LOCUS       NM_025321               1179 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus succinate dehydrogenase complex, subunit C, integral
            membrane protein (Sdhc), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_025321
VERSION     NM_025321.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1179)
  AUTHORS   Lewis,E.P., Al Khazal,F., Wilbanks,B., Gades,N.M., Ortega-Saenz,P.,
            Lopez-Barneo,J., Adameyko,I. and Maher,L.J. 3rd.
  TITLE     Mouse developmental defects, but not paraganglioma tumorigenesis,
            upon conditional Complex II loss in early Sox10+ cells
  JOURNAL   FASEB Bioadv 6 (9), 327-336 (2024)
   PUBMED   39399478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1179)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   3  (bases 1 to 1179)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1179)
  AUTHORS   Baysal,B.E., Alahmari,A.A., Rodrick,T.C., Tabaczynski,D.,
            Curtin,L., Seshadri,M., Jones,D.R. and Sexton,S.
  TITLE     Succinate dehydrogenase inversely regulates red cell distribution
            width and healthy life span in chronically hypoxic mice
  JOURNAL   JCI Insight 7 (17), e158737 (2022)
   PUBMED   35881479
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1179)
  AUTHORS   Balnis,J., Drake,L.A., Vincent,C.E., Korponay,T.C., Singer,D.V.,
            Lacomis,D., Lee,C.G., Elias,J.A., Jourd'heuil,D., Singer,H.A. and
            Jaitovich,A.
  TITLE     SDH Subunit C Regulates Muscle Oxygen Consumption and Fatigability
            in an Animal Model of Pulmonary Emphysema
  JOURNAL   Am J Respir Cell Mol Biol 65 (3), 259-271 (2021)
   PUBMED   33909984
  REMARK    GeneRIF: SDH Subunit C Regulates Muscle Oxygen Consumption and
            Fatigability in an Animal Model of Pulmonary Emphysema.
REFERENCE   6  (bases 1 to 1179)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1179)
  AUTHORS   Albayrak,T., Scherhammer,V., Schoenfeld,N., Braziulis,E., Mund,T.,
            Bauer,M.K., Scheffler,I.E. and Grimm,S.
  TITLE     The tumor suppressor cybL, a component of the respiratory chain,
            mediates apoptosis induction
  JOURNAL   Mol Biol Cell 14 (8), 3082-3096 (2003)
   PUBMED   12925748
  REMARK    GeneRIF: a sensor for apoptosis induction
REFERENCE   8  (bases 1 to 1179)
  AUTHORS   Paddenberg,R., Ishaq,B., Goldenberg,A., Faulhammer,P., Rose,F.,
            Weissmann,N., Braun-Dullaeus,R.C. and Kummer,W.
  TITLE     Essential role of complex II of the respiratory chain in
            hypoxia-induced ROS generation in the pulmonary vasculature
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 284 (5), L710-L719 (2003)
   PUBMED   12676762
  REMARK    GeneRIF: complex II plays an essential role in hypoxic reactive
            oxygen species production.
REFERENCE   9  (bases 1 to 1179)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1179)
  AUTHORS   Corbin,J.D., Ogreid,D., Miller,J.P., Suva,R.H., Jastorff,B. and
            Doskeland,S.O.
  TITLE     Studies of cGMP analog specificity and function of the two
            intrasubunit binding sites of cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 261 (3), 1208-1214 (1986)
   PUBMED   3003061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY711932.1, AK002459.1 and AV356234.1.
            
            On Apr 29, 2009 this sequence version replaced NM_025321.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005779.1, AK002459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BY711932.1         2-112
            112-1171            AK002459.1         114-1173
            1172-1179           AV356234.1         225-232
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.99 cM"
     gene            1..1179
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /note="succinate dehydrogenase complex, subunit C,
                     integral membrane protein"
                     /db_xref="GeneID:66052"
                     /db_xref="MGI:MGI:1913302"
     exon            1..45
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..535
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /note="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial; QPs1; QPs-1; integral membrane protein
                     CII-3; malate dehydrogenase [quinone] cytochrome b560
                     subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase cytochrome b560 subunit,
                     mitochondrial precursor"
                     /protein_id="NP_079597.2"
                     /db_xref="CCDS:CCDS35772.1"
                     /db_xref="GeneID:66052"
                     /db_xref="MGI:MGI:1913302"
                     /translation="MAAFLLRHVSRHCLRAHLNAQLCIRNAAPLGTTAKEEMERFWKK
                     NTSSNRPLSPHLTIYKWSLPMALSVCHRGSGIALSGGVSLFGLSALLLPGNFESYLMF
                     VKSLCLGPTLIYSAKFVLVFPLMYHSLNGIRHLLWDLGKGLAIPQVWLSGVAVVVLAV
                     LSSGGLAAL"
     exon            46..102
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            103..204
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            205..266
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..430
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            431..1179
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1172
                     /gene="Sdhc"
                     /gene_synonym="0610010E03Rik"
                     /note="major polyA site"
ORIGIN      
        1 atttccgtcc aggccggaac tcaagatggc tgcgttcttg ctgagacatg tcagccgtca
       61 ctgcctccga gcccacctga atgctcagct ttgtatcaga aatgctgctc ctttgggaac
      121 cacagctaag gaggagatgg agcggttctg gaagaagaac acgagttcaa accgtcctct
      181 gtctccccat ttgactatct acaaatggtc tcttcctatg gcactgtccg tttgccaccg
      241 aggctctgga atagccttga gtggaggggt ctctcttttt ggcctgtcgg cactgctgct
      301 tcctgggaac tttgagtcat atttgatgtt tgtgaagtcc ctgtgtttgg ggccaacact
      361 gatctactcg gctaagtttg tgcttgtctt cccgctcatg taccactcac tgaatgggat
      421 ccgacacttg ctatgggacc taggaaaagg cctggcaata ccccaggtct ggctgtctgg
      481 agtggcggtc gtggttcttg ctgtgttgtc ctctggcggg ctggccgccc tgtgaagagc
      541 tggagttccc agcacccctg tacatcatca aactgattta tattcctgtt tatcactatc
      601 cccacccctc ccccccagcc tcccaggttc tcctgatttg tttagatgcc acatgctttc
      661 aatccccttg gagtgcagta gagcggctta aagacctgtt gtagtaagaa agggtcatcc
      721 tccctgggcc tgggagccct tgctccggtt ccacatttga ctgatttgtg ctgagggtca
      781 gctttccgct gctttctgct gagacagtgg aaacaatgcc agttctgtga ccgccccgag
      841 tgccactgcc tgtgggctgc tggcttaaag gacacttctg tccattggtc agcttagggc
      901 ctttagcacc cacaccgcgt gactgagagg agagaggtgg aggaggaggg attgtcctgc
      961 tcagctagag ggagataaag agcagcctgg gagcttggag ctcgagcctg ggaacagata
     1021 cagcttttga tgtatgagga agatcaaaaa aaattgtatt aagtttctgt tctgtttttc
     1081 atttctagga aaatacacct ttaatgtcat attttctaat ctaaattctt gtaccatctt
     1141 ctttggaaac gattaaagta ctactcattt tatgcttga
//
