LOCUS       NM_001080710            1181 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus short chain dehydrogenase/reductase family 16C, member
            6 (Sdr16c6), mRNA.
ACCESSION   NM_001080710 XM_143619 XM_905488 XM_973713
VERSION     NM_001080710.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1181)
  AUTHORS   Butovich,I.A., Wilkerson,A., Goggans,K.R., Belyaeva,O.V.,
            Kedishvili,N.Y. and Yuksel,S.
  TITLE     Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation
            point between meibogenesis and sebogenesis
  JOURNAL   J Biol Chem 299 (6), 104725 (2023)
   PUBMED   37075844
  REMARK    GeneRIF: Sdr16c5 and Sdr16c6 control a dormant pathway at a
            bifurcation point between meibogenesis and sebogenesis.
REFERENCE   2  (bases 1 to 1181)
  AUTHORS   Wu,L., Belyaeva,O.V., Adams,M.K., Klyuyeva,A.V., Lee,S.A.,
            Goggans,K.R., Kesterson,R.A., Popov,K.M. and Kedishvili,N.Y.
  TITLE     Mice lacking the epidermal retinol dehydrogenases SDR16C5 and
            SDR16C6 display accelerated hair growth and enlarged meibomian
            glands
  JOURNAL   J Biol Chem 294 (45), 17060-17074 (2019)
   PUBMED   31562240
  REMARK    GeneRIF: SDR16C5 and SDR16C6 enzymes are not critical for survival
            but are responsible for most of the retinol dehydrogenase activity
            in skin, essential for the regulation of the hair-follicle cycle,
            and required for the maintenance of both sebaceous and meibomian
            glands
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC125450.1.
            
            On Jun 3, 2007 this sequence version replaced NM_001080710.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125450.1, AK076465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.27 cM"
     gene            1..1181
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /note="short chain dehydrogenase/reductase family 16C,
                     member 6"
                     /db_xref="GeneID:242286"
                     /db_xref="MGI:MGI:2685269"
     exon            1..91
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     exon            92..438
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1068
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /codon_start=1
                     /product="short-chain dehydrogenase/reductase family 16C
                     member 6"
                     /protein_id="NP_001074179.1"
                     /db_xref="CCDS:CCDS38688.1"
                     /db_xref="GeneID:242286"
                     /db_xref="MGI:MGI:2685269"
                     /translation="MNSVADTAIFFGKFLYYFLESLVFKVIPKRKKDVSGEIVLITGA
                     GSGLGRLLAIHFASHGATLVLWDINQEGNMETCRLVKQKGDVKVFAYKCDCSSRIEVY
                     RVADQVKEEVGDVTILINNAGVVTGKSFLNTPDHLVEKSFLVNAISHFWTCKAFLPAM
                     VKANHGHLVCISSIAGLVGINGLSDYSSSKFAAFGFAESLFLELTMIMKTKVKSTIVC
                     PYFIKTGMFEGCTTKYPLLLPLLEQEYVAQKIFNAILEEQVYLIIPKFAYVALFLKQI
                     ISPKMMIALGEYLGVDTCMTSFTGRVKAEELQMETKRKEQ"
     exon            439..570
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     exon            571..670
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     exon            671..815
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     exon            816..941
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1181
                     /gene="Sdr16c6"
                     /gene_synonym="4833413O15Rik; Gm423"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgtccacgg tctctgcttc actttctgcc tcagattcct acctttaact cctttcttga
       61 cttcccttca tgacggactg taacctgtaa ggacgttgct ttcttcaatc aatcaacatg
      121 aattcagtgg cagacacagc tatctttttt ggaaagtttc tatattactt tttagaatct
      181 ttagttttca aagtaattcc taaaaggaaa aaggatgttt ctggagagat tgtacttata
      241 acaggagctg gaagtggact tggaaggcta ctggccatac attttgccag ccacggggcc
      301 actttagttc tctgggacat taatcaagaa ggcaatatgg aaacctgtag actggtcaaa
      361 caaaaaggtg atgtgaaagt ctttgcctat aagtgtgatt gcagcagcag gatagaggtc
      421 tacagagttg ctgatcaggt taaagaagaa gtcggtgatg tcacaattct tattaataat
      481 gcaggtgttg tgacaggaaa gtcattcctc aatactccgg atcacttggt ggaaaaatca
      541 tttcttgtca atgccatttc tcacttctgg acttgtaagg ccttccttcc tgccatggtt
      601 aaagctaacc atggtcacct ggtctgtatt tcaagcatag caggactcgt tggtattaat
      661 ggactgtcag attattcttc aagcaaattt gcagcctttg gctttgccga gtctctcttc
      721 cttgaattaa ctatgataat gaaaactaaa gttaaaagta ccatcgtttg cccctatttc
      781 atcaaaactg gaatgtttga aggctgtaca accaagtatc cacttctctt acctctcctg
      841 gagcaggagt atgtggctca aaaaattttc aatgctattt tagaggaaca agtttacctc
      901 atcataccca agtttgcata tgttgcattg tttctcaaac aaataatatc tccaaaaatg
      961 atgattgccc tgggcgagta ccttggtgtg gacacatgta tgacttcgtt cacagggaga
     1021 gtcaaagcag aggagctgca gatggaaaca aaaaggaaag agcaatagct cagccattga
     1081 ccatgataat cacatgtaca gatgagacag tacactgttg ggaatccctg taatggttgc
     1141 agcatgccag cataacctag ggtcatccag gcattgggaa a
//
