LOCUS       NM_001004366            6699 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus signal peptide, CUB domain, EGF-like 3 (Scube3),
            transcript variant 1, mRNA.
ACCESSION   NM_001004366 XM_148768
VERSION     NM_001004366.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6699)
  AUTHORS   Wang,Z., Chen,C., Zhang,J., He,J., Zhang,L., Wu,J. and Tian,Z.
  TITLE     Epithelium-derived SCUBE3 promotes polarized odontoblastic
            differentiation of dental mesenchymal stem cells and pulp
            regeneration
  JOURNAL   Stem Cell Res Ther 14 (1), 130 (2023)
   PUBMED   37189178
  REMARK    GeneRIF: Epithelium-derived SCUBE3 promotes polarized odontoblastic
            differentiation of dental mesenchymal stem cells and pulp
            regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6699)
  AUTHORS   Liu,Y., Guerrero-Juarez,C.F., Xiao,F., Shettigar,N.U., Ramos,R.,
            Kuan,C.H., Lin,Y.C., de Jesus Martinez Lomeli,L., Park,J.M.,
            Oh,J.W., Liu,R., Lin,S.J., Tartaglia,M., Yang,R.B., Yu,Z., Nie,Q.,
            Li,J. and Plikus,M.V.
  TITLE     Hedgehog signaling reprograms hair follicle niche fibroblasts to a
            hyper-activated state
  JOURNAL   Dev Cell 57 (14), 1758-1775 (2022)
   PUBMED   35777353
REFERENCE   3  (bases 1 to 6699)
  AUTHORS   Rios,J.J., Denton,K., Yu,H., Manickam,K., Garner,S., Russell,J.,
            Ludwig,S., Rosenfeld,J.A., Liu,P., Munch,J., Sucato,D.J.,
            Beutler,B. and Wise,C.A.
  TITLE     Saturation mutagenesis defines novel mouse models of severe spine
            deformity
  JOURNAL   Dis Model Mech 14 (6) (2021)
   PUBMED   34142127
REFERENCE   4  (bases 1 to 6699)
  AUTHORS   Lin,Y.C., Niceta,M., Muto,V., Vona,B., Pagnamenta,A.T.,
            Maroofian,R., Beetz,C., van Duyvenvoorde,H., Dentici,M.L.,
            Lauffer,P., Vallian,S., Ciolfi,A., Pizzi,S., Bauer,P.,
            Gruning,N.M., Bellacchio,E., Del Fattore,A., Petrini,S.,
            Shaheen,R., Tiosano,D., Halloun,R., Pode-Shakked,B., Albayrak,H.M.,
            Isik,E., Wit,J.M., Dittrich,M., Freire,B.L., Bertola,D.R.,
            Jorge,A.A.L., Barel,O., Sabir,A.H., Al Tenaiji,A.M.J., Taji,S.M.,
            Al-Sannaa,N., Al-Abdulwahed,H., Digilio,M.C., Irving,M.,
            Anikster,Y., Bhavani,G.S.L., Girisha,K.M., Haaf,T., Taylor,J.C.,
            Dallapiccola,B., Alkuraya,F.S., Yang,R.B. and Tartaglia,M.
  CONSRTM   Genomics England Research Consortium
  TITLE     SCUBE3 loss-of-function causes a recognizable recessive
            developmental disorder due to defective bone morphogenetic protein
            signaling
  JOURNAL   Am J Hum Genet 108 (1), 115-133 (2021)
   PUBMED   33308444
REFERENCE   5  (bases 1 to 6699)
  AUTHORS   Adikusuma,F., Pederick,D., McAninch,D., Hughes,J. and Thomas,P.
  TITLE     Functional Equivalence of the SOX2 and SOX3 Transcription Factors
            in the Developing Mouse Brain and Testes
  JOURNAL   Genetics 206 (3), 1495-1503 (2017)
   PUBMED   28515211
REFERENCE   6  (bases 1 to 6699)
  AUTHORS   Xavier,G.M., Panousopoulos,L. and Cobourne,M.T.
  TITLE     Scube3 is expressed in multiple tissues during development but is
            dispensable for embryonic survival in the mouse
  JOURNAL   PLoS One 8 (1), e55274 (2013)
   PUBMED   23383134
  REMARK    GeneRIF: Scube3 is expressed in multiple tissues during development
            but is dispensable for embryonic survival in the mouse.
            Erratum:[PLoS One. 2013;8(9).
            doi:10.1371/annotation/b65bdf5d-4917-4936-9d9d-f217ab2602cd]
REFERENCE   7  (bases 1 to 6699)
  AUTHORS   Xavier,G.M., Economou,A., Senna Guimaraes,A.L., Sharpe,P.T. and
            Cobourne,M.T.
  TITLE     Characterization of a mouse Scube3 reporter line
  JOURNAL   Genesis 48 (12), 684-692 (2010)
   PUBMED   20957652
REFERENCE   8  (bases 1 to 6699)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   9  (bases 1 to 6699)
  AUTHORS   Haworth,K., Smith,F., Zoupa,M., Seppala,M., Sharpe,P.T. and
            Cobourne,M.T.
  TITLE     Expression of the Scube3 epidermal growth factor-related gene
            during early embryonic development in the mouse
  JOURNAL   Gene Expr Patterns 7 (5), 630-634 (2007)
   PUBMED   17258941
REFERENCE   10 (bases 1 to 6699)
  AUTHORS   Wu,B.T., Su,Y.H., Tsai,M.T., Wasserman,S.M., Topper,J.N. and
            Yang,R.B.
  TITLE     A novel secreted, cell-surface glycoprotein containing multiple
            epidermal growth factor-like repeats and one CUB domain is highly
            expressed in primary osteoblasts and bones
  JOURNAL   J Biol Chem 279 (36), 37485-37490 (2004)
   PUBMED   15234972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126937.3.
            
            On Feb 22, 2019 this sequence version replaced NM_001004366.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY639609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC126937.3         49784-50085
            303-425             AC126937.3         59873-59995
            426-551             AC126937.3         61034-61159
            552-686             AC126937.3         63367-63501
            687-812             AC126937.3         64237-64362
            813-929             AC126937.3         64548-64664
            930-1046            AC126937.3         68287-68403
            1047-1169           AC126937.3         69791-69913
            1170-1286           AC126937.3         70429-70545
            1287-1412           AC126937.3         71207-71332
            1413-1529           AC126937.3         71520-71636
            1530-1634           AC126937.3         71773-71877
            1635-1751           AC126937.3         72149-72265
            1752-1910           AC126937.3         72538-72696
            1911-2126           AC126937.3         72902-73117
            2127-2288           AC126937.3         73462-73623
            2289-2456           AC126937.3         73832-73999
            2457-2618           AC126937.3         74501-74662
            2619-2816           AC126937.3         74985-75182
            2817-2969           AC126937.3         75604-75756
            2970-3049           AC126937.3         75857-75936
            3050-6699           AC126937.3         78671-82320
FEATURES             Location/Qualifiers
     source          1..6699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.63 cM"
     gene            1..6699
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /note="signal peptide, CUB domain, EGF-like 3"
                     /db_xref="GeneID:268935"
                     /db_xref="MGI:MGI:3045253"
     exon            1..302
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3199
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; signal peptide, CUB and EGF-like
                     domain-containing protein 3"
                     /codon_start=1
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 3 isoform 1 precursor"
                     /protein_id="NP_001004366.1"
                     /db_xref="CCDS:CCDS37527.1"
                     /db_xref="GeneID:268935"
                     /db_xref="MGI:MGI:3045253"
                     /translation="MGSGRVPGLCLLLLLVHARAAQHGKAAQDVDECVEGTDNCHIDA
                     ICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFH
                     LAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCRDGFFLSDNQHTCIQRPEEGMN
                     CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQG
                     PRCGCHVKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCSCPVGFMLQPDRKTCK
                     DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERSCQDIDECSFDRTCDHMCVN
                     TPGSFQCLCHRGYLLYGVTHCGDVDECSINKGGCRFGCINTPGSYQCTCPAGQGRLHW
                     NGKDCTEPVKCQSSLGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTP
                     SPKAAPARVIHSGNSTVSSSCHEAAVLPVKQRASFKIKDAKCRLHLRNKGKAEEASRI
                     LGPGSVPCSDCLVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTAG
                     CGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLGAGDRAELVEV
                     CRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLG
                     ATNVTTCAGQCPPGHHSGDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAVSF
                     QDCDTKVQCSPGHYYNTSIHRCIRCAVGSYQPDFRQNFCTRCPGNTSTDFDGSTSVAQ
                     CKNRQCGGELGEFTGYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDE
                     CGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYV
                     TYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEM
                     LPKSFIKLLRSKVSSFLRPYK"
     exon            303..425
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            426..551
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..686
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            687..812
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..929
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1046
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1169
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1286
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1412
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1529
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1634
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1751
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1910
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2126
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2288
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2456
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2618
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2816
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2969
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3049
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..6699
                     /gene="Scube3"
                     /gene_synonym="CEGF3; D030038I21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctacagc tccccgcggg cgaagctggg cgtcgggtgc gatagcccgg gccgcccctc
       61 gggccgccgc cccgcgcctg cccgcgttcc ccaccgcgcg ctccccacgc ccagcccgga
      121 gcctccgcgg ggcgccttcc agtcccctcc ccctcctcct cgcgccctcc ccggggctgc
      181 gacacccccg cggccccgcc gcgcggagct ccaggccatg ggctcggggc gcgtccccgg
      241 gctctgcctg ctcctcctgc tggtccacgc gcgcgccgcc cagcatggca aagctgcgca
      301 agatgtagat gagtgtgtgg aaggcacgga caattgccac atcgatgcca tctgccagaa
      361 taccccacgg tcttacaagt gcatctgcaa gtccggctac acgggggacg ggaagcactg
      421 caaagacgtg gatgagtgtg aacgggagga caacgcaggc tgtgtgcacg actgtgtcaa
      481 catccctggt aattaccggt gtacctgcta cgacggattt cacctggcac atgacggaca
      541 caactgtctg gatgtggatg agtgtgcaga gggcaacggt ggctgccagc agagctgtgt
      601 caacatgatg ggcagctacg agtgccattg cagagatggc ttcttcctca gtgacaacca
      661 gcacacctgt atccagcggc cagaagaagg aatgaactgc atgaacaaga accacggctg
      721 tgcccacatt tgccgggaga ctcccaaggg gggcattgcc tgtgaatgcc gccctggctt
      781 cgagctcacc aagaaccaac gggactgtaa attgacctgc aactatggta atggcggctg
      841 ccagcacacc tgcgatgaca cggagcaggg tcctcggtgc ggctgccacg tcaagtttgt
      901 gctccacacc gacgggaaga catgcattga aacctgtgct gtcaacaacg gaggctgcga
      961 cagtaagtgc catgatgcag cgaccggagt ccactgcagc tgtcctgtgg gtttcatgct
     1021 gcagccagac agaaagacct gcaaagatat agacgagtgc cgcttaaaca acgggggctg
     1081 tgaccacatc tgccgcaaca cagtgggcag cttcgagtgc agctgcaaga agggctacaa
     1141 gcttctcatc aacgaaagga gctgccagga tatagatgag tgctccttcg accgaacctg
     1201 tgaccacatg tgtgtcaaca ccccggggag cttccagtgt ctctgtcatc gtggctacct
     1261 tctatatggt gtcactcact gcggggatgt ggacgaatgt agcatcaata agggaggctg
     1321 ccgctttggc tgcatcaaca ccccaggcag ctatcagtgt acctgcccag caggccaggg
     1381 ccgccttcac tggaacggga aggattgcac agagccagtg aagtgtcaga gcagtcttgg
     1441 agcctcaaaa gccatgctta gctgcaatcg ctcgggcaag aaggatactt gtgccctgac
     1501 ctgtccctcc cgggcccggt tcttgccaga gtcagagaac ggtttcaccg tgagctgtgg
     1561 taccccgagc cctaaagctg ctccagcccg agtgatccac tctgggaaca gcaccgtctc
     1621 cagctcctgc catgaggctg cagtgctgcc agtcaagcag agagcctcct tcaagatcaa
     1681 ggatgccaaa tgtcgcctgc atctgcgaaa caaaggcaaa gccgaggagg ccagcaggat
     1741 cctggggcca ggtagtgtcc cctgctctga ctgcctggtc actttcatcc accttaagtg
     1801 tgactcttct cggaagggca agggcaggcg ggcccggacc cccccaggca aggaggttac
     1861 ccggctcacc ctggaattgg aagctgaggt cagagcagaa gaaacgacag ctggctgtgg
     1921 gctgccttgc ctccgacagc ggatggaacg gaggctgaaa gggtccctga agatgctcag
     1981 aaagtccatc aaccaagacc ggttcctgct gcgtctggca ggccttgact atgagctagc
     2041 ccacaagcca ggcctgggag ctggggaccg agcagagctg gtggaggtct gccgacctgg
     2101 gcagcaccga gcaggcacca agtgtgtcag ctgcccgcag ggaacgtatt accacggcca
     2161 gacggagcag tgtgtgccat gcccagcggg caccttccag gagagggaag ggcagctctc
     2221 ctgcgacctt tgccctggga gtgatgccca tgggcctctt ggagccacca acgtcaccac
     2281 gtgtgcaggt cagtgcccac ctggccacca ttcaggagat gggtttaagc cctgccagcc
     2341 atgcccccgg ggcacctatc agcctgaagc agggcgaacc ctgtgcttcc cctgtggcgg
     2401 aggcctcacc accaagcatg agggggcagt ctccttccag gactgcgaca ccaaagtcca
     2461 gtgctccccg ggccactact ataacactag catccatcgc tgtatccgct gtgctgtggg
     2521 ctcctaccag ccagatttcc gtcagaactt ctgcacccgc tgcccaggaa atacaagcac
     2581 tgactttgat ggctcgacca gtgtggccca gtgcaagaat cggcagtgtg gcggggagct
     2641 aggtgagttc actggctaca tcgagtctcc caactacccg ggcaactacc cggccggtgt
     2701 ggagtgcgtc tggaacatca accccccacc caagcgcaag atcctcatcg tggtccccga
     2761 gatcttcctg ccctccgagg atgagtgtgg ggacgtcctg gtcatgagaa agaactcctc
     2821 cccatcctct atcaccactt acgagacctg ccagacctac gagcggccca ttgccttcac
     2881 cgcccggtcc aggaaactct ggatcaactt caagaccagt gaggccaaca gcgctcgagg
     2941 cttccagatt ccctatgtga cctacgatga ggactatgag cagctggtgg aagacatagt
     3001 gcgtgatggc cggctgtatg cctcagaaaa ccaccaggag atcctaaagg acaagaagct
     3061 tatcaaggcc ttctttgagg tcctggccca ccctcaaaac tacttcaagt acacagagaa
     3121 acacaaggag atgctgccaa aatccttcat caagctactg cgctccaaag tctccagctt
     3181 cctgaggcct tacaaatagt gcctgtgggc ccgagaccca gttcagagct cccacctccc
     3241 tggccctcag agttggcacc ccaacctcag acaagaaact gtctctcttg aaggagagat
     3301 atcaccacac caggcgctct ccctttcggc ctttctagtt accttgtctt cgttctgtct
     3361 ctctcctgga agtcattcag tgcgtctctg ttccccccag aggtgaagga atagacaccc
     3421 tctattcctc tgccgttata gcatggtgcc ttgctagcca ggagccaaaa caccccctcc
     3481 acagcccccg tgctccccag agtgggtctt cacagcccag agtcctgcca aagaagcctt
     3541 ggacatagca gctttgtgcc agcatcaggc tgctggggca cagagtttaa gcccggggtg
     3601 cccacacagt tggcgttctc atctgtagag cttgctctca tctggccggg gctgactcca
     3661 tagggtttac aagtgatcca taccaatggg atagcaaacc cctgccgggt aagggcgagg
     3721 agcaggcagg ggccctggac atataaagct ctcagatagc tctgcaggac agaaagcggg
     3781 tttttaaaac attgcccaaa acagaaagaa agaaaatgtg tcacctaaag gaacttccta
     3841 cagaacaagt ggaagccagc ctcaaacact aacccttttc ttgccagtac cccccgcccc
     3901 cggccgtgcc ctcaccccac ctaagggctc cctgggggag gcctacccac cccctggtaa
     3961 gcgctgtcct taaagaagct gggctgttga ctttccaagc ctagaccttg ctccacgggt
     4021 gttttccctt gtagccccag gtggcttgtg ggttccacca aagaggaccc cactctgcag
     4081 ccagcctgga gctacctacc tctagcctcg ggctgtgggc agcaggagga acaagtgtga
     4141 gtgcccttgg caagccgcct gtccaccctc tccacatctg agaagtgcaa tcattttgag
     4201 tctttctatg tcgtctagag ggagggggga ttgttttttt gtttgtttct ttttcctctc
     4261 agaataaccc tatttatagc tgcctaggag agaggggtgt gctgaggctg gagaaacagc
     4321 agtctgtctg tcgggagcct taagtgccgg agcggctcat atgtctcagt cctccctgag
     4381 gccacacaga acttcagagc cctcagcagc gcagagctag ggctatccct cagaggtgcc
     4441 ccaagcacag gagactagct ctggtaactt gatgaagcag gaggaggagg cttcctgact
     4501 gagctgatcc tgcctgcctt gtgtctctct gtggattcat ggtaacagaa gcagatggac
     4561 ttggtcagaa tcttgtgcga gtagggacaa cctgtctttc cctatcttca tgctctcccc
     4621 tgacacggca tgggagggga tcgggataaa ctctatggat ggccagcgca ggctcccaag
     4681 acagccagag agggctggag cagcctggaa ttggacagtt ctccgtgtat gaagcggggg
     4741 aaggacagga accagacgtg tgcctgagac ctgccacctg cctcttggag ctgacttcaa
     4801 gcctgattca actactgtct ttcaaaagaa gaatggtgtc tgtgcctgag cccgggctct
     4861 gcatatgctc cacccttaac ctagatgctg cctgtaaagt ctccaattgt tccttcttgt
     4921 tccccgaggc ttagtcctgg acatccacca atgactcctc aggtccaact ttaggtaact
     4981 gccaagagat tcaactatca aatagtctga tccccacaca caccagccag cagcaggcga
     5041 agctcgcttc ctggatgcct tagccaacac ggtgggggtg agggtcgggt ggggtcagag
     5101 agctattgca aagctgttga atggtttcat gcaagagggg cgaatgggca tttagtgggt
     5161 ccccagaagt gccatagaac agcctgagtc acgagtcctt tctccctaac attttgccag
     5221 ctcctggaaa gccacaaagt gagagtgcct cccaatgtat gcctttaggg cgtggcttct
     5281 ccgcactccc ccaccccacc ccccaacccc catctcacca tacatacacg gacacttcct
     5341 ctaatcattt gttctatggc tgatggggca gcacatgaga tctatcgtac ggagagagta
     5401 ggccactaga cttagctgat atcaagatgg atggaggaga tcaagcaagg gctttctact
     5461 gccaaccaag ttggcagcaa ggaatccagg cagagctgtt acgaacttac aggggatatt
     5521 ggccctgagc gcctcactct gggagctgag tgggctgaag gaggagttaa gaactcaggg
     5581 actttctagg actgcacagg ttagacaaaa gaggtttcca ggagaagggg ggatgggaag
     5641 atggtgtgaa caggaaccct tcgtgagctg acctagaagc ttctctgtgg gctatggtgc
     5701 ttacgaggtc atgtaacccc ggcgcctcat ccatcccagt gcaagacctg ctgtgaactg
     5761 agtcccagcg tgggaagcca tttccacatg tgctccaagc acggagtgac aaatgtcaag
     5821 caggccctga tatcctcagc agcacctcgg tgcctcttta gcctctgcct ctatttgtgt
     5881 cattgaccca gccagtcccc aagcctgagg taattaggag aaagccgacc agagcctgga
     5941 cgttagctgc ccaccctgtg ccttcagtga tccttcgagg actgccactg gcctcactac
     6001 ggtcatttcc atgtggaggt gccgatggag aagatggtac agtctgggct ctggctccta
     6061 ggagtctctg tgaatctgcg aagtgttctc catgagcgcg cctgaggtga cttaaatgga
     6121 ttaggaagtc ctatctcagt gtgtaagaga aagcgacagc acattgaagg gcctgtatct
     6181 gctgctgagc tccagagcag gggagcagag gccaaatgta actgacccca agcaggacat
     6241 ggtgccccgc ctggttcctt tcctaagcag actccacgaa ggaacccttt ctgtcggccc
     6301 tgtctcaaag ctggtgcact ctgtctttcc gctattattc ggactgagaa cccgaaggac
     6361 cagaggcccc gttctgcgat cagcttacca agactaaaca atggcagcag tagtttggac
     6421 aagctcaaaa tcttgttcta tgtgagtcgg actttcagag agtaattatc atgtggacgg
     6481 cttttttttt ctttttaacg cagaagaata tcttaaaata ctatatttat atctgccttc
     6541 cactgcctct catacagcaa gcatctcagt tgacaatagg cagcagcaat gtggtacaca
     6601 gagtattttg cacttgggga aaaatatgta tctgaaaact tgtaaaaagg aatgtttgga
     6661 ttttgtattg tcttttttat attattaaaa tactaaatg
//
