LOCUS       NM_145565               1164 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus serine dehydratase (Sds), mRNA.
ACCESSION   NM_145565
VERSION     NM_145565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Benneyworth,M.A. and Coyle,J.T.
  TITLE     Altered acquisition and extinction of amphetamine-paired context
            conditioning in genetic mouse models of altered NMDA receptor
            function
  JOURNAL   Neuropsychopharmacology 37 (11), 2496-2504 (2012)
   PUBMED   22763616
  REMARK    GeneRIF: This persistent conditioned hyperactivity in The SR-/-
            subjects supports the conclusion that intact NMDA receptor
            signaling is critical to extinction learning.
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Zhang,M., Teng,H., Shi,J. and Zhang,Y.
  TITLE     Disruption of beta-arrestins blocks glucocorticoid receptor and
            severely retards lung and liver development in mice
  JOURNAL   Mech Dev 128 (7-10), 368-375 (2011)
   PUBMED   21824517
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Lovgren,A.K., Kovarova,M. and Koller,B.H.
  TITLE     cPGES/p23 is required for glucocorticoid receptor function and
            embryonic growth but not prostaglandin E2 synthesis
  JOURNAL   Mol Cell Biol 27 (12), 4416-4430 (2007)
   PUBMED   17438133
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Edgar,A.J.
  TITLE     Mice have a transcribed L-threonine aldolase/GLY1 gene, but the
            human GLY1 gene is a non-processed pseudogene
  JOURNAL   BMC Genomics 6, 32 (2005)
   PUBMED   15757516
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Kaestner,K.H., Katz,J., Liu,Y., Drucker,D.J. and Schutz,G.
  TITLE     Inactivation of the winged helix transcription factor HNF3alpha
            affects glucose homeostasis and islet glucagon gene expression in
            vivo
  JOURNAL   Genes Dev 13 (4), 495-504 (1999)
   PUBMED   10049364
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Lia,M., Bali,D. and Gluecksohn-Waelsch,S.
  TITLE     Regulatory genes linked to the albino locus in the mouse confer
            competence for inducible expression on the structural gene encoding
            serine dehydratase
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2453-2455 (1992)
   PUBMED   1312724
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC021950.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            39 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021950.1, AK149438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1164              BC021950.1         1-1164
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.63 cM"
     gene            1..1164
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /note="serine dehydratase"
                     /db_xref="GeneID:231691"
                     /db_xref="MGI:MGI:98270"
     exon            1..51
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            52..206
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1037
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /note="TDH; L-serine deaminase; L-threonine dehydratase"
                     /codon_start=1
                     /product="L-serine dehydratase/L-threonine deaminase"
                     /protein_id="NP_663540.1"
                     /db_xref="CCDS:CCDS19619.1"
                     /db_xref="GeneID:231691"
                     /db_xref="MGI:MGI:98270"
                     /translation="MAAQESLHVKTPLRDSMALSKLAGTSVFLKMDSSQPSGSFKIRG
                     IGHLCKMKAKQGCRHFVCSSAGNAGMATAYAARRLGIPATIVVPNTTPALTIERLKNE
                     GATVEVVGEMLDEAIQVAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKP
                     GAIVLSVGGGGLLCGVVQGLREVGWEDVPIIAMETFGAHSFHAAIKEGKLVTLPKITS
                     VAKALGVNTVGAQTLKLFYEHPIFSEVISDQEAVSALEKFVDDEKILVEPACGAALAA
                     VYSRVVCRLQDEGRLQTPLASLVVIVCGGSNISLAQLQALKVQLGLNGLPE"
     exon            207..246
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            247..386
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            387..478
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            479..706
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            707..831
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1164
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacacaat ctactcctct cgctcgctct gtccagctcc tcctgtgccg gccatggctg
       61 cccaggagtc cctgcatgtg aagaccccac ttcgtgacag catggcgttg tccaaattgg
      121 ccggcaccag cgtgttccta aaaatggaca gctcccagcc ctcaggctcc ttcaagatcc
      181 gaggcattgg gcatctctgc aagatgaaag caaaacaagg ctgtagacat tttgtctgtt
      241 cttcagctgg caacgcgggc atggcgaccg cctacgctgc caggaggctg ggcatcccag
      301 ccactatcgt tgtgcccaac accacacctg ccctcaccat tgagcggctc aagaatgaag
      361 gcgccacagt tgaagtggtg ggagagatgc tggatgaggc catccaagtg gccaaggctc
      421 tggaaaagaa caacccgggt tgggtgtaca tttccccctt tgatgaccct ctcatctggg
      481 aaggccacac ttcccttgtg aaagagctga aggagacgct gagcgccaag cccggggcta
      541 tcgtgctgtc tgtgggcggt ggaggcctgc tgtgcggagt ggtccagggg ctgcgggagg
      601 tgggctggga ggatgtgccc atcatcgcca tggagacctt tggcgcccac agcttccatg
      661 ctgccatcaa ggaaggaaag ctggtcaccc tgcccaagat caccagtgtc gccaaggcct
      721 tgggcgtgaa cactgtcggg gcgcagaccc tgaagctgtt ttacgaacac cccattttct
      781 ccgaggtcat ctcagaccag gaggctgtgt ctgctcttga gaagttcgtg gacgatgaga
      841 agattctggt ggagcccgcg tgcggcgcgg cgctggctgc tgtgtacagc cgcgtggtgt
      901 gcaggctgca ggatgaaggc cggctgcaaa ccccactggc ctcgctggtt gtcatcgtgt
      961 gtggcggcag caacataagc ctggcgcagc tgcaggcact caaggtgcag ctgggcctga
     1021 acgggctgcc cgagtgatat ctgctgctgc cctggcctcc ctcagagggg tcaccggcac
     1081 cccctagtgg ggtgggatac acttgacaat ggccccaccc tcctttacct gtgtttataa
     1141 tgtgcacttt tccattgtaa ataa
//
