LOCUS       NM_026503                675 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus succinate dehydrogenase complex assembly factor 4
            (Sdhaf4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026503
VERSION     NM_026503.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 675)
  AUTHORS   Wang,X., Zhang,X., Cao,K., Zeng,M., Fu,X., Zheng,A., Zhang,F.,
            Gao,F., Zou,X., Li,H., Li,M., Lv,W., Xu,J., Long,J., Zang,W.,
            Chen,J., Gao,F., Ding,J., Liu,J. and Feng,Z.
  TITLE     Cardiac disruption of SDHAF4-mediated mitochondrial complex II
            assembly promotes dilated cardiomyopathy
  JOURNAL   Nat Commun 13 (1), 3947 (2022)
   PUBMED   35803927
  REMARK    GeneRIF: Cardiac disruption of SDHAF4-mediated mitochondrial
            complex II assembly promotes dilated cardiomyopathy.
            Erratum:[Nat Commun. 2022 Aug 10;13(1):4690. doi:
            10.1038/s41467-022-32492-w.. PMID: 35948556]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 675)
  AUTHORS   Van Vranken,J.G., Bricker,D.K., Dephoure,N., Gygi,S.P., Cox,J.E.,
            Thummel,C.S. and Rutter,J.
  TITLE     SDHAF4 promotes mitochondrial succinate dehydrogenase activity and
            prevents neurodegeneration
  JOURNAL   Cell Metab 20 (2), 241-252 (2014)
   PUBMED   24954416
REFERENCE   3  (bases 1 to 675)
  AUTHORS   Yang,I.V., Wade,C.M., Kang,H.M., Alper,S., Rutledge,H.,
            Lackford,B., Eskin,E., Daly,M.J. and Schwartz,D.A.
  TITLE     Identification of novel genes that mediate innate immunity using
            inbred mice
  JOURNAL   Genetics 183 (4), 1535-1544 (2009)
   PUBMED   19805818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015824.1, BC028981.1 and BF147474.1.
            
            On May 7, 2009 this sequence version replaced NM_026503.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015824.1, CB951758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AK015824.1         2-90
            90-662              BC028981.1         55-627
            663-675             BF147474.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 9.86 cM"
     gene            1..675
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /note="succinate dehydrogenase complex assembly factor 4"
                     /db_xref="GeneID:68002"
                     /db_xref="MGI:MGI:1915252"
     exon            1..95
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..355
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /note="UPF0369 protein C6orf57 homolog; SDH assembly
                     factor 4; succinate dehydrogenase assembly factor 4,
                     mitochondrial"
                     /codon_start=1
                     /product="succinate dehydrogenase assembly factor 4,
                     mitochondrial precursor"
                     /protein_id="NP_080779.2"
                     /db_xref="CCDS:CCDS14852.1"
                     /db_xref="GeneID:68002"
                     /db_xref="MGI:MGI:1915252"
                     /translation="MVSTTLSVSRMTFVWRAARPSLLNHSLRKMSYQEGKPEPAKQAL
                     KKSKLPLGRFDSLEDSPEEREPLQKFPDDVNPVTKEKGGPKGPEPTRYGDWERKGRCI
                     DF"
     exon            96..245
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            246..667
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      628..633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /note="hexamer: AATACA"
     regulatory      640..645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /note="hexamer: AATAAA"
     polyA_site      645
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
     polyA_site      661
                     /gene="Sdhaf4"
                     /gene_synonym="1110058L19Rik; 1700001E18Rik; C6orf57"
                     /note="major polyA site"
ORIGIN      
        1 accttggtgc gcgtgcgcag acgctgtggg agccggcgca atggtctcca cgaccctttc
       61 cgtttcacgg atgactttcg tctggagagc agcaagacca tctcttctga atcattcttt
      121 gaggaaaatg agttatcagg aaggaaagcc tgagcctgcg aagcaagccc ttaagaagtc
      181 aaagctgcca ctcggtcgtt ttgactcact ggaggattca cccgaagaga gagagccact
      241 gcagaagttt ccggatgatg taaatccagt taccaaagaa aaaggtggac ccaagggccc
      301 ggagcctaca cgatatggag actgggaacg gaagggacgc tgcattgact tttaagtcac
      361 gcactctcac aactgcagaa tcattacctg aactgtttac ttcaagttgt tttctttttc
      421 tgtgtccttt aagtgtgtaa tttccatcgt atgtcctaaa atgcatgtga cagctttgaa
      481 tagcaaatgc tgctatagat gaggaatgtg gaaacgcttc cattagcatc ttaacctcac
      541 cttaagtgtg tcagggcaga gtctgggatg agagcatcaa gtctttgcca cgatcttttt
      601 gtcatttatt taatcagttg cttataaaat acatgtgtaa ataaagacct cttgaaattt
      661 ttctttaaaa aaaaa
//
