LOCUS       NM_001164562            5676 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus SEC22 homolog C, vesicle trafficking protein (Sec22c),
            transcript variant 2, mRNA.
ACCESSION   NM_001164562
VERSION     NM_001164562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5676)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044249.1, BC046289.1, AC159810.2 and CJ247427.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044249.1, SRR9219380.47745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK044249.1         1-45
            46-2656             BC046289.1         1-2611
            2657-5289           AC159810.2         53393-56025
            5290-5676           CJ247427.1         127-513
FEATURES             Location/Qualifiers
     source          1..5676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.54 cM"
     gene            1..5676
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /note="SEC22 homolog C, vesicle trafficking protein"
                     /db_xref="GeneID:215474"
                     /db_xref="MGI:MGI:2447871"
     exon            1..106
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     exon            107..315
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1045
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /note="SEC22 vesicle trafficking protein-like 3; SEC22
                     vesicle trafficking protein-like C; SEC22 vesicle
                     trafficking protein homolog C"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22c"
                     /protein_id="NP_001158034.1"
                     /db_xref="CCDS:CCDS23634.1"
                     /db_xref="GeneID:215474"
                     /db_xref="MGI:MGI:2447871"
                     /translation="MSMILFASIVRVRDGLPLSASTDFYYAQEFLECRRQLKTLAQRL
                     ARHPGRGCAESCDFLIYFSSSGDVACMAICSRQCPAAMAFCFLEALWWDFIASYDTTC
                     VGLASRPYAFLEFDSVIQKTKWHFNHMSSSQMKSGLEKIQEELEFQPPAVLSLEDTDV
                     ANGMLNGHTPVHSEPAPNLRMKPVTALGVLSLVLNIMCAALNLIRGVHLAEHSLQVAQ
                     EEVGNILAFFIPSVACIVQCYLYLFYSPARTLKVLLMLASICLGNAYLHGLRNTWQIL
                     FHVGVAFLSSYQILTRQLQERQSDYGV"
     exon            316..479
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..659
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..778
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..844
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..5658
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5636..5641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /note="hexamer: AATAAA"
     polyA_site      5658
                     /gene="Sec22c"
                     /gene_synonym="4932412K21; 5930407I15Rik; C530046H07;
                     Sec22l3"
                     /note="major polyA site"
ORIGIN      
        1 gagcaccaca tcctgcctcc tacagccggg ccgcgggtaa cctgcacccc gccggccgcc
       61 ggggtgggct gcggtggccg aggcggaggt cggccgcggg ggcgaggtgt ccccatgact
      121 tctctctcgg accatgtcca tgatcctttt tgccagcatc gtacgggtga gggatggact
      181 gcccctctca gcctccactg acttttacta cgcccaggag tttctggaat gcaggaggca
      241 gctcaagacc ttagcccaga ggctggcccg gcatccaggc cgaggctgtg cggaaagttg
      301 tgacttcctt atctattttt catcatcggg ggacgtggcc tgcatggcca tctgctcgcg
      361 ccagtgcccg gcagccatgg ccttctgctt cttggaggct ctgtggtggg acttcatagc
      421 ttcctacgac accacctgcg ttggcctggc ctcccggcct tacgcctttc ttgagtttga
      481 cagtgtcatt cagaaaacaa agtggcattt taaccacatg agctcctccc agatgaagag
      541 tggcttagaa aagatccaag aggagctcga gttccagcct ccagcagtcc tgtccctaga
      601 ggacacagat gtggcaaatg gcatgctgaa cggccacacc ccagtgcact ctgagcctgc
      661 tccgaacctc cggatgaagc cggtgacagc cctgggtgtc ctctcccttg ttctcaacat
      721 catgtgcgcg gccctgaacc tcatccgtgg agttcacctc gcagagcatt ctttacaggt
      781 tgcccaagag gaagttggaa acatcctggc tttctttatt ccttctgtgg cctgcatcgt
      841 ccagtgttat ctgtacctgt tctacagtcc agcccggacg ctgaaggtgc tgctgatgct
      901 ggcctccatc tgcctgggca atgcgtacct gcacgggctg aggaacacct ggcaaatcct
      961 cttccacgta ggagtggctt ttctgtcttc atatcagatc ctgaccagac agctgcagga
     1021 gaggcaatct gactatggag tgtgatgagg gcatcctgca gtagatggcg cctttgactt
     1081 tcccccctct ggaaggccag tctgtgtcca ctcctgcttc tcagcttcac ctcaaccctc
     1141 catccttgac gctcccaagg tcacagattc tggcaggtgc atcggagggc ccgggctgct
     1201 ggttgccagt cctggtctgt atggaacgtt tgtgcagagc tgccagccga gctaggacag
     1261 ggcggctgga gcaggagctt gctcagagag catctgtgat ggtcagagtg gcggtatcgt
     1321 gtcctcctaa atctaatgat aactgcagac cactagattc cacaatggta gacttagtaa
     1381 ctggcagggt gtctgtgagg aaactcttca atgttggcgt cagtttgcgg gttcagtgta
     1441 attcagtttt ccttacggtg tcagcacagg gtaaattaaa gcttgagagt acggttcaca
     1501 aacacaagct aggtaaattt tgtttatgtt tttgataact tgggttcgat aaacttttgg
     1561 aatatttaaa tatattttgg atataaattg aagctcattc agaatgaagc aaacttaggc
     1621 tgagaaaatg ctaaggaaat ccgagtttat ttaaattaca gagacctttt atggtggtgg
     1681 ggctttatgg ataccagtgt ggtttatatt tatttgcaga gcctatctga attatgtacg
     1741 tatggattaa taaccagtat cactggatca taagcacata ggcacaagca gatgcggggg
     1801 cttcagggtc ctcttagagg ggccgagtgg agagagaaag gccagggttt cagagatcct
     1861 tagcagaaat gggggaggct gctgttctct gcctttgttg tggcagctgg gtgctcgcca
     1921 ctgtagcatt gctggagatg tggccctgtg cacctcctcc tagagagact tcccaagtta
     1981 attactgccc caaacctctc ttgagcacct aattagagca cggggcctca ttttatggac
     2041 aggtattaag taggtgttaa cactcaaaag ctttgtgtaa ctggcacttc tctgtaaagc
     2101 tgctacggct tgcttctggg taagagcccc cgtatctcca gtgtgggtat ctggtggtac
     2161 tcaagaaacc atgttggggt tcacccctct agcttgttct tggaatatac ccaaaatttc
     2221 atgggttgac tcatgaggct ccacaagtga taaaccctgt tttggtagtt ttaaaaggag
     2281 aatcctgtta aaattgttgg ctgttactgg taccctatgt taatcagcca ccaggtgtca
     2341 tttcaggaac gaggctatgt gactcaagaa ctggattgaa aaagtatctc cattttaatt
     2401 ttctttcctt ataagagaat tttctatttt taatcaaatc tttattgtct gggtatgaat
     2461 gtcgtattgg cagcttcctc ggacgtgaac ttcagcctca cgtcaatgtt gatctcacgt
     2521 acgttcgtgt ctactgtaca ggcaaatgct cactcttcct gacacagaat tttgaagtgg
     2581 gaaagaggaa agcagaagag gaagaaaatt cttttaattc aaagcacaca ttcaaaaaaa
     2641 aatttttttt aagtaattaa aaaaaaaaag tcagcctaaa actgtattgt tttcctcctg
     2701 atcctgtgtg gttctctgtt gctctagatc tggacaccgc acacactcta gggtctgagc
     2761 ctgtggttgt tactgacact ttacacttcg taaatgctag tgggagtgtt acctgtgctt
     2821 ggtgacacgg ctcgggactt atcatccaga cagggttcca tactgattct tacaagtgga
     2881 aggaaaaggc gtcctgaagg gaaacgatgc accgactgac agagtccagc ctagagaagc
     2941 ctcacctccc tggaggaggg cagggaagac agacgcccca gagacagaca ccctggggct
     3001 tcaggtacgg tgggtggttc aggattaggt atttgtagcc cagtgggatt cttgatgcca
     3061 ggacaatctg gttccaaggc aggcgtgttt ctttgcctgt cgctggctgc tcttccggag
     3121 gatgctgctt gcccagcagc tcacaggaac cggtgcagac agcctaaacg gaaggtgctt
     3181 tcctgttcgg tgccacctgt ctgctgttag ccggtgagcg ggcttaggca gaaggctttt
     3241 gggttgggtt gctttttact cagccagcct caccttgacc ggaactctac ctggcactcc
     3301 ccttttggag tggaggcagc tgggccatct gaggtcgact tccccctcag tcccagatgc
     3361 tgcacagacc ccaccggagt agtagggttg tggttcttgc tatccgtgaa ccctgtcgac
     3421 gtgcgtgtgg gcctcttcct ttcttttcta gtcaccatgt gctccacctc ccctacctgt
     3481 ttccgcccac ctcctacatt cctgcctcca gatggagatg caggctagag tctgtggaga
     3541 gacagaagcc tcccatcagt gatggagagg gaggcagctt tggaatccca tcctctgccc
     3601 caccttggct cagtactcag gggaagcagc gctttggtcg tcagcactgc ttggggtcaa
     3661 gggccatagc cagcaggccg aagcaggtgg ctatctggag cataggagtt ggcctgaggt
     3721 ggggaagaga agtggctgtc cgtctgtagg tgccctgggt gtgtggaggg ctgcatgcct
     3781 cactctcatt cagtccttta ctgtgctgct tcccgaggga gccgcctgta acagcaacac
     3841 ttccagctct ctactgtgtg tttgacaggg atgacatgtg tctgaggctg tacatggcca
     3901 ggggtactgt cagctgtgtc cagcaaacac ttggctaaac tgttgcttgc atctgactgt
     3961 ctctcccagg tcgggggggc cactctgcct gtgtgccgta agagcccaga atggtggaga
     4021 aagagaaacc agggtgccct tgagagatga ggtgggggaa aggaacacac aggtcagcca
     4081 acccagtgga ctggaggtca gcttggttct tccactcagg cctgggttac agtagaagtc
     4141 cctgcctgcg ctcctcagtg cccttagtga ggattgtggg tggtcacaga ggggactgtt
     4201 gtacatgtac aggaagaaag ggttacaagg cctctgggtg tgtgcagcag gcagcaggct
     4261 gcactagtgt tcgagcatcg acacagtggc atttcatgtg gctgcagtac gtaaggcccc
     4321 atgccttcat cccagaaagg aaacggcccc tttcattccc ggggctgcct cgtggtttct
     4381 gtgcaaggag cccctgatac agtcagcacc agcagacctg cttcaggatc caagaaagct
     4441 ggctttgtag gctgtcttca gtctcaacaa ggaaaggccc tatgccccac cacgcctggc
     4501 taacagaatg gggctatcac tcctcctcct cctcctcctc ctcctcctct tcctcctcct
     4561 cctcctcctc ttcctcctct tcttcctctt cctcctcctc ttcttcctcc tcctcctcct
     4621 cttcttcttc ttcttcctct tcttcctcct ctttttcctc cttttcctcc tcctcctttt
     4681 cctccttttc ctcctcctcc ttttcccctt ttccttttcc tccttttcct cctcctcctc
     4741 ttcccccttt tcctcttctt cctctctctt cttcctcctc ctcctcctct tcctcctcct
     4801 cctcctcttc ctcctcctcc tcttcctcct cttcttcctc ttcttcttcc tcctcttctt
     4861 cctcctcctc ttcctcctct tcctcctcct cttcctcttc ctcctcctcc tcttcctttt
     4921 gttttctttt gttttgtttt tcaatacagg gtttctccag ccttggctgt cctgaaactt
     4981 gctctgtaga tcaggctggc cttgaactca cagaggtcca cctgcctctg cctcccaagt
     5041 gctgagatta aagtggtgtg ccaccaccac ctggctggca ctgtcactct tgcattgctg
     5101 gggagataga tggcagcagg acagctgtgg acaggggctt ggtgttcaca tctgggaata
     5161 gtgggctagg gaaatgtctg cacacctgag ggcaagggca ggagtgtggc cctcagatgc
     5221 cttttatctt aaggtaaaat gaaacccgtt ctttctttaa cctttgagct gtgtttgctg
     5281 cgtctatgtg cccttgatcc ttacagatcc tttgattgat tcaggaatgt tatgagttct
     5341 ttgtataact cagccttggg atttgatttg acttaatggg cttttctagt aagaacataa
     5401 aaactgagac tagtttcaaa tccagtcacc ccctgagtcg ccctcagtat gtgctgccca
     5461 tgtgacgagc tacttttcca ttgacaacaa agatctattg tgagtccacg atgggcacat
     5521 tctaactttc acatgctcaa actgaaatgt atgtcaacgt gcggatttca tacagctctt
     5581 tatatactgt gtatattaaa actaaaatga catgaggtgg cttaagtgtg tggagaataa
     5641 atctaaagtg tttactaaaa aaaaaaaaaa aaaaaa
//
