LOCUS       NM_001287171             533 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus secretin (Sct), transcript variant 1, mRNA.
ACCESSION   NM_001287171
VERSION     NM_001287171.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Zhang,F., Qiao,W., Wei,J.A., Tao,Z., Chen,C., Wu,Y., Lin,M.,
            Ng,K.M.C., Zhang,L., Yeung,K.W. and Chow,B.K.C.
  TITLE     Secretin-dependent signals in the ventromedial hypothalamus
            regulate energy metabolism and bone homeostasis in mice
  JOURNAL   Nat Commun 15 (1), 1030 (2024)
   PUBMED   38310104
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 533)
  AUTHORS   Zhang,F., Tao,Z., Chen,C. and Chow,B.K.C.
  TITLE     Effects of secretin gene knockout on the diversity, composition,
            and function of gut microbiota in adult male mice
  JOURNAL   Front Cell Infect Microbiol 13, 1257857 (2023)
   PUBMED   38156312
  REMARK    GeneRIF: Effects of secretin gene knockout on the diversity,
            composition, and function of gut microbiota in adult male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 533)
  AUTHORS   Zhang,F., Mak,S.O.K., Liu,Y., Ke,Y., Rao,F., Yung,W.H., Zhang,L.
            and Chow,B.K.C.
  TITLE     Secretin receptor deletion in the subfornical organ attenuates the
            activation of excitatory neurons under dehydration
  JOURNAL   Curr Biol 32 (22), 4832-4841 (2022)
   PUBMED   36220076
REFERENCE   4  (bases 1 to 533)
  AUTHORS   Chen,L., Wu,N., Kennedy,L., Francis,H., Ceci,L., Zhou,T.,
            Samala,N., Kyritsi,K., Wu,C., Sybenga,A., Ekser,B., Dar,W.,
            Atkins,C., Meadows,V., Glaser,S. and Alpini,G.
  TITLE     Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD
            Phenotypes
  JOURNAL   Hepatology 74 (4), 1845-1863 (2021)
   PUBMED   33928675
  REMARK    GeneRIF: Inhibition of Secretin/Secretin Receptor Axis Ameliorates
            NAFLD Phenotypes.
REFERENCE   5  (bases 1 to 533)
  AUTHORS   Piccand,J., Vagne,C., Blot,F., Meunier,A., Beucher,A., Strasser,P.,
            Lund,M.L., Ghimire,S., Nivlet,L., Lapp,C., Petersen,N.,
            Engelstoft,M.S., Thibault-Carpentier,C., Keime,C., Correa,S.J.,
            Schreiber,V., Molina,N., Schwartz,T.W., De Arcangelis,A. and
            Gradwohl,G.
  TITLE     Rfx6 promotes the differentiation of peptide-secreting
            enteroendocrine cells while repressing genetic programs controlling
            serotonin production
  JOURNAL   Mol Metab 29, 24-39 (2019)
   PUBMED   31668390
REFERENCE   6  (bases 1 to 533)
  AUTHORS   Lay,J.M., Gillespie,P.J. and Samuelson,L.C.
  TITLE     Murine prenatal expression of cholecystokinin in neural crest,
            enteric neurons, and enteroendocrine cells
  JOURNAL   Dev Dyn 216 (2), 190-200 (1999)
   PUBMED   10536058
REFERENCE   7  (bases 1 to 533)
  AUTHORS   Rindi,G., Ratineau,C., Ronco,A., Candusso,M.E., Tsai,M. and
            Leiter,A.B.
  TITLE     Targeted ablation of secretin-producing cells in transgenic mice
            reveals a common differentiation pathway with multiple
            enteroendocrine cell lineages in the small intestine
  JOURNAL   Development 126 (18), 4149-4156 (1999)
   PUBMED   10457023
REFERENCE   8  (bases 1 to 533)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 533)
  AUTHORS   Offield,M.F., Jetton,T.L., Labosky,P.A., Ray,M., Stein,R.W.,
            Magnuson,M.A., Hogan,B.L. and Wright,C.V.
  TITLE     PDX-1 is required for pancreatic outgrowth and differentiation of
            the rostral duodenum
  JOURNAL   Development 122 (3), 983-995 (1996)
   PUBMED   8631275
REFERENCE   10 (bases 1 to 533)
  AUTHORS   Lan,M.S., Kajiyama,W., Donadel,G., Lu,J. and Notkins,A.L.
  TITLE     cDNA sequence and genomic organization of mouse secretin
  JOURNAL   Biochem Biophys Res Commun 200 (2), 1066-1071 (1994)
   PUBMED   8179583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163434.5.
            
            On Mar 1, 2023 this sequence version replaced NM_001287171.1.
            
            Summary: This gene encodes the precursor of a gastrointestinal
            peptide hormone of the secretin-glucagon family. The encoded
            protein is secreted as a prohormone that undergoes proteolytic
            processing to generate a mature peptide hormone. The mature peptide
            regulates secretion of gastric acid, biocarbonate ions from
            pancreatic and biliary duct epithelia and water homeostasis in the
            gastrointestinal system. Mice lacking the encoded protein display
            decreased survival of neuroprogenitor cells during early postnatal
            period and impaired long-term potentiation and spatial learning in
            adulthood. Alternative splicing results in multiple transcript
            variants encoding different isoforms. All of these isoforms may be
            processed in a similar manner to generate the mature peptide
            hormone. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048484.1, BU939421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC163434.5         75247-75362         c
            117-218             AC163434.5         75064-75165         c
            219-323             AC163434.5         74849-74953         c
            324-533             AC163434.5         74561-74770         c
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.59 cM"
     gene            1..533
                     /gene="Sct"
                     /note="secretin"
                     /db_xref="GeneID:20287"
                     /db_xref="MGI:MGI:99466"
     exon            1..116
                     /gene="Sct"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..453
                     /gene="Sct"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="secretin isoform 1 precursor"
                     /protein_id="NP_001274100.1"
                     /db_xref="CCDS:CCDS72069.1"
                     /db_xref="GeneID:20287"
                     /db_xref="MGI:MGI:99466"
                     /translation="MEPPLPTPMLLLLLLLLSSSAALPAPPRTPRHSDGMFTSELSRL
                     QDSARLQRLLQGLVGKRSEQDTENIPENSLARSKPLEDQLCLLWSNTQTLQDCPLSFH
                     RLLPRLSLDGSLSLWLPPGPRSAVDRSEWTETTRPPR"
     exon            117..218
                     /gene="Sct"
                     /inference="alignment:Splign:2.1.0"
     exon            219..323
                     /gene="Sct"
                     /inference="alignment:Splign:2.1.0"
     exon            324..533
                     /gene="Sct"
                     /inference="alignment:Splign:2.1.0"
     regulatory      510..515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sct"
                     /note="hexamer: AATAAA"
     polyA_site      533
                     /gene="Sct"
                     /note="major polyA site"
ORIGIN      
        1 agttgcagca tttgtcacac ccagagcccg accatggagc ctccgctgcc cacgccgatg
       61 ctactgctgt tgctgctgct gctctccagt tccgccgcgc tccctgcacc tcccaggacc
      121 ccaagacact cagacggaat gttcaccagc gagctcagcc gcttgcagga cagtgccagg
      181 ctgcagcgcc tgctgcaggg tctggtgggg aagcgcagcg agcaggacac agaaaatatc
      241 ccagagaaca gcctggcccg gtccaagccc ttagaggacc agctctgctt gctgtggtcg
      301 aacactcaga ccctacagga ctgtcccctc tccttccaca ggcttctgcc caggctgtcc
      361 ctggatgggt ccctgtctct ctggctgcct cctggaccaa ggtctgctgt tgatcgttca
      421 gagtggactg aaacaaccag gccacccaga tgagggagga agagtctcta ggaccctggc
      481 tggagtaggg attggttgtc cttggcatca ataaaaaagg aatttagacc ctg
//
