LOCUS       NM_025848               1287 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus succinate dehydrogenase complex, subunit D, integral
            membrane protein (Sdhd), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_025848
VERSION     NM_025848.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Baysal,B.E., Alahmari,A.A., Rodrick,T.C., Tabaczynski,D.,
            Curtin,L., Seshadri,M., Jones,D.R. and Sexton,S.
  TITLE     Succinate dehydrogenase inversely regulates red cell distribution
            width and healthy life span in chronically hypoxic mice
  JOURNAL   JCI Insight 7 (17), e158737 (2022)
   PUBMED   35881479
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Chen,X., Sunkel,B., Wang,M., Kang,S., Wang,T.,
            Gnanaprakasam,J.N.R., Liu,L., Cassel,T.A., Scott,D.A.,
            Munoz-Cabello,A.M., Lopez-Barneo,J., Yang,J., Lane,A.N., Xin,G.,
            Stanton,B.Z., Fan,T.W. and Wang,R.
  TITLE     Succinate dehydrogenase/complex II is critical for metabolic and
            epigenetic regulation of T cell proliferation and inflammation
  JOURNAL   Sci Immunol 7 (70), eabm8161 (2022)
   PUBMED   35486677
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Gomez,V., Eykyn,T.R., Mustapha,R., Flores-Borja,F., Male,V.,
            Barber,P.R., Patsialou,A., Green,R., Panagaki,F., Li,C.W.,
            Fruhwirth,G.O., Ros,S., Brindle,K.M. and Ng,T.
  TITLE     Breast cancer-associated macrophages promote tumorigenesis by
            suppressing succinate dehydrogenase in tumor cells
  JOURNAL   Sci Signal 13 (652) (2020)
   PUBMED   33023985
  REMARK    GeneRIF: Breast cancer-associated macrophages promote tumorigenesis
            by suppressing succinate dehydrogenase in tumor cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1287)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1287)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (bases 1 to 1287)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1287)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   9  (bases 1 to 1287)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1287)
  AUTHORS   Corbin,J.D., Ogreid,D., Miller,J.P., Suva,R.H., Jastorff,B. and
            Doskeland,S.O.
  TITLE     Studies of cGMP analog specificity and function of the two
            intrasubunit binding sites of cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 261 (3), 1208-1214 (1986)
   PUBMED   3003061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025500.8, AK135970.1 and BF662071.1.
            
            On Sep 11, 2009 this sequence version replaced NM_025848.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013962.2, AK135970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC025500.8         68021-68132         c
            113-1268            AK135970.1         73-1228
            1269-1287           BF662071.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..1287
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /note="succinate dehydrogenase complex, subunit D,
                     integral membrane protein"
                     /db_xref="GeneID:66925"
                     /db_xref="MGI:MGI:1914175"
     exon            1..112
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..540
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /note="succinate dehydrogenase complex subunit D;
                     succinate-ubiquinone reductase membrane anchor subunit;
                     malate dehydrogenase [quinone] cytochrome b small subunit;
                     succinate-ubiquinone oxidoreductase cytochrome b small
                     subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase [ubiquinone] cytochrome
                     b small subunit, mitochondrial"
                     /protein_id="NP_080124.1"
                     /db_xref="CCDS:CCDS40623.1"
                     /db_xref="GeneID:66925"
                     /db_xref="MGI:MGI:1914175"
                     /translation="MAVLLKLGVLCSGQGARALLLRSRVVRPAYVSAFLQDQPTQGRC
                     GTQHIHLSPSHHSGSKAASLHWTSERVVSVLLLGLIPAGYLNPCSVVDYSLAAALTLH
                     SHWGLGQVVTDYVHGDTLPKAARAGLLALSALTFAGLCYFNYHDVGICRAVAMLWKL"
     exon            113..229
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /inference="alignment:Splign:2.1.0"
     exon            230..374
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..1285
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /note="hexamer: AATAAA"
     polyA_site      1283
                     /gene="Sdhd"
                     /gene_synonym="3110001M13Rik; AVLL5809; CII-4; cybS;
                     PRO19626; QPs3"
                     /note="major polyA site"
ORIGIN      
        1 cgggacttac tacataactg tttccgggtt gtagagtgac cttgagccct cgaaagcgac
       61 atggcggttc tcttaaagct gggcgttctc tgcagtggcc aaggagctcg agctctccta
      121 ctccgaagcc gggtggtcag acccgcttat gtgtcagcat ttctccagga ccagcctacc
      181 caaggacggt gtggtaccca gcacattcac ctgtcaccaa gccaccactc tggttccaag
      241 gctgcatctc tccactggac cagtgagagg gttgtcagtg ttctgctctt ggggctgatc
      301 cctgctgggt acttgaatcc ctgctctgtg gtggactact ctctggctgc agccctcacc
      361 ctgcacagtc actggggcct tggacaagtg gttaccgact acgttcatgg ggacaccctg
      421 ccgaaggctg ccagggcagg cctcttggca ctctcagctt tgacctttgc tgggctttgc
      481 tacttcaatt accacgatgt cggcatctgc agagcggttg ccatgctgtg gaagctctga
      541 cctgggtgca gcactttgat tgtgtgcctc cttgcctctg ctttaccaat gccgttcacc
      601 tcgcagtgag gggggatgaa ggataagccc attggtgggc agaatgtctt ctaattacat
      661 ggttattttc agaatttatt tgttgaggaa gaggtttgag gagttaggtt cgaccattcg
      721 tgagtctgtg ttccatactc cactgagtgt gggcactagc tcacagcctc gcggtgagac
      781 tgaacatttc atgagctcat gttgcctttg accaccattt cttaaggaga gccagctgat
      841 tgctgtcagg ataagagcat ctcttcagcc aggagggagg cctgttccct cctgagttag
      901 actttgcatg aagctcgaaa gtattccctt tggaacctcc cattcttgtt caggtgacac
      961 cagctctgtt gatggctctg cttctaggga acatttaatc aggagatgct ctcaatgact
     1021 aatttgtcta agtcttagga aggaggttga ggaaagctgg atttagacaa gttcaattta
     1081 gggagttctc cttgtttgtg gattaaaata tgacagattg caaacagact actcttcaaa
     1141 tgtatctcaa ttgtgcagaa gtgagctgtc caaaagtata agactaagtg ataaactgtc
     1201 ttcccaccgt gggagttgtt aatgagaaag aaagtgtact ctgaaaaaac aaaattttta
     1261 aataaaatat tatataatga aaataaa
//
