LOCUS       NP_001012322             464 aa            linear   ROD 14-JAN-2025
DEFINITION  secretin receptor isoform 1 precursor [Mus musculus].
ACCESSION   NP_001012322 XP_148959
VERSION     NP_001012322.2
DBSOURCE    REFSEQ: accession NM_001012322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Aiko,M., Hiroaki,F., Yoan,C., Go,M. and Nobuhiro,F.
  TITLE     Effects of sleep deprivation on sleep and sleep
            electroencephalogram in secretin-receptor knockout mice
  JOURNAL   Neurosci Res 200, 41-47 (2024)
   PUBMED   37774845
  REMARK    GeneRIF: Effects of sleep deprivation on sleep and sleep
            electroencephalogram in secretin-receptor knockout mice.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Zhang,F., Qiao,W., Wei,J.A., Tao,Z., Chen,C., Wu,Y., Lin,M.,
            Ng,K.M.C., Zhang,L., Yeung,K.W. and Chow,B.K.C.
  TITLE     Secretin-dependent signals in the ventromedial hypothalamus
            regulate energy metabolism and bone homeostasis in mice
  JOURNAL   Nat Commun 15 (1), 1030 (2024)
   PUBMED   38310104
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Berg,P., Jensen,T., Andersen,J.F., Svendsen,S.L., Modvig,I.M.,
            Wang,T., Frische,S., Chow,B.K.C., Malte,H., Holst,J.J.,
            Sorensen,M.V. and Leipziger,J.
  TITLE     Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion
            and Aggravates Metabolic Alkalosis in Mice during Acute
            Base-Loading
  JOURNAL   J Am Soc Nephrol 34 (8), 1329-1342 (2023)
   PUBMED   37344929
  REMARK    GeneRIF: Loss of the Secretin Receptor Impairs Renal Bicarbonate
            Excretion and Aggravates Metabolic Alkalosis in Mice during Acute
            Base-Loading.
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Zhang,F., Mak,S.O.K., Liu,Y., Ke,Y., Rao,F., Yung,W.H., Zhang,L.
            and Chow,B.K.C.
  TITLE     Secretin receptor deletion in the subfornical organ attenuates the
            activation of excitatory neurons under dehydration
  JOURNAL   Curr Biol 32 (22), 4832-4841 (2022)
   PUBMED   36220076
  REMARK    GeneRIF: Secretin receptor deletion in the subfornical organ
            attenuates the activation of excitatory neurons under dehydration.
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Sugiyama,M., Nishijima,I., Nakamura,W. and Nakamura,T.J.
  TITLE     Secretin receptor-deficient mice exhibit robust food anticipatory
            activity
  JOURNAL   Neurosci Lett 772, 136462 (2022)
   PUBMED   35051436
  REMARK    GeneRIF: Secretin receptor-deficient mice exhibit robust food
            anticipatory activity.
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Lee,V.H., Lee,L.T., Chu,J.Y., Lam,I.P., Siu,F.K., Vaudry,H. and
            Chow,B.K.
  TITLE     An indispensable role of secretin in mediating the osmoregulatory
            functions of angiotensin II
  JOURNAL   FASEB J 24 (12), 5024-5032 (2010)
   PUBMED   20739612
  REMARK    GeneRIF: Findings identify SCT and SCTR as novel elements of the
            ANGII osmoregulatory pathway in maintaining fluid balance in the
            body.
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Glaser,S., Lam,I.P., Franchitto,A., Gaudio,E., Onori,P., Chow,B.K.,
            Wise,C., Kopriva,S., Venter,J., White,M., Ueno,Y., Dostal,D.,
            Carpino,G., Mancinelli,R., Butler,W., Chiasson,V., DeMorrow,S.,
            Francis,H. and Alpini,G.
  TITLE     Knockout of secretin receptor reduces large cholangiocyte
            hyperplasia in mice with extrahepatic cholestasis induced by bile
            duct ligation
  JOURNAL   Hepatology 52 (1), 204-214 (2010)
   PUBMED   20578263
  REMARK    GeneRIF: Stable knockdown of SR expression reduced basal
            cholangiocyte proliferation. SR is an important trophic regulator
            sustaining biliary growth.
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Chu,J.Y., Chung,S.C., Lam,A.K., Tam,S., Chung,S.K. and Chow,B.K.
  TITLE     Phenotypes developed in secretin receptor-null mice indicated a
            role for secretin in regulating renal water reabsorption
  JOURNAL   Mol Cell Biol 27 (7), 2499-2511 (2007)
   PUBMED   17283064
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Nishijima,I., Yamagata,T., Spencer,C.M., Weeber,E.J.,
            Alekseyenko,O., Sweatt,J.D., Momoi,M.Y., Ito,M., Armstrong,D.L.,
            Nelson,D.L., Paylor,R. and Bradley,A.
  TITLE     Secretin receptor-deficient mice exhibit impaired synaptic
            plasticity and social behavior
  JOURNAL   Hum Mol Genet 15 (21), 3241-3250 (2006)
   PUBMED   17008357
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032652.1 and BC089355.1.
            
            On Apr 25, 2007 this sequence version replaced NP_001012322.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032652.1, SRR7345562.4320682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.57 cM"
     Protein         1..464
                     /product="secretin receptor isoform 1 precursor"
                     /note="SCT-R"
                     /calculated_mol_wt=49718
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3045
     Region          77..140
                     /region_name="HRM"
                     /note="Hormone receptor domain; pfam02793"
                     /db_xref="CDD:397086"
     Region          153..419
                     /region_name="7tmB1_secretin"
                     /note="secretin receptor, member of the class B family of
                     seven-transmembrane G protein-coupled receptors; cd15275"
                     /db_xref="CDD:320403"
     Region          155..180
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320403"
     Site            order(160,164,206,209..210,213,230,237,308..309,311,313,
                     369,372,384,388)
                     /site_type="other"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]"
                     /db_xref="CDD:320403"
     Region          189..211
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320403"
     Region          230..257
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320403"
     Region          269..289
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320403"
     Region          305..334
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320403"
     Region          350..377
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320403"
     Region          381..406
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320403"
     CDS             1..464
                     /gene="Sctr"
                     /gene_synonym="6530402O03Rik"
                     /coded_by="NM_001012322.2:278..1672"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS48341.1"
                     /db_xref="GeneID:319229"
                     /db_xref="MGI:MGI:2441720"
ORIGIN      
        1 mlstmsprls llllwlllli naahpvgalp rlcdvrrvll eeraeclrel seekkalgpk
       61 tasaivfsps apsytvhqgc erfwdnmscw pssalaqtve vpcpkflrmf sgrngslfrn
      121 ctkdgwsetf prpdlacgvn mngsfnerrh ayllklkvmy tvgyssslam llvalsilcs
      181 frrlhctrny ihmhlfvsfi lralsnfikd avlfpaddvt ycdahragck lvmiffqyci
      241 manyawllve glylhtllai sffserkclq afvlfgwgsp aifvalwavt rhfledfgcw
      301 dinsnasiww virgpvilsi vinfiffini lrilmrklrt qetrgnethh ykrlakstll
      361 liplfgihyi vfafspegam evqlffelal gsfqglvvav lycflngevq levqkkwrqw
      421 hlqefplrpv alsnsfsnat ngpthstkag tseqsrsipg anvi
//
