LOCUS       NM_023912               2655 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus SCY1-like 1 (S. cerevisiae) (Scyl1), transcript
            variant 1, mRNA.
ACCESSION   NM_023912
VERSION     NM_023912.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2655)
  AUTHORS   Cassidy,A. and Pelletier,S.
  TITLE     CRISPR-Cas9-mediated insertion of a short artificial intron for the
            generation of conditional alleles in mice
  JOURNAL   STAR Protoc 4 (1), 102116 (2023)
   PUBMED   36853660
REFERENCE   2  (bases 1 to 2655)
  AUTHORS   Cassidy,A.M., Thomas,D.B., Kuliyev,E., Chen,H. and Pelletier,S.
  TITLE     One-step generation of a conditional allele in mice using a short
            artificial intron
  JOURNAL   Heliyon 8 (12), e12630 (2022)
   PUBMED   36619446
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2655)
  AUTHORS   Kuliyev,E., Gingras,S., Guy,C.S., Howell,S., Vogel,P. and
            Pelletier,S.
  TITLE     Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron
            Viability
  JOURNAL   J Neurosci 38 (10), 2615-2630 (2018)
   PUBMED   29437892
  REMARK    GeneRIF: SCYL1 and SCYL3 play overlapping roles in maintaining
            motor neuronal viability in vivo and confirm that SCYL family
            members are critical regulators of neuronal function and survival
REFERENCE   4  (bases 1 to 2655)
  AUTHORS   Gingras,S., Kuliyev,E. and Pelletier,S.
  TITLE     SCYL1 does not regulate REST expression and turnover
  JOURNAL   PLoS One 12 (6), e0178680 (2017)
   PUBMED   28570664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2655)
  AUTHORS   Schmidt,W.M., Rutledge,S.L., Schule,R., Mayerhofer,B., Zuchner,S.,
            Boltshauser,E. and Bittner,R.E.
  TITLE     Disruptive SCYL1 Mutations Underlie a Syndrome Characterized by
            Recurrent Episodes of Liver Failure, Peripheral Neuropathy,
            Cerebellar Atrophy, and Ataxia
  JOURNAL   Am J Hum Genet 97 (6), 855-861 (2015)
   PUBMED   26581903
REFERENCE   6  (bases 1 to 2655)
  AUTHORS   Lisovoski,F., Blot,S., Lacombe,C., Bellier,J.P., Dreyfus,P.A. and
            Junier,M.P.
  TITLE     Transforming growth factor alpha expression as a response of murine
            motor neurons to axonal injury and mutation-induced degeneration
  JOURNAL   J Neuropathol Exp Neurol 56 (5), 459-471 (1997)
   PUBMED   9143258
REFERENCE   7  (bases 1 to 2655)
  AUTHORS   Sedehizade,F., Klocke,R. and Jockusch,H.
  TITLE     Expression of nerve-regulated genes in muscles of mouse mutants
            affected by spinal muscular atrophies and muscular dystrophies
  JOURNAL   Muscle Nerve 20 (2), 186-194 (1997)
   PUBMED   9040657
REFERENCE   8  (bases 1 to 2655)
  AUTHORS   Kaestner,K.H., Schutz,G. and Monaghan,A.P.
  TITLE     Expression of the winged helix genes fkh-4 and fkh-5 defines
            domains in the central nervous system
  JOURNAL   Mech Dev 55 (2), 221-230 (1996)
   PUBMED   8861101
REFERENCE   9  (bases 1 to 2655)
  AUTHORS   Blot,S., Poirier,C. and Dreyfus,P.A.
  TITLE     The mouse mutation muscle deficient (mdf) is characterized by a
            progressive motoneuron disease
  JOURNAL   J Neuropathol Exp Neurol 54 (6), 812-825 (1995)
   PUBMED   7595654
REFERENCE   10 (bases 1 to 2655)
  AUTHORS   Glaser,T., Matthews,K.E., Hudson,J.W., Seth,P., Housman,D.E. and
            Crerar,M.M.
  TITLE     Localization of the muscle, liver, and brain glycogen phosphorylase
            genes on linkage maps of mouse chromosomes 19, 12, and 2,
            respectively
  JOURNAL   Genomics 5 (3), 510-521 (1989)
   PUBMED   2575583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134563.5.
            
            On Mar 30, 2018 this sequence version replaced NM_023912.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276514.1, AK145869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC134563.5         9722-9921
            201-341             AC134563.5         10278-10418
            342-691             AC134563.5         10589-10938
            692-782             AC134563.5         11330-11420
            783-938             AC134563.5         11517-11672
            939-1097            AC134563.5         14825-14983
            1098-1205           AC134563.5         15724-15831
            1206-1319           AC134563.5         16359-16472
            1320-1475           AC134563.5         19333-19488
            1476-1664           AC134563.5         20240-20428
            1665-1740           AC134563.5         20533-20608
            1741-1905           AC134563.5         20996-21160
            1906-2045           AC134563.5         21337-21476
            2046-2117           AC134563.5         21799-21870
            2118-2324           AC134563.5         21995-22201
            2325-2385           AC134563.5         22281-22341
            2386-2655           AC134563.5         22445-22714
FEATURES             Location/Qualifiers
     source          1..2655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..2655
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /note="SCY1-like 1 (S. cerevisiae)"
                     /db_xref="GeneID:78891"
                     /db_xref="MGI:MGI:1931787"
     exon            1..200
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2510
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-terminal kinase-like protein; SCY1-like protein 1; 105
                     kDa kinase-like protein; mitosis-associated kinase-like
                     protein NTKL; ubiquitous protein kinase-like (105 kDa)"
                     /codon_start=1
                     /product="N-terminal kinase-like protein isoform 1"
                     /protein_id="NP_076401.1"
                     /db_xref="CCDS:CCDS29480.1"
                     /db_xref="GeneID:78891"
                     /db_xref="MGI:MGI:1931787"
                     /translation="MWFFARDPVRDFPFELSPEPPEGGPPGPWILHRGRKKATGSAVS
                     IFVYDVKPGAEEQTQVAKAAFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTY
                     LKARAEAGGLKEQELSWGLHQIVKALSFLVNDCNLIHNNVCMAAVFVDRAGEWKLGGL
                     DYMYSAQGNGGGPPSKGIPELEQYDPPELADSSSRAVREKWSADMWRLGCLIWEVFNG
                     SLPRAAALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETN
                     LFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPL
                     FKVGKSLRAEEYQEKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPH
                     VTHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDDQGPIRCNTTV
                     CLGKIGSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKIL
                     PVLCGLTVDPEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEVEKDVHAASSPGTGGAA
                     ASWAGWAVTGVSSLTSKLIRAHPTPVPSDTTVPQRPVPEGNPAPAPALAQAIPATSGH
                     WETQEDKDTAEDSATADRWDDEDWGSLEQEAESVLAQQDDWSAKGQGSRAGQINHPDH
                     KSLESHWSSWEVEGSWDQGWQEPSSVEPPPEGTRLASEYNWGGAEPSDKGDPFAALSV
                     RPSAQPRPDPDSWGEDNWEGLEAESRQVKAELARKKREERRREMEAKRAEKKTTKGPM
                     KLGARKLD"
     exon            201..341
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            342..691
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            692..782
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            783..938
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1097
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1205
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1319
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1475
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1664
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1740
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1905
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2045
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2117
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2324
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2385
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2655
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /note="hexamer: AATAAA"
     polyA_site      2655
                     /gene="Scyl1"
                     /gene_synonym="2810011O19Rik; mdf; mfd; Ntkl; p105"
                     /note="major polyA site"
ORIGIN      
        1 gactggctcc gccctcgccc cgccccgccc cggctcgggc ggccggagga cccggagtgg
       61 aggctcccga gcccgtggcg gcggcgacga tgtggttctt tgcccgggac ccggtccggg
      121 acttcccgtt cgagctgagc cctgagcccc ccgaaggcgg gccgcccggg ccctggatcc
      181 tgcaccgagg ccgcaaaaag gccacaggca gcgcagtgtc catcttcgtg tatgatgtga
      241 aaccgggagc tgaagagcag acccaggtgg ccaaagctgc cttcaaacgc ctcaaaactc
      301 tccgacaccc caacatcctg gcctatatcg atgggttgga gacagaaaag tgcctccaca
      361 tcgtgacaga ggctgtgacc cccctgggaa catacctcaa ggcacgagca gaagcaggtg
      421 gcctgaagga gcaggagctg tcatgggggt tacaccagat cgtgaaagcc ctcagcttcc
      481 tggtcaacga ctgcaacctc atccacaata atgtctgcat ggccgctgtg tttgtggaca
      541 gggctggcga gtggaaactt gggggtctgg actacatgta ctcggcacag ggcaacggcg
      601 ggggaccacc cagcaagggg atcccggagc tcgagcagta tgatcccccg gagctggctg
      661 acagcagtag cagagcagtc agagagaagt ggtcagcaga catgtggcgc ttgggctgcc
      721 tcatctggga agttttcaat gggtctctac ctcgggcagc tgccctgcgc aaccctggga
      781 agatccccaa atccctggtg acccattact gtgaactggt gggagctaac ccaaaagtac
      841 gtcccaaccc ggcccgcttc ctgcagaact gccgggcacc cggtggcttc atgagcaacc
      901 gctttgttga gaccaacctc ttcctggagg agattcagat caaagagcca gctgagaagc
      961 agaagttctt ccaagagctg agcaagagtc tagactcatt tcccgaagat ttctgtcgac
     1021 acaaggtgct gccccagcta ctgactgcct ttgagtttgg caatgctggg gccgtggtcc
     1081 tcacacctct cttcaaggtg ggaaaatccc tccgtgctga agagtaccag gagaagatca
     1141 tccccgtggt agttaagatg ttctcatcca ccgaccgggc catgcgcatc cgcctcctcc
     1201 agcagatgga gcagttcatc caataccttg atgagccaac agtcaacacg cagattttcc
     1261 cccacgtcac acatggcttc ctggacacca accccgccat ccgcgagcag acggtcaagt
     1321 ccatgctgct cttggcccca aagctgaatg aggccaatct caatgtggaa ctgatgaagc
     1381 actttgcaag gctacaagcc aaggacgacc agggtcctat ccgctgcaac accacggtct
     1441 gcttgggcaa aatcggctcc tatctcagtg ctagtactag acacagggtc ctcacctccg
     1501 ccttcagcag agccactaag gacccatttg caccatcccg ggttgcgggt gtcctgggct
     1561 ttgctgccac acacaatctc tattcgatgg acgactgtgc ccataagatc ctgcctgtgc
     1621 tctgtggcct tactgtggac cctgagaaat ctgtgcggga ccaggccttt aagaccattc
     1681 gaagcttcct gtccaaatta gagtctgtgt cagaggatcc cacccagctg gcagaagtag
     1741 agaaggatgt ccatgcagcg tccagtcctg gaacaggagg agctgcagcc agctgggcag
     1801 gctgggctgt gactggggta tcctctctca cctccaagct gatccgagca caccccacgc
     1861 ctgtgccgtc tgataccact gtgccccaga gaccagtgcc agagggaaat cctgctccag
     1921 cccctgccct tgcccaagct atccctgcaa cctcagggca ctgggagaca caggaagaca
     1981 aggacactgc agaagacagc gccactgctg acagatggga cgatgaggac tggggcagct
     2041 tggagcagga agctgaatcc gtgttggcac agcaggatga ctggagtgcc aagggccaag
     2101 gaagccgagc tggacagatc aaccacccag accacaaatc tctggaatca cattggagca
     2161 gctgggaagt tgagggctcc tgggaccagg gctggcagga acccagctct gtggagccac
     2221 ctccagaagg cactcggcta gctagcgaat ataactgggg tggtgcagag cccagtgaca
     2281 agggcgaccc ctttgctgcc ctgtctgttc gtcccagcgc tcagcccagg ccagacccag
     2341 actcctgggg tgaagacaac tgggaaggct tggaggctga gagcagacag gtaaaggcag
     2401 agctggcccg gaaaaagcga gaggaaagga gaagagaaat ggaagccaaa cgggcagaga
     2461 aaaagaccac caaggggccc atgaagctgg gagcccggaa gctggactga caaccccacc
     2521 cccaagccac tgggcttcca accactggag agcaggcccg gcggatgtat ttattgtaca
     2581 aaccatgtga gcctggtcag caggtcaggc acatctagtg tacataatca gagccacaat
     2641 aaattctatt tcaca
//
