LOCUS       NM_033354               4611 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SEC16 homolog B, endoplasmic reticulum export factor
            (Sec16b), transcript variant 1, mRNA.
ACCESSION   NM_033354 XM_916812
VERSION     NM_033354.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4611)
  AUTHORS   Shi,R., Lu,W., Tian,Y. and Wang,B.
  TITLE     Intestinal SEC16B modulates obesity by regulating chylomicron
            metabolism
  JOURNAL   Mol Metab 70, 101693 (2023)
   PUBMED   36796587
  REMARK    GeneRIF: Intestinal SEC16B modulates obesity by regulating
            chylomicron metabolism.
REFERENCE   3  (bases 1 to 4611)
  AUTHORS   Oh-Hashi,K., Kohno,H. and Hirata,Y.
  TITLE     Transcriptional regulation of the ER stress-inducible gene Sec16B
            in Neuro2a cells
  JOURNAL   Mol Cell Biochem 476 (1), 35-44 (2021)
   PUBMED   32815086
  REMARK    GeneRIF: Transcriptional regulation of the ER stress-inducible gene
            Sec16B in Neuro2a cells.
REFERENCE   4  (bases 1 to 4611)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4611)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 4611)
  AUTHORS   Misawa,H. and Yamaguchi,M.
  TITLE     Molecular cloning and sequencing of the cDNA coding for a novel
            regucalcin gene promoter region-related protein in rat, mouse and
            human liver
  JOURNAL   Int J Mol Med 8 (5), 513-520 (2001)
   PUBMED   11605020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY151383.1, AK173302.1 and CO043178.1.
            
            On May 8, 2009 this sequence version replaced NM_033354.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               BY151383.1         2-332
            332-4593            AK173302.1         313-4574
            4594-4611           CO043178.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 68.0 cM"
     gene            1..4611
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /note="SEC16 homolog B, endoplasmic reticulum export
                     factor"
                     /db_xref="GeneID:89867"
                     /db_xref="MGI:MGI:2148802"
     exon            1..65
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            66..233
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            234..302
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            303..643
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..3518
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /note="regucalcin gene promotor region related protein;
                     leucine zipper transcription regulator 2; protein SEC16
                     homolog B; regucalcin gene promoter region-related protein
                     p117"
                     /codon_start=1
                     /product="protein transport protein Sec16B"
                     /protein_id="NP_203505.3"
                     /db_xref="CCDS:CCDS15400.1"
                     /db_xref="GeneID:89867"
                     /db_xref="MGI:MGI:2148802"
                     /translation="MEPWVPQTQGRTTGPSRDTNRGLQSGHYRPRLHSQYSGDKYHQW
                     QDAHKNSKSQQDLRDDHQQSHSVSRSGEWSQPVSGADYLKGSYPSHLYSRSGYGDPYQ
                     RYHTPTPRDEYAYGNYYYHGHPQLLPEERVARQGSPYIWHEDHGDQRYFGEHHREKHN
                     GTFGANSDTQFQFTSKNPYRDSPASVSGQEQPGEFFPESEAQKQKPLLTSKSSLLQQH
                     ESGLSSSSYELSQYMTAAPEEYEPMVSAAWRPIQADDTSATVPKAPMRFYVPHVSVSF
                     GPGGQLVCVPPNSPADGQTALVEVHSMEVLLNDFEDQEEMRAFPGPLIREDIHKVDIM
                     TFCQQKATQCLKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYK
                     RQPPVANLINLTDEDWPVLSSGTRDLLTGEIPPNVDTPAQIVEKFTKLLYYGRKKEAL
                     EWAMKNHLWGHALFLASKMDPRTYNWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATV
                     CGDKQWGDWRPHLAVILSNQAGDTELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPF
                     GHYTVKTDHLALVGSSHSQEFMKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLL
                     YASRLADYGLASQALHYCEAIGAAVLSQEGSSHPVLLAELIKLAEKLKLSDPLVLERR
                     RGDRDLEPDWLVQLRRKHKDLEQNRTGAPRDPDSTPSDIYGAGGTTDTPYPDLSGHQN
                     YSEDSEYSSTLWSTAEQTSLTNPLAQQSFPLQRDTYSGHMGTPVPLYSVPATHLAVTS
                     GASGSSVAVTGTPGGRVGEDMLRTHPAFGENTMTQEPLEDPDGLEVISSLQTPAAPRV
                     PSFSEDSAASAKEDEEGSSDGADKPSHPDASQKGKLGDGKNTKSSGFGWFSWFRSKPA
                     SSVSTSGDEDSSDSSDSEESPRASSPHHASPGLSPTPPLTSPSLPGASTFSRGTGGSI
                     LQGSSNSSGIAEGMGIGGFSGTQGVSSEFYSQPGALPPPPTLQGAVPLYNPSQVPQLP
                     TASSLNRPNRLAQRRYPTQPC"
     exon            644..756
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            757..877
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            878..977
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1122
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1274
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1336
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1472
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1703
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1801
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1883
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2001
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2113
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2219
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2360
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2474
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2547
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2841
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2909
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3059
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3158
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3267
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3347
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3446
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..4596
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /note="hexamer: ATTAAA"
     polyA_site      4596
                     /gene="Sec16b"
                     /gene_synonym="Lztr2; Rgpr; Rgpr-p117"
                     /note="major polyA site"
ORIGIN      
        1 agcaggctgt caggatggga tgtcgcagga gcagctgcag cagctcctca tttaggagca
       61 aagatctata cagatgacta ggggcctggt gcctgccaac tgtgacaaat gaggacttgg
      121 cacagagtgg tgagcaagcg gtggctgtgt ggcttctgtt cccaaggttt atatcctgaa
      181 gttgggtcca gagttcctgc tatttgccga gttcataaac catgtgttta cagggcctct
      241 tcccagggag atcaaaagca tcatcgaagc cactggtgag ccagtcctca cggcctagcg
      301 tggaaattaa agtaactaca taacagcctc aagacccaac ggggaaaatc aaagggccag
      361 agatggaacc ttgggttccc cagacacaag gaaggaccac gggaccatca agggatacaa
      421 atagaggact tcagagtgga cattatagac cccgtctgca ttctcagtac agtggagata
      481 agtaccacca atggcaagat gcccacaaga actcaaagtc acagcaggac ctcagggatg
      541 accaccaaca gtctcactct gtatccagga gtggggagtg gtcccagcct gtgtctggtg
      601 ctgactactt gaaaggatct tatcccagtc acctgtactc aaggtcaggc tatggggacc
      661 cctatcagag gtaccacact ccgacaccga gggatgagta tgcttatgga aattactact
      721 accacggaca tccacagctg ctgccggaag aaagagtggc aaggcaaggg agtccttata
      781 tctggcatga agatcatgga gaccagaggt acttcggcga gcatcatcgg gagaagcaca
      841 atggtacatt tggagcaaac agtgataccc agttccaatt taccagtaag aatccatacc
      901 gagacagccc tgcttctgtg tctggacagg aacagcctgg ggaattcttt ccagagagtg
      961 aagcccagaa acaaaagcca ttgctgacca gcaaatccag ccttctccag cagcacgagt
     1021 ctgggctcag ctctagtagc tacgagctca gtcagtacat gacagctgcc cccgaggagt
     1081 atgaacctat ggtgtcagca gcttggaggc ctattcaggc tgatgacacc tcagcgacag
     1141 ttccaaaggc acctatgagg ttctatgttc cccatgtgtc tgtgagcttt gggccaggag
     1201 gccagctagt gtgtgtcccc cccaactctc ctgctgatgg acaaacggcc ctcgttgaag
     1261 tgcacagcat ggaggtttta cttaatgatt ttgaggatca ggaggagatg agagctttcc
     1321 cagggcccct tattagggag gacatacaca aggtggatat catgacgttt tgtcagcaga
     1381 aagcaacgca gtgtctcaaa tctgagacac cagggagcag agactcagct ctactttggc
     1441 aactgctggt tctcctttgt cgacagaatg ggtccatggt gggatctgac attgctgagc
     1501 tgctgatgca ggactgcaag aagctggaga agtacaagag gcagccccct gtagccaacc
     1561 tcatcaacct gactgacgag gactggccgg tactgagctc tgggactcgt gatctcctca
     1621 ctggggagat tccccccaat gtggatacgc cagcgcagat cgtggagaaa ttcaccaagc
     1681 tgctctacta cggaaggaag aaggaggctt tggagtgggc tatgaagaac cacttgtggg
     1741 gacatgcctt gttcctagcc agtaagatgg acccaaggac ctacaactgg gtcatgagtg
     1801 gtttcaccag tacgctggcg ctcaatgacc ctctgcagac cctcttccag ctcatgtcag
     1861 gaaggattcc acaagcagcc acggtttgtg gagacaaaca gtggggagac tggcggcccc
     1921 acttggctgt gatcctgtca aatcaggctg gagatacaga gttgtaccag cgagcgattg
     1981 tcagcatggg ggataccctg gctggaaaag ggcttgtgga ggcatctcac ttctgctatc
     2041 tcatggctca tgtgcccttt ggtcactata cggtgaagac agatcatctg gccttggtgg
     2101 gcagtagcca cagtcaagag tttatgaaat ttgcaacaat tgaggctatc cagcggacgg
     2161 aaatcttcga gtactgccag atgctgggcc gccccaaatc cttcatccct tctttccagg
     2221 tgtataagct cctctatgcc tcccgtctgg cagattatgg cctggcatcc caggccttgc
     2281 attactgtga agccattggt gcagctgtct tgagccagga agggagcagc caccctgtgc
     2341 tattagcgga gctcatcaag ctcgcagaga aactgaagct gtcagatcct ctggttttag
     2401 aaagacgccg tggggacagg gacctggaac cagattggct tgtgcaactg cggaggaagc
     2461 acaaggacct ggagcaaaat agaacaggag ccccgagaga tcctgattcg actccttcag
     2521 atatttatgg agctggagga acaacagaca ctccctaccc tgatctctct ggccatcaaa
     2581 actactcaga agactctgag tacagctcca ccttgtggtc aacagcagag cagacaagcc
     2641 tgaccaatcc cctcgcacag cagtctttcc ccctgcagcg agatacctat tcaggacaca
     2701 tgggaacccc agtgcctctc tactcagttc ctgcaaccca cttggcagtg acgagtggag
     2761 ccagtggtag cagtgtggca gtgacgggga ctcctggggg aagggttgga gaggatatgc
     2821 tgcggacaca tcctgccttt ggagagaaca caatgactca agaacccctg gaagatcctg
     2881 atggtctcga agtcatttcc agtcttcaga caccagcggc tcccagggtt ccaagttttt
     2941 ctgaggattc tgctgcttca gccaaggagg atgaggaggg gtcttctgat ggagcagaca
     3001 aaccatctca ccccgatgct tcacagaaag gaaagctggg agatgggaag aatacaaaga
     3061 gctcgggatt cggctggttc agctggtttc gatcaaagcc tgccagcagt gtgtccacct
     3121 ctggagatga agactcctcg gacagttctg actcagagga gtctcccaga gcatcttctc
     3181 ctcaccatgc gagcccaggc ctctcaccaa cacctcctct cacatcccca tccctgccag
     3241 gtgccagcac cttctcgaga ggcacaggtg ggagtattct ccaaggatcc tcaaacagta
     3301 gtggaatcgc tgaaggcatg gggattggag ggttctcggg gacacagggt gtttcttctg
     3361 agttctactc ccagcctggt gccctgcctc ctccgcctac cttgcaaggt gctgttcctc
     3421 tctacaatcc atctcaggtc cctcagcttc ccactgctag tagcctgaac cggccaaacc
     3481 gcctagccca gcgccgctac ccaacccagc catgctgaga gtgaccatct atcctggatc
     3541 catgaggatg accatcgccc atgctgggct catctcccta tcctgggctc atcttctgga
     3601 gcacatcttt cctgctgctt tctacctctc agtgtccacc tcaccgcatc atatccacac
     3661 ccttgttgtg agcctgctgc acagggggtg cttggagata aaggacagga tatccccaga
     3721 caatagcttg gtccagtcta cagcttagct tggagtgatg ggactcatat catcagatag
     3781 aggaatgggg ccaatgtcca tggtagagtg tcatggcagc agacttgagg tagaagcttg
     3841 agaacctcag gaaagtgagg accccaagaa tcccatggtg aaaacggaag atgataccac
     3901 caggctacgc agcaggagct cagagcaaca tcccagaata actcggactc cctccttaga
     3961 cttgcttaaa gaccagttta tggctcttgt tagcgaagtt tttacattga atttgattat
     4021 cactgccctt cagtgattcc cttttcaatg acatttcagc aattttcctc ccggtcctag
     4081 ttttgtgcac attttctatg tggttcagac taattatatt tctctcactt tcttagcggg
     4141 tcctattttt ttcacattct gacatctggc tatcaagtta gattgctgta ggcatcatat
     4201 cgccatggta actactgaac ctaatgattc agatggatgg aacatcagta taataaataa
     4261 tggaaagtgt ttcctaaaac gtcatccttt ccgtaagagg ggaggaatga atgcctcatc
     4321 gtgctaatac ctgccttcct acctcaggcc gttgcaaact gatgctctgt gagggtcact
     4381 ggggccccac ggaggaggga gatggcttgg aaatttccat ttttttcctt ttcaaaacct
     4441 caaatagaaa tgattcttgc tgtttgtcag atttgcttaa aattgctcct cacaaagacc
     4501 atttttgtat gtgtaattgt acataaaagt tttgtacttt aatgtactat ggttctgatg
     4561 ttgatagcga ttaaatccag ataattttat agcaaaaaaa aaaaaaaaaa a
//
