LOCUS       NM_175255               6798 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SEC24 homolog A, COPII coat complex component
            (Sec24a), transcript variant 1, mRNA.
ACCESSION   NM_175255
VERSION     NM_175255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6798)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6798)
  AUTHORS   Wang,B., Joo,J.H., Mount,R., Teubner,B.J.W., Krenzer,A., Ward,A.L.,
            Ichhaporia,V.P., Adams,E.J., Khoriaty,R., Peters,S.T.,
            Pruett-Miller,S.M., Zakharenko,S.S., Ginsburg,D. and Kundu,M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
REFERENCE   4  (bases 1 to 6798)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   5  (bases 1 to 6798)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    GeneRIF: Hepatic LDLR levels are up-regulated in SEC24A-deficient
            cells as a consequence of specific dependence of PCSK9, a negative
            regulator of LDLR, on SEC24A for efficient exit from the
            ensoplasmic reticulum.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6798)
  AUTHORS   Wansleeben,C., Feitsma,H., Montcouquiol,M., Kroon,C., Cuppen,E. and
            Meijlink,F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   7  (bases 1 to 6798)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163254.1, AK029139.1, CJ055291.1, BG065014.2 and AL645602.14.
            
            On Oct 14, 2006 this sequence version replaced NM_175255.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155182.1, AK029139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1353              AK163254.1         329-1681
            1354-3476           AK029139.1         1107-3229
            3477-3711           CJ055291.1         137-371
            3712-4241           BG065014.2         1-530               c
            4242-6798           AL645602.14        96458-99014         c
FEATURES             Location/Qualifiers
     source          1..6798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.28 cM"
     gene            1..6798
                     /gene="Sec24a"
                     /note="SEC24 homolog A, COPII coat complex component"
                     /db_xref="GeneID:77371"
                     /db_xref="MGI:MGI:1924621"
     exon            1..758
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1223
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1394
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1472
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1630
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1803
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1906
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2033
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2143
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2256
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2375
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2431
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2638
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2759
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2918
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3092
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3203
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3379
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3517
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3622
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3715
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3819
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..6798
                     /gene="Sec24a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4220..4225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec24a"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="Sec24a"
                     /note="major polyA site"
     regulatory      6775..6780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec24a"
                     /note="hexamer: AATAAA"
     polyA_site      6798
                     /gene="Sec24a"
                     /note="major polyA site"
ORIGIN      
        1 ctggcatagc atcggctggg ccaccagcgg tagccgagga catcggtcgt ctcaggtaat
       61 cctcagagaa tcccggaaga ggagccgggt ctctcctgtc ccacccaatc gattctaaaa
      121 atccgcacca cccctgggac tgtcagcaag gtgacgttct ccacgccggg tattttcgca
      181 gtggtgacac aggctacttc cggcgggcgg cgggagtccg tgacgtggca ggcgagtccg
      241 tgcacggtcc tccgggcccg gacacgggac tgtcaggtgc cctcggggca gctccccggg
      301 gacagagagc acggccgcag cctccagccg gaaccggaag tgccacgtgt ccccactgtg
      361 cctgcgcggc cggcggctcc gcccagggcc tccctcctct ccgggttcgg ctgctgcctc
      421 cgagcccggc gttcccagcc cagccggcct gactccggag cctctccgcg ccctggccag
      481 gtcgtggccg ccggcgggca gaagacacgg acacgccatg cctctacttt gacgtgccac
      541 cccgcgtgtt ccgcttctcc ggcctccagg tccctgccct cggttttcct gttggagctc
      601 ttaggctggg cgctgcggtc gaccccgacg gctccgtctt accctgagat ccccgggcgc
      661 catggcccag ccccggatcc ccgctgcccg cggtgccgca gctagcctcc aggcccagaa
      721 cggagccgcc tcagcctcgg ggtctcccta caccaacggt cctgtccaca atacactgat
      781 gtctccacaa gtgtcatcga gtcaaggcta tgattcgcaa cctccaggat cctaccctcg
      841 tccaatgcca gcaaagactt tgaatccatt ctctgcacag tcgaactacg gtggttctca
      901 gggatctggg cagactctta atagtccact tgtgacttcc ggtccagtac taccttcact
      961 tcatagtggt cctgttcccc gaatgccact acctacttct cagaacccag ctgctacacc
     1021 aatgccttct ggtagctttc ttcctggagc caacccaccc ccacctttga attggcaata
     1081 taactatcca tccacaggac cgcagactaa ccattttcct catgtagctc caccaactct
     1141 acctgggaat ccaaatttaa cagcggatca tcaatatgtt tcttctggag accctgcact
     1201 tcaaaccagc ttcaaaaagc caggttctgc acttccctta cagaacccac ctctgccccc
     1261 cacttttcag ccaggagctc ctcctgggcc ccctccagct ggaggcccac ctcccagccg
     1321 gggccccgcg ccccagaaaa cacctcctcg ggctgcaccc ccaccttcat ttaactcagc
     1381 tgtcaatcag gaaggtatta cgtcaaatgc caataatgga tctacggcgg ctcataatac
     1441 ttatgatgag attgaaggag gtggcttctt ggcaacacca cagcttgtta atcagaaccc
     1501 caaaacaagc cgaagtgtgg gctctgcata cccctccctg ccaccaggct accagaacag
     1561 cgcaccacct gtggctggga tgccaccacc ctccctcagt tacccaagtg gcccccaggc
     1621 ctttactcag actcccttag gtgctaatca tttaactgca agcatgagtg gattaagtct
     1681 gcatccagag ggactaagag ttgtcaatct tcttcaagaa aggaacatgc ttccttccac
     1741 accactgcag cctccagtcc caaatctgct tgaagacatc cagaaactca actgtaaccc
     1801 agagttgttc cgatgcacgc tgacgagtgt ccctcagact caggccttac tgaataaagc
     1861 caagcttcct ctggggctgc tgctccaccc cttcaaggac ctagtgcagt tgcccgtggt
     1921 cacctccagc acaattgtga gatgccgttc atgcaggact tacattaacc ctttcgtcaa
     1981 cttccttgat caaagaaggt ggaaatgtaa cttatgttat cgagtcaatg atgttcctga
     2041 agaattcatg tacaaccctt taaccagagt ttatggagaa cctcacaaaa gacctgaagt
     2101 ccagaatgct actattgagt ttatggctcc ttcagaatac atgttacgac caccacaacc
     2161 tccagtgtac ctctttgtat ttgatgtatc tcacaacgca atagaaactg gatacttgaa
     2221 ttcagtttgc cagagtttgt tagacaatct ggatctgctt cctggcaaca ctaggacaaa
     2281 aatcggtttc ataacatttg atagcactat ccatttctac agtcttcagg aaggtctctc
     2341 ccagcctcag atgctaatag tttcagatat tgacgatgtt tttatcccta tgccagagaa
     2401 cttactagta aacttaaatg aaagtaaaga gcttgttcaa gatttactga aaacgctgcc
     2461 acaaatgttt acgaagacgc tggagaccca gagtgccttg ggtcctgcac ttcaggctgc
     2521 attcaagctg atatcaccaa ctggtggtcg aatgtctgtc ttccaaacac aactcccaac
     2581 gcttggtgta ggagctctga aaccacgaga ggaacccaac caaaggtcat ctgctaagga
     2641 aatacatctg acaccatcca ctgacttcta taagaaatta gccttggact gttctgggca
     2701 gcaagcagct gttgacttat tccttctcag tggacagtat tctgatttgg cttccctagg
     2761 ctgcatctct cggtactcag cgggtagtgt gtattactat ccctcgtacc atcaccagca
     2821 caacccagtg caagtacaga aactacagaa ggaactacac aggtacctca ctcggaagat
     2881 tggatttgag gcagtcatga ggatccggtg caccaaaggt ctttccattc atactttcca
     2941 tgggaacttc ttcgtccgtt ctacagactt actgtctctt cccaatgtca acccagatgc
     3001 tgggtatgcg gtccagatgt cagtagaaga gagtctcact gacactcagc tggtttcctt
     3061 ccagtcagca ctcttatata catcaagcaa aggtgaaaga agaatccgtg tgcatacttt
     3121 gtgtttgccg gtagtttcta ccctgaatga agtctttctt ggagctgatg tgcaagcaat
     3181 ttcagggtta ttagccaata tggctgttga caggtcggtg actgccagcc tgagtgatgc
     3241 ccgggatgct ctggtgaacg ctgtcatcga ctctctctca gcttaccgct cttcagtcct
     3301 gagtggtcag cagccaggcc tcatggttcc tttctccttg aggcttttcc cactttttgt
     3361 gttggctctc ctaaaacaga aatctttcca gactgggaca agtatacgtc tagatgaacg
     3421 aatttttgcc atgtgtcaag tgaaaagcca gccattggtt cacctcatgc tcacaacaca
     3481 tcccagtttg tacagagttg acaacctctc agatgaggga gctctcaaca tcaatgacag
     3541 aaccatacct cagcccccca ttcttcagct ctcggtggag aagttgagca gagatggagc
     3601 gttcctcatg gatgcaggct cattactgat gctttgggtt ggaagaaatt gttcacagaa
     3661 ttttctcagc caagttctgg gagttcaaaa ctatgcatca attccacaga caatgacaga
     3721 tcttccagaa cttgatacac cagaatctgc cagaatagca gcgttcatct catggctcag
     3781 agaacagagg ccatttttcc cagtactcta tgtaatcagg gaggagagtc ttatgaaagc
     3841 agccttcctt cagagcttgg tagaagacag aacagagtct gcactgtcat attatgaatt
     3901 cctcctgcac atacagcagc aagtgaacaa gtgaggagtc gctggcggag ttcctgagga
     3961 tgcagtacct ttctttcctc cttaagattg tgaacaaatg tgatgatgat taagatgttt
     4021 cactgtgatt tcaactaact atagcaaaga aaggaccaca gccgagagtc agatgtgcaa
     4081 ctccaaaata ctgtattttt caaatcaaat agatgtctac acaattggaa accttttttt
     4141 ttccctttgc tgccaactat gtttgagttg ttatggattg agatgagaca atattgcaga
     4201 ggcaaagaac attttataaa ataaagactt ctgtgttctg catttctatt tctcattttt
     4261 ttatttttat gagtttttgg ctgctacatt taaaaacgtc acaagactaa gtgttttagg
     4321 gacgtttcaa gtctatcaat aatgatcttt tttaaattgg aaaatccaaa agtcagtaga
     4381 ctgtagaaaa gctggaatcc atccctttac atatctgttt ttgccccgcc cgcccccccc
     4441 cccacttcat tttgtaggga aggaaaagga tcatgttaac tgaaattgga gtacactagc
     4501 tctggtcctg cttgggaaga atataaagta aattgtcaag ctttaacatc tgtcagtatt
     4561 ttctctactt gaacaaagtc actttaattt gaggtgaaaa ctaattaggt ggttttctgc
     4621 tgttttattc tgccgtgaat aaaatttgag ctgtcttcat aaatatatca ggactggcaa
     4681 tgataatagg agctggttct gttggttcgc tgagtgggtt tttgtttggt ccatttctgc
     4741 tgtggttgat agagttaaag tattacaagc agttaaaggt tccctagatg caatcttaga
     4801 atgcatcagc gtatctctag gaagtttaag gattaaattg gaagccgttc atgtattctg
     4861 ggatattaaa accttttaag gtatgaatgc tgctgtttga gttggtggat actaagattg
     4921 tacaaatcca tcattttaaa attataaaag aaacttgatt tgttatcatg ctctaaagac
     4981 tgcttgtttt gattcagtta gagaactatt acagtcaaac tatcagatgg cttttgttta
     5041 caaataggta aattatccat gtgtatttaa agtgctatga tgtgtcttta agagtttgcc
     5101 tcagttttca caggttcatc atcttgtatg aacttcttta gtaatatttg tgtgtaatac
     5161 tcagagattt tttttttttt ttggtttttg ttttcataga ttagaaatgt gtttacaatc
     5221 tccgtctcat gtgatcacca atataatagt aacttccagg tttacaccca cacgggctga
     5281 ctgtaactcc tgggaaggga agcagcaggc ccctggagtg tacagacagc tatgcttgcc
     5341 agctgcttcc ggacaactgt gctttgtgag agtaacagtg ttagagttcc ttttcttttt
     5401 taattccaag ccacacatga tggtggcaca ggatcctaac cccagtgctt ggaaggctac
     5461 ggctacagca ggtcgattgc tagcctgggc tacatagcaa gtgccagacc agctagactt
     5521 tgtctcaaaa agacaattga aaatttttgt ttcagtgtac atatagtaca ttcaattgag
     5581 gttttttttt tttttaaact gcttcattta ttgagaagca gttttcaaac tataaccaat
     5641 taagtgtata ttatttcccc tctttttaag aaacagccat tatatacaat gttcctttaa
     5701 atgaactaaa gttttctttt taatgggatt ttaaatgtta gtatttttag gttctttctt
     5761 catagtaagg aatcttccag agggaaatgt actcctaggg aaaccttcct cgtgccttcc
     5821 ctgagtgagt ctgaccctta ttagcacctg cttggttagt atattttaca aatttacttt
     5881 taaattttat tttagatatt atattatgtg caatccagag taattttata acagttataa
     5941 aaacataact attagggttc acaactttgt tctccagaca agagaatgaa ccgttgtgga
     6001 atattgatat gattattttt ttgctatatt gaatgttttt cagttttgac tttttttttt
     6061 tttgcagtaa gacactaccc gtcctaccat cctgtattac tttctgatgt aaagcaacta
     6121 atatttacac tatgccatat tttttttatt gtagttgtaa attatgaaag atccttgaat
     6181 tttctacaga tctacaacta ctaaagtaac agacaagggc aatcttgata tataaatctg
     6241 agcatgcagt tctaccataa aaagtactct atttttctaa tttctagaat ttttaaaata
     6301 atgttcctgt aagtctgaca tactaatatt cacttacgca gtaacactta ttttagcttg
     6361 catatatttt aatttaatgt aatatactga gtctaataga ctgttttgca ataattagaa
     6421 taaaagattt acttcttcta atcagagatg cataacagct attatctagg ggaccaccaa
     6481 atgtgatttc acagttttaa ctattataaa cacaattgtt acatagaaat tttaattttg
     6541 taaagtagtg tatatgatat tgtaacatta agtccttgtt ctcaaatcaa aagtatatgt
     6601 tgacctccag tgtattgtgc tcagtcttgc tcccctgaaa tgttgagaca agattggtct
     6661 tcctttttac agattgtaat tttcactgtt ttattcctgt ttttttaaaa aaaagtcatt
     6721 tgtaacccat gcaaacaatg tttgatctgt gctaacttat aaatttggct attcaataaa
     6781 gttaatcaaa agagctta
//
