LOCUS       NM_001033140             987 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus succinate dehydrogenase complex assembly factor 1
            (Sdhaf1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001033140 XM_890232 XM_909378
VERSION     NM_001033140.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Fujiwara,H., Seike,K., Brooks,M.D., Mathew,A.V., Kovalenko,I.,
            Pal,A., Lee,H.J., Peltier,D., Kim,S., Liu,C., Oravecz-Wilson,K.,
            Li,L., Sun,Y., Byun,J., Maeda,Y., Wicha,M.S., Saunders,T.L.,
            Rehemtulla,A., Lyssiotis,C.A., Pennathur,S. and Reddy,P.
  TITLE     Mitochondrial complex II in intestinal epithelial cells regulates T
            cell-mediated immunopathology
  JOURNAL   Nat Immunol 22 (11), 1440-1451 (2021)
   PUBMED   34686860
REFERENCE   3  (bases 1 to 987)
  AUTHORS   Boylston,J.A., Sun,J., Chen,Y., Gucek,M., Sack,M.N. and Murphy,E.
  TITLE     Characterization of the cardiac succinylome and its role in
            ischemia-reperfusion injury
  JOURNAL   J Mol Cell Cardiol 88, 73-81 (2015)
   PUBMED   26388266
  REMARK    GeneRIF: Myocardial ischemic reperfusion injury in Sirt5-/- heart
            is restored to wild-type levels by pretreatment with dimethyl
            malonate, a competitive inhibitor of succinate dehydrogenase (SDH),
            implicating alteration in SDH activity as causative of the injury.
REFERENCE   4  (bases 1 to 987)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA050643.1, CA451543.1 and AA266979.1.
            
            On Aug 2, 2006 this sequence version replaced NM_001033140.2.
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AA050643.1         1-28
            29-723              CA451543.1         1-695
            724-987             AA266979.1         250-513
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.39 cM"
     gene            1..987
                     /gene="Sdhaf1"
                     /gene_synonym="0610010E21Rik; Lyrm8"
                     /note="succinate dehydrogenase complex assembly factor 1"
                     /db_xref="GeneID:68332"
                     /db_xref="MGI:MGI:1915582"
     exon            1..967
                     /gene="Sdhaf1"
                     /gene_synonym="0610010E21Rik; Lyrm8"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..403
                     /gene="Sdhaf1"
                     /gene_synonym="0610010E21Rik; Lyrm8"
                     /note="SDH assembly factor 1; LYR motif-containing protein
                     8"
                     /codon_start=1
                     /product="succinate dehydrogenase assembly factor 1,
                     mitochondrial"
                     /protein_id="NP_001028312.2"
                     /db_xref="CCDS:CCDS39881.1"
                     /db_xref="GeneID:68332"
                     /db_xref="MGI:MGI:1915582"
                     /translation="MSRPSRLQRQVLSLYRELLRAGRGTPGAEARVRAEFRQHASLPR
                     TDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPAEEPGDATAPGTRLDDGGAPK
                     NSCEDTGARETRSDGR"
     regulatory      930..935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdhaf1"
                     /gene_synonym="0610010E21Rik; Lyrm8"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="Sdhaf1"
                     /gene_synonym="0610010E21Rik; Lyrm8"
                     /note="major polyA site"
ORIGIN      
        1 ggcggtcctt ccggccagtg tggggcctca ccgcgacgcc gcggtcatga gccggcccag
       61 ccggttgcag aggcaagttc tgagcctgta ccgcgagctg ctgcgcgccg ggcgcgggac
      121 gccgggcgcc gaggcgcggg tgcgggccga gttccggcag cacgccagcc ttccgcgaac
      181 cgacgtgctg cgtatcgagt atctgtatcg ccggggtcgg cgccagctac agctgctgcg
      241 ttcgggccac gccacggcca tgggtacctt cgtgcgcccg cggggtccgg ctgaagagcc
      301 cggcgacgcg acagccccgg ggaccaggct ggatgatggt ggtgccccaa agaattcttg
      361 tgaagataca ggggcgcggg agacgcgatc cgatggacgg tgacagacag acctagagga
      421 aggttccttc tgacagtttg gggaggatcg tgaactcatc taaatggaag ctgagatgtc
      481 ttgagagata accgaatttt cccgatgcat agtgagagat cagacactcc ctcaccaagg
      541 aggttccggg cattctgtgg cactggcgga ctgcataaga catgctgtga tacaccaacc
      601 caaagtcaaa gagagagcac aggcgcactt tctcctccca tcggggccgt ggcacctctt
      661 gacagacagc tctcttgact tcttaagaac acacccacct cctcactccc cgccccttgc
      721 tgtttttaac gtggagaaga cagacttttt gccgcgctcg tttaatagaa taccctgatg
      781 aaccgtgaga aacttggcag tctgactcgt tgtgaagaac cgggttcatg agggagatta
      841 cactagctca tctcagctga tgagcctgag actcttggag aatccctagt ccctactcct
      901 gttagtcctc aggattcttg cataaaggaa ataaaagtga ggtgtgctca cttccttgtt
      961 gtcttaaaaa aaaaaaaaaa aaaaaaa
//
