LOCUS       NM_001160410            3107 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus scratch family zinc finger 2 (Scrt2), mRNA.
ACCESSION   NM_001160410 XM_619828 XM_904795
VERSION     NM_001160410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3107)
  AUTHORS   Ohyama,K., Shinohara,H.M., Takayama,N., Ogawa,R., Omura,S.,
            Hayashida,M. and Takahashi,T.
  TITLE     Differentiation stage-specific expression of transcriptional
            regulators for epithelial mesenchymal transition in dentate granule
            progenitors
  JOURNAL   Front Neurosci 18, 1425849 (2024)
   PUBMED   39268037
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3107)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3107)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 3107)
  AUTHORS   Li,C., Li,X., Bi,Z., Sugino,K., Wang,G., Zhu,T. and Liu,Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3107)
  AUTHORS   Paul,V., Tonchev,A.B., Henningfeld,K.A., Pavlakis,E., Rust,B.,
            Pieler,T. and Stoykova,A.
  TITLE     Scratch2 modulates neurogenesis and cell migration through
            antagonism of bHLH proteins in the developing neocortex
  JOURNAL   Cereb Cortex 24 (3), 754-772 (2014)
   PUBMED   23180754
  REMARK    GeneRIF: This study revealed that a modulatory role of Scrt2
            protein in cortical neurogenesis and neuronal migration.
REFERENCE   6  (bases 1 to 3107)
  AUTHORS   Itoh,Y., Moriyama,Y., Hasegawa,T., Endo,T.A., Toyoda,T. and
            Gotoh,Y.
  TITLE     Scratch regulates neuronal migration onset via an
            epithelial-mesenchymal transition-like mechanism
  JOURNAL   Nat Neurosci 16 (4), 416-425 (2013)
   PUBMED   23434913
REFERENCE   7  (bases 1 to 3107)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   8  (bases 1 to 3107)
  AUTHORS   Marin,F. and Nieto,M.A.
  TITLE     The expression of Scratch genes in the developing and adult brain
  JOURNAL   Dev Dyn 235 (9), 2586-2591 (2006)
   PUBMED   16773660
  REMARK    GeneRIF: From perinatal to adult stages, Scratch2 expression
            progressively diminishes and virtually no expression can be
            detected in the adult brain.
REFERENCE   9  (bases 1 to 3107)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845161.5.
            
            On Nov 8, 2022 this sequence version replaced NM_001160410.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.76587.1,
                                           SRR14777535.2514724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AL845161.5         182989-183354
            367-3107            AL845161.5         194234-196974
FEATURES             Location/Qualifiers
     source          1..3107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..3107
                     /gene="Scrt2"
                     /note="scratch family zinc finger 2"
                     /db_xref="GeneID:545474"
                     /db_xref="MGI:MGI:2139287"
     exon            1..366
                     /gene="Scrt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1169
                     /gene="Scrt2"
                     /note="scratch homolog 2, zinc finger protein; ortholog of
                     human scratch homolog 2, zinc finger protein SCRT2"
                     /codon_start=1
                     /product="transcriptional repressor scratch 2"
                     /protein_id="NP_001153882.1"
                     /db_xref="CCDS:CCDS50750.1"
                     /db_xref="GeneID:545474"
                     /db_xref="MGI:MGI:2139287"
                     /translation="MPRSFLVKKIKADGFQCSGVSAPTYHPLETAYVLPGTRGPPGDN
                     GYVAHCLPPSGYDGEQKPGLELAPAEPAYPAAASEEYSDPESPQSSLSARYFRGEAAV
                     TDSYSMDAFFISDGRSRRRRAGAGGDAAGAGDAGGGGGGGGGGERAGRSGATAGGGHR
                     HACAECGKTYATSSNLSRHKQTHRSLDSQLARKCPTCGKAYVSMPALAMHVLTHNLRH
                     KCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHYRC
                     RQCDKSFALKSYLHKHCEAACVKAAEPPPSAGPAS"
     exon            367..3107
                     /gene="Scrt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrt2"
                     /note="hexamer: ATTAAA"
     polyA_site      3107
                     /gene="Scrt2"
                     /note="major polyA site"
ORIGIN      
        1 acagctacag cgaccgcctg tgtgcgcgcc gccgccgccg ccgtcgccgc cgccgccgcg
       61 cccgagcggc acccgagccc gagccgcgac cgtcgccacc ccgccggctc cgcggacgcc
      121 cgcccgctgg gagctgtcca gtgctgaagc cggcgccgac agccaatcgc gccggccggc
      181 cgcctccccc accgggcctc ccgtgccctg cgagcccccc gcccggctgc accatgccgc
      241 gttccttcct ggtgaagaag atcaaagcgg atggcttcca gtgcagcggg gtgtcagccc
      301 ccacctacca ccccctggag actgcctacg tgctgcctgg cacccgcggg cctccggggg
      361 acaacggtta tgtggcgcac tgtctgcccc ccagcggtta cgatggcgag cagaagcctg
      421 ggctggagct ggcgcccgcc gagcccgcct acccggccgc ggcgtccgaa gagtacagcg
      481 accccgagag cccacagtcc agcctgtcgg cgcgctactt ccgcggggag gcggccgtga
      541 ccgacagcta ctccatggac gccttcttca tctctgacgg gcgttcgcgg cggcgccggg
      601 ccggggctgg cggggacgcg gcgggcgcag gggacgcggg cggcggcggc ggtggcggcg
      661 gcggcgggga gcgcgcgggg cgctcggggg cgacggcggg aggcgggcac cggcacgcat
      721 gcgcagagtg cggcaagacg tacgccacgt cgtcgaacct gagccgccac aagcagacgc
      781 accgcagcct ggacagccag ctggcgcgca agtgcccgac gtgcggcaag gcctacgtgt
      841 ccatgcccgc gctcgccatg cacgtgctca cgcacaacct gcgccacaag tgcggcgtgt
      901 gcggcaaggc cttctcccgg ccctggctgc tccagggcca catgcgctcg cacaccggcg
      961 agaagccctt cggctgcgcg cactgcggca aagccttcgc cgaccgctcc aacctgcgcg
     1021 cgcacatgca gacgcactcg gccttcaagc actaccgctg ccgccagtgc gacaagagct
     1081 tcgcgctcaa gtcctacctc cacaagcact gcgaggctgc gtgcgtcaag gccgccgagc
     1141 cgccgccttc cgccggcccg gccagttgag cctctgccat gcgggatgcc cgccgaggct
     1201 tctctcccac ccctcagtct gcgtctcccc tgcctgcgcc ctcggtgggg tgggggtgaa
     1261 ccccatcttg gcctagaact ttcttttcaa cccccgactg aacccaccac tcatttcctg
     1321 catcggatct cccttcgcac ccacccactt tgtccattct ggccaccact cggaccttga
     1381 cccccatgtc tggccttcaa ggctcccaac tcaggcacca ggtccgtacc tcttccatgt
     1441 cccggcgctg gaagtttctc cggccccgac tctaggctgt gctccttaac tagatctttc
     1501 ttttcatttc tcagcagagt cattggccat tcctctattg gagccctcaa tccaaaccca
     1561 aatgtaccct tgatttccta tctgcctcag tttccctgtc cacacagtcc aatcccttgg
     1621 gtctctgctg aatttccgtg tgtgtgtgtg tgtatgtgtg tgtgtgtccc cataccgtaa
     1681 tctaatcttc accactcttg gagtcctctg cctgtccatt cctgagcccc tccatgcttg
     1741 ggccttaggt ccagcctctt acacacacga ttccacctga cattatcagt cctcccggat
     1801 ctcatcagac atcctgctct ctccagctcc atcttcccac tagtagctcc cagtcctcag
     1861 ttttcctagc tgggaacaga cttgggaggc agcccaaggc tctgccctct caggtgaccc
     1921 ctcttgcccc aggaaagttc ctgtctaggc ctcaggcctg gagctgcgat ttcccagact
     1981 atctgagcac tttccctcgc cccaggacta caggttcgcc tctgcctttg ctagagaaca
     2041 gcctggagca cctcacccat ggacacatcc cctcgtccgg cagggcccct tccgctattt
     2101 atttgtgtat ttatttattt atctatttat tattctattt aatctcttgg cttcacccag
     2161 ggactgtctg gcttccccag ctggactggg aagtcaaagg gtagagtcag caaggccgtc
     2221 cgtcgctggc tgctcctccc cttatgggtc tggggagaag cccaccctta tcagagcctc
     2281 aactccttag gaagagaggc ctggagaaat ggggggaggc ggagcctgct tagcctcagc
     2341 tgggtgggga ggggccatca gaaggtccta tttgggggca ggtccccggc cttctgcgcc
     2401 ttccactcct gtcccaggaa gcccttctgg agcctctccc tttgtttcgt atttattcct
     2461 ctttcagagg gaccccaggt tccagggacc gactgagccc cggacccgct ggggcctctg
     2521 gcctgctccc gggaggagtg ctctctcccg gccacgacta tgcaactctc ccgggcagag
     2581 gggccgggac tgccagccag gcgcctattg gccaccacta cctcctccac cgcgcttttg
     2641 catgcccggg cgaggaccga agcacacacc tccgcgccca cctgcccggc cccctctgct
     2701 ttaagcacac gcctctttcc acgtccctct gcgttccctt tgtgggcaaa agtcctggac
     2761 actcagacct ccttcccctc cccctagcca caaaagaggg tggagattgc agaccgctcc
     2821 aggttgctct ctagggtttc ggaggggtgg agcttcgtta ggccccaggc tccaggagga
     2881 agtctgcaga gatggtggga gagagagggg tcaccagaag caattttgga gggtgctgac
     2941 cctgtaaata ggaacttctg acagcaataa tttcccatgc atgctaaatc ttttggaccc
     3001 tcccttgccg tacccccaac tcaccccccc acccctattc cttccccacc ttcagcagta
     3061 ttacttgtaa cgcaattcag ggatattaaa gggactttgg ccactca
//
