LOCUS       NM_001310543            5486 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus scribbled planar cell polarity (Scrib), transcript
            variant 3, mRNA.
ACCESSION   NM_001310543 XM_006520241
VERSION     NM_001310543.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5486)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5486)
  AUTHORS   Bermejo-Rodriguez,C., Araos Henriquez,J., Caligiuri,G., Pinto
            Teles,S., Park,Y., Evans,A., Barrera,L.N., Neesse,A., Grutzmann,R.,
            Aust,D., Rummele,P., Knosel,T., Narita,M., Narita,M., Campbell,F.,
            Ohlund,D., Pilarsky,C., Dow,L.E., Humbert,P.O., Biffi,G.,
            Tuveson,D.A. and Perez-Mancera,P.A.
  TITLE     Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma
            Development and Metastasis
  JOURNAL   Cancer Res 84 (18), 2968-2984 (2024)
   PUBMED   39037766
REFERENCE   3  (bases 1 to 5486)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5486)
  AUTHORS   Sun,X., Lu,L., Wang,K., Song,L., Jiao,J., Wu,Y., Wang,X., Song,Y.
            and Zhan,L.
  TITLE     Scribble deficiency mediates colon inflammation by inhibiting
            autophagy-dependent oxidative stress elimination
  JOURNAL   Sci Rep 13 (1), 18327 (2023)
   PUBMED   37884590
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5486)
  AUTHORS   Almeida,S.M., Ivantsiv,S., Niibori,R., Dunham,W.H., Green,B.A.,
            Zhao,L., Gingras,A.C. and Cordes,S.P.
  TITLE     An interaction between OTULIN and SCRIB uncovers roles for linear
            ubiquitination in planar cell polarity
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37589075
REFERENCE   6  (bases 1 to 5486)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 5486)
  AUTHORS   Murdoch,J.N., Henderson,D.J., Doudney,K., Gaston-Massuet,C.,
            Phillips,H.M., Paternotte,C., Arkell,R., Stanier,P. and Copp,A.J.
  TITLE     Disruption of scribble (Scrb1) causes severe neural tube defects in
            the circletail mouse
  JOURNAL   Hum Mol Genet 12 (2), 87-98 (2003)
   PUBMED   12499390
  REMARK    GeneRIF: Scrb1, encodes a member of the LAP protein family related
            to Drosophila scribble.Disruption of scribble (Scrb1) gene causes
            severe neural tube defects in the circletail mouse
REFERENCE   8  (bases 1 to 5486)
  AUTHORS   Rachel,R.A., Wellington,S.J., Warburton,D., Mason,C.A. and
            Beermann,F.
  TITLE     A new allele of Gli3 and a new mutation, circletail (Crc),
            resulting from a single transgenic experiment
  JOURNAL   Genesis 33 (2), 55-61 (2002)
   PUBMED   12112872
  REMARK    GeneRIF: Heterozygotes are incompletely penetrant for a
            circled-tail phenotype, while homozygotes die at birth of a severe
            neural tube defect.
REFERENCE   9  (bases 1 to 5486)
  AUTHORS   Murdoch,J.N., Rachel,R.A., Shah,S., Beermann,F., Stanier,P.,
            Mason,C.A. and Copp,A.J.
  TITLE     Circletail, a new mouse mutant with severe neural tube defects:
            chromosomal localization and interaction with the loop-tail
            mutation
  JOURNAL   Genomics 78 (1-2), 55-63 (2001)
   PUBMED   11707073
REFERENCE   10 (bases 1 to 5486)
  AUTHORS   Rachel,R.A., Murdoch,J.N., Beermann,F., Copp,A.J. and Mason,C.A.
  TITLE     Retinal axon misrouting at the optic chiasm in mice with neural
            tube closure defects
  JOURNAL   Genesis 27 (1), 32-47 (2000)
   PUBMED   10862153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122211.1 and BC062888.1.
            
            On Jul 14, 2015 this sequence version replaced XM_006520241.2.
            
            Transcript Variant: This variant (3) lacks two in-frame coding
            exons in the 3' region compared to variant 1. The resulting isoform
            (3) is shorter, missing two internal protein segments compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK122211.1         1-62
            63-2159             BC062888.1         1-2097
            2160-4264           AK122211.1         2160-4264
            4265-5486           BC062888.1         4203-5424
FEATURES             Location/Qualifiers
     source          1..5486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.29 cM"
     gene            1..5486
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /note="scribbled planar cell polarity"
                     /db_xref="GeneID:105782"
                     /db_xref="MGI:MGI:2145950"
     exon            1..556
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..5236
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /note="isoform 3 is encoded by transcript variant 3;
                     PDZ-domain protein scribble; protein scribble homolog;
                     circletail; scribble homolog 1; scribbled homolog"
                     /codon_start=1
                     /product="protein scribble homolog isoform 3"
                     /protein_id="NP_001297472.1"
                     /db_xref="CCDS:CCDS79381.1"
                     /db_xref="GeneID:105782"
                     /db_xref="MGI:MGI:2145950"
                     /translation="MLKCIPLWRCNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLD
                     ANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK
                     FCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRE
                     NLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN
                     LRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQN
                     RLCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGC
                     VALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHLNLKALWLAENQA
                     QPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDAGQQSSPSESCSDAPLSRVSVIQF
                     EDTLEGEEDAEEAAAEKRGLQRRATPHPSELKVMKRGIEERRNEAFVCKPDPSPPSPS
                     EEEKRLSAESALSGGSVPSASTASEGEPEILPAEVQGLGQHEAMPAQEEYTEDDYNEP
                     TVHFAEDTLIPREDGESEEGQPEAAWPLPSGRQRLIRKDTPHYKKHFKISKLPQPEAV
                     VALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEEEEEENRDEEEGEATTEEDDKEE
                     AVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIAGGKGSTPYKGD
                     DEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQMRVW
                     RERMVEPENAVTITPLRPEDDYSPREWRGGGLRLPLLQPETPVSLRQRHAACLVRSEK
                     GLGFSIAGGKGSTPYRAGDGGIFISRIAEGGAAHRAGTLQVGDRVLSINGVDMTEARH
                     DHAVSLLTAASPTISLLLERETGGTYPPSPPPHSSPTPAATVAATVSTAVPGEPLLPR
                     LSPSLLATALEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFGVQDPGVFISKVLPR
                     GLAARCGLRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPPPPGMRELC
                     IQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV
                     NQQSLLGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTTTALEVSPGVIANPFAAGLGHR
                     NSLESISSIDRELSPEGPGKEKELASQALPWESESAETTGRNLEPLKLDYRALAALPS
                     AGSLQRGPSATTGGKTTEAPCSPGSQQPPSPDELPANVKQAYRAFAAVPTVHPPENSA
                     TQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARK
                     LQQKRAQMLREEAVTSGPDMGLASDRESPDDQQEAEQPWAVPSHAGGSSPSSPPPLGG
                     NAPVRTAKAERRHQERLRMQSPELPAPERALSPAERRALEAEKRALWRAARMKSLEQD
                     ALRAQMVLSKSQEGRGKRGPLERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLSPDFV
                     EELRTLEASPSPGSQEEDGEVALVLLGRPSPGAVGPEDMTLCSSRRSVRPGRRGLGPV
                     PS"
     exon            557..674
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            675..753
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            754..843
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            844..900
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            901..964
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1039
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1184
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1303
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1503
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1670
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1801
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1927
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2092
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2470
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2533
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2623
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2701
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..3025
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3106
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3364
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3475
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3769
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3958
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4069
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4070..4126
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4201
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4202..4264
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4363
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4523
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4671
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4857
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5000
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5038
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5090
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     exon            5091..5465
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5445..5450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /note="hexamer: AATAAA"
     polyA_site      5465
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /note="major polyA site"
ORIGIN      
        1 agcagagagg gcgggcctag gcttcccggc gggctgcgcg gctgggcggt tgtcgcgggc
       61 agcggcggcg gttccggctg cggtgctgcg ggcggatgag ctgctaggtg agcaggccgg
      121 gcgggatgcg gagccgccgc cgcgccccca gcgcctaaga aagcgctgcc gggtcaggcc
      181 gtgctgccag ctgtgtgccg ccgtcggagc ctacagctcg tattgaacgc gggccgagcc
      241 gagcgccgac cccggccaca gtccgggacc cggctgcccg ccccaccccc gcgcgcgccg
      301 ctccgcccgc gctcggcgct catgcgggcc gagccccgcc ccccggcccg agcccgccga
      361 gcgcctcccg agcccgcgct cactgcccgc ccgcatcatg ctgaagtgca tcccgctctg
      421 gcgttgtaac cggcacgtgg agtcggtgga taagcggcac tgctcgctgc aggttgtgcc
      481 agaggagatt taccgctaca gtcgtagcct cgaggagctg ctcctcgacg ccaaccagct
      541 gcgcgagcta cctaagccct tcttccgact gttgaacttg agaaagttgg gcctcagtga
      601 caacgagatc cagcggctgc ctcctgaagt ggccaacttc atgcagctgg tggagctaga
      661 tgtgtcccgg aacgatattc ctgagatacc tgagagcata aagttctgta aggctctgga
      721 gattgcagac ttcagtggga accccctgtc tagacttccg gatggcttca cacagctacg
      781 cagcctggct cacctggccc tgaatgacgt gtccctgcag gcactgcctg gagatgtggg
      841 caacctggcc aatctggtga ccctggaact ccgggagaac ctgcttaaat ctctccctgc
      901 gtccctgtct ttcctggtga agctggaaca gctggatctg ggaggcaacg acctggaagt
      961 gctgcctgac accctggggg ctctgcctaa ccttcgggag ctatggttag accgaaacca
     1021 actgtcagcg ctgcccccgg agctaggcaa tctgcggcgg ctggtgtgcc tggatgtgtc
     1081 agagaacagg ctggaggagc tgcctgtgga gttgggtggg ctggcactgc tcacggatct
     1141 gctgctttcc cagaacttgc ttcagcggct gccagagggc atcggtcagc tgaagcagct
     1201 gtctatcctg aaggtggacc agaaccggct gtgtgaggtc actgaggcca taggggactg
     1261 tgagaacctc tcggagctga tcctcacgga gaacctgtta acggccttac cccactcgct
     1321 gggcaagctg accaagctga ctaacctcaa tgtggaccgg aaccatcttg aggtgctgcc
     1381 tcctgaaatc ggaggctgtg tggcccttag tgtcctctct ttgagagaca atcgcctggc
     1441 tgtcctccct cctgagcttg cccataccgc tgagctgcac gtgcttgatg tggctgggaa
     1501 ccggctgcgg agtctgccgt ttgcgctcac ccacctcaac ctcaaggcac tgtggctggc
     1561 cgagaaccag gcacagccca tgctccgctt ccagactgag gatgatgccc agacgggtga
     1621 aaaggtgctc acctgctacc tgctgcccca gcagcccctg ccaagtctcg aagacgctgg
     1681 acagcagagc agtccctcag agagctgtag tgatgcccct ctgagccgtg tcagtgtcat
     1741 ccagttcgag gacaccctgg aaggtgaaga ggatgctgag gaagctgcgg ccgagaagcg
     1801 gggcctacag cgtagggcca cacctcatcc cagtgagctc aaggtgatga agaggggcat
     1861 tgaagagcgc cggaatgagg ccttcgtctg caagcctgac cccagcccac cctcgccttc
     1921 agaggaggag aagaggctga gtgcagagtc tgccttgagt ggaggctctg tcccgtcagc
     1981 aagcacagcc tcggaaggtg agcctgagat cctgccggct gaggtacaag ggctaggcca
     2041 gcatgaggcc atgcctgcac aggaggagta tacagaagac gactataacg agcccacagt
     2101 gcactttgca gaggacacac tgatccctag ggaagacggt gaaagtgaag agggacagcc
     2161 tgaggctgcc tggccgctgc ctagtggccg gcagaggctc atccgcaaag acacgcccca
     2221 ctacaagaag cacttcaaga tctccaagct cccacagcct gaagctgtcg tggccctgct
     2281 gcaaggggtg cagaccgaca gggagggccc cactgcaggt tggcacaatg gcccacacac
     2341 accttgggct cctcgagccc atgaggagga agaggaggag gaggaggaga acagggatga
     2401 ggaggaaggc gaggccacca cggaagaaga tgacaaagaa gaggctgtgg cttctgctcc
     2461 ctctgtcaag ggggtgtcgt ttgaccaggc caataacctg ctgatagagc ctgctcgcat
     2521 tgaggaggaa gagttaacac tcacgatcgt gcggcagacg gggggcctgg gcatcagtat
     2581 cgcaggggga aaaggctcta ccccctacaa aggagatgac gagggcattt tcatctctcg
     2641 agtgtctgaa gagggccctg cagcccgtgc tggagtccga gttggtgaca aacttcttga
     2701 ggtgaatggt gtagccttgc aggacgcaga gcaccacgag gccgtggaag cacttcgggg
     2761 ggcaggtgct gctgtgcaga tgcgagtgtg gagggaaaga atggtggagc cggagaacgc
     2821 agtcactatt acccccttac gccctgaaga tgactatagt ccccgagagt ggcggggagg
     2881 tggcctgcgc cttcccctgc tccagcctga gactcctgta tccctccgtc agcgtcatgc
     2941 tgcctgtctc gtgcgcagtg aaaaggggct gggcttcagc attgctggtg gaaagggctc
     3001 cacaccttac cgggctggtg atgggggcat ctttatatcc cgcattgcag agggaggggc
     3061 tgctcaccgg gcaggcactc tacaggttgg cgaccgtgtc ctctcgatca atggagtgga
     3121 catgactgag gccaggcacg accatgctgt ctccctgctg actgctgctt cccctaccat
     3181 ctccctgctt ctggagaggg agactggagg gacttaccca cctagccctc ccccccattc
     3241 ctccccaacc cctgctgcta ctgttgctgc taccgtgagc actgctgtcc ccggagaacc
     3301 tctgctacct aggctgtccc ctagcctctt ggccactgcc ttggaaggac cataccctgt
     3361 ggaggaaatc tgcctgccca gggctggtgg cccattgggg cttagcattg taggaggttc
     3421 tgatcactcc agccacccgt ttggtgtcca agatcctggt gtattcatct ccaaggtgct
     3481 tcctcggggc ctagctgctc gctgtggcct tcgggttggg gaccgcatcc tagcagtgaa
     3541 tgggcaggat gttcgggagg ccacacatca agaggcagtc agtgccctgc tcaggccctg
     3601 cctggagctg tgtctgcttg tgcggaggga cccaccaccc ccgggcatgc gggaactctg
     3661 catccagaaa gcccctgggg agaagctggg tatcagcatc cgcggaggtg ccaagggtca
     3721 cgcggggaac ccctgtgacc ctacagatga gggcatcttt atctccaagg tgagccccac
     3781 aggagctgcc gggcgtgatg ggcggctgcg tgtggggctg cggctgctag aagtgaacca
     3841 acagagcctg ctgggcctta cccatgcgga agcagtgcag ctgctgcgca gcgtaggcga
     3901 cacccttacc gtgcttgtct gtgatggttt tgacaccagc accaccacag ccctggaggt
     3961 gtccccaggt gtcattgcca acccatttgc agcaggcctt ggccacagga acagtctgga
     4021 aagcatttcg tccattgacc gggaactgag tcctgaaggc ccaggcaagg agaaagagtt
     4081 ggccagtcaa gccctaccct gggagtctga gtctgcagag accacgggtc ggaatctaga
     4141 gcccctgaag ctggactacc gtgccctggc cgccctgccc agtgctggga gtttacagag
     4201 aggaccatct gcgaccaccg gagggaagac gactgaggct ccctgttccc ctggcagtca
     4261 gcaaccaccc tcccctgatg aactgccagc caatgtgaag caggcgtata gggcctttgc
     4321 agctgtgccc accgtgcatc ctcctgagaa cagtgctacc cagcctccaa cacctggtcc
     4381 cgcagcctcc ccagagcagc tgtccttccg tgaacgacaa aagtacttcg agctggaggt
     4441 acgggtgcct caagcagagg gtcccccaaa gcgtgtgtcc ctggtgggtg ctgatgactt
     4501 gcggaagatg caagaggagg aagctcgcaa gctgcagcag aagagggcac agatgcttcg
     4561 ggaagaagca gtaacctcag ggcctgacat ggggctcgcc tcagacaggg agtccccaga
     4621 tgatcagcag gaggctgagc agccctgggc tgtgccaagc catgcagggg gctctagccc
     4681 atcatcaccc ccacccctgg gaggcaacgc ccctgtgagg acagccaaag ctgagcgacg
     4741 ccatcaggaa cggttacgca tgcagagccc cgagcttcct gccccggaac gggccctgtc
     4801 tcctgcagag cgacgggctc tagaggcaga gaagcgagct ctgtggaggg cagccagaat
     4861 gaagtctctg gagcaggatg ctctccgtgc acagatggtc cttagcaagt cccaggaagg
     4921 ccgtggcaag agaggaccct tggaacggct ggctgaggcc ccttcacctg cccccacccc
     4981 atcacccaca ccattggaag acttcggcct ccagaccagt gcctcccctg gacgcttgtc
     5041 accagatttc gtggaggagc tgaggacttt ggaagcatct cccagtcctg gctcccagga
     5101 agaagatgga gaagtggcct tggtgctcct tggcaggccc tcacctggcg ctgtgggccc
     5161 tgaagacatg acgctgtgca gcagccgtcg gtctgtgcgg ccgggacgcc ggggcctggg
     5221 ccctgtgccc tcctagggcc aggtgcctcc ccagacttag ggtgggagcc tgccagcttc
     5281 atcacctccc ttatcccaag tctgttagcc ttggtgttag cattttaaag agacccctca
     5341 ggagttctgg cttctgatta actgccccgt agccgggatc tcgtggcgag actgtaacta
     5401 gtgatgtttg tacaaccaaa gactctattt tgtggtttaa gaagaataaa gttacctacg
     5461 ttttaaaaaa aaaaaaaaaa aaaaaa
//
