LOCUS       NM_001012322            1939 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus secretin receptor (Sctr), transcript variant 1, mRNA.
ACCESSION   NM_001012322 XM_148959
VERSION     NM_001012322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1939)
  AUTHORS   Aiko,M., Hiroaki,F., Yoan,C., Go,M. and Nobuhiro,F.
  TITLE     Effects of sleep deprivation on sleep and sleep
            electroencephalogram in secretin-receptor knockout mice
  JOURNAL   Neurosci Res 200, 41-47 (2024)
   PUBMED   37774845
  REMARK    GeneRIF: Effects of sleep deprivation on sleep and sleep
            electroencephalogram in secretin-receptor knockout mice.
REFERENCE   2  (bases 1 to 1939)
  AUTHORS   Zhang,F., Qiao,W., Wei,J.A., Tao,Z., Chen,C., Wu,Y., Lin,M.,
            Ng,K.M.C., Zhang,L., Yeung,K.W. and Chow,B.K.C.
  TITLE     Secretin-dependent signals in the ventromedial hypothalamus
            regulate energy metabolism and bone homeostasis in mice
  JOURNAL   Nat Commun 15 (1), 1030 (2024)
   PUBMED   38310104
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1939)
  AUTHORS   Berg,P., Jensen,T., Andersen,J.F., Svendsen,S.L., Modvig,I.M.,
            Wang,T., Frische,S., Chow,B.K.C., Malte,H., Holst,J.J.,
            Sorensen,M.V. and Leipziger,J.
  TITLE     Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion
            and Aggravates Metabolic Alkalosis in Mice during Acute
            Base-Loading
  JOURNAL   J Am Soc Nephrol 34 (8), 1329-1342 (2023)
   PUBMED   37344929
  REMARK    GeneRIF: Loss of the Secretin Receptor Impairs Renal Bicarbonate
            Excretion and Aggravates Metabolic Alkalosis in Mice during Acute
            Base-Loading.
REFERENCE   4  (bases 1 to 1939)
  AUTHORS   Zhang,F., Mak,S.O.K., Liu,Y., Ke,Y., Rao,F., Yung,W.H., Zhang,L.
            and Chow,B.K.C.
  TITLE     Secretin receptor deletion in the subfornical organ attenuates the
            activation of excitatory neurons under dehydration
  JOURNAL   Curr Biol 32 (22), 4832-4841 (2022)
   PUBMED   36220076
  REMARK    GeneRIF: Secretin receptor deletion in the subfornical organ
            attenuates the activation of excitatory neurons under dehydration.
REFERENCE   5  (bases 1 to 1939)
  AUTHORS   Sugiyama,M., Nishijima,I., Nakamura,W. and Nakamura,T.J.
  TITLE     Secretin receptor-deficient mice exhibit robust food anticipatory
            activity
  JOURNAL   Neurosci Lett 772, 136462 (2022)
   PUBMED   35051436
  REMARK    GeneRIF: Secretin receptor-deficient mice exhibit robust food
            anticipatory activity.
REFERENCE   6  (bases 1 to 1939)
  AUTHORS   Lee,V.H., Lee,L.T., Chu,J.Y., Lam,I.P., Siu,F.K., Vaudry,H. and
            Chow,B.K.
  TITLE     An indispensable role of secretin in mediating the osmoregulatory
            functions of angiotensin II
  JOURNAL   FASEB J 24 (12), 5024-5032 (2010)
   PUBMED   20739612
  REMARK    GeneRIF: Findings identify SCT and SCTR as novel elements of the
            ANGII osmoregulatory pathway in maintaining fluid balance in the
            body.
REFERENCE   7  (bases 1 to 1939)
  AUTHORS   Glaser,S., Lam,I.P., Franchitto,A., Gaudio,E., Onori,P., Chow,B.K.,
            Wise,C., Kopriva,S., Venter,J., White,M., Ueno,Y., Dostal,D.,
            Carpino,G., Mancinelli,R., Butler,W., Chiasson,V., DeMorrow,S.,
            Francis,H. and Alpini,G.
  TITLE     Knockout of secretin receptor reduces large cholangiocyte
            hyperplasia in mice with extrahepatic cholestasis induced by bile
            duct ligation
  JOURNAL   Hepatology 52 (1), 204-214 (2010)
   PUBMED   20578263
  REMARK    GeneRIF: Stable knockdown of SR expression reduced basal
            cholangiocyte proliferation. SR is an important trophic regulator
            sustaining biliary growth.
REFERENCE   8  (bases 1 to 1939)
  AUTHORS   Chu,J.Y., Chung,S.C., Lam,A.K., Tam,S., Chung,S.K. and Chow,B.K.
  TITLE     Phenotypes developed in secretin receptor-null mice indicated a
            role for secretin in regulating renal water reabsorption
  JOURNAL   Mol Cell Biol 27 (7), 2499-2511 (2007)
   PUBMED   17283064
REFERENCE   9  (bases 1 to 1939)
  AUTHORS   Nishijima,I., Yamagata,T., Spencer,C.M., Weeber,E.J.,
            Alekseyenko,O., Sweatt,J.D., Momoi,M.Y., Ito,M., Armstrong,D.L.,
            Nelson,D.L., Paylor,R. and Bradley,A.
  TITLE     Secretin receptor-deficient mice exhibit impaired synaptic
            plasticity and social behavior
  JOURNAL   Hum Mol Genet 15 (21), 3241-3250 (2006)
   PUBMED   17008357
REFERENCE   10 (bases 1 to 1939)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032652.1 and BC089355.1.
            
            On Apr 25, 2007 this sequence version replaced NM_001012322.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032652.1, SRR7345562.4320682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-852               AK032652.1         3-854
            853-1501            BC089355.1         754-1402
            1502-1507           AK032652.1         1502-1507
            1508-1939           BC089355.1         1403-1834
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.57 cM"
     gene            1..1939
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /note="secretin receptor"
                     /db_xref="GeneID:319229"
                     /db_xref="MGI:MGI:2441720"
     exon            1..352
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1672
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; SCT-R"
                     /codon_start=1
                     /product="secretin receptor isoform 1 precursor"
                     /protein_id="NP_001012322.2"
                     /db_xref="CCDS:CCDS48341.1"
                     /db_xref="GeneID:319229"
                     /db_xref="MGI:MGI:2441720"
                     /translation="MLSTMSPRLSLLLLWLLLLINAAHPVGALPRLCDVRRVLLEERA
                     ECLRELSEEKKALGPKTASAIVFSPSAPSYTVHQGCERFWDNMSCWPSSALAQTVEVP
                     CPKFLRMFSGRNGSLFRNCTKDGWSETFPRPDLACGVNMNGSFNERRHAYLLKLKVMY
                     TVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFPADD
                     VTYCDAHRAGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKCLQAFVLFG
                     WGSPAIFVALWAVTRHFLEDFGCWDINSNASIWWVIRGPVILSIVINFIFFINILRIL
                     MRKLRTQETRGNETHHYKRLAKSTLLLIPLFGIHYIVFAFSPEGAMEVQLFFELALGS
                     FQGLVVAVLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVALSNSFSNATNGPTHSTKAG
                     TSEQSRSIPGANVI"
     exon            353..467
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..512
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            513..620
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..724
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            725..822
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..955
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1109
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1170
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1240
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1332
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1459
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1501
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1924
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1924
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctgctattc cctgcagggt ggagtcgcga gctgtcgtcc agtctttatc aataggcact
       61 gcaggttagt taacagtctt gccacctcct tcagggagca gcagtcccta gcctggctgt
      121 gggtctggtc ggattgggta ggtccagcca tggcttctct gggcttgggg gtcgcccagg
      181 gtcctggacg acatgcagga cgctgagctg gacacagaga cggacaccca gctcctgaag
      241 aggccagagc acaaagggga tcaacagtgg gcggagcatg ctcagcacca tgagcccccg
      301 gctgtcactg cttctgctgt ggctgctgct gctcatcaat gcagcgcacc ctgttggagc
      361 tctgcccaga ttgtgtgatg tgcggcgtgt gctgctcgag gaacgggccg agtgcctgcg
      421 ggaactctcc gaagagaaga aggcgctggg cccgaagaca gcatcagcca tcgtattctc
      481 accgtctgct ccttcgtaca cggttcatca aggctgtgag aggttttggg acaacatgag
      541 ctgctggccc tcctcggcac tggcacagac agtggaagtg ccatgtccga agttcctgag
      601 gatgttctct ggcagaaatg ggtctctgtt ccggaactgc acaaaggatg gctggtcaga
      661 aaccttcccc aggcctgacc tggcctgtgg ggtcaacatg aatggctcct ttaatgagag
      721 acggcatgca tacctgctga agctcaaggt catgtacact gtaggctaca gttcctcctt
      781 ggccatgctc ctggtcgccc tcagcatcct gtgctctttc cggaggctgc actgcactcg
      841 caactacatc cacatgcacc tgtttgtgtc cttcatcctt cgcgccctgt ccaacttcat
      901 caaggacgcc gtactcttcc ccgcagatga cgtcacctac tgtgatgccc acagggcagg
      961 ctgcaagctg gtcatgatct tcttccagta ctgcatcatg gccaactacg cgtggctgct
     1021 ggtggagggc ctctatcttc acacgctcct ggccatctcc ttcttctcag aaaggaagtg
     1081 cctgcaggca tttgtgctct tcggatgggg ttctccagcc atttttgttg ctttgtgggc
     1141 tgtcaccaga cactttctgg aggactttgg atgctgggac atcaactcca acgcttccat
     1201 ctggtgggtc attcgagggc ctgtgattct gtccatcgtg atcaatttca tctttttcat
     1261 aaacattcta agaatcctga tgagaaaact tagaactcaa gaaacaagag gaaatgaaac
     1321 acaccattat aagcgcctgg ccaagtccac cctcctgctg atccctctct ttggcatcca
     1381 ctacattgtc ttcgccttct ccccagaggg tgccatggag gtccagctgt tctttgaatt
     1441 ggccctgggc tccttccagg ggctggtggt agctgtcctt tactgcttcc tcaatggtga
     1501 ggtgcagctg gaagttcaga aaaaatggcg ccagtggcac ctccaagagt tcccgctgcg
     1561 ccctgtggcc ctcagcaact ccttcagcaa cgccaccaac ggccccaccc acagcaccaa
     1621 ggctggcacc tctgagcaga gccggagcat ccccggggcc aatgtcatct gaggctgcag
     1681 caagccagca gcagacaaag ggttggatgc tcggtaggat ggacatcggc caggtagcca
     1741 ttttgtgttc gagtggctgc acaggcctgt ccccgaggtc tgagcttcct cagagatcaa
     1801 gcaagaggag actaggtcat cctggagcag gaaacaggcc tgggatttgg tctttctagt
     1861 tcttctaaga agagcacttc agcggcccca gaaggggcag agaaataaaa tgacatccag
     1921 aaaaaaaaaa aaaaaaaaa
//
