LOCUS       NM_001355379            3056 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus SEC23 homolog B, COPII coat complex component
            (Sec23b), transcript variant 6, mRNA.
ACCESSION   NM_001355379
VERSION     NM_001355379.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Wei,W., Liu,Z., Zhang,C., Khoriaty,R., Zhu,M. and Zhang,B.
  TITLE     A common human missense mutation of vesicle coat protein SEC23B
            leads to growth restriction and chronic pancreatitis in mice
  JOURNAL   J Biol Chem 298 (1), 101536 (2022)
   PUBMED   34954140
  REMARK    GeneRIF: A common human missense mutation of vesicle coat protein
            SEC23B leads to growth restriction and chronic pancreatitis in
            mice.
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Kim,S., Khoriaty,R., Li,L., McClune,M., Kalfa,T.A., Wu,J.,
            Peltier,D., Fujiwara,H., Sun,Y., Oravecz-Wilson,K., King,R.A.,
            Ginsburg,D. and Reddy,P.
  TITLE     ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T
            cell alloimmunity
  JOURNAL   J Clin Invest 131 (2) (2021)
   PUBMED   33463537
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Khoriaty,R., Hesketh,G.G., Bernard,A., Weyand,A.C.,
            Mellacheruvu,D., Zhu,G., Hoenerhoff,M.J., McGee,B., Everett,L.,
            Adams,E.J., Zhang,B., Saunders,T.L., Nesvizhskii,A.I.,
            Klionsky,D.J., Shavit,J.A., Gingras,A.C. and Ginsburg,D.
  TITLE     Functions of the COPII gene paralogs SEC23A and SEC23B are
            interchangeable in vivo
  JOURNAL   Proc Natl Acad Sci U S A 115 (33), E7748-E7757 (2018)
   PUBMED   30065114
  REMARK    GeneRIF: these data demonstrate an equivalent function for
            SEC23A/B, with evolutionary shifts in the transcription program
            likely accounting for the distinct phenotypes of SEC23A/B
            deficiency within and across species, a paradigm potentially
            applicable to other sets of paralogous genes.
REFERENCE   4  (bases 1 to 3056)
  AUTHORS   Khoriaty,R., Vogel,N., Hoenerhoff,M.J., Sans,M.D., Zhu,G.,
            Everett,L., Nelson,B., Durairaj,H., McKnight,B., Zhang,B.,
            Ernst,S.A., Ginsburg,D. and Williams,J.A.
  TITLE     SEC23B is required for pancreatic acinar cell function in adult
            mice
  JOURNAL   Mol Biol Cell 28 (15), 2146-2154 (2017)
   PUBMED   28539403
  REMARK    GeneRIF: Acinar Sec23b deletion results in induction of ER stress
            and increased apoptosis in the pancreas, potentially explaining the
            loss of pancreatic cells and decreased pancreatic weight. These
            findings demonstrate that SEC23B is required for normal function of
            pancreatic acinar cells in adult mice.
REFERENCE   5  (bases 1 to 3056)
  AUTHORS   Khoriaty,R., Everett,L., Chase,J., Zhu,G., Hoenerhoff,M.,
            McKnight,B., Vasievich,M.P., Zhang,B., Tomberg,K., Williams,J.,
            Maillard,I. and Ginsburg,D.
  TITLE     Pancreatic SEC23B deficiency is sufficient to explain the perinatal
            lethality of germline SEC23B deficiency in mice
  JOURNAL   Sci Rep 6, 27802 (2016)
   PUBMED   27297878
  REMARK    GeneRIF: SEC23B but not SEC23A is essential for murine pancreatic
            development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3056)
  AUTHORS   Tao,J., Zhu,M., Wang,H., Afelik,S., Vasievich,M.P., Chen,X.W.,
            Zhu,G., Jensen,J., Ginsburg,D. and Zhang,B.
  TITLE     SEC23B is required for the maintenance of murine professional
            secretory tissues
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), E2001-E2009 (2012)
   PUBMED   22745161
  REMARK    GeneRIF: In SEC23B-deficient embryonic pancreas, defects occur in
            exocrine and endocrine tissues shortly after differentiation.
REFERENCE   7  (bases 1 to 3056)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3056)
  AUTHORS   Merte,J., Jensen,D., Wright,K., Sarsfield,S., Wang,Y., Schekman,R.
            and Ginty,D.D.
  TITLE     Sec24b selectively sorts Vangl2 to regulate planar cell polarity
            during neural tube closure
  JOURNAL   Nat Cell Biol 12 (1), 41-6 (2010)
   PUBMED   19966784
REFERENCE   9  (bases 1 to 3056)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   10 (bases 1 to 3056)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808119.6.
            
            On Oct 3, 2022 this sequence version replaced NM_001355379.1.
            
            Transcript Variant: This variant (6) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2, 3, 4,
            6, and 7 all encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.1627969.1,
                                           SRR7345562.2292110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AL808119.6         139076-139443
            369-603             AL808119.6         142003-142237
            604-661             AL808119.6         144928-144985
            662-748             AL808119.6         147362-147448
            749-985             AL808119.6         149559-149795
            986-1071            AL808119.6         149897-149982
            1072-1216           AL808119.6         150679-150823
            1217-1375           AL808119.6         151412-151570
            1376-1491           AL808119.6         151896-152011
            1492-1615           AL808119.6         155275-155398
            1616-1696           AL808119.6         157463-157543
            1697-1786           AL808119.6         161128-161217
            1787-1893           AL808119.6         162093-162199
            1894-2047           AL808119.6         164740-164893
            2048-2125           AL808119.6         166487-166564
            2126-2287           AL808119.6         168394-168555
            2288-2374           AL808119.6         169170-169256
            2375-2530           AL808119.6         169662-169817
            2531-2596           AL808119.6         170298-170363
            2597-3056           AL808119.6         173082-173541
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.02 cM"
     gene            1..3056
                     /gene="Sec23b"
                     /note="SEC23 homolog B, COPII coat complex component"
                     /db_xref="GeneID:27054"
                     /db_xref="MGI:MGI:1350925"
     exon            1..368
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            369..603
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2686
                     /gene="Sec23b"
                     /note="isoform 1 is encoded by transcript variant 6;
                     protein transport protein Sec23B; SEC23-related protein B"
                     /codon_start=1
                     /product="protein transport protein Sec23B isoform 1"
                     /protein_id="NP_001342308.1"
                     /db_xref="CCDS:CCDS16822.1"
                     /db_xref="GeneID:27054"
                     /db_xref="MGI:MGI:1350925"
                     /translation="MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTP
                     LKERPDLPPVQYEPVLCSRPTCKAILNPLCQVDYRAKLWACNFCFQRNQFPPAYAGIS
                     EVNQPAELMPQFSTIEYMIQRGARSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPP
                     DALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQEMLGLTKSAMPVQQARP
                     AQPQEQPFVSSRFLQPIHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGL
                     LEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKTPIRSWHDIEKDNARFMKKATKHYE
                     MLANRTATNGHCIDIYACALDQTGLLEMKCCPNLTGGHMVMGDSFNTSLFKQTFQRIF
                     SKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
                     CGLDPSSTLGIYFEVVNQHNAPVPQGGRGAIQFVTQYQHSSTQKRIRVTTIARNWADA
                     QSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKED
                     PTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPI
                     LYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYEN
                     FKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQET
                     GAPILTDDVSLQVFMDHLKKLAVSSAS"
     exon            604..661
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            662..748
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            749..985
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1071
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1216
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1375
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1491
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1615
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1696
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1786
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1893
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2047
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2125
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2287
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2374
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2530
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2596
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..3056
                     /gene="Sec23b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec23b"
                     /note="hexamer: AATAAA"
     polyA_site      3056
                     /gene="Sec23b"
                     /note="major polyA site"
ORIGIN      
        1 ggagttgagc tctggtgtcc gtggggcgcg gaaggttcag tcccggtgag tggctccgga
       61 caggtgagcg gctggctctg caatggtgaa ggggcgcata ggaggagggc cgaagccaga
      121 caggccgagg caaggtgggc ttgcttatgg gaagaatcag agagagttga tgacccagaa
      181 gccggctcag agtgactcgt ccgcgccgtg cctgagagcc gacggccggt ttctgactcc
      241 ttagccctcg gaattggggt gttggtggtg gtgactcgaa catccggaag gaccgaatcc
      301 ccatgaaaac cttgagtttt gctttgtgat aagtgaaacc agaaaccaga tcttcagtac
      361 aggattagtt tccttttaga ccatggcaac gtatctggaa ttcattcagc agaatgaaga
      421 acgagatggt gtgcgtttca gttggaacgt gtggccttct agccgccttg aagccacaag
      481 aatggttgtg cccttggctt gtctcctcac tcctttaaaa gaacgcccag acttacctcc
      541 tgtacagtat gaacctgtgc tttgcagtag gcctacctgc aaagctattc tcaatccact
      601 ttgtcaagtg gattaccgag caaaactctg ggcctgcaat ttctgttttc aaagaaatca
      661 gttccctcca gcatatgcag gcatatctga ggtgaatcaa cctgctgaat tgatgcccca
      721 gttctccaca attgagtaca tgatccagag aggtgctcgg tctcctctga tctttctcta
      781 tgtggttgac acgtgtttgg aggaagatga ccttcaagca ctcaaagagt ccctgcagat
      841 gtctctgagt ctccttcctc cagatgccct ggttggtctc atcacttttg ggaggatggt
      901 gcaggttcat gagctaagct gtgaaggaat ctccaagagc tatgtcttcc gagggaccaa
      961 ggatttaact gcaaagcaaa tacaggagat gctgggcctg accaagtcag ccatgcctgt
     1021 gcagcaagcc agacctgctc aacctcagga gcagcctttt gtttccagca gatttctaca
     1081 gcccattcac aagattgaca tgaacctcac agatcttctc ggggagctgc agagggaccc
     1141 atggccagta actcagggga agagaccact gcggtccact ggtgttgctt tgtccattgc
     1201 tgttggcttg ttggagggga ctttcccaaa tactggagcc aggatcatgc tgttcactgg
     1261 cgggcccccg acccaaggac ctggcatggt ggttggagat gagttgaaga ctcctattcg
     1321 ttcctggcac gacattgaga aagataacgc acgattcatg aagaaggcaa ccaagcatta
     1381 tgagatgctt gctaatcgaa ctgctacaaa tggccactgc attgatattt atgcttgtgc
     1441 ccttgaccaa actggacttc tggagatgaa gtgctgtcca aatcttacag gaggccacat
     1501 ggtgatggga gattctttca acacttctct tttcaagcag acattccaaa gaatttttag
     1561 taaagacttc aacggagatt tcagaatggc gtttggtgct acgttggatg taaagacctc
     1621 tcgggaactg aagattgcag gagccattgg tccatgcgtg tctctgaatg tgaaagggcc
     1681 atgcgtgtca gaaaatgagc ttggtgttgg tggcacaagt cagtggaaga tctgtggcct
     1741 ggatccctca tctactcttg gcatctactt tgaagttgtc aatcagcaca atgctccagt
     1801 tccccaggga ggcagaggtg ccatccagtt tgtcacacag tatcagcatt ccagcactca
     1861 gaagcgcatc cgagtgacca ccattgcccg caattgggca gatgcacaga gtcagctgag
     1921 gcacatagaa gcagcatttg accaggaggc cgcagcagtc ctgatggcac ggcttggagt
     1981 gttccgcgca gagtcagagg aggggcctga cgtgcttcgg tggctggatc ggcaactcat
     2041 cagactgtgt cagaagtttg ggcagtataa caaagaagac cctacgtctt tcagattgtc
     2101 agactccttt tctctgtatc ctcagttcat gttccatctg agaagatctc catttcttca
     2161 agtatttaac aacagtcctg atgagtcctc ctattataga caccattttg cccggcagga
     2221 tctgactcag tccctcatta tgatccagcc cattctctat tcttactcct tccacggacc
     2281 accagagcct gtactcctgg acagcagtag cattctagct gacagaattc tgctgatgga
     2341 tactttcttc caaattgtca tttaccttgg tgagaccata gcccagtggc ggaaggctgg
     2401 ataccaggac atgcccgagt atgaaaactt caagcacctt cttcaggcgc ccctggatga
     2461 tgcccaagaa attctgcaag cacgcttccc aatgccacgt tatatcaaca cagagcatgg
     2521 cggcagtcag gctcggttcc tgttgtctaa agttaaccca tctcagacac acaataacct
     2581 gtatgcctgg gggcaggaaa ctggagcgcc catcctgaca gacgatgtca gcctacaggt
     2641 gttcatggat cacctgaaga agctggctgt gtctagtgcc tcttaagctg gtggccccgc
     2701 ctggaagtgg aagacaatgc tgtcagattg tgctcacgtt gttgatagcg tcctagcaac
     2761 attcaccttt cggggaggtt ctaataaata acccaaggaa tttttatata tgtatgtctt
     2821 caggctataa tacgtcttca ggttgtaatt tatttgtatt cctctctgtc tgttttcctc
     2881 cacatgaaat tatatgtcat aagtgtcctg ctaattgtag atgtttactt actttttgta
     2941 ccttaatgtt ttagagtcta taaaatcaga ggttatgtat ttttagctac ctgtttaagt
     3001 cttaatgatc ataaaggaaa taaatctgtg tgaggacggc attggccaaa ataata
//
