LOCUS       NM_001417703            2920 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus secernin 1 (Scrn1), transcript variant 3, mRNA.
ACCESSION   NM_001417703 XM_011241459
VERSION     NM_001417703.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Yang,X. and Tohda,C.
  TITLE     Axonal Regeneration Mediated by a Novel Axonal Guidance Pair,
            Galectin-1 and Secernin-1
  JOURNAL   Mol Neurobiol 60 (3), 1250-1266 (2023)
   PUBMED   36437381
  REMARK    GeneRIF: Axonal Regeneration Mediated by a Novel Axonal Guidance
            Pair, Galectin-1 and Secernin-1.
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Houston,B.J., Nagirnaja,L., Merriner,D.J., O'Connor,A.E., Okuda,H.,
            Omurtag,K., Smith,C., Aston,K.I., Conrad,D.F. and O'Bryan,M.K.
  TITLE     The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable
            for male fertility in the mouse
  JOURNAL   Dev Dyn 250 (7), 922-931 (2021)
   PUBMED   33442887
  REMARK    GeneRIF: The Sertoli cell expressed gene secernin-1 (Scrn1) is
            dispensable for male fertility in the mouse.
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Crisol,B.M., Lenhare,L., Gaspar,R.S., Gaspar,R.C., Munoz,V.R., da
            Silva,A.S.R., Cintra,D.E., de Moura,L.P., Pauli,J.R. and
            Ropelle,E.R.
  TITLE     The role of physical exercise on Sestrin1 and 2 accumulations in
            the skeletal muscle of mice
  JOURNAL   Life Sci 194, 98-103 (2018)
   PUBMED   29273527
  REMARK    GeneRIF: While acute aerobic exercise increased Sesn1 accumulation
            and induced a discrete augment of Sesn2 protein content and AMPK
            threonine phosphorylation, chronic exercise reduced the basal
            levels of Sesn1 and Sesn2 as well as of AMPK threonine
            phosphorylation in the quadriceps muscles of C57BL/6J mice.
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Way,G., Morrice,N., Smythe,C. and O'Sullivan,A.J.
  TITLE     Purification and identification of secernin, a novel cytosolic
            protein that regulates exocytosis in mast cells
  JOURNAL   Mol Biol Cell 13 (9), 3344-3354 (2002)
   PUBMED   12221138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084800.5 and AC087841.4.
            
            On Mar 9, 2023 this sequence version replaced XM_011241459.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4949950.1,
                                           SRR17253011.5276026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC084800.5         71588-71695         c
            109-268             AC084800.5         53572-53731         c
            269-450             AC084800.5         39761-39942         c
            451-653             AC087841.4         189246-189448       c
            654-848             AC087841.4         186497-186691       c
            849-1014            AC087841.4         184437-184602       c
            1015-1195           AC087841.4         175786-175966       c
            1196-1355           AC087841.4         172940-173099       c
            1356-2920           AC087841.4         138565-140129       c
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 26.98 cM"
     gene            1..2920
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="secernin 1"
                     /db_xref="GeneID:69938"
                     /db_xref="MGI:MGI:1917188"
     exon            1..108
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..268
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1354
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="isoform a is encoded by transcript variant 3"
                     /codon_start=1
                     /product="secernin-1 isoform a"
                     /protein_id="NP_001404632.1"
                     /db_xref="GeneID:69938"
                     /db_xref="MGI:MGI:1917188"
                     /translation="MSGAPPSYSFVALPPRAKDGLVVFGKNSARPRDEVQEVVYFPAV
                     DHDAESKVECTYISIDQVPRTHAIVISRPAWLWGAEMGANEHGVCIANEAINAREPAA
                     ETEALLGMDLVRLGLERGTTAKEALDIIVSLLDEHGQGGNYYEDAHSCHSFQSAYLLV
                     DRDEAWVLETVGKYWAAERITEGVRCICNHLSLATKLDEEHPELRTYAQSQGWWTGDD
                     EFNFAQVFSPADDRLDCCAGQDSLEKQEESITVQTMINILRDKASGVCIDSESFLTTA
                     SIVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKAQSPCFGDDDPAKKE
                     PRFQEKPDRRHELYKAHEWARAVIESDEEQGRTLRKTMLELEKQGLEAMDEILSSPEP
                     PDPAEVGDLFYDCVDTEMKFFK"
     exon            269..450
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..653
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..848
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1014
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1195
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1355
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..2920
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="hexamer: AATAAA"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="hexamer: ACTAAA"
     polyA_site      2914
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="major polyA site"
     polyA_site      2920
                     /gene="Scrn1"
                     /gene_synonym="2810019K23Rik; 6330535A03Rik; mKIAA0193;
                     SES1"
                     /note="major polyA site"
ORIGIN      
        1 cttctgcgct acggatgcag aggctgtaac ctagccgccg cagcgccccc aactccgcag
       61 tcgcagcatc agcaccgttg gacccggctg gagccggctg cttggcagga tgtctggcgc
      121 gcctccaagt tactcttttg tggctctgcc acctcgagct aaggacggtc tggtggtatt
      181 tgggaaaaat tcagctcggc ccagagatga agtccaggag gttgtgtatt tcccagctgt
      241 tgaccatgac gctgagagca aagttgagtg cacttacatc tcaatcgacc aagtccccag
      301 gacccacgcc atcgtgataa gcagacctgc ctggctctgg ggggcagaaa tgggagccaa
      361 tgaacatggg gtatgcatag ccaacgaagc catcaatgcc agagaaccag ctgctgagac
      421 ggaagcctta ctgggaatgg atctggtcag gcttggctta gaacgaggga caacagctaa
      481 agaagcccta gacatcattg tttctttatt ggatgagcac ggacaaggtg gaaattatta
      541 tgaagatgcc cactcctgcc atagcttcca aagtgcatat ctgctggtgg accgagatga
      601 agcctgggtg ctggagactg tagggaagta ttgggctgct gagagaatca cagagggagt
      661 gaggtgcatt tgcaaccatc tttccctcgc gactaagctg gatgaagagc acccagaact
      721 caggacttat gctcagagtc aaggctggtg gacgggagac gacgaattca actttgccca
      781 ggttttttct ccagccgatg accgtttgga ctgctgtgca ggccaagaca gcttagaaaa
      841 gcaagaagaa agcatcactg tgcagacgat gattaacatc ttacgagaca aagccagtgg
      901 tgtttgcata gattctgagt ctttcctcac cacagccagt atagtgtctg tcttgcctca
      961 gaacagaagt tcaccgtgta tccactactt caccgggacc ccagatcctt ccaggtccat
     1021 attcaagcct ttcatctttg ttgatgatgt aaaacttgtc cccaaagcac agtcaccctg
     1081 ttttggtgac gatgacccag ccaaaaagga acctcggttc caggagaagc cagaccgccg
     1141 acatgagctg tacaaggcac acgagtgggc acgtgctgtc atcgagagtg acgaggagca
     1201 aggtcgcacc ctgaggaaga ccatgctgga gttggagaag caaggcctgg aggccatgga
     1261 cgagattctg agcagccccg agcccccgga ccccgccgag gtgggggacc tattctatga
     1321 ctgtgtggac accgagatga agttctttaa gtgataattc caaattgcaa ttcaaattcg
     1381 tgagcagaat caacggcctg tctaacctct gcaaaagccg gatatccaca ccaaggctgc
     1441 gcgaacacat gcgcagaact gtacttgctc gcttcttgct tggagacagg atgagcggcc
     1501 ccttcgctgg tgctgaagaa tacaggtgat gtctggactt tttgctaccc catgaaaggt
     1561 tatcttatgc aatggtgcaa ctctgctgtc tagatgggcc actgtcggct tcgttccctg
     1621 ccccattcct tcacaaattc ctgcattgtc tcctggggct gtgtcataaa gcaagctctc
     1681 atgcttgtgt ccagccctcc tccacatagc aaccagcctg accttttcaa gggtaaacgg
     1741 gcatgaggtt taccatggca ctttcctcta taaaattcat ttctgtctca gaactgctct
     1801 tctgcatcca gctcaaaatc ccctatagca caaggtcctt agggaccagc ctagattttc
     1861 catttcacca gcgagcttac ctccagaccc tgactcgagc tatcgcattg atctttttat
     1921 actggcgttt tggcaatctt ccaagaagcc ttgcgatcct ggaagactcc gtgttcctag
     1981 agcagtgttc ctaccttcaa cagagcacct gccacccaga tcactccagg aatacctgca
     2041 atggccttcc atctcataca gaataaaaca ttcatgcccc tgcctgagct cccatgttca
     2101 cccataagca gcagcaatag cagcattcct agacaagatc gcggagcaca ttagtttagg
     2161 tattacgtta gtaactgagg gcttttctct tgagcctcct caagtcctgg gaactaatgt
     2221 ataaagtcgt tcatcagtga caaatgctgt atgttttggt tggaaatcca gtctccttat
     2281 atatctaatg tcctttagaa cttgtggctc tggggcagtt ggacttctgg ttttctatgt
     2341 acagcctaaa tctttctctc tccacagtga cttactactc ctctgatgtt tcttcctact
     2401 tttcaaagga tttcctattg aagggacttc aagacttgtt atcagagaat atggttcttc
     2461 tgtttgttta tttgtttagc tgtagtcatt ttgtaatgat cctgactcca cagaccccag
     2521 cctgcctgtt cttagaaagc acccgaatgc aggagaaagc tgcagccctc caaggctatc
     2581 tcaagactga ttccccatag tatcctctca cctatattct gtggtgattt gacggagaac
     2641 aggccccata gcctcatata cttgaatgtt catcaccaga gaatagcact atttgcaagg
     2701 attagaggtt gggaggtgtg gccctgttgg aggaaatttg tcactgaggg gttgggggtg
     2761 gggttgaggt ttcaaaagcc agcgccagga cctggttctt tctggttcct tgcctccaga
     2821 ccagggtcta gctcttagct actgctccag ggcttgtctg catgcacacc accacgatcc
     2881 ccgacatgac aataaacgga ctaaacctct gaaactgtaa
//
