LOCUS       NM_011342               1815 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus SEC22 homolog B, vesicle trafficking protein (Sec22b),
            mRNA.
ACCESSION   NM_011342
VERSION     NM_011342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Tondeur,E.G.M., Voerman,J.S.A., Geleijnse,M.A.A., van
            Hofwegen,L.S., van Krimpen,A., Koerner,J., Mishra,G., Song,Z. and
            Schliehe,C.
  TITLE     Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation
            of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long
            Peptide In Vitro
  JOURNAL   J Immunol 211 (8), 1203-1215 (2023)
   PUBMED   37638825
  REMARK    GeneRIF: Sec22b and Stx4 Depletion Has No Major Effect on
            Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a
            Synthetic Long Peptide In Vitro.
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Biscari,L., Maza,M.C., Farre,C., Kaufman,C.D., Amigorena,S.,
            Fresno,M., Girones,N. and Alloatti,A.
  TITLE     Sec22b-dependent antigen cross-presentation is a significant
            contributor of T cell priming during infection with the parasite
            Trypanosoma cruzi
  JOURNAL   Front Cell Dev Biol 11, 1138571 (2023)
   PUBMED   36936692
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Bonaud,A., Gargowitsch,L., Gilbert,S.M., Rajan,E.,
            Canales-Herrerias,P., Stockholm,D., Rahman,N.F., Collins,M.O.,
            Taskiran,H., Hill,D.L., Alloatti,A., Alouche,N., Balor,S.,
            Soldan,V., Gillet,D., Barbier,J., Bachelerie,F., Smith,K.G.C.,
            Jellusova,J., Bruhns,P., Amigorena,S., Balabanian,K.,
            Linterman,M.A., Peden,A.A. and Espeli,M.
  TITLE     Sec22b is a critical and nonredundant regulator of plasma cell
            maintenance
  JOURNAL   Proc Natl Acad Sci U S A 120 (2), e2213056120 (2023)
   PUBMED   36595686
  REMARK    GeneRIF: Sec22b is a critical and nonredundant regulator of plasma
            cell maintenance.
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Arango Duque,G., Dion,R., Matte,C., Fabie,A., Descoteaux,J.,
            Stager,S. and Descoteaux,A.
  TITLE     Sec22b Regulates Inflammatory Responses by Controlling the Nuclear
            Translocation of NF-kappaB and the Secretion of Inflammatory
            Mediators
  JOURNAL   J Immunol 207 (9), 2297-2309 (2021)
   PUBMED   34580108
  REMARK    GeneRIF: Sec22b Regulates Inflammatory Responses by Controlling the
            Nuclear Translocation of NF-kappaB and the Secretion of
            Inflammatory Mediators.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Jang,S.B., Kim,Y.G., Cho,Y.S., Suh,P.G., Kim,K.H. and Oh,B.H.
  TITLE     Crystal structure of SEDL and its implications for a genetic
            disease spondyloepiphyseal dysplasia tarda
  JOURNAL   J Biol Chem 277 (51), 49863-49869 (2002)
   PUBMED   12361953
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Gonzalez,L.C. Jr., Weis,W.I. and Scheller,R.H.
  TITLE     A novel snare N-terminal domain revealed by the crystal structure
            of Sec22b
  JOURNAL   J Biol Chem 276 (26), 24203-24211 (2001)
   PUBMED   11309394
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Zhang,T., Wong,S.H., Tang,B.L., Xu,Y. and Hong,W.
  TITLE     Morphological and functional association of Sec22b/ERS-24 with the
            pre-Golgi intermediate compartment
  JOURNAL   Mol Biol Cell 10 (2), 435-453 (1999)
   PUBMED   9950687
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131746.3.
            
            On Apr 28, 2007 this sequence version replaced NM_011342.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037918.1, AK088514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC131746.3         163626-163819
            195-304             AC131746.3         169620-169729
            305-465             AC131746.3         174978-175138
            466-612             AC131746.3         176899-177045
            613-1815            AC131746.3         183515-184717
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.35 cM"
     gene            1..1815
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="SEC22 homolog B, vesicle trafficking protein"
                     /db_xref="GeneID:20333"
                     /db_xref="MGI:MGI:1338759"
     exon            1..194
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..767
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="ERS24; mSec22b; ER-Golgi SNARE of 24 kDa; SEC22
                     vesicle trafficking protein-like 1; SEC22 vesicle
                     trafficking protein homolog B"
                     /codon_start=1
                     /product="vesicle-trafficking protein SEC22b"
                     /protein_id="NP_035472.1"
                     /db_xref="CCDS:CCDS17658.1"
                     /db_xref="GeneID:20333"
                     /db_xref="MGI:MGI:1338759"
                     /translation="MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKL
                     NEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKK
                     VPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRG
                     EALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL"
     exon            195..304
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..465
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..612
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1815
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="hexamer: ATTAAA"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="hexamer: ATTATA"
     polyA_site      1352
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="major polyA site"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="hexamer: ATTATA"
     polyA_site      1362
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="major polyA site"
     polyA_site      1386
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /note="major polyA site"
ORIGIN      
        1 agcgggaagc ggagacgcca gcggctagct gttggggacc tcagccggag gtgtaactgg
       61 ccgccgccgg agaagaaggg acagtgactg aggcggcctg gtctccgtag ccagggaaga
      121 tggtgctgct gacgatgatc gcccgtgtgg cggacggcct tccgctggcc gcctcgatgc
      181 aggaggacga gcagtcaggc cgggaccttc aacagtatca gagtcaggct aagcaactct
      241 ttcgaaagtt gaatgagcag tcccctaccc gatgtacctt ggaagcagga gccatgactt
      301 ttcactacat tattgagcag ggggtgtgtt acttggtttt gtgtgaagct gccttcccta
      361 agaagttggc ctttgcctac ctagaagatt tgcactcgga atttgatgaa cagcatggga
      421 agaaggtgcc cactgtgtct aggccctatt ccttcatcga gtttgatacc ttcattcaga
      481 aaaccaagaa actctacatt gatagccgtg ctcggagaaa tctaggctcc attaacactg
      541 aattgcagga tgtgcagagg atcatggtgg ccaatattga agaagtccta cagcggggag
      601 aagcactctc agcattggat tcaaaggcta acaatttgtc cagtctatct aagaaatacc
      661 gccaggatgc gaagtacctg aacatgcgct ccacttacgc caagcttgca gcagtagctg
      721 tgtttttcat catgctgata gtgtatgtgc ggttttggtg gctgtgagat gtgaacctag
      781 tcactagtaa gggagaacct agaaccccgc agtgtatgtt ttcaggaaac tgagctcaca
      841 gggctgtgta ttagaatcca cgtggaactt ctgcctctaa agaccttgca agaaaagacc
      901 tgtcctgaaa atgaaagatg gcgcctcgtt taaggaagct tgacccatgt ggaagtctct
      961 ctgggacaga ctttctctgg gtgctgagct atatgtatta gggaacagta ggttgtctgt
     1021 tttgtttctc tccctcccag tacatgtgtg aggcagcaga actggggcat tctctctctg
     1081 atggagccat cagtgagatt taaggtagcc aacccattct agcagcatcc tgaaattctg
     1141 tcaaagaagg cggccctctg gggagtccta actttaatcg acattcctgt gttggtagca
     1201 gtgtgattga ctttcaagtg agacacagta tgtgaaggtt catgatgcac agatcctatg
     1261 tgttggccat tgtaagaagt taactttcgt tgtttccctt ttatattttg cttattgcac
     1321 agttgctttg gaattaaatc aattatataa tatgccttga aattatatag tattgcttga
     1381 ctaaaaggat gaattttttt tttctgtcat ttactctttg ttgtttgttt ttcttttctt
     1441 tttgtttttt tttttgtttg tttggttagt ttgttttgtt ttgttttgtt ttgttgagac
     1501 agggtctctc tagcctcagt tgtcctggaa ctcatgaacc aggctggcct tgaaatgaca
     1561 aagatccacc ttcctcttcg tttactcttt aactctcttg ggacattatt atttgggact
     1621 gtttggtctc tgtagagttg gtgtagcgca gggtagtcag aggccctgct ttacgagaag
     1681 aaaggcccag cttaaagctc caactctgcc tgccccttcc tcccactttg tctatgcgtt
     1741 cccaattctt ggttttcttt tttttttttt ttttttatta catattttcc tcaattacat
     1801 ttccaatgct atccc
//
