LOCUS       NM_177879               8513 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus sidekick cell adhesion molecule 1 (Sdk1), mRNA.
ACCESSION   NM_177879
VERSION     NM_177879.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8513)
  AUTHORS   Rochon,P.L., Theriault,C., Rangel Olguin,A.G. and Krishnaswamy,A.
  TITLE     The cell adhesion molecule Sdk1 shapes assembly of a retinal
            circuit that detects localized edges
  JOURNAL   Elife 10, e70870 (2021)
   PUBMED   34545809
  REMARK    GeneRIF: The cell adhesion molecule Sdk1 shapes assembly of a
            retinal circuit that detects localized edges.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8513)
  AUTHORS   Yamagata,M. and Sanes,J.R.
  TITLE     Expression and Roles of the Immunoglobulin Superfamily Recognition
            Molecule Sidekick1 in Mouse Retina
  JOURNAL   Front Mol Neurosci 11, 485 (2019)
   PUBMED   30687002
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8513)
  AUTHORS   Tang,H., Chang,H., Dong,Y., Guo,L., Shi,X., Wu,Y., Huang,Y. and
            He,Y.
  TITLE     Architecture of cell-cell adhesion mediated by sidekicks
  JOURNAL   Proc Natl Acad Sci U S A 115 (37), 9246-9251 (2018)
   PUBMED   30150416
  REMARK    GeneRIF: The results suggest that the Ig-like domains and the
            fibronectin III (FnIII) domains of Sidekicks play different roles
            in cell adhesion. The Ig-like domains mediate the homophilic
            transinteractions bridging adjacent cells, while the FnIII domains
            interact with membranes, resulting in a tight adhesion interface
            between cells
REFERENCE   4  (bases 1 to 8513)
  AUTHORS   Yamagata,M. and Sanes,J.R.
  TITLE     Reporter-nanobody fusions (RANbodies) as versatile, small,
            sensitive immunohistochemical reagents
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), 2126-2131 (2018)
   PUBMED   29440485
REFERENCE   5  (bases 1 to 8513)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8513)
  AUTHORS   Kaufman,L., Potla,U., Coleman,S., Dikiy,S., Hata,Y., Kurihara,H.,
            He,J.C., D'Agati,V.D. and Klotman,P.E.
  TITLE     Up-regulation of the homophilic adhesion molecule sidekick-1 in
            podocytes contributes to glomerulosclerosis
  JOURNAL   J Biol Chem 285 (33), 25677-25685 (2010)
   PUBMED   20562105
  REMARK    GeneRIF: Data conclude that the up-regulation of sdk-1 in podocytes
            is an important pathogenic factor in glomerulosclerosis and that
            the mechanism involves disruption of the actin cytoskeleton
            possibly via alterations in MAGI-1 function.
REFERENCE   7  (bases 1 to 8513)
  AUTHORS   Kaufman,L., Yang,G., Hayashi,K., Ashby,J.R., Huang,L., Ross,M.J.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     The homophilic adhesion molecule sidekick-1 contributes to
            augmented podocyte aggregation in HIV-associated nephropathy
  JOURNAL   FASEB J 21 (7), 1367-1375 (2007)
   PUBMED   17307840
  REMARK    GeneRIF: -1 is an important mediator of cellular adhesion in
            HIV-infected podocytes and may contribute to podocyte clustering
            that is characteristic of pseudocrescent formation in
            HIV-associated nephropathy
REFERENCE   8  (bases 1 to 8513)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   9  (bases 1 to 8513)
  AUTHORS   Hayashi,K., Kaufman,L., Ross,M.D. and Klotman,P.E.
  TITLE     Definition of the critical domains required for homophilic
            targeting of mouse sidekick molecules
  JOURNAL   FASEB J 19 (6), 614-616 (2005)
   PUBMED   15703275
  REMARK    GeneRIF: results establish that the first and second immunoglobulin
            domains of sidekick-1 and -2 are necessary and sufficient to
            mediate and target homophilic adhesion
REFERENCE   10 (bases 1 to 8513)
  AUTHORS   Kaufman,L., Hayashi,K., Ross,M.J., Ross,M.D. and Klotman,P.E.
  TITLE     Sidekick-1 is upregulated in glomeruli in HIV-associated
            nephropathy
  JOURNAL   J Am Soc Nephrol 15 (7), 1721-1730 (2004)
   PUBMED   15213259
  REMARK    GeneRIF: sidekick is expressed in ureteric bud and ureteric
            bud-derived tissues and may play a role in branching morphogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147578.1 and AK086302.1.
            
            On Jan 9, 2008 this sequence version replaced NM_177879.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147578.1, BC060237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8511              AK147578.1         46-8556
            8512-8513           AK086302.1         86-87
FEATURES             Location/Qualifiers
     source          1..8513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.81 cM"
     gene            1..8513
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="sidekick cell adhesion molecule 1"
                     /db_xref="GeneID:330222"
                     /db_xref="MGI:MGI:2444413"
     exon            1..559
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..6897
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="sidekick homolog 1"
                     /codon_start=1
                     /product="protein sidekick-1"
                     /protein_id="NP_808547.3"
                     /db_xref="CCDS:CCDS39360.2"
                     /db_xref="GeneID:330222"
                     /db_xref="MGI:MGI:2444413"
                     /translation="MARARPSVAGGGVAAPPERAGPGRPRRSRTGHHCDPECPGLRAA
                     PRTPGPGAGRRAAKLRPGRGWWALLLLQLHLLRALAQDDVAPYFKTEPGLPQIHLEGN
                     RLVLTCLAEGSWPLEFKWIRNDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGAL
                     LQRKSEIQVAYMGNFMDTDQRKTVSQGHAALLNLLPIVSCPQPQVTWFREGHKIIPSS
                     RIAITLENQLVILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPI
                     IVVAPGNRSVVAGSSETTLECIANARPVEELSVHWKRNGVRLTSGLHSYGRRLTITNP
                     TSADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRILGEVEETMDIPCRA
                     MGVPLPTLQWYKDAVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGIFQCFASNEGGEVQ
                     THTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHILASGSVR
                     IPRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVHPPEDRV
                     VIKGTTATLCCGATHDPRTSLRYVWKKDNVVITASSSSRIVVEKDGSLVISQTWSGDI
                     GDYTCEIISEGGSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPV
                     LYYIVQVSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTET
                     SRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE
                     HQQRNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQ
                     NVQAEAVNSTTVHFLWNPPPQQFINGINQGYKLLAWPADAPETVTVVTIAPDFHGIHH
                     GYITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSFTEILDTSLKV
                     SWQEPLERNGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTTYTIDVAAL
                     TAAGVGVTTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVE
                     GQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSR
                     VIQTLQAPPDVAPTSLTVRTASETSLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPS
                     SALAQVVSDRLERELTIEELEEWTEYELRMQAFNAIGAGPWSELVRGRTRESVPSAAP
                     ENVSAEAVSSTQILLTWASVPEQDQNGLILGYKVLYCAKDLDPEPRSHVVRGNHTQSA
                     LLAGLRKFVVYELQVLAFTRIGNGVPSSPLILERTKDDTPGPPVRLVFPEVRLTAVRI
                     VWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEVGATVRQFTATELAPESAYIFRLSA
                     KTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYF
                     TVQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIGDSDFSAETEA
                     VTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELESETGMS
                     PEPKTLKSPSALRAELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIGES
                     PASVPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVYYWEA
                     DSRNETEKMKVLFLPEPVVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAP
                     GPPSFLAFSEITSTTLNVSWGEPSAANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNW
                     QRWLKVRDLTKGVTYFFRVQARTIAYGPELQANVTAGPAEGSPGSPRNVLVTKSASEL
                     TLQWTEGNAGTTPTTGYVIEARPSDEGLWDMFAKDIPRSATSYTVDLDKLRQGVTYEF
                     RVVAVNKAGFGEPSRPSIAVSAQAEAPFYEEWWFLLVMALSSLLLILLVVFVLVLHGQ
                     SKKYKSCSTGKGISNMEETVTLDNGGFAALELNSRHLNVKSTFSKKNGTRSPPRPSPG
                     GLHYSDEDICNKYNGAVLTESVNLKEKSVDGSESEASDSDYEEALPKHSFVNHYMSDP
                     TYYNSWKRRPPAAAPHRYEAVAGAEAGPHLHTVITTQSAGGVYTPAGPGARAPLTGFS
                     SFV"
     exon            560..719
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..826
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            827..974
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1108
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1220
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1411
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1495
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1690
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1807
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1975
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2078
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2255
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2392
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2540
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2681
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2863
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2979
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3172
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3271
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3463
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3585
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3695
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3846
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..4084
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4200
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4390
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4489
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4684
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4886
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..4990
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4991..5061
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5197
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5198..5257
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5359
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5360..5475
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5476..5662
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5663..5800
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5801..5962
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5963..6088
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6089..6253
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6254..6391
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6392..6512
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6513..6642
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6643..8513
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7889..7894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7916
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="major polyA site"
     regulatory      8469..8474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="hexamer: AATAAA"
     regulatory      8478..8483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      8487
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
     polyA_site      8504
                     /gene="Sdk1"
                     /gene_synonym="5330440E10; 6720466O15Rik"
ORIGIN      
        1 gaggcgagag ccggcgcgcg ggcgggcgca ctttctcctc agcgccgggc gggggcggcg
       61 gcggcagagg cggcggcaga ggcgttctgc tcagctcccc tcacagagcg ctgcggggcc
      121 ggcgctgtgc ggctgcgagg agcgggggcg acgtgctggg catttcctcg ctcgctgaca
      181 acttctcctc gacccggctc gctgctcatc ggagcccgga cgccgcccct cggcgctcgc
      241 cgctgcctca gcgggtctgc gcgctcccgc ccgccctgcc cgtcccgcgg cgcccggggg
      301 tggcggctcc gcggcatggc ccgcgcccgg ccctcggtgg cgggcggcgg agtcgcggcg
      361 ccccctgagc gagcggggcc cgggcggccg cggaggagcc ggaccggtca ccactgcgac
      421 cccgagtgcc cagggctgcg cgcagcgccc aggacccccg ggccgggcgc gggccggcgg
      481 gcggcaaagt tgaggccggg ccgcgggtgg tgggcgctgc tgttgctcca gctgcacttg
      541 ctgcgggcgc tggcgcaaga tgacgttgca ccgtatttca aaacggagcc gggcctgcca
      601 cagatccacc tggaagggaa ccgcctggtg ctcacctgcc tggctgaagg gagctggcct
      661 ctggaattca agtggatacg gaacgacagt gagcttacca cctacagcag cgaatataag
      721 tatatcatcc cctctttgca gaagctggac gccgggtttt accgctgcgt ggtgcggaac
      781 aggatgggag ctctcttgca gagaaaatca gaaattcaag tagcatatat ggggaacttc
      841 atggatacag accagaggaa aacagtttct caagggcatg cggcacttct caacttactg
      901 cctatcgtca gctgccccca acctcaagtg acgtggttta gagaaggaca caagattatt
      961 cccagcagca gaatagccat cacattggag aatcagctgg tgatccttgc tacaacagcg
     1021 agtgatgctg gggcttacta cgtgcaggct gtgaatgaga agaacggaga gaacaagaca
     1081 agcccgttca tccacctgag cgtagcacga gatactggta cccacgaggc catggcccca
     1141 atcatcgtgg ttgccccagg caacagaagt gtggtagcag ggtccagtga gaccaccttg
     1201 gagtgcatag ccaatgccag gcccgtggag gagctgagtg tgcactggaa gagaaacgga
     1261 gttcgactca caagtggact acacagctac gggaggcgcc ttaccatcac caatccgaca
     1321 tcagcagaca ccgggatgta cgtgtgcgag gcgacactcc gggggagcac atttgagcca
     1381 gccagggcca gagccttcct ttccatcata gagccaccat atttcactgc tgagccagag
     1441 agtcggattt taggggaagt ggaagaaact atggacatcc catgtcgagc catgggggtt
     1501 cctcttccca ctctccagtg gtacaaagat gctgttcccc tcagcaaact ccagaaccct
     1561 aggtataaag ttctccccag cggaggcctc cacattcaga agttgagtcc agaagactct
     1621 ggaatcttcc agtgctttgc cagtaacgaa ggaggagagg tccagactca cacctacctg
     1681 gatgtgacca atattgctcc tgccttcacc cagcgtccag tggacaccac ggttactgac
     1741 gggatgacgg ctgtcctgag gtgtgaggtg tccggagctc ccaaacccgc catcacatgg
     1801 aagagaggga accacattct ggccagtggc tctgtccgga ttcctaggtt catgctgctg
     1861 gaatctgggg ggctgagaat agcccccgtc ttcatccagg atgctggcaa ctacacctgc
     1921 tatgcagcca acacggaggc ttctgtgaac gcctccgcca tgctcaccgt gtggaatcga
     1981 acgtccatcg ttcaccctcc agaagaccgc gtggtgatta aggggacgac ggccaccctg
     2041 tgctgcggag ctacccacga ccctcggacc tctctccgct acgtttggaa aaaggacaac
     2101 gtggtcatca cagcgtctag cagctccaga attgtggtgg aaaaggatgg gtcgcttgtc
     2161 attagccaga cgtggtcagg ggacattggt gactacacct gtgaaatcat atccgaggga
     2221 gggagtgact cccggacggc acggctggaa gtgattgagc tgcctcaccc acctcaaaac
     2281 ctgctggcca gcttgagtcc agcacgcagc cactcggtga cactatcttg ggttcggccc
     2341 tttgatggaa acagcccggt cctttactac attgtgcaag tatctgaaaa caactctcca
     2401 tggaaagtgc atttgtcaaa tgttggcccg gagatgacag gcgtcactgt gagtggcttg
     2461 actccagccc ggacctatca gttcagggtg tgcgctgtga atcaagtggg caagggccag
     2521 tacagcacag agacaagcag attgatgtta cccgaagaac caccgagtgc tcccccaaaa
     2581 aacattgtgg ccagtgggag aaccaaccag tccatcatgg tacagtggca gccaccaccc
     2641 gaaacagagc acaatggggt gcttcggggc tacatcctca ggtaccgcct ggctggcctg
     2701 cctggggaac accagcagag gaacatcagc agcccagagg tgaactactg cctggtcacc
     2761 gacctcatca tctggaccca gtatgagatc caggtggctg cctacaacgg ggcaggcctg
     2821 ggtgtcttca gcagggcagt gaccgagtac accttacaag gagtgcccac tgcacctccc
     2881 cagaacgtgc aggcagaggc tgtgaattcc accactgtgc acttcctgtg gaacccgcca
     2941 ccccagcagt tcatcaacgg catcaaccag ggatacaagc tcctagcatg gccggcagat
     3001 gctcctgaga ctgtcactgt agtcactatt gctcctgact tccatggaat ccatcatggg
     3061 tacataacaa acttgaagaa gttcactgcc tacttcacat ccgtcctgtg ttttaccacc
     3121 ccgggggatg ggcctccaag ttcacctcag ctcgtgtgga cccatgagga caagccggga
     3181 gctgtggggc acctgagctt cacggagatt ttggacacct ctctcaaggt cagctggcag
     3241 gagcccctgg agagaaacgg catcattatg ggctatcaga tttcctggga ggtgtatggg
     3301 aggaatgact ctcgactcac gcacaccctc aacagcacga tgcacgagta taagatccaa
     3361 ggactgtcat cactcaccac ctataccatc gatgtggctg ccttgaccgc cgcaggcgtg
     3421 ggcgtgacca catcatccac catctcttca ggtgtacccc cagatcttcc tggcgctcca
     3481 tccaatctgg tcatttccaa catcagccct cgctcagcca cactccagtt ccgacctggc
     3541 tatgatggga agacggccat ctgcaggtgg attgtggagg ggcaggttgg tgccatcggg
     3601 gacgaggagg agtgggttac cctctatgag gaggagaatg agcccgatgc ccagatgttg
     3661 gagataccaa acctcacacc ctacacacac tacaggtttc gaatgaggca agtgaacatc
     3721 gtgggtccca gccccttcag ccagtcatcc agggtcatcc agaccctaca ggccccacct
     3781 gatgtggctc caaccagcct cactgtccga acagccagtg agaccagcct gaggctacgc
     3841 tgggtgcctc tgcctgattc ccagtacaat gggaaccctg agtctgtggg ctacagggtg
     3901 aagtattggc gttctgacca accatcgtca gctctggccc aagttgtcag tgaccgtctg
     3961 gagagggagc tgaccatcga ggaactggag gagtggacag agtacgagtt gcggatgcag
     4021 gccttcaacg ccattggggc tgggccctgg agtgagctgg tgcggggccg cacgcgggag
     4081 tcagttcctt cagcagctcc tgaaaatgtg tctgcagagg ctgtcagctc cacccagatc
     4141 ctactgactt gggcttcagt tcctgagcag gaccagaatg ggctcatcct aggctacaag
     4201 gttctatact gtgccaaaga cctggaccca gagcccagaa gccacgtggt acgagggaac
     4261 cacacgcagt ctgcgctgct ggctggcctg cgaaagttcg tggtctatga gctccaagtg
     4321 ctggcgttca cacggatcgg gaatggggtc cccagctcac ctctcatcct ggagcgcacc
     4381 aaagatgaca ccccaggtcc ccccgtgcgg ctggtgttcc ccgaagtaag acttactgca
     4441 gtgcggattg tgtggcagcc cccagaggag cccaatggtg tgattctggg gtaccagatc
     4501 gcctaccgcc tggccagcgg tagtcctcac accttcacca ctgttgaggt gggtgccacg
     4561 gtgcggcaat tcacagccac agagctggcc ccggagtctg cctacatctt cagactgtct
     4621 gctaagacga gacagggttg gggtgagccc ctggaggcca cagttatcac tactgagaag
     4681 agagagaggc cagcgccccc cagagagctc ctggtacccc aggctgaagt gacagctcgt
     4741 agcctcaggc tccagtgggt ccctggcagt gatggggcct ctccgatccg gtacttcacg
     4801 gtgcaggtgc gagagctgcc aggtggagag tggcagacct actcctcatc tatcagtcat
     4861 gaggccacag cctgtgctgt tgagaggctg aggcctttca cctcctacaa gctgcgcctg
     4921 aaggccacca atgacattgg ggacagtgac ttcagtgcag aaacagaggc tgtgaccact
     4981 ttgcaagatg ttccaggaga gccaccaggg tctgtctcag ccacaccgca caccacgtcc
     5041 tccgttctga tccagtggca gcctccccgg gatgagagcc tgaacggtct tctgcaaggc
     5101 tacaggatct actaccgtga gctggagtct gagacaggca tgagccctga gcccaagaca
     5161 ctcaagagcc cctctgcctt acgtgctgaa ctcaccgctc aaagcagctt caagaccgtg
     5221 aacagcagct cctcgttaac cacctatgaa ttaacacatc tgaagaagta ccggcgctat
     5281 gaagtcatca tgactgctta taacatcatt ggtgagagcc cagccagtgt accagtggaa
     5341 gtcttcgttg gtgaggctgc cccagcgatg gccccacaga atgtccaggt gaccccactc
     5401 acggccagcc agctggaggt cacatgggac ccaccgcccc cagagagcca gaatgggaac
     5461 atccagggtt ataaggttta ctactgggag gcagacagtc gcaatgagac agagaaaatg
     5521 aaggtcctct tcctccccga gcctgtggtg aagatcaagg atctcaccag ccacacaaag
     5581 tacctgatca gcatctcagc cttcaatgct gctggtgatg ggcccaagag tgacccgtgc
     5641 caaggacgca cacatcaggc ggctccaggg ccccccagct tcttggcatt ctcagaaata
     5701 acttctacca cactcaacgt atcctgggga gagccatcag ctgccaacgg catcctacag
     5761 ggctatcgag tggtgtatga gcccttagca ccagtgcaag gcgtgagcaa ggtggtgacc
     5821 gtggacgtga aaggcaactg gcaacgttgg ctgaaggtgc gggacctcac caagggagtg
     5881 acctacttct tccgtgtcca ggcgcggacc atcgcctacg ggccggagct ccaagccaat
     5941 gtcactgcag ggccagccga ggggtcccca ggctcaccaa gaaatgtcct tgtcaccaaa
     6001 tctgcctctg agctgaccct tcagtggaca gagggaaatg ctggtaccac acccactaca
     6061 ggctacgtca tagaagccag gccatcagat gaaggcttat gggacatgtt tgcaaaggac
     6121 attcccagga gtgctacatc atacactgtg gacctggata agttgcggca aggggtgacc
     6181 tacgagttcc gggtggtggc tgtgaacaag gcaggctttg gggagcccag ccgcccttcc
     6241 attgcagtgt cagcacaagc tgaagccccg ttctacgagg agtggtggtt cctgctggtg
     6301 atggcgctct ccagccttct cctcatcctc ctggtggtct tcgtgctggt cctgcatgga
     6361 caaagcaaga agtacaagag ctgcagcaca ggtaagggca tctccaacat ggaggagaca
     6421 gtgaccctgg ataacggagg ttttgccgcc ttggagctca acagccgcca cctcaatgtc
     6481 aagagcacct tctcaaagaa gaacggaacc agatctccac cccgaccaag ccccggaggt
     6541 cttcactact ctgacgagga catctgcaac aaatacaacg gcgccgtgct gacggagagt
     6601 gtgaacctca aggagaagtc ggtggatggg tcggaatccg aggcctctga ctcagactat
     6661 gaggaagccc tgcccaagca ctccttcgtc aaccactaca tgagcgaccc cacctactac
     6721 aactcttgga agcggcgtcc ccctgccgca gcaccacata ggtacgaggc ggtggcaggg
     6781 gcagaagccg gcccacacct gcacacggtc atcaccacac agagcgcggg cggagtctac
     6841 acaccagctg gccccggagc ccgggccccc ctcaccggct tctcctcctt cgtgtgacat
     6901 cacgcctcca tcagggtaga cgggtgcaga acttctggag tctatttttg ttaagacaat
     6961 caactccgat aactgagctg aatttttttg tttaaaagat aataataata attctgataa
     7021 gcgatcttac ctactggtga aaactaggat tcacttagga agggtttttt ttaatggctt
     7081 tttgtaacat cgctgcagga agcgggtttc tttgttttct tttctttcta agagaaggta
     7141 tctccctggt gcaatagctc ggcaccgccg gcgggggcgc tctcgacaca ccccagccct
     7201 gggctcctct ggcctccaaa tcattcagga tggtgaggga ggatgggaag gaggggggag
     7261 ggggacaggt aaatcgcatc tgcggcccac ttctctctct acctcctttt ggagaaccag
     7321 ccagcctgga ccactttctc catcttagga caacttgagg ctccttgctc tcatctgtgc
     7381 ttcagagaat tgctctttcc ctcgctgggt tctgtctggt tctcagcagg gttcgcgcga
     7441 ggccactgtg cgagtggcat ctagctggcc acggagggct cagctctgtg acctctcttt
     7501 agggtggctg caaaacctgg aggtttccct ttccctccct cttcctctct tctctcaagc
     7561 tgacagttac aagaacagga agtccctccc ccaactggct ctggaggtcc cccaggccca
     7621 tccaaagcca gctaggtcct tctggtgacc acacaacaca gcacacagcc cacccgcgct
     7681 gagcaagaaa ggagcggaga cgcgtggttt ttgcagttgc ttgtggcagt agcagatgtg
     7741 cattgttgaa ccagagtatt ttttaaacct ttttatcttt ttttaatcta tgtcacatga
     7801 aatgaatgcg tctttgctgt ctccaggtgc cttttaattc attgttcagc tttgtacgtg
     7861 ggaaagacga gaagcgactg tgtctccaaa taaaacaatc ggctctgaga aaccaaccgg
     7921 ggccacgagt cacctagcgc accccccaca catggcgcac agtagggaca gcccttccct
     7981 ttcttctcct gtgctcactg ctgtcccgct tctgacccct ggtgctgtcc cctctaccct
     8041 gccatccaag gccagctttt tagccttaac aggttttctg agaacgtttt cttttacttt
     8101 tcgttgttta aatgtttctg gctaagtgca aagtggcact caagacccca tgagtgtcct
     8161 gccaccccta gtccagcgcc ccaccccact cccccatctg gatgtgacca gctggatcca
     8221 accacagtgt gccccagacc tggcatcgtg gctccacatc cccacatcct cgggcactca
     8281 gagcaggtga gaagggtctg tcctcccagg ggtcttggcg cccggtggag ggtactaagc
     8341 tcttcagtgc caccactggg agattctata accctgtgag gcaggggaca tggatcttgt
     8401 cttgacttgc tgccttggaa gttgctggtg tggccccagg acacaagagg ttccacttgg
     8461 ggttaaaaaa taaactaatt aaaggccttt cagtttttcc aaaatcgaga att
//
