LOCUS       NM_181989               1379 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus short chain dehydrogenase/reductase family 16C, member
            5 (Sdr16c5), mRNA.
ACCESSION   NM_181989
VERSION     NM_181989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Butovich,I.A., Wilkerson,A., Goggans,K.R., Belyaeva,O.V.,
            Kedishvili,N.Y. and Yuksel,S.
  TITLE     Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation
            point between meibogenesis and sebogenesis
  JOURNAL   J Biol Chem 299 (6), 104725 (2023)
   PUBMED   37075844
  REMARK    GeneRIF: Sdr16c5 and Sdr16c6 control a dormant pathway at a
            bifurcation point between meibogenesis and sebogenesis.
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Wu,L., Belyaeva,O.V., Adams,M.K., Klyuyeva,A.V., Lee,S.A.,
            Goggans,K.R., Kesterson,R.A., Popov,K.M. and Kedishvili,N.Y.
  TITLE     Mice lacking the epidermal retinol dehydrogenases SDR16C5 and
            SDR16C6 display accelerated hair growth and enlarged meibomian
            glands
  JOURNAL   J Biol Chem 294 (45), 17060-17074 (2019)
   PUBMED   31562240
  REMARK    GeneRIF: SDR16C5 and SDR16C6 enzymes are not critical for survival
            but are responsible for most of the retinol dehydrogenase activity
            in skin, essential for the regulation of the hair-follicle cycle,
            and required for the maintenance of both sebaceous and meibomian
            glands
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY277588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY277588.1, BC104134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.23 cM"
     gene            1..1379
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /note="short chain dehydrogenase/reductase family 16C,
                     member 5"
                     /db_xref="GeneID:242285"
                     /db_xref="MGI:MGI:2668443"
     exon            1..215
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            216..562
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1159
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /EC_number="1.1.1.105"
                     /note="retinal short chain dehydrogenase reductase 2;
                     retinal short chain dehydrogenase reductase (Rdhe2);
                     EPHD-2; RDH-E2; retSDR2; short chain dehydrogenase
                     reductase 9; epidermal retinal dehydrogenase 2"
                     /codon_start=1
                     /product="epidermal retinol dehydrogenase 2"
                     /protein_id="NP_871789.1"
                     /db_xref="CCDS:CCDS17944.1"
                     /db_xref="GeneID:242285"
                     /db_xref="MGI:MGI:2668443"
                     /translation="MSQNLESVKNLLVFLGKSLLSVLEALLFHVISKPRKNVAGEIVL
                     ITGAGSGLGRLLALQFARLGAVLVLWDVNKEANDETHQLAREAGAARVHAYTCDCSRR
                     EEVYRVADQVKKEVGDVSILINNAGIVTGRNFLDCPDDLMEKSFDVNFKAHLWMYKAF
                     LPAMIANNHGHLVCISSSAGLIGVNGLSDYCASKFAALGFAESMFIETLAKKQWGIKT
                     TIVCPFFIKTGMFEGCTTKCPTLLPILDPEYAVRKIIDAILQEQLYLYMPKFLYFIVF
                     LKSILPIKTGILIADYLGVFHMTEGFTGQKKKT"
     exon            563..694
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            695..794
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            795..939
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1065
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1379
                     /gene="Sdr16c5"
                     /gene_synonym="Rdhe2; Scdr9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacaagtca ggtctccact atccttacca tcttctgcag gaaagggcgc ctgcacgagg
       61 cccctccccg gagggatcac agtccagtct ttcgcttggg gcccagccta ctcagggata
      121 aacatctgaa ccttgctgct taaccaggga cttgggtgcc tgaggcctaa gacgcctgct
      181 tctccaccgg ggacagagag gggactgttt gcgaggtgtt tgccagaaca tgtctcaaaa
      241 cctggaatca gtgaagaact tgcttgtttt cttgggaaaa tcactgttga gtgttttgga
      301 ggccctactt tttcatgtca tctcaaaacc acggaagaac gttgccggtg agatagtgct
      361 cataacaggt gctgggagtg gactaggaag gctcttagca ttgcagtttg cccgcctggg
      421 agcagtgctt gttctctggg atgtgaacaa ggaggcaaat gatgagactc atcagttagc
      481 tcgggaagca ggagctgcca gagtacatgc ctacacctgt gactgcagcc ggagggaaga
      541 agtgtacaga gtggctgacc aggttaagaa agaagttggt gatgtctcta tcctcatcaa
      601 caatgccggc attgtaacag gcagaaattt ccttgactgc ccagatgacc tcatggaaaa
      661 gtcatttgat gtcaatttca aagcacattt atggatgtat aaagccttcc tgcctgccat
      721 gattgctaac aaccacggcc atttggtttg catttcaagt tcagctggat taattggagt
      781 aaatgggctg tcagactatt gtgcaagtaa attcgcagcc cttggatttg cagaatctat
      841 gtttatcgaa acacttgcca agaaacaatg ggggatcaaa acgacaattg tgtgcccatt
      901 ctttataaaa actggaatgt ttgaaggttg cactactaag tgtcctactc tgttaccaat
      961 tctggatcca gaatatgcag ttaggaaaat catagatgcc attctccagg agcagctcta
     1021 cttgtatatg cccaagtttt tatacttcat agtgtttcta aaaagcatct tgccaatcaa
     1081 gacaggaata cttatagctg actacctggg agtctttcat atgacagagg gcttcactgg
     1141 ccaaaagaag aaaacttaac aataagttcc atgccctgtg tcgtctgaga cccattgcta
     1201 catcaggctt acttcaaaga agaaaggtat ttctgacaga acccaaagac aagtatgttc
     1261 tgctgtggat cagaatgtcc ttccagtgtc atttaaatgc aacgttactg ttttcttttg
     1321 ttgttgttga gtgtattttt gtttgtttgt tgtttgaaaa ataaaaatag ctctttgtc
//
