LOCUS       NM_023281               2859 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus succinate dehydrogenase complex, subunit A,
            flavoprotein (Fp) (Sdha), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_023281 XM_127445
VERSION     NM_023281.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Alexander,L.E.C., Borok,Z., Shen,Y.,
            Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Schilling,B., Murray,J., Yoo,C.B., Row,R.H., Cusack,M.P.,
            Capaldi,R.A. and Gibson,B.W.
  TITLE     Proteomic analysis of succinate dehydrogenase and
            ubiquinol-cytochrome c reductase (Complex II and III) isolated by
            immunoprecipitation from bovine and mouse heart mitochondria
  JOURNAL   Biochim Biophys Acta 1762 (2), 213-222 (2006)
   PUBMED   16120479
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Corbin,J.D., Ogreid,D., Miller,J.P., Suva,R.H., Jastorff,B. and
            Doskeland,S.O.
  TITLE     Studies of cGMP analog specificity and function of the two
            intrasubunit binding sites of cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 261 (3), 1208-1214 (1986)
   PUBMED   3003061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034928.1 and AK010561.1.
            
            On Oct 25, 2004 this sequence version replaced XM_127445.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034928.1, SRR1660815.49108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1198              AK034928.1         2-1199
            1199-1647           AK010561.1         1188-1636
            1648-2859           AK034928.1         1649-2860
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..2859
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /note="succinate dehydrogenase complex, subunit A,
                     flavoprotein (Fp)"
                     /db_xref="GeneID:66945"
                     /db_xref="MGI:MGI:1914195"
     exon            1..95
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            96..182
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            183..344
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            345..488
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            489..653
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            654..802
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            803..927
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1096
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1292
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1464
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1583
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1695
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1826
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1940
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2859
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /note="hexamer: AATAAA"
     polyA_site      2299
                     /gene="Sdha"
                     /gene_synonym="1500032O14Rik; 2310034D06Rik; 4921513A11;
                     FP; SDH2; SDHF"
                     /note="major polyA site"
ORIGIN      
        1 agtctgtcgc tggggcttgc gggaaggcag acatggccgg ggttggcgca gtttcgaggc
       61 ttcttcgcgg gcggcgcttg gcgttaactg gggcgtggcc aggaacactc caaaaacaga
      121 cctgcggctt tcacttctct gttggtgaga acaagaaggc atcagctaaa gtttcagatg
      181 caatttctac tcaataccca gtggtggatc atgaatttga tgctgtggtt gtaggcgctg
      241 gaggggcagg cttgcgagct gcatttggcc tttctgaggc agggtttaat actgcatgcc
      301 ttacaaagct ctttcctacc cgatcacata ctgttgcagc acagggaggt atcaatgctg
      361 ctctggggaa catggaagag gacaactgga gatggcattt ctatgacact gtgaaaggct
      421 ccgactggct gggggatcag gatgccatcc attacatgac agagcaagct cctgcctctg
      481 tggttgagct agaaaattat ggtatgccat ttagcagaac tgaagatggg aagatttatc
      541 agcgtgcatt tggtggacag agcctcaagt ttgggaaagg cgggcaggct catcggtgtt
      601 gctgtgtggc tgatcggaca ggccactcac tcttacacac gttgtatgga agatctctgc
      661 gatatgacac cagttatttt gtggaatatt ttgcactgga tcttctgatg gaaaatgggg
      721 agtgccgtgg tgtcattgca ctgtgcatag aagatgggtc catacaccga ataagagcaa
      781 aaaacactgt tattgctact gggggctacg ggcgaaccta cttcagctgt acatctgccc
      841 ataccagcac aggggacggc acagccatgg tcactagggc tggtttgcct tgccaggact
      901 tagaatttgt tcagttccac cccacaggta tatacggtgc tggctgcctc atcacagaag
      961 ggtgtcgtgg agaggggggg attctcatca acagtcaagg tgaaaggttc atggagagat
     1021 acgcacctgt tgccaaggac ctggcatcaa gagatgttgt gtctcgatcc atgactcttg
     1081 agatccgtga aggaagaggc tgtggccctg agaaagatca cgtctacctg cagttgcatc
     1141 atctgcctcc tgagcaactg gccacacgtc tacccggaat ttcagagacg gccatgatct
     1201 tcgctggtgt ggatgtcact aaggagccca tcccagtcct ccccactgtg cattacaaca
     1261 tgggtgggat tcccactaac tacaagggac aggtgctgaa gcatgtgaat ggccaggatc
     1321 agattgtgcc tggtctgtat gcctgtgggg aggctgcctg cgcctcagtg catggtgcca
     1381 accggcttgg agcaaattct ctcttggacc ttgtagtctt tggcagagcc tgtgccctga
     1441 gcattgcaga atcttgcagg cctggagata aagttccttc aattaaggca aatgctggag
     1501 aagaatcggt tatgaatctt gacaagttga gatttgccga tggaagtata agaacatcag
     1561 aactacgcct aaacatgcag aagtcgatgc agaaccatgc tgcagtgttc cgtgtgggga
     1621 gtgtattgca agaaggctgt gaaaaaatca gtcagctcta tggagaccta aagcatctaa
     1681 agacattcga caggggaatg gtttggaaca cagacctggt ggagaccctg gagctgcaga
     1741 atctgatgct gtgcgcactg cagaccatat atggtgcaga agctcggaag gagtcccggg
     1801 gagcccatgc cagggaagat tacaaagtgc gggtcgatga gtatgattac tccaagccca
     1861 tccagggaca gcagaagaag ccgtttgggg aacactggag gaagcacacc ctctcatatg
     1921 tggacatcaa gactggcaag gttactttgg agtacagacc tgttatcgac aagaccttga
     1981 atgaggctga ctgtgccacc gtacctcctg ctatccgctc ctactgatga aacctgacag
     2041 ctacaggacc agcttatgtg attatatagc atagcttacc tgcgtttccc ctcatacttg
     2101 tcttggtaaa attctgctct catgaacaag gagtcacttc atagattgtg atcaacagct
     2161 tggtagtact tgctgtaagg gattgagttg cgccagactt tgtctcttta ttcttgtgca
     2221 gtgataaaac tggcataatt cttaagtgaa gtacaaatga gcaatctttt atttccaaat
     2281 aaaaccatgt agtagtggat tttagttcta tctattggtc tgaaacagca aatataattt
     2341 tcttccgctg tctagctgca gcacaagtat tgttttgttc attctctgtg tgaagtaggg
     2401 caggtccttc ataatttgaa ggaaagtttg gatatggtaa gtatcgagcc agtgccttgt
     2461 ttaggttcct ggtgggtaga ggtatatgca tatgtccatg tttatttgag ggcgtatgtg
     2521 ctggctagct ttgtcaactt gacaaaaatc tagcatcacc taagaagaga gtctcaatga
     2581 aggattgctt ctgtttgctt ggtccatggg catgtctctg agggattggc ttgattaatt
     2641 taattgttaa ggaagacagc ccactgtggg caccatcatt ctctggtcaa atcagtctgg
     2701 actgtataag agcaagctga gccttcccca tgcatgcagt tattcattgt ctacttctca
     2761 ctgtgaatgt aactagtttc ttcaagttca tgccctgact tccttgaaat gaaggacttt
     2821 aaccagcaat tgtaagccaa ataaaccctt tctcaaagt
//
