVCLLANMAVDRSVSSSLSDARDALVNAVV
                     DPLSAYSSAVASVPRSTLTAPSSLKLLPLYVLALLKQKAFRTGTSTRLDDRVYAMCQM
                     KSQPLVHLMKMIHPNLYRIDRLTDEGAIHVNDRVVPQPPLQKLSAEKLTREGAFLMDC
                     GSVFYIWVGKGCDSNFIENVLGYPDFASIPQKMTHLPELDTLPSERTRSFVTWLRDSR
                     PLSPVLHLVKDESPAKTDFFQHLLEDRTEAALSYYEFLIHIQQQVCK"
     exon            113..886
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1030
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1135
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1216
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1449
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1634
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1737
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1864
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1974
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2087
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2206
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2262
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2469
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2593
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2752
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2926
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3037
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3213
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3351
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3456
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3549
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3653
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..4901
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4456..4461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /note="hexamer: ATTAAA"
     polyA_site      4477
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /note="major polyA site"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
                     /note="hexamer: TATAAA"
     polyA_site      4901
                     /gene="Sec24b"
                     /gene_synonym="SEC24"
ORIGIN      
        1 agccgcgccg tcatgtcggc ccccgccggg tcccctcacc cggccgccgg cgcccggatg
       61 ccgcccaagc tcggcggagc tgtctccggc ctggcaccgc cgcagcagaa cggtccagca
      121 cagagtccaa tgcaagttcc atctgggtat gggctgcctc atcaaaacta tatggtccct
      181 tcaggacatt actctcaagg acctgggaaa atgacctcct tgccattgga tagccagtgt
      241 gatagttact actctcgtcc atatacagta ccaacacaaa attcggggac tcccagctca
      301 gcaaaccaac caggagcaca gcagatgtat ggcagaggtc cttccgctcc tcacatgggg
      361 ggctccatgc ccggatcttt ccaaggaatt ccagcatcag catcccattc ctattcgagt
      421 gcctcccagc cctactcctc tcttgggaat cgctacagta gtcctaccac gtactctgcc
      481 aatgcttctg ttgcttctca gggatatccc tctacctgta gtcattatcc catctcaact
      541 gtgtctaatg tggtgtatcc taatgtttcc tatccctcgc tgcctgccag tgagccatat
      601 gggcagatgt ttacctcaca gagtgctcct ccacctgcca ggccagttaa agagtcatac
      661 tctggcccca gcacagctct tacctacccc tcgagacctc cacctccacc ttctcagcac
      721 cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagagtca ttcaggatat
      781 agttctctac catggtcagg tccagccctt ccaccagccc aagacagcct catccgaaac
      841 caaatgggat ccttggctac agcgaacagc cacccaacta ataatgaaaa tgtccaacct
      901 cccaagtcaa gctccgtagt atccacagtt ttgccaggac cctcatcaac aagaatgcca
      961 cctgctccaa gtcacccagt tgggcctgtg ccctctgctc cacccccccc agagcagatg
     1021 cagactaaag gcatgcagta tggtgactat ggtaataatc aagctagctc cacagcgact
     1081 cccttgtcat cagcttccga tgatgaggag gagcaggagg aggatgagga agcaggtgtt
     1141 gacagctctt ccaccaccag cagtgcttcg cccttgccca acagttacga tgccttggaa
     1201 ggaggcagct acccagatat gcattcttct tcagcaagca gccctgttcc tgaccatgcc
     1261 ctggaaccca gtcccaccct cgcccaggct ctgtctgcag cccccactcc ccctgcagct
     1321 cagccagcca aggtggcaaa gccttttggc tatggctacc cagctctgca gcctgcctat
     1381 cagaacgcag caccaccacc catgcccgca gcacatccca gcggcccagc gtacactgga
     1441 tatcctcagc attacccagg tgtgaaccag ctgtcctcag gtctcggagg actaagcctg
     1501 cagagttctc cacagccaga aagcctaaga cctgtcaacc tcacccagga gaaaaatatt
     1561 ttacctccaa ctcctatttg ggctcctgta cctaacctga gtgcagaact cagcaagtta
     1621 aactgtagtc cagactcgtt tcgatgtacc ttgaccagta tcccccagac acaggcttta
     1681 ctgaataaag ctaagcttcc tttaggattg ctgttgcatc ccttcagaga cctgacgcaa
     1741 ttgccagtga taacctcaaa caccatcgtg aggtgccggt cctgtcggac gtacatcaac
     1801 ccttttgtgt ccttcattga tcagcgaaga tggaaatgca acctgtgtta tagagttaat
     1861 gatgttccag aagagttttt gtacaacccc ctgactcggt cttacggaga gcctcataaa
     1921 cggccagaag tccagaattc tactgtggag ttcatcgcat cctcagacta catgctccgg
     1981 cctcctcagc ccgcggtcta cttgtttgtt ttagatgtgt ctcataacgc agtggaagct
     2041 gggtatttga cagttttatg ccagtcctta ttagaaaact tagacaagct tcctggagat
     2101 tcacgaacaa gaataggatt catgactttt gacagcacca ttcacttcta caatctacaa
     2161 gaagggttat cccagccgca gatgttgatt gtatctgata tagacgatgt ttttctgccc
     2221 acgccggata gtctgcttgt gaatctgtat gaaagcaaag agcttataaa agacttactg
     2281 aatgcattac caagtatgtt catcaatacc agagaaacac acagtgccct tggacctgca
     2341 cttcaggctg ccttcaaact catgtctccc acgggcggcc gcgtgtctgt atttcagaca
     2401 cagttacctt ccttgggggc aggacttctg cagtccagag aagatccgaa tcagaggtcg
     2461 agtaccaagg tggtgcacca tcttggccct gcaaccgact tttataagaa gctcgcttta
     2521 gattgctcag ggcagcaaac tgcagtggat ttgttccttc taagttcaca gtattctgac
     2581 cttgcttctc tggcttgcat gtccaagtac tctgcagggt gcatattcta ctatccatct
     2641 ttccactcta cccacaatcc ttcgcaagca gaaaagttac aaaaagacct aaaacggtac
     2701 ctcacgagga agattggatt tgaagctgtt atgagaataa gatgcactaa agggctctca
     2761 atgcacactt tccacgggaa cttctttgtc cgctccaccg acttactgtc tcttgccaac
     2821 atcaatcctg atgctgggtt tgcagtacag ttgtcaatcg aagagagcct gacagatact
     2881 gccttagtgt gctttcagac agccctgctg tacacatcta gcaaaggcga gcggagaatt
     2941 cgagtgcata cactgtgctt gccagtcgta agttccctcg ctgacgttta tgcaggagtg
     3001 gatgtgcaag ccgctgtctg ccttctcgcc aacatggctg tggaccgctc agtgtcatcg
     3061 agcctgtcgg atgccaggga tgccctggtg aacgctgtgg tggatcccct gtctgcctac
     3121 agctccgccg tggcaagtgt gccccgctcc accctgacag caccaagctc acttaagctg
     3181 ctcccactct atgttttggc acttcttaaa cagaaagcat ttagaacagg gacaagcaca
     3241 cgcctggatg accgtgtcta tgccatgtgc cagatgaagt cgcagccgct tgtgcatctc
     3301 atgaaaatga ttcatcccaa cttatacagg atagacaggc tgacagacga gggcgccatc
     3361 cacgtgaatg acagggtagt acctcagcca ccgcttcaga agctgtctgc agagaagctg
     3421 acccgagaag gcgctttcct catggactgc ggctcagttt tctacatttg ggttggcaaa
     3481 ggctgtgaca gtaacttcat agagaacgtg cttggatacc ctgactttgc atcaatacca
     3541 cagaaaatga cacatcttcc agagctagac acacttccat cagaaagaac tagatccttt
     3601 gtgacttggc tcagggacag ccgaccgtta agccctgtcc ttcacttggt aaaagatgag
     3661 agccctgcca aaacagactt tttccagcat ttgcttgaag accgcacgga agccgcactc
     3721 tcctactatg agtttctgat tcacatccaa cagcaggttt gtaagtgaca tcagcagagc
     3781 cgggtcagct gagcagctcc gcagccatcg gagaagcaca caggggactg gacacgaggt
     3841 gtttgctgct agaagaacga tgcacatcac tctgaggctt gggccagaga ttaaggggaa
     3901 gagagaacaa gacacagcag agcccctcca aggacgctga ggcagcagac agagtcggtt
     3961 tttgcgtcct ctcaggagag cagcagtgcg gtgcccctct gccagccagc agacctgagg
     4021 accacggaat gacatgtcat gctctggaac tagatagagt catcgtacag ttagcattct
     4081 ggacttgaac tctgatgaga gatgccgaag ggcagcggca ctgtggtact cgcttgtatg
     4141 aattacttct taacaggaac gactcatgtt catgaaatga attcaacatt tccctgtaag
     4201 gacaatagag cttcattaca cggactatag aaaaatatat atactgtaca taagtgttac
     4261 atttgtaaag aaaatgtaag ctgtaactaa gaagatgaat tgcttcaact gtgctgcaat
     4321 gttggctgac aactctgtca cagtgaggga atgaggttga ctaatgcata ttatgaattg
     4381 agtccacaaa agaaacatga gactttgtaa ttctgttaaa tcttttatgt ggatttattt
     4441 atgatcagcc tactaattaa aaatattttg cttgacagtt ggtttggtgg tttgtttgtt
     4501 tgtagaagtt ttttggtttt ggtggtattg gtgatatttt ttaaacagta ggaatcttaa
     4561 atttgccgct tggagaagat gcaataccaa gtctcattca ttagtgaatg aatacactgt
     4621 cattagtttg tggatacttc aagtaattac tgtttgtatt ctaaaaacat gatgttattt
     4681 tcagaataca tttaatgact aaggataatc ttaaatctca tttaaattaa ggattttttt
     4741 cctacctatt tgtaatgaga atttttttaa aaacatgtga ctttcctttt taattgactt
     4801 gatgattatc atattgaact ctgagagatt tttgttctga tcaggaattc tgtcgttccc
     4861 agcaggctgt ttactataaa gattggtgat gatccattgc a
//
