LOCUS       NM_146027               1534 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus secernin 2 (Scrn2), mRNA.
ACCESSION   NM_146027
VERSION     NM_146027.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Houston,B.J., Nagirnaja,L., Merriner,D.J., O'Connor,A.E., Okuda,H.,
            Omurtag,K., Smith,C., Aston,K.I., Conrad,D.F. and O'Bryan,M.K.
  TITLE     The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable
            for male fertility in the mouse
  JOURNAL   Dev Dyn 250 (7), 922-931 (2021)
   PUBMED   33442887
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN691874.1, AK075869.1 and BF464943.1.
            
            On Aug 26, 2009 this sequence version replaced NM_146027.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021346.1, AK075869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CN691874.1         1-38
            39-1516             AK075869.1         3-1480
            1517-1534           BF464943.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.62 cM"
     gene            1..1534
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /note="secernin 2"
                     /db_xref="GeneID:217140"
                     /db_xref="MGI:MGI:1343092"
     exon            1..104
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1382
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /codon_start=1
                     /product="secernin-2"
                     /protein_id="NP_666139.1"
                     /db_xref="CCDS:CCDS25310.1"
                     /db_xref="GeneID:217140"
                     /db_xref="MGI:MGI:1343092"
                     /translation="MASSSPDAPCSCDCFVSVPPASAIPAVIFAKNSDRPRDEVQEVV
                     FIPAGTHVPGSRLQCTYIEVEQVGKTHAVILSRPSWLWGAEMGANELGVCIGNEAVWT
                     KEPVGQGEALLGMDLLRLALERSSTAQEAVHVIAGLLDRYGQGGSCREDPEPFCYHNT
                     FLLADRTEAWVLETAGSLWAAQRIQGGARNISNQLSIGTDISAEHPELRSHAKAQGWW
                     TGQGLFDFAEVFSLTQQPVRMEAAKARFRAGCEMLQRHQGNITAEVMMGILRDKESGI
                     CMDSGGFRTTASMVSVLPQDPTKPCVHFLTATPDPSRSVFKPFIFEVGVSQSPQVLSP
                     TFGAQDPVRILPRFQTRVDRRHSLYRGHQAALGLMEDEQEQAQQLRKKQQRLEQEGLE
                     ALRGLLTGEQTPPAQGLGSLFQAFVEREEQAYA"
     exon            105..278
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..460
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..660
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..876
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1042
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1223
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1518
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /note="hexamer: AATAAA"
     polyA_site      1518
                     /gene="Scrn2"
                     /gene_synonym="D11Moh48; SES2"
                     /note="major polyA site"
ORIGIN      
        1 tccaggtcac ctaccagaga acctgggtcc aggggaacag atctgacctg aagaggagga
       61 agtggcgccc ggaaccgagc ctgggggtct tggatgcaga gaggatggcg tcgtcgagcc
      121 ccgatgcccc ttgttcctgc gactgttttg tctctgtgcc cccggcctca gccatcccag
      181 ctgtaatctt tgcaaagaac tcagaccggc cccgagatga ggtgcaggag gtggtgttta
      241 taccagcagg cactcacgtc cctgggagcc ggcttcagtg tacctatatc gaggtggaac
      301 aggtggggaa gacacacgct gtgattctga gccgcccctc ttggctgtgg ggagctgaga
      361 tgggggccaa cgagcttggt gtctgcattg gaaacgaagc agtgtggacc aaagagcctg
      421 tggggcaggg ggaagccctg ctgggtatgg acctgctcag gctggctttg gaacggagca
      481 gcactgccca ggaggctgtt cacgtgattg caggcttgct ggaccgctat gggcagggag
      541 gcagctgccg ggaggatcca gagccgttct gctatcacaa caccttttta ctggctgatc
      601 ggacagaggc gtgggtgctg gagacagctg ggagcctgtg ggctgctcag cggatccagg
      661 gaggtgcccg gaatatttcc aaccagctga gcattggtac agacatctca gctgaacacc
      721 cggagctccg cagccatgcc aaggctcagg gttggtggac tgggcagggc ctctttgact
      781 ttgcggaggt cttctccctg acccagcagc ctgtgcgcat ggaggctgcc aaggcccgct
      841 tccgggcagg gtgtgagatg ctgcagcggc atcaagggaa catcacagca gaggtgatga
      901 tgggcatcct cagggacaag gagagcggca tctgcatgga ctccggaggc ttccgcacca
      961 cagccagtat ggtatcggtc ctgccccagg atcccacaaa gccctgtgtc cacttcctca
     1021 ctgccacccc agacccatcc aggtcggtat tcaagccttt catctttgaa gtgggggtgt
     1081 cccagtcccc ccaggtgttg tcccccactt ttggagccca ggaccctgtt cggatcctcc
     1141 cacgattcca gactcgggtg gaccgtcggc actcactcta tcgtggacac caggcagccc
     1201 tggggctgat ggaggatgag caggagcagg cacagcaact ccggaaaaag cagcagaggc
     1261 tggagcagga aggcctagag gctctcagag ggctgcttac gggtgaacag accccaccag
     1321 cccagggcct gggcagcctc ttccaggcct ttgtggagag ggaagagcag gcctatgctt
     1381 aagcatgcag gagctctggg gccggctgcc ctgagctgtg gtgggtgcgg tggtggggtt
     1441 gagtcacagc catcccttca ccctgctcat ccaggtttgg agtgacttaa taaatgtttt
     1501 atctccttct tcagtgaaaa aaaaaaaaaa aaaa
//
