LOCUS       NM_130893               4010 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus scratch family zinc finger 1 (Scrt1), mRNA.
ACCESSION   NM_130893
VERSION     NM_130893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4010)
  AUTHORS   Monaghan,C.E., Nechiporuk,T., Jeng,S., McWeeney,S.K., Wang,J.,
            Rosenfeld,M.G. and Mandel,G.
  TITLE     REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate
            the proliferation-differentiation balance in the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 114 (3), E406-E415 (2017)
   PUBMED   28049845
REFERENCE   2  (bases 1 to 4010)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   3  (bases 1 to 4010)
  AUTHORS   Itoh,Y., Moriyama,Y., Hasegawa,T., Endo,T.A., Toyoda,T. and
            Gotoh,Y.
  TITLE     Scratch regulates neuronal migration onset via an
            epithelial-mesenchymal transition-like mechanism
  JOURNAL   Nat Neurosci 16 (4), 416-425 (2013)
   PUBMED   23434913
  REMARK    GeneRIF: Scratch proteins (1 and 2) mediate the conversion of
            neuroepithelial cells to migrating neurons through an
            epithelial-mesenchymal transition.
REFERENCE   4  (bases 1 to 4010)
  AUTHORS   Bastid,J., Bouchet,B.P., Ciancia,C., Pourchet,J., Audoynaud,C.,
            Grelier,G., Puisieux,A. and Ansieau,S.
  TITLE     The SNAIL family member SCRATCH1 is not expressed in human tumors
  JOURNAL   Oncol Rep 23 (2), 523-529 (2010)
   PUBMED   20043117
  REMARK    GeneRIF: SCRT1 transcripts are undetectable in nearly all of the
            examined tumors suggesting that SCRATCH1 plays a minor role, if
            any, in tumorigenesis.
REFERENCE   5  (bases 1 to 4010)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4010)
  AUTHORS   Langer,E.M., Feng,Y., Zhaoyuan,H., Rauscher,F.J. 3rd, Kroll,K.L.
            and Longmore,G.D.
  TITLE     Ajuba LIM proteins are snail/slug corepressors required for neural
            crest development in Xenopus
  JOURNAL   Dev Cell 14 (3), 424-436 (2008)
   PUBMED   18331720
REFERENCE   7  (bases 1 to 4010)
  AUTHORS   Marin,F. and Nieto,M.A.
  TITLE     The expression of Scratch genes in the developing and adult brain
  JOURNAL   Dev Dyn 235 (9), 2586-2591 (2006)
   PUBMED   16773660
  REMARK    GeneRIF: From perinatal to adult stages, Scratch1 remains strongly
            expressed in almost all brain regions, although it is not found in
            some ventral structures such as motor nuclei and hypothalamic
            regions.
REFERENCE   8  (bases 1 to 4010)
  AUTHORS   MacLaren,E.J., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     Expression profiling identifies novel candidate genes for ethanol
            sensitivity QTLs
  JOURNAL   Mamm Genome 17 (2), 147-156 (2006)
   PUBMED   16465594
REFERENCE   9  (bases 1 to 4010)
  AUTHORS   Nakakura,E.K., Watkins,D.N., Sriuranpong,V., Borges,M.W.,
            Nelkin,B.D. and Ball,D.W.
  TITLE     Mammalian Scratch participates in neuronal differentiation in P19
            embryonal carcinoma cells
  JOURNAL   Brain Res Mol Brain Res 95 (1-2), 162-166 (2001)
   PUBMED   11687288
REFERENCE   10 (bases 1 to 4010)
  AUTHORS   Nakakura,E.K., Watkins,D.N., Schuebel,K.E., Sriuranpong,V.,
            Borges,M.W., Nelkin,B.D. and Ball,D.W.
  TITLE     Mammalian Scratch: a neural-specific Snail family transcriptional
            repressor
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4010-4015 (2001)
   PUBMED   11274425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB525529.1, BC089316.1 and AC157566.6.
            
            On Mar 8, 2007 this sequence version replaced NM_130893.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB525529.1, BC089316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               CB525529.1         1-605
            606-1195            BC089316.1         390-979
            1196-4010           AC157566.6         117370-120184
FEATURES             Location/Qualifiers
     source          1..4010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.01 cM"
     gene            1..4010
                     /gene="Scrt1"
                     /note="scratch family zinc finger 1"
                     /db_xref="GeneID:170729"
                     /db_xref="MGI:MGI:2176606"
     exon            1..539
                     /gene="Scrt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1471
                     /gene="Scrt1"
                     /note="SCRT; mScrt; scratch 1; scratch homolog 1, zinc
                     finger protein"
                     /codon_start=1
                     /product="transcriptional repressor scratch 1"
                     /protein_id="NP_570963.1"
                     /db_xref="CCDS:CCDS37123.1"
                     /db_xref="GeneID:170729"
                     /db_xref="MGI:MGI:2176606"
                     /translation="MPRSFLVKKVKLDTFSSADLDSSYGRARSDLGVRLQDKGYLSDY
                     VGPASVYDGDAEAALLKGPSPEPMYAAAVRGELGPAASGSAPPPTPRPELATAAGGYI
                     NGDAAVSEGYAADAFFITDGRSRRKAANANAAAAPSTASVAAPDSDAGGGGGPGTRGS
                     GSGSASRGGTRVGAGTEARAGSGATGAGGRHACGECGKTYATSSNLSRHKQTHRSLDS
                     QLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPF
                     GCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGASG
                     PATPAPPQLSPVQA"
     exon            540..4010
                     /gene="Scrt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3982..3987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrt1"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="Scrt1"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgggc cagccctgca cccattcgca gcctccgggc ccgggacgga gccgctcccc
       61 ccctctccgc ccccccagcc tcctcccccg cctgtccagg ggcggcactg cgggctggga
      121 agccgggacc agaggaggga aggaaggaag gaaggaaaga agagaaaaga agagaagagg
      181 aggaaggaag gaaagaagga aggaaggaag gagagagaaa gagaggaggg atccggagag
      241 gaagaagaaa agacgcaggg cagaaagaag agagaggacc acactcgccc agcagcatcc
      301 acaggccaga caggggacag tgctgcttcc accgctcctc ggatggtgac ggggcctcgc
      361 cgcggacgca gtccccctga gccccggctc tgcaggccct cactgccgga gccctgcagg
      421 aatcatgccc aggtccttcc tggttaagaa ggtcaaactt gacacattct cttcggcaga
      481 cctcgacagc tcctacgggc gcgcccgcag cgatctcgga gtgcgactgc aagataaagg
      541 atacctcagt gactacgtgg ggcctgcgtc ggtctacgat ggcgacgctg aggcggcgtt
      601 gctcaaaggg ccatccccgg agcctatgta tgctgcggct gtgcggggag agctgggtcc
      661 cgcggcctct ggctcagcac cgccgcccac ccctcgccca gagctggcta ctgctgctgg
      721 cggctacatc aacggcgacg cggcggtcag cgaaggctac gcggccgacg ccttcttcat
      781 cactgacggg cgctcacgcc gtaaggctgc taatgccaac gctgccgcgg ccccctcgac
      841 agcctcggtg gcagcccccg acagcgacgc tggaggtggg ggcgggccgg gcacgcgagg
      901 ctctggatca gggtccgcta gtcggggcgg cacgcgcgtg ggggcgggca ccgaggcgcg
      961 tgcggggtcg ggagccacgg gcgctggtgg ccggcacgcg tgcggagagt gtggcaaaac
     1021 ttacgccacg tcgtcgaacc tgagccgcca caagcaaacg caccgcagct tggacagcca
     1081 gctggcaagg cgttgcccaa cgtgtggcaa ggtgtacgtg tccatgccgg ccatggctat
     1141 gcacctgctc acgcacgatc tgcgccacaa gtgcggcgtg tgcggcaaag ccttctcccg
     1201 gccctggctg ctgcagggcc atatgcgctc gcacacgggc gagaaaccct tcggctgtgc
     1261 gcactgcggc aaggcctttg cagaccgctc caacctgcgc gcgcacatgc agacgcactc
     1321 cgccttcaag cacttccagt gcaagcgctg caagaagagc ttcgcgctca agtcttatct
     1381 caacaagcac tacgagtcag cctgcttcaa gggcggcgct agcggccccg caacccctgc
     1441 gccgccgcag ctcagcccgg ttcaagccta gggcagcggg gcctccgcca gccaggtcgg
     1501 ctctcagcaa tacgggcccc cagggaaatc tccgctggcg tccgggcgga ggggctggag
     1561 ggcgggcccc tcctcacagc aataggggca gggagccggc cccaccccgc cccgctcgcc
     1621 aggagccttg ccagcccctt caagcaatag ggtcctgagg ggagacccac cccgaaaacc
     1681 ctcccctctc ctccagggtg ccccaggctt tctcccagca atagggtcga ccagacccag
     1741 aaccgaacct catctcttag ttgggtctct gaagacaggg ggtgaggtga ggtaaggagc
     1801 gccctcctcc ctcctctgcg cccctggatc gcgttgcaga gactcaggtc ttccccaccc
     1861 cttcccaagc cttccaggcc aagccttcag tccggcgtcc agggagtcag ctccactcgg
     1921 gcagctggcc ggaggaggag caggatatca ggcgggccac agaggcgttc tgttccgcag
     1981 gctttgcaaa cctcccggga gtgctagacg atttggggat ggggaggggc gcggacggcg
     2041 gcaaccctct tcctcgggtt ctttctaggg cctcagtccg agcctccctc caacccacgc
     2101 ctcgcatcct ctgccaaatc ctaattcttc cagcccggct tccggggctc tgtcctccat
     2161 aacgaataat aatgacgcat atcggaatcg catgaactta tccgacctac tcagaccccg
     2221 atcccgccct gccccgggcc ccctccctcg ctccccaggc ttcgggtgtt ggaggacgga
     2281 tgcccgggcc ggcaggctgg cgtgccactg ccctctacac acctctgtat ttgctttgcg
     2341 ggtaaagccc cctggggggg ggggttgcgg acgcgtcggg tttctttctt tctgtattta
     2401 tacgttttat ttatgaacgg attgcactcg ggtcagggag ggggcgccga accctcatcc
     2461 ttcccgccga cgcccggggc ttaggctgtc caggaccact tcctctgccc ccgaggccgg
     2521 ccctttcctg gaggcccagg ccccactccc actcggttgc caactttcac ccgtctatgc
     2581 caaagcctcg gcggtgaccc tatcccaagg gccccgctcc attggccgcc gcctttgtga
     2641 catcactgca tgcagtccca cccttcttcc caacccttcc cggggctgcc cgctcccctt
     2701 cctcttagtt agtccgatgc agactataga gcaataatgc gcactgcatg tgaagctgcc
     2761 gcagcctcta gagttactga gaatcaggta tcccctgccc tacccatccc ataggcccct
     2821 agatcaggga tgctgcgcgg ggccggccac gcagactttc tttccccata ccctacccca
     2881 gggcagagcc cggcaggcgt catggttcca gaggctggga tggaatggta tcacccaagt
     2941 cctctcttgt cagtccttca tcactcaccg acccatcatt gggtacctac gatatgccag
     3001 gcccattcct gaatccgtca gagatgtggc aaccttctgg aggtgcccat cagtgacagg
     3061 gcccaatacg cataggtagg ccagggtgga aggcagatgc agagggctga atccctgggc
     3121 ccctatggcc tctcctaccc acctcagtcc tagaatacgc tgggtgtagt caggctctgc
     3181 ctttgacttg ggccttatgt tcccagctca aattggacag gtcccagggt ctctggggcc
     3241 cagcttcacc agggccaccc atacaggtac ccattttctg attccctgag atacgaggct
     3301 ctgctgtctc tgtgccgcta aggtgcaaca tgctggagta tatgatatgg ccagtctcaa
     3361 cccagcacca agcttggcta accctcctgg tgcggacccg caggcctagc ataacagtgc
     3421 ccatatctaa cccccttact ccacctggca aaatgcccac agttcctagc ctgggcctgc
     3481 cagcctgtgc cgcatgcaca cgcacacaga ggcgcccacc ccgccccact ctctactcct
     3541 gtctacctac ctatggagaa ggctggaagg gctgtgggcc cgccaggatc tcccgcttcg
     3601 cccacaccct gccgccgtgg aaagccatgg gccccctccc gcccccataa ctaagcagca
     3661 caataaccga cttagcgaat tcaggtagaa ggaacgttta ggtagcacct attttgtact
     3721 gattctacaa gtagggcccg aggtgcgggg ggccctcggg tgggggctgt ggctgccggc
     3781 ccgccccgcc cccacccccg cctgcgcccc gccaccttgt acatactcct ggcccgcaac
     3841 aggccgggat ttttactcgg gccgtgtccc tcttccgccc ccgtttgggg ccgggccggc
     3901 cggacagacg gacggacgga cagacctcct tcctaagcac aatagcacca gctcctcgga
     3961 gcgccgcacc tccacgagga gaataaatgc cactcttgat agaatttgga
//
