LOCUS       NM_011519               3057 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus syndecan 1 (Sdc1), mRNA.
ACCESSION   NM_011519
VERSION     NM_011519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Lee,N.Y., Ture,H.Y., Lee,E.J., Jang,J.A., Kim,G. and Nam,E.J.
  TITLE     Syndecan-1 Plays a Role in the Pathogenesis of Sjogren's Disease by
            Inducing B-Cell Chemotaxis through CXCL13-Heparan Sulfate
            Interaction
  JOURNAL   Int J Mol Sci 25 (17), 9375 (2024)
   PUBMED   39273320
  REMARK    GeneRIF: Syndecan-1 Plays a Role in the Pathogenesis of Sjogren's
            Disease by Inducing B-Cell Chemotaxis through CXCL13-Heparan
            Sulfate Interaction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Jurjus,R., Dosh,L., Farhat,R., Daccache,T., El Masri,J., Ghazi,M.,
            Hawi,J., Leone,A. and Jurjus,A.
  TITLE     Lack of Syndecan-1 promotes the pathogenesis of experimental
            rheumatoid arthritis
  JOURNAL   Immunogenetics 76 (3), 145-154 (2024)
   PUBMED   38451352
  REMARK    GeneRIF: Lack of Syndecan-1 promotes the pathogenesis of
            experimental rheumatoid arthritis.
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Baucom,M.R., Weissman,N., Price,A.D., England,L., Schuster,R.M.,
            Pritts,T.A. and Goodman,M.D.
  TITLE     Syndecan-1 as the Effect or Effector of the Endothelial
            Inflammatory Response?
  JOURNAL   J Surg Res 295, 611-618 (2024)
   PUBMED   38096775
  REMARK    GeneRIF: Syndecan-1 as the Effect or Effector of the Endothelial
            Inflammatory Response?
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Vainio,S., Jalkanen,M., Bernfield,M. and Saxen,L.
  TITLE     Transient expression of syndecan in mesenchymal cell aggregates of
            the embryonic kidney
  JOURNAL   Dev Biol 152 (2), 221-232 (1992)
   PUBMED   1644217
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Inki,P., Gomez,M., Quintanilla,M., Cano,A. and Jalkanen,M.
  TITLE     Expression of syndecan in transformed mouse keratinocytes
  JOURNAL   Lab Invest 67 (2), 225-233 (1992)
   PUBMED   1501448
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Kojima,T., Shworak,N.W. and Rosenberg,R.D.
  TITLE     Molecular cloning and expression of two distinct cDNA-encoding
            heparan sulfate proteoglycan core proteins from a rat endothelial
            cell line
  JOURNAL   J Biol Chem 267 (7), 4870-4877 (1992)
   PUBMED   1537865
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Bernfield,M., Kokenyesi,R., Kato,M., Hinkes,M.T., Spring,J.,
            Gallo,R.L. and Lose,E.J.
  TITLE     Biology of the syndecans: a family of transmembrane heparan sulfate
            proteoglycans
  JOURNAL   Annu Rev Cell Biol 8, 365-393 (1992)
   PUBMED   1335744
  REMARK    Review article
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Sutherland,A.E., Sanderson,R.D., Mayes,M., Seibert,M.,
            Calarco,P.G., Bernfield,M. and Damsky,C.H.
  TITLE     Expression of syndecan, a putative low affinity fibroblast growth
            factor receptor, in the early mouse embryo
  JOURNAL   Development 113 (1), 339-351 (1991)
   PUBMED   1765004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154906.3.
            
            On Mar 21, 2007 this sequence version replaced NM_011519.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143529.1, AK132236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC154906.3         100106-100411
            307-388             AC154906.3         118117-118198
            389-870             AC154906.3         119095-119576
            871-1006            AC154906.3         120001-120136
            1007-3057           AC154906.3         120348-122398
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.94 cM"
     gene            1..3057
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /note="syndecan 1"
                     /db_xref="GeneID:20969"
                     /db_xref="MGI:MGI:1349162"
     exon            1..306
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1176
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /note="synstatin"
                     /codon_start=1
                     /product="syndecan-1 precursor"
                     /protein_id="NP_035649.1"
                     /db_xref="CCDS:CCDS25803.1"
                     /db_xref="GeneID:20969"
                     /db_xref="MGI:MGI:1349162"
                     /translation="MRRAALWLWLCALALRLQPALPQIVAVNVPPEDQDGSGDDSDNF
                     SGSGTGALPDTLSRQTPSTWKDVWLLTATPTAPEPTSSNTETAFTSVLPAGEKPEEGE
                     PVLHVEAEPGFTARDKEKEVTTRPRETVQLPITQRASTVRVTTAQAAVTSHPHGGMQP
                     GLHETSAPTAPGQPDHQPPRVEGGGTSVIKEVVEDGTANQLPAGEGSGEQDFTFETSG
                     ENTAVAAVEPGLRNQPPVDEGATGASQSLLDRKEVLGGVIAGGLVGLIFAVCLVAFML
                     YRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA"
     exon            307..388
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..870
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1006
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..3057
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /note="hexamer: AATAAA"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /note="hexamer: TATAAA"
     polyA_site      2433
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
                     /note="major polyA site"
     polyA_site      2448
                     /gene="Sdc1"
                     /gene_synonym="CD138; Sstn; syn-1; Synd; Synd1"
ORIGIN      
        1 agctccgcgg gagaggtgcg ggccagagga gacagagcct aacgcagagg aagggacctg
       61 gcagtcggga gctgactcca gccggcgaaa cctacagccc tcgctcgaga gagcagcgag
      121 ctgggcagga gcctgggaca gcaaagcgca gagcaatcag cagagccggc ccggagctcc
      181 gtgcaaccgg caactcggat ccacgaagcc caccgagctc ccgccgccgg tctgggcagc
      241 atgagacgcg cggcgctctg gctctggctc tgcgcgctgg cgctgcgcct gcagcctgcc
      301 ctcccgcaaa ttgtggctgt aaatgttcct cctgaagatc aggatggctc tggggatgac
      361 tctgacaact tctctggctc tggcacaggt gctttgccag atactttgtc acggcagaca
      421 ccttccactt ggaaggacgt gtggctgttg acagccacgc ccacagctcc agagcccacc
      481 agcagcaaca ccgagactgc ttttacctct gtcctgccag ccggagagaa gcccgaggag
      541 ggagagcctg tgctccatgt agaagcagag cctggcttca ctgctcggga caaggaaaag
      601 gaggtcacca ccaggcccag ggagaccgtg cagctcccca tcacccaacg ggcctcaaca
      661 gtcagagtca ccacagccca ggcagctgtc acatctcatc cgcacggggg catgcaacct
      721 ggcctccatg agacctcggc tcccacagca cctggtcaac ctgaccatca gcctccacgt
      781 gtggagggtg gcggcacttc tgtcatcaaa gaggttgtcg aggatggaac tgccaatcag
      841 cttcccgcag gagagggctc tggagaacaa gacttcacct ttgaaacatc tggggagaac
      901 acagctgtgg ctgccgtaga gcccggcctg cggaatcagc ccccggtgga cgaaggagcc
      961 acaggtgctt ctcagagcct tttggacagg aaggaagtgc tgggaggtgt cattgccgga
     1021 ggcctagtgg gcctcatctt tgctgtgtgc ctggtggctt tcatgctgta ccggatgaag
     1081 aagaaggacg aaggcagcta ctccttggag gagcccaaac aagccaatgg cggtgcctac
     1141 cagaaaccca ccaagcagga ggagttctac gcctgatggg gaaatagttc tttctccccc
     1201 cacagcccct gccactcact aggctcccac ttgcctcttc tgtgaaaaac ttcaagccct
     1261 ggcctcccca ccactgggtc atgtcctctg cacccaggcc cttccagctg ttcctgcccg
     1321 agcggtccca gggtgtgctg ggaactgatt cccctccttt gacttctgcc tagaagcttg
     1381 ggtgcaaagg gtttcttgca tctgatcttt ctaccacaac cacacctgtc gtccactctt
     1441 ctgacttggt ttctccaaat gggaggagac ccagctctgg acagaaaggg gacccgactg
     1501 ctttggacct agatggccta ttgcggctgg aggatcctga ggacaggaga ggggcttcgg
     1561 ctgaccagcc atagcactta cccatagaga ccgctagggt tggccgtgct gtggtggggg
     1621 atggaggcct gagctccttg gaatccactt ttcattgtgg ggaggtctac tttagacaac
     1681 ttggttttgc acatattttc tctaatttct ctgttcagag ccccagcaga ccttattact
     1741 ggggtaaggc aagtctgttg actggtgtcc ctcacctcgc ttccctaatc tacattcagg
     1801 agaccgaatc gggggttaat aagacttttt ttgttttttg tttttgtttt taacctagaa
     1861 gaaccaaatc tggacgccaa aacgtaggct tagtttgtgt gttgtctctg agtttgtcgc
     1921 tcatgcgtac aacagggtat ggactatctg tatggtgccc catttttggc ggcccgtaag
     1981 taggctggct agtccaggat actgtggaat agccacctct tgaccagtca tgcctgtgtg
     2041 catggactca gggccacggc cttggcctgg gccaccgtga cattggaaga gcctgtgtga
     2101 gaacttactc gaagttcaca gtctaggagt ggaggggagg agactgtaga gttttggggg
     2161 aggggtggca agggtgccca agcgtctccc acctttggta ccatctctag tcatccttcc
     2221 tcccggaagt tgacaagaca catcttgagt atggctggca ctggttcctc catcaagaac
     2281 caagttcacc ttcagctcct gtggccccgc ccccaggctg gagtcagaaa tgtttcccaa
     2341 agagtgagtc ttttgctttt ggcaaaacgc tacttaatcc aatgggttct gtacagtaga
     2401 ttttgcagat gtaataaact ttaatataaa ggagtcctat gaactctact gcttctgctt
     2461 cttcttctct ggactggtgg tatagatata gccacccttt gcccaaaccc tggtagctcg
     2521 gggaagcttg gcttaaggct gcacgcctcc aatcccccaa agggtaggat cctggctggg
     2581 tccagggttc ctctgattta tttggttttg ttgtgttgtg ttgtgttttt cttttggcta
     2641 aacttctttt ggaagttggt aagttcagcc aaggttttac aggccctgat gtctgttctt
     2701 ctaaatggtt taagtaattg ggactctagc acatcttgac ctagggtcac tagagctaag
     2761 cttgctttgc agggcagaca cctgggacag ccttcctccc tcatgtttgc tgggacactg
     2821 ctgagcaccc cttgcttact tagctcagtg atgttccagc tcctggctag gctgctcagc
     2881 cactcagcta gacaaaagat ctgtgccctg tgtttcatcc cagagcttgt tgccagatca
     2941 catggctgga tgtgatgtgg ggtgggggtg gggtcatatc tgagacagcc ctcagctgag
     3001 ggcttgtggg acagtgtcca agcctcaggc tgggctcatt catataattg caataaa
//
