LOCUS       NM_023374               1096 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus succinate dehydrogenase complex, subunit B, iron
            sulfur (Ip) (Sdhb), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_023374
VERSION     NM_023374.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1096)
  AUTHORS   O'Carroll,S.M., Peace,C.G., Toller-Kawahisa,J.E., Min,Y.,
            Hooftman,A., Charki,S., Kehoe,L., O'Sullivan,M.J., Zoller,A.,
            Mcgettrick,A.F., Zotta,A., Day,E.A., Simarro,M., Armstrong,N.,
            Annes,J.P. and O'Neill,L.A.J.
  TITLE     Itaconate drives mtRNA-mediated type I interferon production
            through inhibition of succinate dehydrogenase
  JOURNAL   Nat Metab 6 (11), 2060-2069 (2024)
   PUBMED   39406969
  REMARK    Erratum:[Nat Metab. 2025 Jan;7(1):228. doi:
            10.1038/s42255-024-01204-7.. PMID: 39668260]
REFERENCE   2  (bases 1 to 1096)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   3  (bases 1 to 1096)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   4  (bases 1 to 1096)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1096)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1096)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1096)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 1096)
  AUTHORS   Bjorkman,J., Gould,S.J. and Crane,D.I.
  TITLE     Pex13, the mouse ortholog of the human peroxisome biogenesis
            disorder PEX13 gene: gene structure, tissue expression, and
            localization of the protein to peroxisomes
  JOURNAL   Genomics 79 (2), 162-168 (2002)
   PUBMED   11829486
REFERENCE   9  (bases 1 to 1096)
  AUTHORS   Baumgart,E., Vanhorebeek,I., Grabenbauer,M., Borgers,M.,
            Declercq,P.E., Fahimi,H.D. and Baes,M.
  TITLE     Mitochondrial alterations caused by defective peroxisomal
            biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout
            mouse)
  JOURNAL   Am J Pathol 159 (4), 1477-1494 (2001)
   PUBMED   11583975
REFERENCE   10 (bases 1 to 1096)
  AUTHORS   Corbin,J.D., Ogreid,D., Miller,J.P., Suva,R.H., Jastorff,B. and
            Doskeland,S.O.
  TITLE     Studies of cGMP analog specificity and function of the two
            intrasubunit binding sites of cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 261 (3), 1208-1214 (1986)
   PUBMED   3003061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051934.1 and AI835380.1.
            
            On Sep 19, 2017 this sequence version replaced NM_023374.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051934.1, BC013509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1073              BC051934.1         1-1073
            1074-1096           AI835380.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 73.24 cM"
     gene            1..1096
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /note="succinate dehydrogenase complex, subunit B, iron
                     sulfur (Ip)"
                     /db_xref="GeneID:67680"
                     /db_xref="MGI:MGI:1914930"
     exon            1..206
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..983
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /EC_number="1.3.5.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; succinate dehydrogenase [ubiquinone]
                     iron-sulfur subunit, mitochondrial; succinate
                     dehydrogenase complex subunit B; ip; iron-sulfur subunit
                     of complex II; malate dehydrogenase [quinone] iron-sulfur
                     subunit"
                     /codon_start=1
                     /product="succinate dehydrogenase [ubiquinone] iron-sulfur
                     subunit, mitochondrial isoform 1 precursor"
                     /protein_id="NP_075863.2"
                     /db_xref="CCDS:CCDS18858.1"
                     /db_xref="GeneID:67680"
                     /db_xref="MGI:MGI:1914930"
                     /translation="MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKF
                     AIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGS
                     CAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLK
                     KKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAY
                     RWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYK
                     EKRALA"
     exon            207..340
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            341..426
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..563
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            564..680
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..782
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..905
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1079
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1074
                     /gene="Sdhb"
                     /gene_synonym="0710008N11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagaaaccgg aagcggcctt ccactcgttg gcgcttaggc ggctagcggt cctcagggtg
       61 agaggccggc ttcccaccgc ggtgttcgac gggatgccgg aggggaaggg gtggggctga
      121 cgtcaggagc caaaatggcg gcgacggtcg gggtctcctt gaagcgcggc ttcccggctg
      181 ccgttctcgg cagagtcggc ctgcagtttc aggcctgtcg aggggcacag acagctgctg
      241 ctgcagctcc cagaatcaaa aaatttgcca tttaccgatg ggacccagac aagactggag
      301 ataaacctcg aatgcagacg tacgaggtgg atctgaataa gtgcggacct atggtgttgg
      361 atgctttaat caagatcaag aatgaagtgg attctacttt aaccttccga agatcttgta
      421 gagaaggcat ctgtggctct tgcgccatga acatcaacgg aggcaatact ctggcgtgca
      481 cacgcaggat cgacacggac ctcagcaaag tctccaaaat ctaccctctt ccacatatgt
      541 atgtgatcaa ggatctagtc cctgatttga gtaacttcta cgcacaatac aaatccattg
      601 agccttatct gaagaagaag gatgagtccc aggagggcaa gcaacagtat ctgcagtcca
      661 tcgaggaccg ggagaagctg gacgggctgt acgagtgcat cctgtgtgcc tgctgcagca
      721 ccagctgccc cagctactgg tggaacggag acaagtacct ggggcctgca gttctcatgc
      781 aggcctatcg ctggatgatc gactccagag acgacttcac agaggaacgc ctggccaagc
      841 tgcaggaccc cttctctgtc taccgctgcc acaccatcat gaactgcaca cagacctgcc
      901 ccaagggtct gaatccgggg aaagcgattg cggaaatcaa gaagatgatg gcgacctaca
      961 aggagaagcg agcattggct taacccagtc cgtgctgagt gtgcctgtca actctggtgt
     1021 caaacagctg gagtctccct aagtacagca tatgtaataa acatttaaga taaataggca
     1081 aaaaaaaaaa aaaaaa
//
