LOCUS       NP_780464               1090 aa            linear   ROD 28-APR-2025
DEFINITION  protein transport protein Sec24A isoform 1 [Mus musculus].
ACCESSION   NP_780464
VERSION     NP_780464.2
DBSOURCE    REFSEQ: accession NM_175255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1090)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1090)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1090)
  AUTHORS   Wang,B., Joo,J.H., Mount,R., Teubner,B.J.W., Krenzer,A., Ward,A.L.,
            Ichhaporia,V.P., Adams,E.J., Khoriaty,R., Peters,S.T.,
            Pruett-Miller,S.M., Zakharenko,S.S., Ginsburg,D. and Kundu,M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
REFERENCE   4  (residues 1 to 1090)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   5  (residues 1 to 1090)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    GeneRIF: Hepatic LDLR levels are up-regulated in SEC24A-deficient
            cells as a consequence of specific dependence of PCSK9, a negative
            regulator of LDLR, on SEC24A for efficient exit from the
            ensoplasmic reticulum.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1090)
  AUTHORS   Wansleeben,C., Feitsma,H., Montcouquiol,M., Kroon,C., Cuppen,E. and
            Meijlink,F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   7  (residues 1 to 1090)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163254.1, AK029139.1, CJ055291.1, BG065014.2 and AL645602.14.
            
            On Oct 14, 2006 this sequence version replaced NP_780464.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155182.1, AK029139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.28 cM"
     Protein         1..1090
                     /product="protein transport protein Sec24A isoform 1"
                     /note="protein transport protein Sec24A; SEC24-related
                     protein A; Sec24 related gene family, member A"
                     /calculated_mol_wt=118652
     Region          1..260
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U2P1.1)"
     Region          <5..367
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          272..325
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U2P1.1)"
     Region          295..1090
                     /region_name="COG5028"
                     /note="Vesicle coat complex COPII, subunit SEC24/subunit
                     SFB2/subunit SFB3 [Intracellular trafficking and
                     secretion]"
                     /db_xref="CDD:227361"
     Region          428..452
                     /region_name="Zinc finger-like"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U2P1.1)"
     Region          963..1036
                     /region_name="Gelsolin-like. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U2P1.1)"
     CDS             1..1090
                     /gene="Sec24a"
                     /coded_by="NM_175255.3:662..3934"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24660.2"
                     /db_xref="GeneID:77371"
                     /db_xref="MGI:MGI:1924621"
ORIGIN      
        1 maqpripaar gaaaslqaqn gaasasgspy tngpvhntlm spqvsssqgy dsqppgsypr
       61 pmpaktlnpf saqsnyggsq gsgqtlnspl vtsgpvlpsl hsgpvprmpl ptsqnpaatp
      121 mpsgsflpga npppplnwqy nypstgpqtn hfphvapptl pgnpnltadh qyvssgdpal
      181 qtsfkkpgsa lplqnpplpp tfqpgappgp ppaggpppsr gpapqktppr aapppsfnsa
      241 vnqegitsna nngstaahnt ydeiegggfl atpqlvnqnp ktsrsvgsay pslppgyqns
      301 appvagmppp slsypsgpqa ftqtplganh ltasmsglsl hpeglrvvnl lqernmlpst
      361 plqppvpnll ediqklncnp elfrctltsv pqtqallnka klplglllhp fkdlvqlpvv
      421 tsstivrcrs crtyinpfvn fldqrrwkcn lcyrvndvpe efmynpltrv ygephkrpev
      481 qnatiefmap seymlrppqp pvylfvfdvs hnaietgyln svcqslldnl dllpgntrtk
      541 igfitfdsti hfyslqegls qpqmlivsdi ddvfipmpen llvnlneske lvqdllktlp
      601 qmftktletq salgpalqaa fklisptggr msvfqtqlpt lgvgalkpre epnqrssake
      661 ihltpstdfy kklaldcsgq qaavdlflls gqysdlaslg cisrysagsv yyypsyhhqh
      721 npvqvqklqk elhryltrki gfeavmrirc tkglsihtfh gnffvrstdl lslpnvnpda
      781 gyavqmsvee sltdtqlvsf qsallytssk gerrirvhtl clpvvstlne vflgadvqai
      841 sgllanmavd rsvtaslsda rdalvnavid slsayrssvl sgqqpglmvp fslrlfplfv
      901 lallkqksfq tgtsirlder ifamcqvksq plvhlmltth pslyrvdnls degalnindr
      961 tipqppilql sveklsrdga flmdagsllm lwvgrncsqn flsqvlgvqn yasipqtmtd
     1021 lpeldtpesa riaafiswlr eqrpffpvly vireeslmka aflqslvedr tesalsyyef
     1081 llhiqqqvnk
//
