LOCUS       NM_008304               3313 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus syndecan 2 (Sdc2), mRNA.
ACCESSION   NM_008304
VERSION     NM_008304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3313)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3313)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3313)
  AUTHORS   Corti,F., Ristori,E., Rivera-Molina,F., Toomre,D., Zhang,J.,
            Mihailovic,J., Zhuang,Z.W. and Simons,M.
  TITLE     Syndecan-2 selectively regulates VEGF-induced vascular permeability
  JOURNAL   Nat Cardiovasc Res 1 (5), 518-528 (2022)
   PUBMED   36212522
  REMARK    Erratum:[Nat Cardiovasc Res. 2022 Jun;1(6):592. doi:
            10.1038/s44161-022-00092-y.. PMID: 39195875]
REFERENCE   4  (bases 1 to 3313)
  AUTHORS   Jang,B., Song,H.K., Hwang,J., Lee,S., Park,E., Oh,A., Hwang,E.S.,
            Sung,J.Y., Kim,Y.N., Park,K., Lee,Y.M. and Oh,E.S.
  TITLE     Shed syndecan-2 enhances colon cancer progression by increasing
            cooperative angiogenesis in the tumor microenvironment
  JOURNAL   Matrix Biol 107, 40-58 (2022)
   PUBMED   35139425
  REMARK    GeneRIF: Shed syndecan-2 enhances colon cancer progression by
            increasing cooperative angiogenesis in the tumor microenvironment.
REFERENCE   5  (bases 1 to 3313)
  AUTHORS   Tsoyi,K., Esposito,A.J., Sun,B., Bowen,R.G., Xiong,K., Poli,F.,
            Cardenas,R., Chu,S.G., Liang,X., Ryter,S.W., Beeton,C., Doyle,T.J.,
            Robertson,M.J., Celada,L.J., Romero,F., El-Chemaly,S.Y.,
            Perrella,M.A., Ho,I.C. and Rosas,I.O.
  TITLE     Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD
            fibroblasts
  JOURNAL   Sci Rep 12 (1), 2847 (2022)
   PUBMED   35181688
  REMARK    GeneRIF: Syndecan-2 regulates PAD2 to exert antifibrotic effects on
            RA-ILD fibroblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3313)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   7  (bases 1 to 3313)
  AUTHORS   Kim,C.W., Goldberger,O.A., Gallo,R.L. and Bernfield,M.
  TITLE     Members of the syndecan family of heparan sulfate proteoglycans are
            expressed in distinct cell-, tissue-, and development-specific
            patterns
  JOURNAL   Mol Biol Cell 5 (7), 797-805 (1994)
   PUBMED   7812048
REFERENCE   8  (bases 1 to 3313)
  AUTHORS   Spring,J., Goldberger,O.A., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Bernfield,M.
  TITLE     Mapping of the syndecan genes in the mouse: linkage with members of
            the myc gene family
  JOURNAL   Genomics 21 (3), 597-601 (1994)
   PUBMED   7959737
REFERENCE   9  (bases 1 to 3313)
  AUTHORS   Sutherland,A.E., Sanderson,R.D., Mayes,M., Seibert,M.,
            Calarco,P.G., Bernfield,M. and Damsky,C.H.
  TITLE     Expression of syndecan, a putative low affinity fibroblast growth
            factor receptor, in the early mouse embryo
  JOURNAL   Development 113 (1), 339-351 (1991)
   PUBMED   1765004
REFERENCE   10 (bases 1 to 3313)
  AUTHORS   Marynen,P., Zhang,J., Cassiman,J.J., Van den Berghe,H. and David,G.
  TITLE     Partial primary structure of the 48- and 90-kilodalton core
            proteins of cell surface-associated heparan sulfate proteoglycans
            of lung fibroblasts. Prediction of an integral membrane domain and
            evidence for multiple distinct core proteins at the cell surface of
            human lung fibroblasts
  JOURNAL   J Biol Chem 264 (12), 7017-7024 (1989)
   PUBMED   2523388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC139845.19
            and AC129537.8.
            
            On Nov 17, 2006 this sequence version replaced NM_008304.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U00674.1, AK011042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AC139845.19        182952-183534
            584-695             AC129537.8         120932-121043       c
            696-832             AC129537.8         114360-114496       c
            833-968             AC129537.8         109963-110098       c
            969-3313            AC129537.8         103424-105768       c
FEATURES             Location/Qualifiers
     source          1..3313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.74 cM"
     gene            1..3313
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /note="syndecan 2"
                     /db_xref="GeneID:15529"
                     /db_xref="MGI:MGI:1349165"
     exon            1..583
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..1132
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /note="HSPG; heparan sulfate proteoglycan core protein;
                     heparan sulfate proteoglycan 1, cell surface-associated
                     (fibroglycan)"
                     /codon_start=1
                     /product="syndecan-2 precursor"
                     /protein_id="NP_032330.1"
                     /db_xref="CCDS:CCDS27413.1"
                     /db_xref="GeneID:15529"
                     /db_xref="MGI:MGI:1349165"
                     /translation="MQRAWILLTLGLMACVSAETRTELTSDKDMYLDNSSIEEASGVY
                     PIDDDDYSSASGSGADEDIESPVLTTSQLIPRIPLTSAASPKVETMTLKTQSITPAQT
                     ESPEETDKEEVDISEAEEKLGPAIKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLF
                     AIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA"
     exon            584..695
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..832
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..968
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..3313
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
                     /note="hexamer: AATAAA"
     polyA_site      2227
                     /gene="Sdc2"
                     /gene_synonym="4833414L08Rik; Hspg1; Synd2; syndecan-2"
ORIGIN      
        1 gtgagatcga gggggaggac ccaggaggag gcggcgcgta gaaggagggg cgctgcagcc
       61 aagccaccag tctagctgta gagtgctgta ctccagatac tcctggagct ccagcccctc
      121 agaccgcgcg tccccgccgc cgttcgcctt tcggcatcct aaacttgagc ggcagctcgg
      181 tttcaaccca tcgactgctt gcttcaaatc agacagcatt gcgacccaga caccggagtc
      241 cgccgagtga aagcacaacg ctgccctgta ggaccagacc aagaaaacag cctcgcgaag
      301 cagcaactct gggttgggag tacagaagcc aacaagtgag aaggcgccgc gtttccgggg
      361 cgcagggaga acgctagagc aggcgccaga gaagacagct agagctcgga atcggagccc
      421 aaacctctct cctggaggcg gctcagcttc ttttttttct aggccctctt aggcttgctc
      481 tgggcttcct tttatccggg taggagccac atccctgggg aatatgcagc gcgcgtggat
      541 cctgctcacc ttgggcttga tggcctgtgt gtccgcagag acgagaacag agctgacatc
      601 cgataaggat atgtaccttg acaatagctc cattgaggaa gcttcaggag tatatcctat
      661 tgatgatgat gactattctt ctgcctcagg ctcaggagct gatgaagaca tagagagtcc
      721 agttctgaca acatcccaac tgattccaag aatcccactc actagtgctg cttcccccaa
      781 agtggaaacc atgacgttga agacacaaag cattacacct gctcagactg agtcacctga
      841 agaaactgac aaggaggaag ttgacatttc tgaggcagaa gagaagctgg gccctgctat
      901 aaaaagcaca gatgtgtaca cggagaaaca ttcagacaat ctgtttaaac ggacagaagt
      961 tctagcagcc gtcattgctg gtggtgtgat cggctttctc tttgccattt tcctcatcct
     1021 gctattggtg taccgcatgc ggaagaaaga tgaaggaagc tacgaccttg gagaacgcaa
     1081 accatccagc gcagcttacc agaaggcacc cactaaggag ttttatgcat aaagctccca
     1141 tttagtgtct ctatttagga gagcactgaa cttttcaaaa taaagctttg gcatagaata
     1201 atgaagatct ttgttatctg ttttgttcat tacagagcca tactggccct ttaatgatga
     1261 gaattccatt gtatttaaat tttttcgtgt atttctttag aatgacataa aagtaaaaat
     1321 ctaacatctg cagtgttctg tgaatagcag tggcaaaata ttatgttatg aaaacccctg
     1381 acattcatgg aattgatttg aacatctatg tgcaaataca aaatgattgt gtttgtcctc
     1441 tggttcaaag atgactgcta ctcccccttg tcagcaagtc tccagttaac cttactgagt
     1501 tggtcttcat ttatttatct cttgtccctc ttctctaccc tcccttcttg tcacctttct
     1561 tagaaacaaa accttatgcc ttttgtagct gtcatggtgc aatttgtctt tgaatgatta
     1621 caataatggt aatttagtgt atatgtgatt tttctcaaat atgttaacct taacctccac
     1681 tttatataat gtttttaaat atcagactat ccattttatg cttgctttaa atttcattac
     1741 ttgtagcttc aggcagattt gcaaaggcaa attaatgtgt aaaattggat tattactacg
     1801 aaactgttta gtcctagcta tcttcttttg ggaggatttg acataacgga caagcctcag
     1861 caaacccaaa gatgctaaca gtattttgag aagttgctgc agattcctct ggccactgta
     1921 cttgttaatt tcttgtcatt tgaaggtacg agaaagagtt taaagaaaaa aaaaaaagat
     1981 cagtttttgt tcttaacatg catttaaatt gcaaacatct ttttaagcct ttgaagtgcc
     2041 tatgattcta tgtaacttgt tgcggactgg tgttaatgag tatatataac agtttttaaa
     2101 aagttggtat tttataagca cagacaattc taatggtaac ttttgtagtc ttatgaatag
     2161 acataaattg taatttggaa acaacaaaaa aacctgctga ataaatcaca tggcctaata
     2221 ttgaaaatgt cactgttata aattttgtac atttcttacc aaatgtacat ctccccttgc
     2281 tgtgactgac cgtctgctct cagtgactat atgggtttgg tttctgagta tctcatggtg
     2341 tctgtcaatc aagaccaaag aacccctcag tgaggctgtt aattacgaga tttacctcta
     2401 aattgttcag aggaaaagta ttgttattct gcatgtattt gggtgcagga ataggatgac
     2461 tgccagggga tttcaaggtt tgcagccttt gtagtgtagc tactgacaat attgagagag
     2521 atgccttctt ttgcaattta ctcttaaaag tataaattcc aaagaagcaa agcgaccttt
     2581 ctagaagtag gtgtctgggg aacagaccta tagaattgct tacctgtcaa agctccccta
     2641 cagaagaacc ctgtaagtga caaccacagc cactccatgg ggtaggaggg aaggtagggg
     2701 gctctgcctg ttgaatgaca gcctggctgc ttaagatgga tgtttctaga aaaggtaatg
     2761 ccagaggagg agttggaggc atgggggtgc cccgattggg tactcactga acagagcatt
     2821 tccttttttt gttctgtttt ctattttacc attagttttt agttttaaac tgtgagccat
     2881 ggaagtagaa agaagacagc aagatccgca gcttttccag cataaaatta acttttgata
     2941 aagtttggct acttcgtttg agcaccttcc ctgagcttgt cacagaacac atttaaacaa
     3001 aactaaagta acacttgaaa cagtgctgtg tctgaatctt taatggcctt aattcatacc
     3061 tttctgtcca attacagctg taattcacca tgttaaaagg aaatgatggg cccttccaaa
     3121 gctgcacaat gcccctcaat tacggaggct gagaatgtag tgggtatacc tctaactgtg
     3181 tgaaacagtg gaatttaatt tgtagaataa cttgcttgga atatctatgc cagggaaaaa
     3241 aaaatcctgg caaatatttt gtcactgctg taaagcacat ttgttaaaag tgccaaaata
     3301 aagtctgtca tgc
//
