LOCUS       NM_009147               4108 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SEC23 homolog A, COPII coat complex component
            (Sec23a), transcript variant 1, mRNA.
ACCESSION   NM_009147
VERSION     NM_009147.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4108)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4108)
  AUTHORS   Zeng,B., Sun,Z., Zhao,Q., Liu,D., Chen,H., Li,X., Xing,H.R. and
            Wang,J.
  TITLE     SEC23A Inhibit Melanoma Metastatic through Secretory PF4
            Cooperation with SPARC to Inhibit MAPK Signaling Pathway
  JOURNAL   Int J Biol Sci 17 (12), 3000-3012 (2021)
   PUBMED   34421345
  REMARK    GeneRIF: SEC23A Inhibit Melanoma Metastatic through Secretory PF4
            Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4108)
  AUTHORS   Kim,S., Khoriaty,R., Li,L., McClune,M., Kalfa,T.A., Wu,J.,
            Peltier,D., Fujiwara,H., Sun,Y., Oravecz-Wilson,K., King,R.A.,
            Ginsburg,D. and Reddy,P.
  TITLE     ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T
            cell alloimmunity
  JOURNAL   J Clin Invest 131 (2) (2021)
   PUBMED   33463537
REFERENCE   4  (bases 1 to 4108)
  AUTHORS   Ariyasu,D., Kubo,E., Higa,D., Shibata,S., Takaoka,Y., Sugimoto,M.,
            Imaizumi,K., Hasegawa,T. and Araki,K.
  TITLE     Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly
            Inherited GH Deficiency in Humanized GH1 Mouse Models
  JOURNAL   Endocrinology 160 (11), 2673-2691 (2019)
   PUBMED   31436800
REFERENCE   5  (bases 1 to 4108)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4108)
  AUTHORS   Volta,M., Bulfone,A., Gattuso,C., Rossi,E., Mariani,M.,
            Consalez,G.G., Zuffardi,O., Ballabio,A., Banfi,S. and Franco,B.
  TITLE     Identification and characterization of CDS2, a mammalian homolog of
            the Drosophila CDP-diacylglycerol synthase gene
  JOURNAL   Genomics 55 (1), 68-77 (1999)
   PUBMED   9889000
REFERENCE   7  (bases 1 to 4108)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 4108)
  AUTHORS   Paccaud,J.P., Reith,W., Carpentier,J.L., Ravazzola,M., Amherdt,M.,
            Schekman,R. and Orci,L.
  TITLE     Cloning and functional characterization of mammalian homologues of
            the COPII component Sec23
  JOURNAL   Mol Biol Cell 7 (10), 1535-1546 (1996)
   PUBMED   8898360
REFERENCE   9  (bases 1 to 4108)
  AUTHORS   Carding,S.R., Allan,W., McMickle,A. and Doherty,P.C.
  TITLE     Activation of cytokine genes in T cells during primary and
            secondary murine influenza pneumonia
  JOURNAL   J Exp Med 177 (2), 475-482 (1993)
   PUBMED   8426116
REFERENCE   10 (bases 1 to 4108)
  AUTHORS   Wadhwa,R., Kaul,S.C., Komatsu,Y., Ikawa,Y., Sarai,A. and
            Sugimoto,Y.
  TITLE     Identification and differential expression of yeast SEC23-related
            gene (Msec23) in mouse tissues
  JOURNAL   FEBS Lett 315 (2), 193-196 (1993)
   PUBMED   8417978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034610.1, AK028152.1 and BY760439.1.
            
            On Jun 17, 2005 this sequence version replaced NM_009147.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034610.1, SRR1660817.242512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2703              BC034610.1         1-2703
            2704-3692           AK028152.1         2592-3580
            3693-4108           BY760439.1         264-679
FEATURES             Location/Qualifiers
     source          1..4108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 25.97 cM"
     gene            1..4108
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="SEC23 homolog A, COPII coat complex component"
                     /db_xref="GeneID:20334"
                     /db_xref="MGI:MGI:1349635"
     exon            1..172
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            173..418
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2495
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="SEC23-related protein A"
                     /codon_start=1
                     /product="protein transport protein Sec23A"
                     /protein_id="NP_033173.2"
                     /db_xref="CCDS:CCDS25931.1"
                     /db_xref="GeneID:20334"
                     /db_xref="MGI:MGI:1349635"
                     /translation="MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTP
                     LKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGIS
                     ELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCIEDEDLQALKESMQMSLSLLPP
                     TALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGP
                     QVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLE
                     CTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKYVKKGTKHFEAL
                     ANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTK
                     DIHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICG
                     LSPTTTLAIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSSGQRRIRVTTIARNWADAQT
                     QIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPN
                     SFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILY
                     AYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFR
                     HLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGA
                     PILTDDVSLQVFMDHLKKLAVSSAA"
     exon            419..476
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            477..563
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            564..800
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            801..880
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1025
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1184
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1300
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1424
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1505
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1595
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1702
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1856
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1934
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2096
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2183
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2339
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2405
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..4108
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3626..3631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="hexamer: AATAAA"
     polyA_site      3655
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="major polyA site"
     regulatory      3681..3686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="hexamer: AATAAA"
     polyA_site      3703
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="major polyA site"
     regulatory      3725..3730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
                     /note="hexamer: AGTAAA"
     polyA_site      3753
                     /gene="Sec23a"
                     /gene_synonym="Msec23; Sec23r"
ORIGIN      
        1 cccctttgac gtggcagagg cggcaccagc catgttgtcc tggcccaggc cctccaagag
       61 gccgggggcg gggcggggcc gcccctgatt gcggtgccac ggctgctaca gggctttgga
      121 gcggactgac gactgtgcaa ggcggaggct gtggccgtca cggagcttct agacagaaat
      181 aagaatcaag tgctaccatg acaacctatt tggaatttat ccaacaaaat gaagaacgag
      241 atggggtccg gttcagttgg aatgtttggc catcgagtcg tctggaagct acaagaatgg
      301 ttgtcccagt ggcagccctg tttacacctc tgaaggagag acccgaccta ccacccatcc
      361 agtacgagcc tgtcctgtgc agtaggacca cttgccgtgc agttttgaat cctttatgcc
      421 aagtggatta tcgagcaaaa ctctgggctt gcaacttttg ttaccaaagg aatcagtttc
      481 cacctacata tgctgggata tctgaattga accagcctgc agagctttta cctcagtttt
      541 caagcattga atatgtagtt ctgcgtggtc cccagatgcc tttgatattt ctctatgtgg
      601 ttgatacttg catagaagat gaggatttgc aggctctgaa ggagtccatg cagatgtcgt
      661 tgagcctttt gccacctaca gctttggttg gacttattac ctttgggaga atggtgcagg
      721 ttcatgagct tggatgcgaa ggcatctcaa agagctatgt cttcagagga acaaaggatc
      781 tgtctgccaa acaactgcag gaaatgctgg gactctctaa agtacctgtt actcaagcca
      841 cacgcggtcc tcaggtacag caaccgcctc cttccaatag attcttacag ccagtacaga
      901 aaatagacat gaatctcaca gatcttctgg gagaacttca gcgagaccct tggcctgtac
      961 cacaaggaaa gagaccgctg cgttcctcag gagtggcgct ttccatagct gtgggactgc
     1021 ttgagtgtac tttccccaac actggtgctc ggatcatgat gttcatcggt ggtcctgcta
     1081 cccaggggcc tggcatggtg gtgggagatg agctaaagac acctataaga tcctggcacg
     1141 acattgagaa ggacaatgcc aaatatgtta aaaagggaac taagcatttt gaagcgttgg
     1201 ctaatcgagc tgctacaacg gggcatgtca ttgatatcta cgcctgtgcg ttggaccaga
     1261 caggcctgct ggagatgaag tgctgtccta accttactgg aggatacatg gtaatgggtg
     1321 actctttcaa tacttcctta ttcaagcaaa cttttcaaag agtcttcacc aaagatatac
     1381 atggccagtt taaaatgggc tttggtggca cattagaaat aaagacttca agggaaataa
     1441 agatttcagg agctattgga ccctgtgtgt ctcttaattc aaaaggacct tgcgtgtctg
     1501 aaaatgagat tggaacagga ggcacttgtc agtggaaaat ctgtggcctc agccccacca
     1561 caaccttagc catatatttt gaagttgtta atcagcataa tgctccaatt cctcaaggag
     1621 gacgaggtgc agtccaattt gtgacccagt atcagcactc aagtggccag agacgcatcc
     1681 gagtgaccac aattgctagg aactgggcag atgctcaaac tcaaatccaa aatattgctg
     1741 catcttttga ccaggaagca gctgccattc tcatggccag gctggcaata tacagagcag
     1801 aaacagagga agggccagac gtgctaagat ggttggacag acaactcatt cgactgtgtc
     1861 aaaaatttgg agagtatcac aaagatgatc caaattcctt ccggttttca gaaacatttt
     1921 ctctttatcc tcagtttatg tttcatttaa gaagatctcc tttcttgcaa gtttttaaca
     1981 atagtcctga tgagagttca tactatcgtc accatttcat gcgtcaggat ctgacccagt
     2041 ctctgatcat gattcagccc attctgtacg cctactcctt cagtggcccg ccagagccag
     2101 ttcttctaga cagcagcagc attcttgcag atcggattct cctcatggac acgttcttcc
     2161 agattttgat ttatcacggt gagactatag cacagtggcg gaagtcagga taccaggaca
     2221 tgccagaata tgagaatttc cggcaccttc tgcaagcccc agtagatgat gcacaagaga
     2281 ttcttcactc cagatttcca atgccgagat acattgacac ggagcatggt ggcagccagg
     2341 ctcgtttcct cctttcgaaa gtcaaccctt cacagactca taataacatg tatgcctggg
     2401 ggcaggagtc cggagcacca attctcacgg atgatgttag cttacaagtg ttcatggatc
     2461 atttgaagaa acttgcagtg tcgagtgctg cttgacatgc cagatgtgtc agacactcaa
     2521 ctgacattac tactttagtt ccttttgctt ttttcattta tctgtggaaa caacagaggt
     2581 ctctctctaa acctgttttg tgtcagtttg gtgtgaggtg acatggaaaa atgttgatga
     2641 ttgtagatta agctgaaaca tataatgaga gcaatgagaa caagtttgtt ttgcctgata
     2701 cagtattata attggttttg taactttgaa gtcttgtatg atttaattat gtttaatgag
     2761 ttagaatggt ttgctttgta ttacagatac cacttatttg tatactgcag acagctctag
     2821 agtggcactg ggcatcctcc ctgacctgtt aggggttatt taataagagc caggaacaaa
     2881 tcaatagtga tgatatatgg ctagtttgct ttttttgtga agtaattttc tggttttctt
     2941 tttagcatac attgtatatg ccattctgta ttttgttaaa ttggatttat tttatggctt
     3001 aagaattatt tgactttata gtagcaattt tttgttaagg taatttaata tttttggtta
     3061 tttaaaaaaa ttatttagag ctaaaaaatt tgagtgaggt aataaaccca cagcagacat
     3121 taaatgtgaa attcccacag agagcccaac tcacattact aactagagta attttttaaa
     3181 gaaggacgtt ctcactacta accatatctt tttttttgtt ttatcattta ttgtttccct
     3241 tcttagataa tttcccattg tgttcttcag tattttaaca ctattctagg agttttcact
     3301 tcactctttg tttctgtttc cttgtgaatt tatgaatttg tggttcttac tgagacagta
     3361 ttaatataat gtttaattat gtcatgtgga gatggttctg tttgatttat tgattagtat
     3421 cattcacttt taccttttaa agtttacttg tagcaagtgt ttacattgct gagcagataa
     3481 gtctgacaat gaaatgtatg tatcaagtgc tgcacatgta agggtgctct ggtgggcgca
     3541 gcagtgggga ctgactgcac ccgcatgaac acaatcagac gacggcgaag cagaaacgta
     3601 aattgttatt atactcaact atctaaataa attactttgt tctgttttat ttgaattgaa
     3661 ctgtgctagg ccaaaatgcc aataaaatat acctttctct gttttcttag ttattttaaa
     3721 atctagtaaa agcctgggaa acatcatgta aaataagagt gctttttttg ttttttttgt
     3781 ttttgccagg gcttcattac gttactctgg ctgtcctgga gctcattagt agaccagggt
     3841 gacctcatgc tcacagagat ctgcatccct ccctggtggt gggattaaag gcatgcatca
     3901 ccacactggg cctacatttt ttgattggca cacagctgta caaatgtatt agtacaatgt
     3961 gataattcaa tacctgttca tagaaatggt cagattacct taattagtgt tttcatttct
     4021 tctaaacaac attgctttgt gttggaaact ttcagacctt tctctcttaa ttcttataaa
     4081 aatatgcaat aaattgttgt aaactgcc
//
