LOCUS       NM_001412496            2744 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus SEC23 homolog B, COPII coat complex component
            (Sec23b), transcript variant 12, mRNA.
ACCESSION   NM_001412496
VERSION     NM_001412496.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Wei,W., Liu,Z., Zhang,C., Khoriaty,R., Zhu,M. and Zhang,B.
  TITLE     A common human missense mutation of vesicle coat protein SEC23B
            leads to growth restriction and chronic pancreatitis in mice
  JOURNAL   J Biol Chem 298 (1), 101536 (2022)
   PUBMED   34954140
  REMARK    GeneRIF: A common human missense mutation of vesicle coat protein
            SEC23B leads to growth restriction and chronic pancreatitis in
            mice.
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Kim,S., Khoriaty,R., Li,L., McClune,M., Kalfa,T.A., Wu,J.,
            Peltier,D., Fujiwara,H., Sun,Y., Oravecz-Wilson,K., King,R.A.,
            Ginsburg,D. and Reddy,P.
  TITLE     ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T
            cell alloimmunity
  JOURNAL   J Clin Invest 131 (2) (2021)
   PUBMED   33463537
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Khoriaty,R., Hesketh,G.G., Bernard,A., Weyand,A.C.,
            Mellacheruvu,D., Zhu,G., Hoenerhoff,M.J., McGee,B., Everett,L.,
            Adams,E.J., Zhang,B., Saunders,T.L., Nesvizhskii,A.I.,
            Klionsky,D.J., Shavit,J.A., Gingras,A.C. and Ginsburg,D.
  TITLE     Functions of the COPII gene paralogs SEC23A and SEC23B are
            interchangeable in vivo
  JOURNAL   Proc Natl Acad Sci U S A 115 (33), E7748-E7757 (2018)
   PUBMED   30065114
  REMARK    GeneRIF: these data demonstrate an equivalent function for
            SEC23A/B, with evolutionary shifts in the transcription program
            likely accounting for the distinct phenotypes of SEC23A/B
            deficiency within and across species, a paradigm potentially
            applicable to other sets of paralogous genes.
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Khoriaty,R., Vogel,N., Hoenerhoff,M.J., Sans,M.D., Zhu,G.,
            Everett,L., Nelson,B., Durairaj,H., McKnight,B., Zhang,B.,
            Ernst,S.A., Ginsburg,D. and Williams,J.A.
  TITLE     SEC23B is required for pancreatic acinar cell function in adult
            mice
  JOURNAL   Mol Biol Cell 28 (15), 2146-2154 (2017)
   PUBMED   28539403
  REMARK    GeneRIF: Acinar Sec23b deletion results in induction of ER stress
            and increased apoptosis in the pancreas, potentially explaining the
            loss of pancreatic cells and decreased pancreatic weight. These
            findings demonstrate that SEC23B is required for normal function of
            pancreatic acinar cells in adult mice.
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Khoriaty,R., Everett,L., Chase,J., Zhu,G., Hoenerhoff,M.,
            McKnight,B., Vasievich,M.P., Zhang,B., Tomberg,K., Williams,J.,
            Maillard,I. and Ginsburg,D.
  TITLE     Pancreatic SEC23B deficiency is sufficient to explain the perinatal
            lethality of germline SEC23B deficiency in mice
  JOURNAL   Sci Rep 6, 27802 (2016)
   PUBMED   27297878
  REMARK    GeneRIF: SEC23B but not SEC23A is essential for murine pancreatic
            development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   Tao,J., Zhu,M., Wang,H., Afelik,S., Vasievich,M.P., Chen,X.W.,
            Zhu,G., Jensen,J., Ginsburg,D. and Zhang,B.
  TITLE     SEC23B is required for the maintenance of murine professional
            secretory tissues
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), E2001-E2009 (2012)
   PUBMED   22745161
  REMARK    GeneRIF: In SEC23B-deficient embryonic pancreas, defects occur in
            exocrine and endocrine tissues shortly after differentiation.
REFERENCE   7  (bases 1 to 2744)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2744)
  AUTHORS   Merte,J., Jensen,D., Wright,K., Sarsfield,S., Wang,Y., Schekman,R.
            and Ginty,D.D.
  TITLE     Sec24b selectively sorts Vangl2 to regulate planar cell polarity
            during neural tube closure
  JOURNAL   Nat Cell Biol 12 (1), 41-6 (2010)
   PUBMED   19966784
REFERENCE   9  (bases 1 to 2744)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   10 (bases 1 to 2744)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808119.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861859.4527516.1,
                                           SRR17253012.2399517.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL808119.6         139076-139138
            64-298              AL808119.6         142003-142237
            299-356             AL808119.6         144928-144985
            357-443             AL808119.6         147362-147448
            444-680             AL808119.6         149559-149795
            681-766             AL808119.6         149897-149982
            767-911             AL808119.6         150679-150823
            912-1070            AL808119.6         151412-151570
            1071-1186           AL808119.6         151896-152011
            1187-1310           AL808119.6         155275-155398
            1311-1391           AL808119.6         157463-157543
            1392-1481           AL808119.6         161128-161217
            1482-1588           AL808119.6         162093-162199
            1589-1742           AL808119.6         164740-164893
            1743-1820           AL808119.6         166487-166564
            1821-1982           AL808119.6         168394-168555
            1983-2069           AL808119.6         169170-169256
            2070-2218           AL808119.6         169669-169817
            2219-2284           AL808119.6         170298-170363
            2285-2744           AL808119.6         173082-173541
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.02 cM"
     gene            1..2744
                     /gene="Sec23b"
                     /note="SEC23 homolog B, COPII coat complex component"
                     /db_xref="GeneID:27054"
                     /db_xref="MGI:MGI:1350925"
     exon            1..63
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            64..298
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2306
                     /gene="Sec23b"
                     /note="isoform 5 is encoded by transcript variant 12;
                     protein transport protein Sec23B; SEC23-related protein B"
                     /codon_start=1
                     /product="protein transport protein Sec23B isoform 5"
                     /protein_id="NP_001399425.1"
                     /db_xref="GeneID:27054"
                     /db_xref="MGI:MGI:1350925"
                     /translation="MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTP
                     LKERPDLPPVQYEPVLCSRPTCKAILNPLCQVDYRAKLWACNFCFQRNQFPPAYAGIS
                     EVNQPAELMPQFSTIEYMIQRGARSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPP
                     DALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQEMLGLTKSAMPVQQARP
                     AQPQEQPFVSSRFLQPIHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGL
                     LEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKTPIRSWHDIEKDNARFMKKATKHYE
                     MLANRTATNGHCIDIYACALDQTGLLEMKCCPNLTGGHMVMGDSFNTSLFKQTFQRIF
                     SKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
                     CGLDPSSTLGIYFEVVNQHNAPVPQGGRGAIQFVTQYQHSSTQKRIRVTTIARNWADA
                     QSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKED
                     PTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPI
                     LYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGEPSGGRLDTRTCPSMKTSS
                     TFFRRPWMMPKKFCKHASQCHVISTQSMAAVRLGSCCLKLTHLRHTITCMPGGRKLER
                     PS"
     exon            299..356
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            357..443
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            444..680
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            681..766
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            767..911
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1070
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1186
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1310
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1391
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1481
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1588
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1742
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1820
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1982
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2069
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2218
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2284
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2744
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2707..2712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec23b"
                     /note="hexamer: AATAAA"
     polyA_site      2744
                     /gene="Sec23b"
                     /note="major polyA site"
ORIGIN      
        1 ggagttgagc tctggtgtcc gtggggcgcg gaaggttcag tcccggtgag tggctccgga
       61 cagtttcctt ttagaccatg gcaacgtatc tggaattcat tcagcagaat gaagaacgag
      121 atggtgtgcg tttcagttgg aacgtgtggc cttctagccg ccttgaagcc acaagaatgg
      181 ttgtgccctt ggcttgtctc ctcactcctt taaaagaacg cccagactta cctcctgtac
      241 agtatgaacc tgtgctttgc agtaggccta cctgcaaagc tattctcaat ccactttgtc
      301 aagtggatta ccgagcaaaa ctctgggcct gcaatttctg ttttcaaaga aatcagttcc
      361 ctccagcata tgcaggcata tctgaggtga atcaacctgc tgaattgatg ccccagttct
      421 ccacaattga gtacatgatc cagagaggtg ctcggtctcc tctgatcttt ctctatgtgg
      481 ttgacacgtg tttggaggaa gatgaccttc aagcactcaa agagtccctg cagatgtctc
      541 tgagtctcct tcctccagat gccctggttg gtctcatcac ttttgggagg atggtgcagg
      601 ttcatgagct aagctgtgaa ggaatctcca agagctatgt cttccgaggg accaaggatt
      661 taactgcaaa gcaaatacag gagatgctgg gcctgaccaa gtcagccatg cctgtgcagc
      721 aagccagacc tgctcaacct caggagcagc cttttgtttc cagcagattt ctacagccca
      781 ttcacaagat tgacatgaac ctcacagatc ttctcgggga gctgcagagg gacccatggc
      841 cagtaactca ggggaagaga ccactgcggt ccactggtgt tgctttgtcc attgctgttg
      901 gcttgttgga ggggactttc ccaaatactg gagccaggat catgctgttc actggcgggc
      961 ccccgaccca aggacctggc atggtggttg gagatgagtt gaagactcct attcgttcct
     1021 ggcacgacat tgagaaagat aacgcacgat tcatgaagaa ggcaaccaag cattatgaga
     1081 tgcttgctaa tcgaactgct acaaatggcc actgcattga tatttatgct tgtgcccttg
     1141 accaaactgg acttctggag atgaagtgct gtccaaatct tacaggaggc cacatggtga
     1201 tgggagattc tttcaacact tctcttttca agcagacatt ccaaagaatt tttagtaaag
     1261 acttcaacgg agatttcaga atggcgtttg gtgctacgtt ggatgtaaag acctctcggg
     1321 aactgaagat tgcaggagcc attggtccat gcgtgtctct gaatgtgaaa gggccatgcg
     1381 tgtcagaaaa tgagcttggt gttggtggca caagtcagtg gaagatctgt ggcctggatc
     1441 cctcatctac tcttggcatc tactttgaag ttgtcaatca gcacaatgct ccagttcccc
     1501 agggaggcag aggtgccatc cagtttgtca cacagtatca gcattccagc actcagaagc
     1561 gcatccgagt gaccaccatt gcccgcaatt gggcagatgc acagagtcag ctgaggcaca
     1621 tagaagcagc atttgaccag gaggccgcag cagtcctgat ggcacggctt ggagtgttcc
     1681 gcgcagagtc agaggagggg cctgacgtgc ttcggtggct ggatcggcaa ctcatcagac
     1741 tgtgtcagaa gtttgggcag tataacaaag aagaccctac gtctttcaga ttgtcagact
     1801 ccttttctct gtatcctcag ttcatgttcc atctgagaag atctccattt cttcaagtat
     1861 ttaacaacag tcctgatgag tcctcctatt atagacacca ttttgcccgg caggatctga
     1921 ctcagtccct cattatgatc cagcccattc tctattctta ctccttccac ggaccaccag
     1981 agcctgtact cctggacagc agtagcattc tagctgacag aattctgctg atggatactt
     2041 tcttccaaat tgtcatttac cttggtgagc ccagtggcgg aaggctggat accaggacat
     2101 gcccgagtat gaaaacttca agcaccttct tcaggcgccc ctggatgatg cccaagaaat
     2161 tctgcaagca cgcttcccaa tgccacgtta tatcaacaca gagcatggcg gcagtcaggc
     2221 tcggttcctg ttgtctaaag ttaacccatc tcagacacac aataacctgt atgcctgggg
     2281 gcaggaaact ggagcgccca tcctgacaga cgatgtcagc ctacaggtgt tcatggatca
     2341 cctgaagaag ctggctgtgt ctagtgcctc ttaagctggt ggccccgcct ggaagtggaa
     2401 gacaatgctg tcagattgtg ctcacgttgt tgatagcgtc ctagcaacat tcacctttcg
     2461 gggaggttct aataaataac ccaaggaatt tttatatatg tatgtcttca ggctataata
     2521 cgtcttcagg ttgtaattta tttgtattcc tctctgtctg ttttcctcca catgaaatta
     2581 tatgtcataa gtgtcctgct aattgtagat gtttacttac tttttgtacc ttaatgtttt
     2641 agagtctata aaatcagagg ttatgtattt ttagctacct gtttaagtct taatgatcat
     2701 aaaggaaata aatctgtgtg aggacggcat tggccaaaat aata
//
