LOCUS       NP_073560                988 aa            linear   ROD 30-APR-2024
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 1
            isoform b precursor [Mus musculus].
ACCESSION   NP_073560
VERSION     NP_073560.2
DBSOURCE    REFSEQ: accession NM_022723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 988)
  AUTHORS   Sahoo,B.K., Lin,Y.C., Tu,C.F., Lin,C.C., Liao,W.J., Li,F.A.,
            Li,L.H., Mou,K.Y., Roffler,S.R., Wang,S.P., Yeh,C.T., Yao,C.Y.,
            Hou,H.A., Chou,W.C., Tien,H.F. and Yang,R.B.
  TITLE     Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted
            FLT3 signaling is critical for the initiation and maintenance of
            MLL-rearranged acute leukemia
  JOURNAL   Haematologica 108 (5), 1284-1299 (2023)
   PUBMED   36005562
  REMARK    GeneRIF: Signal peptide-CUB-EGF-like repeat-containing protein
            1-promoted FLT3 signaling is critical for the initiation and
            maintenance of MLL-rearranged acute leukemia.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 988)
  AUTHORS   Qiu,T., Huteckova,B., Seppala,M., Cobourne,M.T., Chen,Z.,
            Hovorakova,M., Buchtova,M. and Tucker,A.S.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   4  (residues 1 to 988)
  AUTHORS   Grimaldi,A., Comai,G., Mella,S. and Tajbakhsh,S.
  TITLE     Identification of bipotent progenitors that give rise to myogenic
            and connective tissues in mouse
  JOURNAL   Elife 11, e70235 (2022)
   PUBMED   35225230
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 988)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 988)
  AUTHORS   Xavier,G.M., Panousopoulos,L. and Cobourne,M.T.
  TITLE     Scube3 is expressed in multiple tissues during development but is
            dispensable for embryonic survival in the mouse
  JOURNAL   PLoS One 8 (1), e55274 (2013)
   PUBMED   23383134
  REMARK    Erratum:[PLoS One. 2013;8(9).
            doi:10.1371/annotation/b65bdf5d-4917-4936-9d9d-f217ab2602cd]
REFERENCE   7  (residues 1 to 988)
  AUTHORS   Zhuang,J., Deane,J.A., Yang,R.B., Li,J. and Ricardo,S.D.
  TITLE     SCUBE1, a novel developmental gene involved in renal regeneration
            and repair
  JOURNAL   Nephrol Dial Transplant 25 (5), 1421-1428 (2010)
   PUBMED   20042401
  REMARK    GeneRIF: SCUBE1 may be involved in the regulation of tubular cell
            proliferation and re-epithelialization during the resolution of
            kidney injury.
REFERENCE   8  (residues 1 to 988)
  AUTHORS   Xavier,G.M., Sharpe,P.T. and Cobourne,M.T.
  TITLE     Scube1 is expressed during facial development in the mouse
  JOURNAL   J Exp Zool B Mol Dev Evol 312B (5), 518-524 (2009)
   PUBMED   19101956
  REMARK    GeneRIF: During tooth development, Scube1 localized to the dental
            papilla of both incisor and molar teeth, suggestina a role for
            Scube1 during early craniofacial development.
REFERENCE   9  (residues 1 to 988)
  AUTHORS   Tu,C.F., Yan,Y.T., Wu,S.Y., Djoko,B., Tsai,M.T., Cheng,C.J. and
            Yang,R.B.
  TITLE     Domain and functional analysis of a novel platelet-endothelial cell
            surface protein, SCUBE1
  JOURNAL   J Biol Chem 283 (18), 12478-12488 (2008)
   PUBMED   18303018
  REMARK    GeneRIF: These results support the dual roles of SCUBE1 on brain
            morphogenesis and cell-cell adhesions through its distinct domain
            function.
REFERENCE   10 (residues 1 to 988)
  AUTHORS   Grimmond,S., Larder,R., Van Hateren,N., Siggers,P., Hulsebos,T.J.,
            Arkell,R. and Greenfield,A.
  TITLE     Cloning, mapping, and expression analysis of a gene encoding a
            novel mammalian EGF-related protein (SCUBE1)
  JOURNAL   Genomics 70 (1), 74-81 (2000)
   PUBMED   11087664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104466.1, AK041590.1, BC080278.1 and AL583887.9.
            
            On May 27, 2006 this sequence version replaced NP_073560.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (b) is shorter
            than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     Protein         1..988
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 1 isoform b precursor"
                     /note="signal peptide, CUB and EGF-like domain-containing
                     protein 1"
                     /calculated_mol_wt=105543
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2622
     Region          37..72
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          84..115
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          121..156
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          166..202
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          206..241
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          245..280
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          286..321
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <318..354
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          366..401
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          636..683
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          690..737
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          746..793
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          798..909
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(806,808,810,837,842,880,904,906,908..909)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..988
                     /gene="Scube1"
                     /gene_synonym="7330410C13Rik; A630023E24Rik"
                     /coded_by="NM_022723.3:134..3100"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS49684.1"
                     /db_xref="GeneID:64706"
                     /db_xref="MGI:MGI:1890616"
ORIGIN      
        1 mgaaavrwhl ylllalgarg rlvggsglpg avdvdecseg tddchidaic qntpksykcl
       61 ckpgykgegr qcedidecen dyynggcvhd cinipgnyrc tcfdgfmlah dghncldvde
      121 cqdnnggcqq icvnamgsye cqchsgffls dnqhtcihrs negmncmnkd hgcahicret
      181 pkggvacdcr pgfdlaqnqk dctltcnygn ggcqhscedt dtgpmcgchq kyalhadgrt
      241 cietcavnng gcdrtckdta tgvrcscpvg ftlqpdgktc kdineclmnn ggcdhfcrnt
      301 vgsfecgcqk ghklltdert cqdidecsfe rtcdhicins pgsfqclcrr gytlygtthc
      361 gdvdecsmnn gsceqgcvnt kgsyecvcpp grrlhwnqkd cvemngclsr skasaqaqls
      421 cgkvggvenc flsclghslf mpdsessyil scgvpglqgk tlpkrngtss stgpgcsdap
      481 ttpirqkarf kirdakchlq prsqerakdt lrhplldnch vtfvtlkcds skkrrrgrks
      541 pskevshita efevemkvde asgtceadcm rkraeqslqa aikilrksig rnqfyvqvlg
      601 teyevaqrpa kalegtgtcg igqilqdgkc vpcapgtyfs gdpgqcmpcv sgtyqdmegq
      661 lsctpcpsse glglagarnv secggqcspg yfsadgfkpc qacpvgtyqp epgrtgcfpc
      721 ggglltkhtg tasfqdceak vhcspghhyn ttthrcircp vgtyqpefgq nhciscpgnt
      781 stdfdgstnv thcknqhcgg elgdytgyie spnypgdypa naecvwhiap ppkrrilivv
      841 peiflpiede cgdvlvmrks asptsvttye tcqtyerpia ftsrsrklwi qfksneansg
      901 kgfqvpyvty dedyqqlied ivrdgrlyas enhqeilkdk klikalfdvl ahpqnyfkyt
      961 aqeskemfpr sfikllrskv srflrpyk
//
