LOCUS       NM_027301               2863 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus 4short chain dehydrogenase/reductase family 9C, member
            7 (Sdr9c7), mRNA.
ACCESSION   NM_027301
VERSION     NM_027301.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Takeichi,T., Hirabayashi,T., Miyasaka,Y., Kawamoto,A., Okuno,Y.,
            Taguchi,S., Tanahashi,K., Murase,C., Takama,H., Tanaka,K.,
            Boeglin,W.E., Calcutt,M.W., Watanabe,D., Kono,M., Muro,Y.,
            Ishikawa,J., Ohno,T., Brash,A.R. and Akiyama,M.
  TITLE     SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin
            barrier formation
  JOURNAL   J Clin Invest 130 (2), 890-903 (2020)
   PUBMED   31671075
  REMARK    GeneRIF: SDR9C7 catalyzes critical dehydrogenation of acylceramides
            for skin barrier formation.
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Song,M.S., Chen,W., Zhang,M. and Napoli,J.L.
  TITLE     Identification of a mouse short-chain dehydrogenase/reductase gene,
            retinol dehydrogenase-similar. Function of non-catalytic amino acid
            residues in enzyme activity
  JOURNAL   J Biol Chem 278 (41), 40079-40087 (2003)
   PUBMED   12855677
  REMARK    GeneRIF: short-chain dehydrogenase/reductase (SDR), retinol
            dehydrogenase-similar (RDH-S), with intense mRNA expression in
            liver and kidney
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Chen,W., Song,M.S. and Napoli,J.L.
  TITLE     SDR-O: an orphan short-chain dehydrogenase/reductase localized at
            mouse chromosome 10/human chromosome 12
  JOURNAL   Gene 294 (1-2), 141-146 (2002)
   PUBMED   12234675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064820.1.
            
            On Jan 11, 2004 this sequence version replaced NM_027301.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064820.1, AK037184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..2863
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="4short chain dehydrogenase/reductase family 9C,
                     member 7"
                     /db_xref="GeneID:70061"
                     /db_xref="MGI:MGI:1917311"
     exon            1..411
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1052
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="orphan short chain dehydrogenase/reductase; RDH-S;
                     retinol dehydrogenase 20"
                     /codon_start=1
                     /product="short-chain dehydrogenase/reductase family 9C
                     member 7"
                     /protein_id="NP_081577.1"
                     /db_xref="CCDS:CCDS24256.1"
                     /db_xref="GeneID:70061"
                     /db_xref="MGI:MGI:1917311"
                     /translation="MAALTDFAFMYRWFKNCNLVKNLSEKYVFITGCDSGFGNLLAKQ
                     LVDRGMKVLAACLTEEGAQKLLQDTSHQLQTFLLDVTKSENVKEAAQWVRDQVGEQGL
                     WALVNNAGVGLPSGPNEWLTIKDFVKVININLVGLIDVTLNMLPMIKKARGRVVNMSS
                     SGGRVAIFGGGYCVSKFGVEAFSDSIRRELHFFGVKVSIIEPGNYKTSILGQEALESR
                     MKKLWDRLPQETRDSYGEEYFQTYTKKLVNLMRSAEPRISDVTNSMEHAIVSRSPRIR
                     YNPGLDVKFLYLTLAKLPTPVTDFILSRYLPRPADSV"
     exon            412..670
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /inference="alignment:Splign:2.1.0"
     exon            671..834
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /inference="alignment:Splign:2.1.0"
     exon            835..2851
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="hexamer: AACAAG"
     polyA_site      1479
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="major polyA site"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="hexamer: AATAAA"
     polyA_site      2851
                     /gene="Sdr9c7"
                     /gene_synonym="1810054F20Rik; Rdh20; Rdhs; SDR-O; Sdro"
                     /note="major polyA site"
ORIGIN      
        1 gcaagtctca gaagctctcc tttcctgtgg gttcctgtgg gctgcctgct gggctctgag
       61 gatcagccta tcctaccatc tcctgggtcc atcctcagac atcagctccc atggcggccc
      121 tcacagactt tgcttttatg taccgctggt tcaaaaattg caatctggtt aaaaacctct
      181 ctgagaagta tgtcttcatc actggctgtg actccggctt tgggaacctg ttggccaaac
      241 aactggttga taggggcatg aaagtgcttg ctgcctgcct cactgaggag ggggctcaga
      301 aactcctgca ggacacctcc caccagctgc agaccttcct cctagatgtc accaagtcgg
      361 agaacgtcaa ggaagcagcc cagtgggtga gggaccaagt gggcgagcaa ggcctctggg
      421 ccctggtgaa caacgctggc gtgggcctgc ccagtggtcc caacgaatgg ctgaccataa
      481 aagactttgt gaaagtgatc aacataaacc tggtggggct gattgatgtc actctgaaca
      541 tgctgccgat gatcaagaaa gcccggggca gggtggtcaa catgtccagc tctggtggcc
      601 gtgtggctat attcggcggt ggttactgtg tctccaagtt tggtgttgaa gccttctctg
      661 atagcatcag gcgcgagctt catttcttcg gggtgaaggt cagcatcatt gagccaggga
      721 actacaagac atccattctg ggccaagaag ctctggaatc acgcatgaag aagctgtggg
      781 atcggctgcc acaggagacc cgggatagct acggagagga gtatttccaa acctatacta
      841 aaaagttggt taacttgatg aggtcagcag agccaagaat cagcgatgtc accaacagca
      901 tggagcacgc cattgtctcc cggagccccc gaatccgcta caaccctggc ctggacgtca
      961 agtttctcta tctcaccctg gctaagctgc ccacccctgt gacagatttc atccttagca
     1021 gatacttgcc aagaccagca gacagtgttt gagctggcga gctcaagggg tagccagtgg
     1081 agcacagggg agagggcaaa ggactggggg atcacaagag gtgttgtcat atatcttgtg
     1141 ggcagagaag agcatactca gctcactccc actgcaggct gatgtctcct tccatctgct
     1201 ggggcctcta gaaacctgat gtgaccccgg ctgatgtaga tagagcgttg cagcataggc
     1261 cgcaagacac ccctcaccaa ggcaggtact agtgctcctg gacctgaaaa gccggcttct
     1321 gttgactgac aagctgtcac cacctccgta aaacaccatg ggacaatcta gcccacagga
     1381 gaatctcggt cccctcccca cagctctcaa agcaggcact ggtttgtgta tatatggaat
     1441 atgtaacatg gcaacaagaa ctgccagagc atactcagag aaggttttaa atagttttct
     1501 tttctttgca tttctctatc tgattgggat ccatataatg cttgcttctc taatcaccat
     1561 tgattcctgt ttcaagtatt tattgagcac ttactacgta ccagcaccaa aactctgggg
     1621 gtatgtgagg gtgatgaaat catgaacttg tcttgttttg ttttgttttg tttgtctcac
     1681 gttttacttt gttacagtag ctagcagcag agataggaca gtgaccaagg ggacaaagat
     1741 cagaaaaagg aaatttgaag gaccctggat ctcaatagtc ctagactcgg atgtttactg
     1801 ggatcactca gttacttaaa atgcgtacgg aagctggaga gatggctcgg aggttaagag
     1861 catttgtgcc tcgcagaatc tggaatagat ccccagtctc cacaccgtgt ctcacagcct
     1921 ccataattcc agttccaggg gatcggatgc ccccttctga cctccacagg taccaagcat
     1981 gaatgtaatg tgtattgata catgcaggca aaaacacgca tacacataaa ataagataaa
     2041 tctttaaaaa gtgaatgtgt aaggaagctg ggcatggtat ctcatgtttg taatcccaac
     2101 atttatgggg ctaagacagg aggatttttg tgagtctaag gaaagactag attacaaaat
     2161 gagacactgt ctcaagaaac aaaccccagg aaacaaacaa aagaactcat aggaacccca
     2221 atgttagaaa atccgattca ataaacctga gtgaggcaga gcccagaact atgaattgtg
     2281 tactaaggac ctaaatgtac ctgcgcacct gggaggcagt gatagtccca caggagaagc
     2341 agccaatcag ctcagagtgg gaagtcattt tcgccaaggc acccagctaa gtggtcaaac
     2401 aaacagaacc cttttccagc agcaggtgat gaactgtttg taacatcttc aaataagtca
     2461 tagaactaaa taattcatgt ctttaaaaat agctaccaac ttctgagtta tatgaactat
     2521 taatgaaaaa ggatactttt ttgatcaagt tcatatactg aatatcaaac ccagagcctg
     2581 agcatcatag acaagcactc accactgacc tacattccca ccctcagatt ttcaattagc
     2641 ttactcagaa gctcaggctg gccttgaact tgctataact ttcaatattc cctcaaactc
     2701 ataattctcc tgcctctact cccagagtgc tatgactaca ggcatgtgcc atcagtccca
     2761 acaataacag tgataaaata aataaataga attgtttaaa attctgcagt ttgtgcaata
     2821 aaggtcaaat attattattt aaaaatcaaa aaaaaaaaaa aaa
//
