LOCUS       NM_144520               2529 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus SEC14-like lipid binding 2 (Sec14l2), mRNA.
ACCESSION   NM_144520
VERSION     NM_144520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2529)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   2  (bases 1 to 2529)
  AUTHORS   Shibata,N., Jishage,K., Arita,M., Watanabe,M., Kawase,Y.,
            Nishikawa,K., Natori,Y., Inoue,H., Shimano,H., Yamada,N.,
            Tsujimoto,M. and Arai,H.
  TITLE     Regulation of hepatic cholesterol synthesis by a novel protein
            (SPF) that accelerates cholesterol biosynthesis
  JOURNAL   FASEB J 20 (14), 2642-2644 (2006)
   PUBMED   17077281
REFERENCE   3  (bases 1 to 2529)
  AUTHORS   Yamauchi,J., Iwamoto,T., Kida,S., Masushige,S., Yamada,K. and
            Esashi,T.
  TITLE     Tocopherol-associated protein is a ligand-dependent transcriptional
            activator
  JOURNAL   Biochem Biophys Res Commun 285 (2), 295-299 (2001)
   PUBMED   11444841
REFERENCE   4  (bases 1 to 2529)
  AUTHORS   Shibata,N., Arita,M., Misaki,Y., Dohmae,N., Takio,K., Ono,T.,
            Inoue,K. and Arai,H.
  TITLE     Supernatant protein factor, which stimulates the conversion of
            squalene to lanosterol, is a cytosolic squalene transfer protein
            and enhances cholesterol biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2244-2249 (2001)
   PUBMED   11226224
REFERENCE   5  (bases 1 to 2529)
  AUTHORS   Zimmer,S., Stocker,A., Sarbolouki,M.N., Spycher,S.E., Sassoon,J.
            and Azzi,A.
  TITLE     A novel human tocopherol-associated protein: cloning, in vitro
            expression, and characterization
  JOURNAL   J Biol Chem 275 (33), 25672-25680 (2000)
   PUBMED   10829015
REFERENCE   6  (bases 1 to 2529)
  AUTHORS   Caras,I.W., Friedlander,E.J. and Bloch,K.
  TITLE     Interactions of supernatant protein factor with components of the
            microsomal squalene epoxidase system. Binding of supernatant
            protein factor to anionic phospholipids
  JOURNAL   J Biol Chem 255 (8), 3575-3580 (1980)
   PUBMED   7364757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807395.8.
            
            On Nov 17, 2006 this sequence version replaced NM_144520.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005759.1, SRR13422597.1351054.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL807395.8         189634-189738       c
            106-181             AL807395.8         187690-187765       c
            182-225             AL807395.8         182903-182946       c
            226-285             AL807395.8         182452-182511       c
            286-474             AL807395.8         182046-182234       c
            475-570             AL807395.8         180158-180253       c
            571-631             AL807395.8         179973-180033       c
            632-715             AL807395.8         179506-179589       c
            716-822             AL807395.8         174904-175010       c
            823-962             AL807395.8         174683-174822       c
            963-1132            AL807395.8         174397-174566       c
            1133-2529           AL807395.8         168048-169444       c
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.87 cM"
     gene            1..2529
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /note="SEC14-like lipid binding 2"
                     /db_xref="GeneID:67815"
                     /db_xref="MGI:MGI:1915065"
     exon            1..105
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1263
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /note="alpha-tocopherol-associated protein; SEC14-like 2"
                     /codon_start=1
                     /product="SEC14-like protein 2"
                     /protein_id="NP_653103.1"
                     /db_xref="CCDS:CCDS24377.1"
                     /db_xref="GeneID:67815"
                     /db_xref="MGI:MGI:1915065"
                     /translation="MSGRVGDLSPKQEEALAKFRENVQDVLPTLPNPDDYFLLRWLRA
                     RSFDLQKSEAMLRKHVEFRKQKDIDKIISWQPPEVIQQYLSGGRCGYDLDGCPVWYDI
                     IGPLDAKGLLFSASKQDLLRTKMRDCELLLQECIQQTTKLGKKIETITMIYDCEGLGL
                     KHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRRKIM
                     VLGANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKQYYVRDQVKQ
                     QYEHTVQVSRGSSHQVEYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMT
                     EVLPNQRYNSHMVPEDGTLTCSEPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKAAEE
                     KMNQQGADTPK"
     exon            106..181
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            182..225
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            226..285
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            286..474
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            475..570
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..631
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            632..715
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            716..822
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            823..962
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1132
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..2529
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /note="hexamer: AATAAA"
     polyA_site      2529
                     /gene="Sec14l2"
                     /gene_synonym="1300013M05Rik; Spf; TAP"
                     /note="major polyA site"
ORIGIN      
        1 gtcggagctc catcagctgc cgcaggcacc gcgccccaag gctgagccac gatgagcggc
       61 agagtcggtg acctgagccc caaacaggag gaggcactgg ccaagttccg agaaaatgtt
      121 caggacgtgc tgcccaccct gcccaatcca gatgactact tcctccttcg atggctccga
      181 gcccgaagct ttgacctgca gaagtcagag gccatgctcc gaaagcatgt ggaattccgg
      241 aagcaaaagg acattgacaa aatcatcagc tggcagccac cagaggtgat ccaacagtat
      301 ctgtcaggcg gcagatgtgg ctacgacttg gacggctgcc ctgtctggta cgacatcatc
      361 ggccctctgg atgccaaagg tctgctgttc tccgcctcca agcaggacct gctcaggacc
      421 aagatgagag actgtgagct gcttctgcag gagtgtatcc agcagaccac aaagctaggg
      481 aagaagatag agaccatcac catgatttat gactgtgaag gactcggcct caagcacctc
      541 tggaaacctg cagtggaggc ctatggagag ttcctcacca tgtttgaaga aaattatcct
      601 gaaacactga agcgtctgtt tgttgttaaa gctcccaagc tgtttcctgt ggcctataac
      661 ctcatcaagc ccttcctaag tgaagacact cggaggaaga tcatggttct gggggcaaac
      721 tggaaggagg ttttactcaa acatatcagc cctgaccagc tgcctgtgga atacggaggc
      781 accatgacag atcctgacgg aaatcccaag tgtaaatcta agatcaacta tgggggcgac
      841 attcccaagc agtactacgt gcgagaccag gtgaagcagc agtatgaaca caccgtgcag
      901 gtctcccgag gctcctccca ccaagtggag tatgagattc ttttcccggg ctgtgtcctc
      961 aggtggcagt ttatgtcgga gggatcagac gtgggttttg ggattttcct gaagaccaag
     1021 atgggggaac ggcagcgggc aggggagatg acggaggtgc tgccaaacca gagatacaat
     1081 tcccacatgg tgcctgagga tggaaccctc acctgcagtg agccaggcat ctatgttctg
     1141 cggttcgaca acacctacag cttcatccat gccaagaaag tcagtttcac cgtggaggtc
     1201 ctgcttccag acaaagcagc cgaagagaag atgaaccagc agggggcaga cacccccaaa
     1261 taacacctcg cccctgcagc aggcctggcc cccccaatgt cttcctgtca gtttctttag
     1321 tcattttcct gcaaccaatt agcccaaaga aactgggctg gagggaagac ttcagactgg
     1381 acggagctcc tgttcagaat cagaatgagg ataaatagct agatgggtcc tcgtcgtcag
     1441 aatactaagg ggtctccagg gaccggctgt aatgatgtct accctgtaga ctttgccaac
     1501 ttcacctgcc caggaacagc tgagacaggg agggaagggt acacaggatg gtggcaggga
     1561 agaacttaga aagaagtgaa gcgattggat gtcatactca gggaagccag ctgctgggga
     1621 gaaacttgct cctaaatgaa catggaccaa acctccatga ttgtaatgat ggttgcaagg
     1681 tagcaggcca ctagatgtga tgggtatcca aagctctttg aaactttttg tcataagcct
     1741 tgagtctctc gtcccccccc ccccccaatc tcaggagtaa cccaagtcag cactggaagg
     1801 aaggctaaca gccccccccc ccagaacctc attaactcct gggttccact ggctgcctgt
     1861 ttaaaccctc cacaagcaca agggtaatta atttcaggga tcatagatag gaaaggacca
     1921 aggaggcggt gggtgggccc caagcctctc actaagtaac cctccgcttg agcagcccta
     1981 cacaaagatg acaattgggg ctgagacagc actgagtgca cttcccagtc cagtctccca
     2041 cagtgcctga gaaccagtct cctgacagga gcaagggctt ggtgggccct tctctgtgga
     2101 ggcgtgtaat agcagcagtg gcttcctctt gcctggggat gcaggtagcc agggtgggcg
     2161 gtttcccggg aaggtagcca tagctgggca aacatttgag ccagggtaaa gaggggggcc
     2221 aggcacaggt gaccttgcaa taaaaagctc ttgaccccac acaacttgag agccaggtta
     2281 caggctgccc agaattcagg aaggatgccc caggcccttg cggggtctgc cttttcctct
     2341 gaacgaggcg ttggcccagc ctcgtctcag gaagcggagg gagctctggg caggtgcagg
     2401 gatggcaagc agagagggcc gaggctaccc aggatctagt cacacatctc aggggcacag
     2461 cctggccttg gtttacaatg ctgttaggta cattaaccaa tgaataaagt gatcaatttt
     2521 caaagcaaa
//
