LOCUS       NM_028776               4386 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus SCY1-like 3 (S. cerevisiae) (Scyl3), transcript
            variant 1, mRNA.
ACCESSION   NM_028776
VERSION     NM_028776.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4386)
  AUTHORS   Kuliyev,E., Gingras,S., Guy,C.S., Howell,S., Vogel,P. and
            Pelletier,S.
  TITLE     Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron
            Viability
  JOURNAL   J Neurosci 38 (10), 2615-2630 (2018)
   PUBMED   29437892
  REMARK    GeneRIF: SCYL1 and SCYL3 play overlapping roles in maintaining
            motor neuronal viability in vivo and confirm that SCYL family
            members are critical regulators of neuronal function and survival
REFERENCE   2  (bases 1 to 4386)
  AUTHORS   Noordermeer,D., de Wit,E., Klous,P., van de Werken,H., Simonis,M.,
            Lopez-Jones,M., Eussen,B., de Klein,A., Singer,R.H. and de Laat,W.
  TITLE     Variegated gene expression caused by cell-specific long-range DNA
            interactions
  JOURNAL   Nat Cell Biol 13 (8), 944-951 (2011)
   PUBMED   21706023
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4386)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653492.1, BC066800.1 and BC043085.1.
            
            On Oct 26, 2013 this sequence version replaced NM_028776.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043085.1, AK030824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               BB653492.1         2-316
            316-1148            BC066800.1         1-833
            1149-4386           BC043085.1         850-4087
FEATURES             Location/Qualifiers
     source          1..4386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.23 cM"
     gene            1..4386
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /note="SCY1-like 3 (S. cerevisiae)"
                     /db_xref="GeneID:240880"
                     /db_xref="MGI:MGI:1921385"
     exon            1..422
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..637
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..2680
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ezrin-binding partner PACE-1; protein-associating with the
                     carboxyl-terminal domain of ezrin; SCY1-like protein 3;
                     ezrin-binding protein PACE-1"
                     /codon_start=1
                     /product="protein-associating with the carboxyl-terminal
                     domain of ezrin isoform 1"
                     /protein_id="NP_083052.1"
                     /db_xref="CCDS:CCDS15430.1"
                     /db_xref="GeneID:240880"
                     /db_xref="MGI:MGI:1921385"
                     /translation="MGSENSALKSYTLRESPFTLPSGLAVYPAILQDGKCASVFVYKR
                     ENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSPAEVCA
                     GIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCQVPQATPEFLRNI
                     QSVRDPASIPPEEMSPEFSGLPESHGHARDAYAFGALVDSLLPIFNEQVSADVLSSFL
                     QILHSALLNPMPECRPALSTLLSHDFFRNDFLEVVNFLKSLTLKSEDEKTEFFKFLLD
                     RVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKENAPGETPCLLSPALF
                     QSRVIPVLLRLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSNSI
                     VAITLRSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTSDLSPEGSPMHVVCSQQSR
                     VSKVLEDPSSNVFPKWLSGNVPSSSRKRIQEECYSSLSQTGDQFSHTIKFPMNGLSDV
                     KNTSEDNGSFPAGSNKPEEWPDWSEPEEPEQQPASIHRWPREPCDVAESQHTNLTAEE
                     VTWDDGEASFGTEINSTATASAPVPVTSGGQSTSAALVPLTEESKPLQSSPSSKTSHR
                     QHEEVKPPQVSQERPLKAPSGLGLGEEFTIQVKKKPVQDPELDWFADMIPEIKPSGTF
                     LILPELRTEVMVPDKDNVSSLMQFSSKFAATEMTEGEAEGWEGEELAWEDNNW"
     exon            638..823
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..937
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..994
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1097
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1209
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1287
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1427
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1612
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1784
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1943
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2623
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..4368
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /note="hexamer: AATAAA"
     polyA_site      3259
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /note="major polyA site"
     regulatory      4334..4339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
                     /note="hexamer: AATAAA"
     polyA_site      4353
                     /gene="Scyl3"
                     /gene_synonym="1200016D23Rik; 6030457O16; Pace1"
ORIGIN      
        1 agaggtggcc attttggatt cgggcggaaa tgaactcaaa agcggctggt taaaaaccca
       61 aacatgaaaa ccgggatgcc cctgcagtcg ggctgaagac acacgcagag aggcttccct
      121 gccgccagag ccggctgccg ggaacaggcg tgcggcgcag gctcccctgg cgcccacacc
      181 tacccgggcc cgcgccctcg cagcacctgt gcggccgctc tagctcggtt ccgggttcgc
      241 gcctcggtgg tggcgtcgga ggaactgaag gcccggctgt tgagccgctt ccgggccctc
      301 ggagagccgc cggagccggg tcctcggggg tgtctgtggg tggaggagcc ggggtctgag
      361 cgtcggagcc agccgcgggc caagagggag cggagccgcc agcctcctcc cgccgcccgc
      421 agagctgttt ggatttgagg aggagctgca gaactgcctc acggcaacag ggatgggatc
      481 agagaacagc gctttaaaga gctacacact gagggagtct ccttttacct taccatctgg
      541 acttgctgtt tatcccgcca tattgcaaga tgggaaatgt gcttccgtgt ttgtatataa
      601 gcgagaaaat gaagacaagg ttaacaaggc tgccaagcac ttaaagacac tccgtcaccc
      661 ttgcttgcta agatttttat cttgtactgt ggaagcagat ggcattcacc tcgtcactga
      721 gagagtgcag cctctggaag tggccttgga aaccctgtct cctgcagaag tctgtgctgg
      781 aatctatgac atactgctgg ctcttatctt ccttcatgac agaggacatt tgacacacaa
      841 caatgtctgc ctgtcgtctg tttttgtgag tgaggatggg cactggaagc ttggaggcat
      901 ggagactgtt tgccaagttc ctcaggccac gccagagttt ctcaggaata tccagtcagt
      961 aagagaccca gcatccattc ctcctgagga gatgtctcca gaattttcag gccttcccga
     1021 gtcccacggc cacgcccggg atgcctatgc ctttggagct ttggtggaca gcttgctccc
     1081 catcttcaat gagcaggttt cagcggacgt tctctccagc ttcctacaga tcctgcactc
     1141 agctctgctg aaccccatgc ccgagtgtcg gccagcactc agcaccttac tgtcccatga
     1201 tttcttcaga aatgattttc tagaagttgt gaacttcttg aaaagcttga cattaaagag
     1261 tgaagatgaa aagactgaat ttttcaaatt tctgctggac cgagtgagct gcctgtcaga
     1321 agaattaata gcttcaagat tggtgcctct tctgcttaac cagctggtgt ttgctgagcc
     1381 agtagctgtt aagagctttc ttccctatct acttggtcct aaaaaagaga acgcaccagg
     1441 agaaacccct tgcttgctct cgccagcgct gttccagtcc cgagtgatcc ctgtgcttct
     1501 ccggctgttc gaggtgcacg aggagcacgt gcggatggtg ttactgtccc acatcgaggc
     1561 ctacgtggag cacttcactc aggaacagct aaagaaagtc atcctgccac aggtactact
     1621 gggccttcgt gataccagca attccattgt ggcaattact ctccgtagcc tggcagtgct
     1681 ggtgtcttta cttggaccag aagtggttgt gggaggagaa cgaaccaaga tctttaagcg
     1741 caccgctcca agcttcacca aaactagtga cctttcccct gaaggttctc ccatgcatgt
     1801 tgtctgcagc cagcagagtc gggtctcaaa agtcttggag gacccctcgt ctaacgtatt
     1861 ccctaaatgg ttgtctggca acgtgcccag cagcagcagg aagcgcatac aggaagaatg
     1921 ttacagctct ctctcacaga caggtgatca gttttctcac accattaaat tccctatgaa
     1981 tggactctca gatgtgaaaa acacttcaga ggacaatgga agcttccctg caggttctaa
     2041 taagcccgag gagtggcctg actggagcga gcctgaggag cctgagcagc agcctgccag
     2101 tattcacaga tggccccgag aaccctgtga tgtagcagag tcccagcaca caaacctgac
     2161 cgcagaggag gtgacctggg atgatggtga ggctagcttt ggcactgaaa taaactcaac
     2221 agctacagcc tctgctcctg tgcctgttac ctcaggggga cagtcaacct ctgcagcttt
     2281 ggttcctctc actgaagagt caaagccttt gcaatccagt ccttcctcaa agaccagtca
     2341 tagacagcat gaggaagtca aaccacccca agtgtcacaa gaaagacccc tgaaggctcc
     2401 gtcaggactt ggtttgggag aagagtttac cattcaagta aaaaagaagc cagtacaaga
     2461 cccggagttg gactggtttg cagatatgat cccagaaatt aagccttcag gtacttttct
     2521 tattctgcct gaactaagga cagaagtgat ggtccctgac aaggataacg tctcatcact
     2581 gatgcagttt tcctcaaagt ttgctgcaac agaaatgacc gagggagagg cagaaggctg
     2641 ggaaggagaa gagctagcct gggaagataa caactggtga cgataatgaa aagcttcagg
     2701 aagaattctc aaagaattaa tacctcaaag caagctgcat ggatgcaaaa ccccaaagca
     2761 gcttgtgttc cccacaccag gagctctttt ttgcagtctg tgccaagtca agcagagacc
     2821 aacctcaggt tgctgactaa gtcctggtgg caaaaggctt cggtgccaga gtccaggaga
     2881 aagtgctgtg tgcacttgac tgaggccagt ttccatacaa agcaaacagc taaagaagtg
     2941 cttttttcca ggacaattct ggaagaaata aaaaattcaa gctggtaagc ttaattttgt
     3001 gccatttctt taaaagagta aattctatta tgaaataact tagtggaaaa agaaaacaaa
     3061 caaacctagc tgtaaattat aacttcagac tgctaaggct ccttaggcag tttgtctgtt
     3121 tacagtctgt ccctctcctt cggacctggg cagttactgt ttcacctgta ttacactgga
     3181 ccaaagctct caatgagaaa tacccaccct catctcccat cttgttcttt atgtcaaata
     3241 aagattattt tcacatttac aaaagctctt ttatgtgcta tgaaaatata caaacataat
     3301 ttacattcac aatttcattt acaaaacacc caggcaggca tctgaagagt cagcccagtt
     3361 ctgtcgatac acaggccatt catattttac cctgtaagca cacagcgttt tagcttctcg
     3421 atccttcctt gcagcgcctc cagttctggc agcagccatg ctggagcaag agagtgtttg
     3481 agtaaaaact cagttgtctc caaagccctt gctgcagctt taaatactga tctgtattct
     3541 tcttcaaagg gcaacacccg acgggctctc tttgtgtgag gctggaaaat aaggaaatca
     3601 tgaaacaagt aatacataat actcattcta aaaataatat aagagaaact agtcatagga
     3661 tcacgaagaa ggcagccttc ccatttgtat taacaataac ctaaatgtgc tactactctc
     3721 cacgtcctaa cttgtatgtg gcagacaaga agtcgcactg tgcaacggtt cccaatgata
     3781 aatgctgtct tgtccaacaa ctatccacga gtagtcttta aaaacatcat taaggaaata
     3841 aaacatgaat ttcctaataa gtttgtaaat gctgagagcc ataatacctt tcaacatact
     3901 tttggagcca attaaggaaa actaaggctc cagacatctt gcatagaagg ggaagaggaa
     3961 ctgaggtgaa actaaaacat atcttaacaa ctagtttttc aaagggaagt cacagtttaa
     4021 attcataggg ctttcgaaca caactgactt aaattgaact ttatatatat tcaggcctac
     4081 agctacatcc aagaaaacaa gttactattg cactataaac ctagaacatt gttttcctta
     4141 ggaccctatt ctatcacctg tgttcaaaac acaattttga atgtatgtag tcgtgtcaaa
     4201 tttctgccaa ttaataggta catgtgatat ttgagaaaag tgattattat tgatgagatg
     4261 aattgaacaa actgacatct aagtgtcaga aaatgcattt atgtcatcat tggtacaata
     4321 tgcaattacc aataataaag agtatatttg gtacaatggt tacaattaaa aaaaaaaaaa
     4381 aaaaaa
//
