LOCUS       NM_001405895            2520 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus secretory blood group 1 (Sec1), transcript variant 1,
            mRNA.
ACCESSION   NM_001405895 XM_030242814
VERSION     NM_001405895.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Cai,J., Wu,H., Wang,C., Chen,Y., Zhang,D., Guan,S., Fu,B., Jin,Y.
            and Qian,C.
  TITLE     Sec1 regulates intestinal mucosal immunity in a mouse model of
            inflammatory bowel disease
  JOURNAL   BMC Immunol 24 (1), 51 (2023)
   PUBMED   38066482
  REMARK    GeneRIF: Sec1 regulates intestinal mucosal immunity in a mouse
            model of inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Ren,Z., Fan,H., Gu,S., Liu,H., Wu,Z., Wang,H., Bao,W. and Wu,S.
  TITLE     Expression Analysis and the Roles of the Sec1 Gene in Regulating
            the Composition of Mouse Gut Microbiota
  JOURNAL   Genes (Basel) 13 (10), 1858 (2022)
   PUBMED   36292744
  REMARK    GeneRIF: Expression Analysis and the Roles of the Sec1 Gene in
            Regulating the Composition of Mouse Gut Microbiota.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Wu,Z., Fan,H., Jin,J., Gao,S., Huang,R., Wu,S. and Bao,W.
  TITLE     Insight into mechanisms of pig lncRNA FUT3-AS1 regulating E. coli
            F18-bacterial diarrhea
  JOURNAL   PLoS Pathog 18 (6), e1010584 (2022)
   PUBMED   35696408
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Esposito,M., Mondal,N., Greco,T.M., Wei,Y., Spadazzi,C., Lin,S.C.,
            Zheng,H., Cheung,C., Magnani,J.L., Lin,S.H., Cristea,I.M.,
            Sackstein,R. and Kang,Y.
  TITLE     Bone vascular niche E-selectin induces mesenchymal-epithelial
            transition and Wnt activation in cancer cells to promote bone
            metastasis
  JOURNAL   Nat Cell Biol 21 (5), 627-639 (2019)
   PUBMED   30988423
  REMARK    GeneRIF: E-selectin binding activity mediated by the alpha1-3
            fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the
            formation of bone metastasis. These findings provide unique
            insights into the functional role of E-selectin as a component of
            the vascular niche critical for metastatic colonization in bone.
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Garrett,A.M., Jucius,T.J., Sigaud,L.P., Tang,F.L., Xiong,W.C.,
            Ackerman,S.L. and Burgess,R.W.
  TITLE     Analysis of Expression Pattern and Genetic Deletion of Netrin5 in
            the Developing Mouse
  JOURNAL   Front Mol Neurosci 9, 3 (2016)
   PUBMED   26858598
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Domino,S.E., Zhang,L. and Lowe,J.B.
  TITLE     Molecular cloning, genomic mapping, and expression of two secretor
            blood group alpha (1,2)fucosyltransferase genes differentially
            regulated in mouse uterine epithelium and gastrointestinal tract
  JOURNAL   J Biol Chem 276 (26), 23748-23756 (2001)
   PUBMED   11323419
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Lin,B., Saito,M., Sakakibara,Y., Hayashi,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     Characterization of three members of murine
            alpha1,2-fucosyltransferases: change in the expression of the Se
            gene in the intestine of mice after administration of microbes
  JOURNAL   Arch Biochem Biophys 388 (2), 207-215 (2001)
   PUBMED   11368156
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Bureau,V., Marionneau,S., Cailleau-Thomas,A., Le Moullac-Vaidye,B.,
            Liehr,T. and Le Pendu,J.
  TITLE     Comparison of the three rat GDP-L-fucose:beta-D-galactoside
            2-alpha-L-fucosyltransferases FTA, FTB and FTC
  JOURNAL   Eur J Biochem 268 (4), 1006-1019 (2001)
   PUBMED   11179967
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Lin,B., Hayashi,Y., Saito,M., Sakakibara,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II,
            and not MFUT-I or -III, is induced in a restricted region of the
            digestive tract of germ-free mice by host-microbe interactions and
            cycloheximide
  JOURNAL   Biochim Biophys Acta 1487 (2-3), 275-285 (2000)
   PUBMED   11018479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167242.4.
            
            On May 5, 2022 this sequence version replaced XM_030242814.2.
            
            Summary: This gene is one of three genes in mouse which encode a
            galactoside 2-L-fucosyltransferase. These genes differ in their
            developmental- and tissue-specific expression. This gene is
            predicted to encode a type II membrane protein, which is anchored
            in the Golgi apparatus and controls the final step in the creation
            of alpha (1,2) fucosylated carbhohydrates by the addition of a
            terminal fucose in an alpha (1,2) linkage. The biological function
            of the fucosylated carbhohydrate products is thought to involve
            cell-adhesion and interactions with microorganisms. [provided by
            RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.189040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC167242.4         94634-95061         c
            429-518             AC167242.4         85926-86015         c
            519-569             AC167242.4         85355-85405         c
            570-681             AC167242.4         84840-84951         c
            682-2520            AC167242.4         78346-80184         c
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.43 cM"
     gene            1..2520
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /note="secretory blood group 1"
                     /db_xref="GeneID:56546"
                     /db_xref="MGI:MGI:1928893"
     exon            1..428
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..518
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /inference="alignment:Splign:2.1.0"
     exon            519..569
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..681
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /inference="alignment:Splign:2.1.0"
     CDS             585..1754
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /EC_number="2.4.1.69"
                     /note="GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase 3; alpha(1,2)FT 3;
                     fucosyltransferase 10; GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase FUT-III"
                     /codon_start=1
                     /product="galactoside 2-alpha-L-fucosyltransferase Sec1"
                     /protein_id="NP_001392824.1"
                     /db_xref="GeneID:56546"
                     /db_xref="MGI:MGI:1928893"
                     /translation="MPPETAWDRSTVAPSRLEAWWPQTSRPRRIQAVLQRLRAICPPL
                     STFYLFFVIFVVSTIFHCHRRLSLVPGPWASPSLVVFPPRHMPREGMFTIRVKGRLGN
                     QMGEYATLFALARMNGRLAFIPASMHSTLAPIFRISLPVLHSDTAKRIPWQNYHLNDW
                     MEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLQVNGS
                     QPSTFVGVHVRRGDYVRVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSDDMAW
                     CRKSITASRGDVAFAGNGLQGSPAKDIALLMQCNHTVITLGTFGIWAAYLTGGDTVYL
                     ANFTQPNSPFHTVFKPEAAYLPEWVGIAADLGQPNTVGSGHASARAPKRHWGALL"
     exon            682..2520
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /note="hexamer: GATAAA"
     polyA_site      2021
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /note="major polyA site"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /note="hexamer: AATAAA"
     polyA_site      2520
                     /gene="Sec1"
                     /gene_synonym="Fut10; Fut3"
                     /note="major polyA site"
ORIGIN      
        1 agtagctcac tttagttcct gggcccaggg ctccgtgtgg gtggcagcag gcctcggcag
       61 gcacctccgc gctccttctg ctgcagtcgc cgcagcggcc gggcccatcg tggtctccag
      121 ggcagcgcga ggccgtggcg gttcaggatg aggcgcgcag ggtcatagtt gtcgtcgtcg
      181 tgggtctgcg cagcacggcc cagcaggagg tagtcagcgc cagggcgcag gcgcaggcag
      241 ccgcagatta ggtcagcacg tggcacccag gcctcctggc caccgcggcg cacgggccac
      301 gcacgctgtt tgaacacagc cagcacgtgc acggccagcc gccaccactc ggggcccacc
      361 gcctcagacg gctgcgacga cgacgctgaa acctgggcgt gcagaactga gggaagacac
      421 cacctcaggt gtgtagccag agaagagtgc tgagggaagg tggtgctgaa ggagctggaa
      481 accaacaaag ccttggagtt agagagcaga cccctcaggt aatttcaagg tcccaccttc
      541 cggctctcaa caccgtgaag taccaggctg gacccttgcc agccatgcca cccgagactg
      601 cgtgggacag gagcactgtc gcccccagca ggcttgaagc ttggtggccc caaacaagcc
      661 ggcctagaag gatccaagca gtgctccagc gactcagggc catctgccca cccctctcca
      721 ccttctacct cttcttcgtg attttcgtgg tgtctaccat cttccactgc caccggcgcc
      781 tgagtctggt gcctggcccc tgggcctcgc catcccttgt ggtcttcccc ccaagacaca
      841 tgccccggga gggcatgttc accatcagag tcaaaggccg cctggggaac cagatgggcg
      901 aatatgccac gctgtttgca ctggcccgga tgaatggacg gcttgccttc atccctgcgt
      961 ccatgcacag cacactagcg cccatcttca ggatcagcct cccggtgttg catagcgaca
     1021 cagccaaaag gatcccgtgg cagaattacc acctcaacga ctggatggag gagcgttacc
     1081 gccacatccc ggggcagtat gtgcgtttca cgggataccc gtgctcctgg accttctacc
     1141 accacctgcg cccagagatc ctgaaggagt tcaccctgca cgaccatgtg cgtgaggagg
     1201 cccaggcctt cctgcgtggc ctgcaggtga atgggagcca gccaagtacc tttgtgggtg
     1261 tccatgtgcg ccgaggggac tatgtgcgtg tcatgcccaa ggtgtggaag ggtgtggtgg
     1321 ctgaccgggg ttacctagaa aaggccctgg acaggttccg ggcacgctat tcatctccag
     1381 tcttcgtggt caccagtgat gacatggcct ggtgccggaa gagcatcact gcctcccgag
     1441 gggacgtggc atttgctggc aatggccttc agggatcgcc tgccaaggac attgcattgc
     1501 tcatgcagtg caaccacacc gtcatcacgc tggggacctt tgggatctgg gctgcctacc
     1561 tcacgggtgg ggacactgtt tacctggcta actttaccca gcccaactcc cccttccaca
     1621 cggttttcaa gccagaagca gcttacctgc ccgagtgggt gggcatcgca gctgacctgg
     1681 gacagccaaa cacagtaggc tctggccatg cctcagccag agcccccaag aggcactggg
     1741 gggccttgct gtagtgcaca tgctcagtgg atttccagtc ctgtcttcca tgctttgcag
     1801 ctgagtgacc acaggtcagt gatgtcacct tactgccttc ctggtgctct gagcacagtc
     1861 tgggcttagc tgagcagcag cacactcggg tgctttgagc ttctcattgc ccactgctag
     1921 ccactgtagg cctaccattc gctgcatctg gagtgctgtc tcatggaggc cagtgtgtag
     1981 ctagggtttc tacagctctg ataaaacacc atgacagtaa acacgttggg gagcaaagag
     2041 cctacttcag cttacagctt acacttccac atcacagccc ttcactgagg aaaatcacag
     2101 caggaacctg gaggcaggag ctgatacagg ggctgtggag gggttctgct cactggcttg
     2161 ctctctgtgc cttgctcaac ctgctgcctc atgccaccca aagggcgtag aaggccgttt
     2221 ctagcacact cacactcact cgcctagagc acaaaacctc tgagctacct cagccctggc
     2281 tggggacctg gttattgtcc cctgctctgg tctcatcagg catggtggga cacagaggct
     2341 ctttagcagg aggcaagcag atggcagtgg gaggtgtgag atgaagggcc ccctgccctg
     2401 cccagcttcg tgtttgcttg gccttgcttg aacaaagata caaatggctt ttactttgta
     2461 aagccctagg aagggctagt aatctgacaa tggtaataaa ttccacattc atccagcaaa
//
