LOCUS       NM_198021               4844 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus SCY1-like 2 (S. cerevisiae) (Scyl2), transcript
            variant 1, mRNA.
ACCESSION   NM_198021
VERSION     NM_198021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4844)
  AUTHORS   Gingras,S., Earls,L.R., Howell,S., Smeyne,R.J., Zakharenko,S.S. and
            Pelletier,S.
  TITLE     SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during
            Functional Maturation of the Mouse Hippocampus
  JOURNAL   J Neurosci 35 (29), 10510-10522 (2015)
   PUBMED   26203146
  REMARK    GeneRIF: our findings clearly establish the SCY1-like family of
            protein pseudokinases as key regulators of neuronal function and
            survival.
REFERENCE   2  (bases 1 to 4844)
  AUTHORS   Terabayashi,T., Funato,Y., Fukuda,M. and Miki,H.
  TITLE     A coated vesicle-associated kinase of 104 kDa (CVAK104) induces
            lysosomal degradation of frizzled 5 (Fzd5)
  JOURNAL   J Biol Chem 284 (39), 26716-26724 (2009)
   PUBMED   19643732
REFERENCE   3  (bases 1 to 4844)
  AUTHORS   Duwel,M. and Ungewickell,E.J.
  TITLE     Clathrin-dependent association of CVAK104 with endosomes and the
            trans-Golgi network
  JOURNAL   Mol Biol Cell 17 (10), 4513-4525 (2006)
   PUBMED   16914521
REFERENCE   4  (bases 1 to 4844)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127279.3 and AI661906.1.
            
            On Dec 12, 2017 this sequence version replaced NM_198021.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042443.1, SRR7345562.112197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AC127279.3         6571-6827
            258-462             AC127279.3         14383-14587
            463-620             AC127279.3         23063-23220
            621-765             AC127279.3         26004-26148
            766-915             AC127279.3         30400-30549
            916-1137            AC127279.3         32509-32730
            1138-1254           AC127279.3         33510-33626
            1255-1380           AC127279.3         34930-35055
            1381-1557           AC127279.3         35981-36157
            1558-1680           AC127279.3         38639-38761
            1681-1794           AC127279.3         39809-39922
            1795-1927           AC127279.3         41905-42037
            1928-2046           AC127279.3         42782-42900
            2047-2147           AC127279.3         46006-46106
            2148-2214           AC127279.3         47122-47188
            2215-2310           AC127279.3         47308-47403
            2311-2430           AC127279.3         50755-50874
            2431-4479           AC127279.3         51749-53797
            4480-4844           AI661906.1         1-365               c
FEATURES             Location/Qualifiers
     source          1..4844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 45.05 cM"
     gene            1..4844
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="SCY1-like 2 (S. cerevisiae)"
                     /db_xref="GeneID:213326"
                     /db_xref="MGI:MGI:1289172"
     exon            1..257
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            258..462
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3078
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SCY1-like protein 2; coated vesicle-associated kinase of
                     104 kDa"
                     /codon_start=1
                     /product="SCY1-like protein 2 isoform 1"
                     /protein_id="NP_932138.1"
                     /db_xref="CCDS:CCDS36027.1"
                     /db_xref="GeneID:213326"
                     /db_xref="MGI:MGI:1289172"
                     /translation="MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNG
                     LAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLL
                     TVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQ
                     VSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEW
                     DPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYK
                     SFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVT
                     LQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPN
                     VLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVL
                     PMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNS
                     LVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQL
                     AGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLD
                     IGNQMSTSEETKVAHSGSQQIDKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEE
                     KQKLAKEQEQAQKLKSQQPLKPQVHTPIAPIKQTKDLTDTLMENMSSLTSLSVSTPKI
                     SASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGLNANMGFQTSGFSMPVNPNQNFFSGT
                     GTAGVTTMSLGAPPTMSNFSPLTIPPASVKQPQQRPTDMSALNNLFGPQKPKVSMNQL
                     SQQKPNQWLNQFAPPQGSPVMGSAAMGTQGNVMGQAAFGMQGNPFFNPQNFAQPPPTT
                     MTSSSSASNDLKDLFG"
     exon            463..620
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            621..765
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            766..915
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1137
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1254
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1380
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1557
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1680
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1794
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1927
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2046
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2147
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2214
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2310
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2430
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..4827
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="hexamer: AATAAA"
     polyA_site      3984
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="major polyA site"
     regulatory      4456..4461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="hexamer: AATAAA"
     polyA_site      4475
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="major polyA site"
     regulatory      4805..4810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
                     /note="hexamer: AATAAA"
     polyA_site      4827
                     /gene="Scyl2"
                     /gene_synonym="CVAK104; D10Ertd802e"
ORIGIN      
        1 ggaagtgacg tcatgcagga gcgggcaggt ctttcggtgc tcttccccct accgtgctct
       61 tcttccctag tcccttccct cccttccccc tttactcctc gatctcgggg ttctgcggac
      121 tcgggggtga cggaggagat ggagtaagcg ttcggtggcg gccaggagcg cggcccgagc
      181 agtcacagcc cggaggcatt gagggagccg gcgggggacc ggccccagca ccgcccctcc
      241 aggtagccgg ctgcgaggtg acttgaacta ccaagtactg cagccatgga gtccatgctt
      301 aataaactga agagtactgt tacaaaagta acagctgatg tcaccagtgc tgtgatggga
      361 aatcccgtca ctagagagtt tgatgttggt cgacacattg ccagtggtgg caatgggttg
      421 gcatggaaga tttttaatgg cacaaagaag tcaacaaaac aggaagtggc tgtttttgtc
      481 tttgataaaa agctgattga caaatatcaa aaatttgaaa aggatcaaat cattgattct
      541 ttaaaacgcg gagtccaaca gctaacccga ctacgacacc ctcgacttct tactgtccag
      601 catcctttag aagagtcaag ggattgcttg gcattttgta cagaaccagt ttttgccagt
      661 ttagccaatg ttcttggtaa ctgggaaaat ctaccctctt caatatctcc agacatcaag
      721 gattataaac tttatgatgt agaaactaag tatggtttgc ttcaggtttc tgaaggattg
      781 tcatttttgc atagcagtgt aaaaatggtt catggaaatg ttactcctga aaatgtcatt
      841 ttgaataaaa gcggagcctg gaaaataatg gggtttgact tctgtgtgtc atcaagcaac
      901 ccttctgaac aggagcctaa gtttccttgt aaagagtggg acccaaactt gccatcattg
      961 tgtcttccga atcctgaata cttggctcct gaatatatcc tgtccgtgag ctgtgagact
     1021 gccagtgaca tgtactcgtt aggagctgtt atgtacgccg tgtttaatca agggagacct
     1081 atatttgaag tcaacaagca ggacatttac aagagcttca gtagacaact ggatcagttg
     1141 agtcgtttag gatctagttc actgaccagt atacccgagg aagttcgtga acacgtaaaa
     1201 ctgttgttaa atgtaactcc aaccgtgaga cccgatgcag atcaaatgac aaaaattccc
     1261 ttctttgatg atgttggtgc agtaacactt caatattttg ataccttatt ccaaagagat
     1321 aatcttcaga aatcacagtt cttcaaagga ttgccaaagg ttctaccaaa gctgcccaag
     1381 cgtgtcattg tgcagaggat tttaccctgt ctgacctcag aatttgtcaa ccctgatatg
     1441 gtacctttcg ttttacctaa tgttctgctc attgctgagg aatgcaccaa agaagaatat
     1501 atcaaattaa ttctgcctga actcggtcct gtattcaaac agcaggagcc aatccagatt
     1561 ttgctaattt ttctacaaaa aatggatttg ctgctaacca aaacccctcc tgatgagata
     1621 aagaacagtg tcctgcccat ggtctacaga gctctggagg ctccttccat tcagatccag
     1681 gagctctgtc taaacatcat tccaacattt gcaaatctta tagactaccc gtccatgaaa
     1741 aacgctttga ttccaagaat taaaaatgcc tgtttacaaa cgtcttccct tgctgtccgt
     1801 gtgaattcat tagtgtgctt agggaagatc ctggagtacc tggataagtg gtttgtgctt
     1861 gatgatatcc tacccttctt acagcagatt ccctccaagg agcctgcagt cctcatgggg
     1921 attttaggta tttataaatg tacttttact cataaaaaat tgggaatcac caaagagcag
     1981 ctggctggga aagtcctgcc tcatctcatc cccctgagca ttgaaaacaa cctcaacctc
     2041 aatcagttca gctccttcat tgccgtcata aaggagatgc tgagcagact ggagtctgag
     2101 cataggacga agctagagca gcttcacgtg atgcaggagc agcagaggtc tttggacata
     2161 gggaatcaaa tgagcacttc tgaggagaca aaagttgcac attctggaag tcagcagatt
     2221 gataaggtct ttaacaacat tggagcggac cttctaagtg gcagtgaatc agaaaataga
     2281 gaagatggga tgcagggaaa acagaaaagg gggtcactaa cacttgaaga aaaacagaaa
     2341 ttagcgaaag aacaggagca ggcacagaag ctgaaaagcc agcagcctct taagccccag
     2401 gtccacactc ccatcgctcc cattaaacag actaaggact tgacagacac actgatggaa
     2461 aacatgtcgt ctctgaccag cctttctgtt agcactccta agatttctgc ttcaagtacc
     2521 ttcaccccag ttccttccac gggcctcggc atgatgtttt caacacccat tgataataca
     2581 aagagaaatt tgacaaatgg cctgaatgcc aacatgggct ttcagacttc agggttcagc
     2641 atgccagtca atccaaacca gaacttcttc agtgggacgg gcacagctgg cgtgaccacc
     2701 atgagtctgg gagcacctcc cactatgtca aactttagcc ctttgactat tcctcctgct
     2761 agcgtgaagc agcctcaaca gagaccaacc gatatgtctg ccctcaataa tctctttggc
     2821 cctcagaaac ccaaagttag catgaaccag ctatcccaac agaaaccaaa tcagtggctg
     2881 aatcagtttg cacctcctca aggctctcct gtcatgggca gcgcagccat gggcacacag
     2941 gggaatgtga tggggcaggc tgcctttggt atgcagggca accctttctt caacccacag
     3001 aactttgcac agccaccacc caccactatg accagcagca gttcagctag caacgatttg
     3061 aaagatcttt ttgggtgacg tgtcgtgtgc ttctttttgg gcggtcactg cagtttcaat
     3121 catgagaaag ctgattttca tcagtgtata gcgggcttga agaaactgct tctgtgggag
     3181 atggattgtt tctgtgacag agagcacctg cttccctgcc agcccgcata ggaggtgtgt
     3241 ggatcctaat aggttgaagt ttttaaagca tggaggattt tctccctatt acgaacttct
     3301 cttcaggttt ttaaagatcc agtccttact agtctcaaag tgcgaaagga caactgaatt
     3361 atcctgaata gcagttttta aatcagatgt tttattttgg cttgtaaatc ttcttattaa
     3421 aaatcttgag ttgatgataa ctggaagtcc acctggtacc tgccttcctg ttcatttgtc
     3481 ttcattgaaa gggaagagcc tcaatgctgt gctagtttgg gtgcttttgt aagacagtgg
     3541 cgctggcacg ggaaggattg ggtcatttgc ttttccggtc ttatttttcg aagaaatgta
     3601 tgcttagtaa aagcacagca aaaatgctgc aaaattatat taatttcatt ggtttaaaac
     3661 acattaacca ttttaaatgc aaactaatca ttgtaagtta tgttttagca tgatctgcct
     3721 caaatagcaa tgtatttttc tgcctttact tgaatatatt taggctcact ttcttccctg
     3781 ttgtatcgca gaagagctgt gtactgatct gtacagaaga cagactgagc actctgacat
     3841 ggtattctca actactgcct tcatacttga ctttcagttc aaacttatga ggttgcagca
     3901 tatatgaatt acattttcaa atggagattt gtaaacaaaa taattacact atatttaatg
     3961 aataaacttt tgagatttct gccatattgt ttcaagtata gtaaagtcta aaaatgagca
     4021 agccattggg taccaacagg ttcaaatgtt agcttgcagt ggtgtctgac ctcgctcgtt
     4081 actactacta cagtttcttt tctagaagtc ccagaaactt tgtgttcaga cattttagta
     4141 tctgtaatca gtcactgtta gaaaggaaag gaggaaggga gggagggagg gaagaaggaa
     4201 ggaaggaagg aagggaggaa ggaaggaagg aaggaaggga ggaaggagtc agttctaaga
     4261 ggccacacct ctgatgtctg ttgttaactt gctgatccta ccacagagcc ttatgctata
     4321 gacgtcattt gtatttttaa aaagtatatt ccactgttat gtgataatta taaaactcct
     4381 taaaaaactc tgtatgtatt atagttgctg ccatacagtt tgtggttttt aattatctgg
     4441 aaccagcaat ccttaaataa atcacatgaa gtttattaaa tggctgaatg ttcattcaga
     4501 attatatgtg tgtgcacatg atgggtataa attgtaggac ttgattacaa agtacagttc
     4561 gtgctgatac cagtgctgat agcatccaga taaagcacac ttgtaaaaac tgtgagacag
     4621 cagtcacacc tcactcccga gtgtgctgca ctcgggtggt atgacttcaa aaggactgca
     4681 gaatgcaaag aagtcactca agaaacgaaa aactaatttt ttgtcagaac tttcaacttc
     4741 acaactttac ctgatttatt tttaacacga tactaatatt tcttttggga aatgttttat
     4801 atggaataaa attcttattg aagaacaaaa aaaaaaaaaa aaaa
//
