LOCUS       NP_663540                327 aa            linear   ROD 02-APR-2024
DEFINITION  L-serine dehydratase/L-threonine deaminase [Mus musculus].
ACCESSION   NP_663540
VERSION     NP_663540.1
DBSOURCE    REFSEQ: accession NM_145565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 327)
  AUTHORS   Benneyworth,M.A. and Coyle,J.T.
  TITLE     Altered acquisition and extinction of amphetamine-paired context
            conditioning in genetic mouse models of altered NMDA receptor
            function
  JOURNAL   Neuropsychopharmacology 37 (11), 2496-2504 (2012)
   PUBMED   22763616
  REMARK    GeneRIF: This persistent conditioned hyperactivity in The SR-/-
            subjects supports the conclusion that intact NMDA receptor
            signaling is critical to extinction learning.
REFERENCE   2  (residues 1 to 327)
  AUTHORS   Zhang,M., Teng,H., Shi,J. and Zhang,Y.
  TITLE     Disruption of beta-arrestins blocks glucocorticoid receptor and
            severely retards lung and liver development in mice
  JOURNAL   Mech Dev 128 (7-10), 368-375 (2011)
   PUBMED   21824517
REFERENCE   3  (residues 1 to 327)
  AUTHORS   Lovgren,A.K., Kovarova,M. and Koller,B.H.
  TITLE     cPGES/p23 is required for glucocorticoid receptor function and
            embryonic growth but not prostaglandin E2 synthesis
  JOURNAL   Mol Cell Biol 27 (12), 4416-4430 (2007)
   PUBMED   17438133
REFERENCE   4  (residues 1 to 327)
  AUTHORS   Edgar,A.J.
  TITLE     Mice have a transcribed L-threonine aldolase/GLY1 gene, but the
            human GLY1 gene is a non-processed pseudogene
  JOURNAL   BMC Genomics 6, 32 (2005)
   PUBMED   15757516
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 327)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
REFERENCE   6  (residues 1 to 327)
  AUTHORS   Kaestner,K.H., Katz,J., Liu,Y., Drucker,D.J. and Schutz,G.
  TITLE     Inactivation of the winged helix transcription factor HNF3alpha
            affects glucose homeostasis and islet glucagon gene expression in
            vivo
  JOURNAL   Genes Dev 13 (4), 495-504 (1999)
   PUBMED   10049364
REFERENCE   7  (residues 1 to 327)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   8  (residues 1 to 327)
  AUTHORS   Lia,M., Bali,D. and Gluecksohn-Waelsch,S.
  TITLE     Regulatory genes linked to the albino locus in the mouse confer
            competence for inducible expression on the structural gene encoding
            serine dehydratase
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2453-2455 (1992)
   PUBMED   1312724
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC021950.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            39 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021950.1, AK149438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Mus musculus"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.63 cM"
     Protein         1..327
                     /product="L-serine dehydratase/L-threonine deaminase"
                     /EC_number="4.3.1.17"
                     /EC_number="4.3.1.19"
                     /note="TDH; L-serine deaminase; L-threonine dehydratase"
                     /calculated_mol_wt=34462
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.2;
                     propagated from UniProtKB/Swiss-Prot (Q8VBT2.3)"
     Region          10..320
                     /region_name="L-Ser-dehyd"
                     /note="Serine dehydratase is a pyridoxal phosphate
                     (PLP)-dependent enzyme which catalyzes the conversion of
                     L-, D-serine, or L-threonine to pyruvate/ketobutyrate and
                     ammonia; cd06448"
                     /db_xref="CDD:107209"
     Site            order(41,67,168..172)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:107209"
     Site            41
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:107209"
     CDS             1..327
                     /gene="Sds"
                     /gene_synonym="4432411H13Rik; SDH"
                     /coded_by="NM_145565.1:54..1037"
                     /db_xref="CCDS:CCDS19619.1"
                     /db_xref="GeneID:231691"
                     /db_xref="MGI:MGI:98270"
ORIGIN      
        1 maaqeslhvk tplrdsmals klagtsvflk mdssqpsgsf kirgighlck mkakqgcrhf
       61 vcssagnagm atayaarrlg ipativvpnt tpaltierlk negatvevvg emldeaiqva
      121 kaleknnpgw vyispfddpl iweghtslvk elketlsakp gaivlsvggg gllcgvvqgl
      181 revgwedvpi iametfgahs fhaaikegkl vtlpkitsva kalgvntvga qtlklfyehp
      241 ifsevisdqe avsalekfvd dekilvepac gaalaavysr vvcrlqdegr lqtplaslvv
      301 ivcggsnisl aqlqalkvql glnglpe
//
