LOCUS       NM_029022               3247 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus secernin 3 (Scrn3), transcript variant 1, mRNA.
ACCESSION   NM_029022 XM_130303
VERSION     NM_029022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Bustin,K.A., Shishikura,K., Chen,I., Lin,Z., McKnight,N., Chang,Y.,
            Wang,X., Li,J.J., Arellano,E., Pei,L., Morton,P.D., Gregus,A.M.,
            Buczynski,M.W. and Matthews,M.L.
  TITLE     Phenelzine-based probes reveal Secernin-3 is involved in thermal
            nociception
  JOURNAL   Mol Cell Neurosci 125, 103842 (2023)
   PUBMED   36924917
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Houston,B.J., Nagirnaja,L., Merriner,D.J., O'Connor,A.E., Okuda,H.,
            Omurtag,K., Smith,C., Aston,K.I., Conrad,D.F. and O'Bryan,M.K.
  TITLE     The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable
            for male fertility in the mouse
  JOURNAL   Dev Dyn 250 (7), 922-931 (2021)
   PUBMED   33442887
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Way,G., Morrice,N., Smythe,C. and O'Sullivan,A.J.
  TITLE     Purification and identification of secernin, a novel cytosolic
            protein that regulates exocytosis in mast cells
  JOURNAL   Mol Biol Cell 13 (9), 3344-3354 (2002)
   PUBMED   12221138
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY203757.1, AK014701.1, AK028703.1, BE945683.1 and AV002033.1.
            
            On Mar 31, 2005 this sequence version replaced XM_130303.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165936.1, AK143725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY203757.1         1-7
            8-1303              AK014701.1         2-1297
            1304-2643           AK028703.1         1278-2617
            2644-2728           BE945683.1         254-338             c
            2729-3061           AK028703.1         2703-3035
            3062-3247           AV002033.1         329-514
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.57 cM"
     gene            1..3247
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /note="secernin 3"
                     /db_xref="GeneID:74616"
                     /db_xref="MGI:MGI:1921866"
     exon            1..62
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            63..223
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1321
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="secernin-3 isoform 1"
                     /protein_id="NP_083298.1"
                     /db_xref="CCDS:CCDS16128.1"
                     /db_xref="GeneID:74616"
                     /db_xref="MGI:MGI:1921866"
                     /translation="MEPYSCDTFVALPPATVGNRVIFGKNSDRLFDEVQEVIYCPAAV
                     HNDLEKRLKCTYIEVDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREDIS
                     KEEALLGMDLVRLGLERADTAEKALDVIVDLLEKYGQGGNCAEGKEFSYYNSFLIADR
                     NEAWILETSGKYWAAERVQGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKEEFD
                     FTAAYSYIDTAAMMTSPSRYCQGYKLLDKHRGNITFETMMEILRDRPSGINMKGEFLT
                     TASMVSVLPQDPSLPCIHLFTATPHPERSVFKPFIFVPHISPLLDTKSPTFEPERPVA
                     KKPYVKPDRRHPLYQKHQEALEMISNSKEKGKTILDKMRKLEKAVSEEIESILQSGHL
                     DEEKTVNLFPQYVKDEIKIYQSNISS"
     exon            224..405
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            406..602
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..812
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..975
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1150
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..3247
                     /gene="Scrn3"
                     /gene_synonym="4833415E20Rik; Ses3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccggcagt cgcttctggt ggctgccgcg gctttggcgg cgtccgcgcg tgcgcagcag
       61 agaaatggaa ccctattcct gtgacacttt tgtggcatta cctccagcaa cagtaggaaa
      121 tagggttatt tttggaaaaa attcagacag actctttgat gaagtacaag aagtaattta
      181 ctgtccagct gcagttcata atgatttgga aaaacgtctc aagtgtactt atatagaagt
      241 tgatcaagtt cctgaaacat atgctgttgt ccttagtcgc ccagcttggc tgtggggggc
      301 agaaatgggt gccaatgagc atggagtctg cattgggaat gaggctgtat ggggaagaga
      361 agacatttct aaggaggaag cacttttggg catggacctt gtcaggctgg gccttgagag
      421 agctgacacg gctgagaaag ctctggatgt cattgttgac ttactagaaa agtatggcca
      481 aggtggaaac tgcgcagagg gcaaagagtt cagctattac aacagtttcc tgatagctga
      541 caggaatgaa gcctggatcc tggagacgtc ggggaagtac tgggcagcag agagagtcca
      601 aggcgttcgt aatatttcca atcagctttc cataacaacc aagattgacc gggaacatcc
      661 agacatgagg aactacgcta agcagagggg ctggtgggat ggcaaagaag aatttgattt
      721 tactgcggcc tattcttaca ttgacacggc tgctatgatg acttcaccaa gcaggtactg
      781 ccagggctac aagcttctgg ataaacacag aggaaacata acttttgaaa cgatgatgga
      841 aattcttcga gacagaccca gtggcatcaa catgaaggga gaattcctga ccacggcaag
      901 catggtttct gttttacctc aggatcccag ccttccttgc attcacctct ttactgcaac
      961 tccgcaccct gagaggtctg tttttaagcc tttcatattt gtaccacaca tttcaccact
     1021 gttggataca aaatcaccaa catttgaacc tgaaaggcca gtggcaaaga agccatatgt
     1081 caagcctgac agaagacacc cactctacca aaaacatcaa gaggccttgg aaatgataag
     1141 taacagtaag gaaaaaggca agacaatatt ggacaagatg aggaagctgg aaaaagcagt
     1201 atctgaagag atagaatcaa tcctccagag tggacatctc gacgaggaga aaactgttaa
     1261 tctctttcct caatatgtga aagatgaaat taaaatttat cagtcaaata ttagttctta
     1321 atggtcattt aagtggtcga aaatcttcct cactgccctg gtaatgatat agagctatgc
     1381 taaggagatc tgattatttc ctcatagtat taggtggtat ttcgactgat aaaccacagt
     1441 aattagtatt tggttgcata aagcatgaaa cataaacatg acgcatgggc tatgctatca
     1501 ttctgtatta ttaagaaagc tcaaggcttt cttttcctta agcagtggaa aatatgtcaa
     1561 gtgcattgtt tgtgctttag gcaaatagta accagcttta acaaggcaga ggtctagatt
     1621 tacgctgttt gacattgcca cacagtctgc agaagccctt tcattaaact caaaagtgac
     1681 ctctgtcaag atttggctga gcagcaagca aacttgtggc tctaattgtt tggctttttc
     1741 tctccctcat cccctcagaa gctattttat tagtcttttt cttatctggg tagattttct
     1801 tttcccagaa tgccaggtat ttggatcttc cagtaggtct tttgggattg gcttcttcaa
     1861 tacacagctt tcaccatgcc tctgtaagcc atgatagctc ctttcttctt aacatgaata
     1921 gtgctttcag ttgggtgtgt cactaccaga aagcctcttg gctgcttcca gattttggca
     1981 attgtgagta agcatccacg tgtgagttgc tgctagctct aagcgttcag cccatgtcag
     2041 atggaactga ggtactgcag aacctgttgt gtgagtgaga aaccaccacc gttgtctcct
     2101 acaccctgtc gcagcactgt tgtgtcctgg ccaactatcg agtgtcagga tttagtcatt
     2161 ctgagtgcag cttctcactt aagaaggtta catggattga agctttggcc ttgcacttta
     2221 gttttcagtt aatctgtaat tccacatggc atttgatact gagtttcttt tcatatgctt
     2281 atttcccatt tgtatacctt ctttgctgag gtgtgtagat cttggccatg ctttttattt
     2341 acttatctta ctaaggagtt taaacttttt tctctaattt aaaatgttga tttcatgtgt
     2401 atgagtgttt tgcctccatg tatatctgta tgaagcacat gcctggtgcc ctcagagggt
     2461 gtgagatcct cttgaactgg agttatagat ggctgtgagc catcgtgtgg gtgctgggga
     2521 ccaaacccag atcctgtgca agagcaagca ctcttacccc tgagccatct ctccagctcc
     2581 tcccagcact caagtctaaa cctcttaaga gctcattgtt cttagggtaa agtccttaac
     2641 aaacggcagc aacagatact caggttcatc atcttggcct ccctttctta ggagtagttc
     2701 tttttagtct tagaacttgc tgagtgagtg tcttaggcgt ttcccttcca tagaatcaag
     2761 attatatgtg gctccaaatt agtcatacat ttaattattt catagtggaa tagaagttcc
     2821 atgaaagctc attgttcagt attatatttg gatgctttga tattatataa tatttgctaa
     2881 atgaacattc aaataccagt ggaaagaatt tagggaagtg ggatatcatt tgagatgtaa
     2941 atgaatggaa tgattaataa aaaaaagaat ttaaacaggt ctttctacag aaatgtaagg
     3001 ttgaataaat tagctagcta atttatctgt ataactcagt agccactgaa atttcaaacc
     3061 caaaaaatac aaggattata tggatatgtg agttaacttg tagagatttt cactgcagga
     3121 tactcattgt gggatactca gtgtggatac tcaggttggt agttaatgcc ttggagtata
     3181 ttttagaaat tttaatgttt tgttaaattt catctgttgt aaaaataaaa agtaataaac
     3241 ttatttt
//
