LOCUS       NM_029756               2771 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus serologically defined colon cancer antigen 8
            (Sdccag8), transcript variant 1, mRNA.
ACCESSION   NM_029756
VERSION     NM_029756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2771)
  AUTHORS   Ren,Z.L., Zhang,H.B., Li,L., Yang,Z.L. and Jiang,L.
  TITLE     Characterization of two novel knock-in mouse models of syndromic
            retinal ciliopathy carrying hypomorphic Sdccag8 mutations
  JOURNAL   Zool Res 43 (3), 442-456 (2022)
   PUBMED   35503560
  REMARK    GeneRIF: Characterization of two novel knock-in mouse models of
            syndromic retinal ciliopathy carrying hypomorphic Sdccag8
            mutations.
REFERENCE   2  (bases 1 to 2771)
  AUTHORS   Tsutsumi,R., Chaya,T., Tsujii,T. and Furukawa,T.
  TITLE     The carboxyl-terminal region of SDCCAG8 comprises a functional
            module essential for cilia formation as well as organ development
            and homeostasis
  JOURNAL   J Biol Chem 298 (3), 101686 (2022)
   PUBMED   35131266
REFERENCE   3  (bases 1 to 2771)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2771)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   5  (bases 1 to 2771)
  AUTHORS   Weihbrecht,K., Goar,W.A., Carter,C.S., Sheffield,V.C. and Seo,S.
  TITLE     Genotypic and phenotypic characterization of the
            Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model
  JOURNAL   PLoS One 13 (2), e0192755 (2018)
   PUBMED   29444170
  REMARK    GeneRIF: ascribe the patterning defects in the limb and the
            secondary palate as well as lung abnormalities to loss of SDCCAG8,
            while the developmental defects in the brain are likely due to the
            loss of AKT3
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2771)
  AUTHORS   Airik,R., Slaats,G.G., Guo,Z., Weiss,A.C., Khan,N., Ghosh,A.,
            Hurd,T.W., Bekker-Jensen,S., Schroder,J.M., Elledge,S.J.,
            Andersen,J.S., Kispert,A., Castelli,M., Boletta,A., Giles,R.H. and
            Hildebrandt,F.
  TITLE     Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response
            signaling
  JOURNAL   J Am Soc Nephrol 25 (11), 2573-2583 (2014)
   PUBMED   24722439
  REMARK    GeneRIF: Our analysis of Sdccag8(gt/gt) mice indicates that the
            pleiotropic phenotypes in these mice may arise through multiple
            tissue-specific disease mechanisms.
REFERENCE   7  (bases 1 to 2771)
  AUTHORS   Insolera,R., Shao,W., Airik,R., Hildebrandt,F. and Shi,S.H.
  TITLE     SDCCAG8 regulates pericentriolar material recruitment and neuronal
            migration in the developing cortex
  JOURNAL   Neuron 83 (4), 805-822 (2014)
   PUBMED   25088364
  REMARK    GeneRIF: results reveal a critical role for SDCCAG8 in controlling
            centrosomal properties and function.
REFERENCE   8  (bases 1 to 2771)
  AUTHORS   Otto,E.A., Hurd,T.W., Airik,R., Chaki,M., Zhou,W., Stoetzel,C.,
            Patil,S.B., Levy,S., Ghosh,A.K., Murga-Zamalloa,C.A., van
            Reeuwijk,J., Letteboer,S.J., Sang,L., Giles,R.H., Liu,Q.,
            Coene,K.L., Estrada-Cuzcano,A., Collin,R.W., McLaughlin,H.M.,
            Held,S., Kasanuki,J.M., Ramaswami,G., Conte,J., Lopez,I.,
            Washburn,J., Macdonald,J., Hu,J., Yamashita,Y., Maher,E.R.,
            Guay-Woodford,L.M., Neumann,H.P., Obermuller,N., Koenekoop,R.K.,
            Bergmann,C., Bei,X., Lewis,R.A., Katsanis,N., Lopes,V.,
            Williams,D.S., Lyons,R.H., Dang,C.V., Brito,D.A., Dias,M.B.,
            Zhang,X., Cavalcoli,J.D., Nurnberg,G., Nurnberg,P., Pierce,E.A.,
            Jackson,P.K., Antignac,C., Saunier,S., Roepman,R., Dollfus,H.,
            Khanna,H. and Hildebrandt,F.
  TITLE     Candidate exome capture identifies mutation of SDCCAG8 as the cause
            of a retinal-renal ciliopathy
  JOURNAL   Nat Genet 42 (10), 840-850 (2010)
   PUBMED   20835237
REFERENCE   9  (bases 1 to 2771)
  AUTHORS   Kenedy,A.A., Cohen,K.J., Loveys,D.A., Kato,G.J. and Dang,C.V.
  TITLE     Identification and characterization of the novel
            centrosome-associated protein CCCAP
  JOURNAL   Gene 303, 35-46 (2003)
   PUBMED   12559564
REFERENCE   10 (bases 1 to 2771)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF250729.1 and AK132316.1.
            
            On Oct 24, 2013 this sequence version replaced NM_029756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132316.1, SRR1660817.3298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AF250729.1         1-204
            205-2771            AK132316.1         1-2567
FEATURES             Location/Qualifiers
     source          1..2771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 82.66 cM"
     gene            1..2771
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /note="serologically defined colon cancer antigen 8"
                     /db_xref="GeneID:76816"
                     /db_xref="MGI:MGI:1924066"
     exon            1..396
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2483
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serologically defined colon cancer antigen 8 homolog;
                     centrosomal colon cancer autoantigen protein"
                     /codon_start=1
                     /product="serologically defined colon cancer antigen 8
                     homolog isoform 1"
                     /protein_id="NP_084032.1"
                     /db_xref="CCDS:CCDS35798.1"
                     /db_xref="GeneID:76816"
                     /db_xref="MGI:MGI:1924066"
                     /translation="MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDVTVE
                     EDALDPSTSINVENEDTGVAWHELQHSHAVNQLKALLRQQTNKENETSPPRRRKLSPS
                     RPSECDDGSMPTMHNLVPIINDQSQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERL
                     QQELKSQRPEETLREQTFLDASGNMQNSWIMTREDSRVDEAAKRPFSHGDAETGKTAS
                     TGDANKWKLELERLKLTYEAKTDLLESQLMLLRKDLAEYQKTCEDLKERLKHKESLLA
                     ASASSRVGGLCLKCAQHEAVLSQTHSNVHIQTIERLTKERDDLMSVLVSVRSSLAEAQ
                     KRETSAYEQVKHAVQMTEEANFEKTKALIQCEQLKSELERQTERLEKELASQQEKRAV
                     EKEMIKKEVAREREDAESKMLILSQNIAKLEAQVEKVTREKTAAVSHLEEIQNHVASQ
                     EMDVTKVCGEMRFQLNKTKMEKDEVEKEHREYKAKSHKDLEMKVQEIEKLRLELSESE
                     QHVEQEQQKAARARQECLRVTELLGEAERQLHLTRLEKDSIQQSFSNEAKAQALQAQQ
                     REQELTQKIQQMETQHDKTESEQYLLLTSQNTFLTKLKEECCLLAKKLEKVSLKSRSQ
                     IVRLSQEKRYLCDKLEKLQKRNDELEEQCIQHGRVHETMKERLRQLDKHGQATAQQLV
                     QLLNKQNQLLLERQNLSEEVARLRAQLPSMPQSDC"
     exon            397..549
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            550..635
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            636..749
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            750..875
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1016
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1081
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1270
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1409
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1562
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1697
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1814
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1957
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2085
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2194
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2326
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2453
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2771
                     /gene="Sdccag8"
                     /gene_synonym="2700048G21Rik; 5730470G24Rik; Cccap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccaacc cgtctcttgg caacagcctc aggccgctaa actgtcggag tggcgctccg
       61 agcgcatagc cctctgggaa gcgtagtata gctggaaggc tcataggact ctcgaggctg
      121 caggctttaa gcctgagaac tacaattccc gacgttcacc atgagggcca gggggtagga
      181 agagccccta ggagctcggt ccggggttcc tggttcccta gtgacagcag cgacaggaag
      241 caggcaggca tcccctcatc cccagcgcta ggcctgtcct cggaggggtg cactggatac
      301 tttcccgcat aactcccatc tctgacccca tggcgaagtc cccagggaac tctaccctgg
      361 aggacagtct ggggcaatac caacggagtc tccgggaacg tgccaataga agcattcacc
      421 agttgaaatg tgccctgaga gaagtggatg tcactgtaga agaagatgca ctggatcctt
      481 ccaccagcat caacgtagaa aatgaggaca caggggtggc ctggcatgag ctgcagcaca
      541 gccatgctgt caatcaactg aaagctttgt tgcgtcaaca aacaaataag gaaaatgaga
      601 catctccacc gcgaagacga aagttgtccc cttcgcggcc gtcagaatgt gacgatggca
      661 gcatgcccac catgcacaac ctcgttccta tcattaacga ccagtctcaa tatatccacc
      721 acttagaagc agaagtcaag ttctgcaagg atgaattgtc tggaatgaaa aatagggtgc
      781 aagtagttgt acttgagaat gaaaggctcc agcaagaact gaaatctcaa agaccggagg
      841 agacattgag ggagcaaaca ttcctggatg catctggaaa catgcagaat tcttggatta
      901 tgacacgaga agattctagg gtggatgaag ctgcaaagag accattttct catggtgatg
      961 ctgaaactgg caaaactgca tccactggtg atgccaataa atggaagctg gagctggaga
     1021 ggctgaaact cacatacgag gcgaagactg accttctgga atctcagctg atgcttctga
     1081 ggaaagactt agctgaatac cagaaaacct gtgaggatct taaggaaaga ttgaagcata
     1141 aagagtctct tctggctgcg agtgcatcca gccgtgtggg tggcctctgt ttgaaatgtg
     1201 ctcagcatga agctgttctt tcccagacac acagcaacgt gcacatccag accatcgaga
     1261 ggctgactaa agagagagat gacttaatgt ctgtgctagt ctctgtgcgg agcagcttgg
     1321 cagaagcgca gaagagagag acaagtgcct atgagcaggt gaagcatgct gtgcagatga
     1381 cagaggaagc caactttgag aagaccaagg ctttgatcca gtgtgagcag ctgaagagtg
     1441 agctggagag gcagacagaa agactggaaa aggagcttgc ctctcagcaa gaaaagaggg
     1501 ctgtggagaa ggagatgata aagaaagaag tagccagaga gagggaagat gcagagtcaa
     1561 agatgttgat cctgtctcag aatattgcca agctggaggc ccaggttgaa aaggtcacca
     1621 gggagaagac tgcagctgtc agtcacttag aggaaattca gaaccacgtt gcgtctcagg
     1681 aaatggacgt cacaaaggtg tgtggagaaa tgcgctttca gttgaataaa accaaaatgg
     1741 agaaggatga ggtggaaaag gaacacagag aatacaaagc aaagtctcac aaggatcttg
     1801 aaatgaaagt ccaggaaata gagaagttga gactagaact gagcgaaagc gagcagcatg
     1861 tggaacagga gcagcagaag gcagctcggg ccagacagga gtgcctgcga gtcacagagc
     1921 tgctgggcga ggccgagcgc caactgcacc tcaccagact ggaaaaagat agcattcagc
     1981 aaagctttag caatgaagca aaggcccaag cccttcaggc ccagcagaga gaacaggagc
     2041 tgacacagaa gatacagcaa atggagaccc agcacgacaa aactgaaagt gaacagtatt
     2101 tactgctgac atcccagaac acatttctga caaaattaaa agaagaatgc tgcttgttag
     2161 ccaagaaact ggaaaaggtc tcactaaaga gcagatcgca aatagttcga cttagtcaag
     2221 agaagagata cttgtgtgac aagctagaga agttacagaa gagaaatgac gaactagaag
     2281 agcaatgcat ccaacatggg agggtgcatg agaccatgaa ggaaagactc aggcagctgg
     2341 ataagcacgg ccaggctaca gcgcagcagc tggtgcagtt gcttaacaag cagaatcagc
     2401 ttctcctgga gcgacagaac ctgtctgagg aagtggcccg gctgcgagcg cagttaccca
     2461 gcatgccaca atctgattgc tgacctggat gaaacagagt gaaataaatg atttacaaag
     2521 agatatttac attcatctga tttgtactta atgtgccaca gtgcaccgaa acctccccag
     2581 ggagacacca ccagggactg cagggggggc tggtcctcat gccatggtct gtccctgtgc
     2641 tatggacagg gagtgcttgc ttcagcatca actggctagg gctcgttggg agtgtgtgct
     2701 cagaacagct tcaagtcact gatttacgtt gtctctaaag tatacacatg gattaataaa
     2761 atgaccttcc t
//
