LOCUS       NM_001384254            1492 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus serine dehydratase-like (Sdsl), transcript variant 2,
            mRNA.
ACCESSION   NM_001384254 XM_011248203
VERSION     NM_001384254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Edgar,A.J.
  TITLE     Mice have a transcribed L-threonine aldolase/GLY1 gene, but the
            human GLY1 gene is a non-processed pseudogene
  JOURNAL   BMC Genomics 6, 32 (2005)
   PUBMED   15757516
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129553.10.
            
            On Jun 12, 2020 this sequence version replaced XM_011248203.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF328927.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC129553.10        22253-22352
            101-325             AC129553.10        27580-27804
            326-519             AC129553.10        31853-32046
            520-559             AC129553.10        32193-32232
            560-699             AC129553.10        32962-33101
            700-788             AC129553.10        34383-34471
            789-1016            AC129553.10        35095-35322
            1017-1141           AC129553.10        35509-35633
            1142-1492           AC129553.10        36527-36877
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.62 cM"
     gene            1..1492
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /note="serine dehydratase-like"
                     /db_xref="GeneID:257635"
                     /db_xref="MGI:MGI:2182607"
     exon            1..100
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            101..325
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            326..519
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1335
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /EC_number="5.1.1.3"
                     /note="SDH; L-serine deaminase; L-threonine dehydratase;
                     L-serine dehydratase/L-threonine deaminase; serine
                     dehydratase related sequence 1; glutamate racemase"
                     /codon_start=1
                     /product="serine dehydratase-like"
                     /protein_id="NP_001371183.1"
                     /db_xref="GeneID:257635"
                     /db_xref="MGI:MGI:2182607"
                     /translation="MEGALAERVGAEPFHRVTPLLESWALSQVAGMPVFLKYENVQIA
                     GSFKIRGIGHFCQQMAKRGCRHLVCSSGGNAGIAAAYSARKLGIPVTIVLPEGTSVQV
                     VRRLEGEGAEVQLTGKVWDEANVKAQELATRDGWVNVSPFDHPLIWEGHASLVRELKE
                     SLGTPPGAVVLAVGGGGLLAGVTAGLLEVGWQHVPIVAMETRGAHSFNSALQAGRPVT
                     LPDITSVAKSLGAKTVAARTLECAKECEVLSEVVEDREAVSAVQRFLDDERMLVEPAC
                     GAALAAIYSGILWRLQAEGRLSSALASVVVIVCGGNNISSQQLQELKIQLGCS"
     exon            520..559
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            560..699
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            700..788
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1016
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1141
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1492
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /note="hexamer: AATAAA"
     polyA_site      1492
                     /gene="Sdsl"
                     /gene_synonym="4432411H13Rik; SDH1; SDS-RS1; TDH"
                     /note="major polyA site"
ORIGIN      
        1 ggctcactgg caagtgaaga ccttgacaga aaacctcaca ccccaagggc acatgcagaa
       61 gaggccttcc tgattctgtc tcacgtggct tcgttcttag atgagcccag gtcgttcatg
      121 agccatgagc tgcgtaagga agacagagag gattgaatac ccccacgggt tcatcttggt
      181 cattttttgt tgtgagttct caccaggacc ccagaatcag gagctgtccc tttaacaagg
      241 aggaggggcc aggccctggt agccggaagc tgatctggta gccagtgcgt ccaggttggt
      301 cctggctggg ctgtccttca ggaaggtggt cagcgcgctg ctggaatgga gggggccttg
      361 gcagaacgcg tcggggcgga gcctttccac agggtcacgc ccctgctgga gagctgggcg
      421 ctgtctcagg tggcaggcat gccggtcttc ctcaaatatg agaatgtgca gatagctggc
      481 tcctttaaga ttcggggcat cggacatttc tgccagcaga tggccaagag gggatgcaga
      541 catctggtgt gctcctcagg gggcaatgcg ggcattgcgg ctgcatactc ggctcgtaag
      601 ctgggcatcc ccgtcaccat cgtgctccca gagggcacct ccgtgcaggt ggtgaggcgg
      661 ctcgaggggg aaggggccga ggtccagctg actgggaaag tctgggatga agccaatgta
      721 aaagcacaag aactggccac aagggatggc tgggtgaacg tctccccgtt tgaccatccc
      781 cttatatggg aaggccatgc cagcctagtg cgggagctga aggagtcact agggacccct
      841 ccaggtgctg tggtgctggc cgtggggggc ggagggctcc tggcaggtgt gactgctggc
      901 ctgctggagg tgggctggca gcatgtgccc atcgttgcca tggagacccg cggggcgcac
      961 agtttcaatt cggccttgca ggcaggcagg ccggtcaccc tgccagacat caccagtgta
     1021 gccaagagcc tcggagccaa gacggtggct gcacggacct tggagtgtgc aaaggagtgt
     1081 gaggtcctct ctgaggtggt agaagaccgg gaggctgtca gcgctgtgca gaggttcctg
     1141 gacgatgagc gcatgctggt ggaacctgcc tgcggtgccg ccctggccgc catctactcg
     1201 ggcatcctgt ggaggctcca ggctgagggc cgcctgagtt ctgccctagc ttccgttgtg
     1261 gtcatcgtgt gcggtggcaa caacattagt agccaacagc ttcaggagct gaaaatccag
     1321 ctgggctgca gctgaagaat ctcaggaact cccccagagg ttcctggaca ccttggtggg
     1381 tcactcaagg gacctcggtt ccagtggtcc tgccctcttc cttccaggta gccctcctgg
     1441 gttgctctca gtggctccct gctgtccagt gaataaacct gactgagctg ag
//
