LOCUS       NP_001297472            1612 aa            linear   ROD 28-APR-2025
DEFINITION  protein scribble homolog isoform 3 [Mus musculus].
ACCESSION   NP_001297472 XP_006520304
VERSION     NP_001297472.1
DBSOURCE    REFSEQ: accession NM_001310543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1612)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1612)
  AUTHORS   Bermejo-Rodriguez,C., Araos Henriquez,J., Caligiuri,G., Pinto
            Teles,S., Park,Y., Evans,A., Barrera,L.N., Neesse,A., Grutzmann,R.,
            Aust,D., Rummele,P., Knosel,T., Narita,M., Narita,M., Campbell,F.,
            Ohlund,D., Pilarsky,C., Dow,L.E., Humbert,P.O., Biffi,G.,
            Tuveson,D.A. and Perez-Mancera,P.A.
  TITLE     Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma
            Development and Metastasis
  JOURNAL   Cancer Res 84 (18), 2968-2984 (2024)
   PUBMED   39037766
REFERENCE   3  (residues 1 to 1612)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1612)
  AUTHORS   Sun,X., Lu,L., Wang,K., Song,L., Jiao,J., Wu,Y., Wang,X., Song,Y.
            and Zhan,L.
  TITLE     Scribble deficiency mediates colon inflammation by inhibiting
            autophagy-dependent oxidative stress elimination
  JOURNAL   Sci Rep 13 (1), 18327 (2023)
   PUBMED   37884590
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1612)
  AUTHORS   Almeida,S.M., Ivantsiv,S., Niibori,R., Dunham,W.H., Green,B.A.,
            Zhao,L., Gingras,A.C. and Cordes,S.P.
  TITLE     An interaction between OTULIN and SCRIB uncovers roles for linear
            ubiquitination in planar cell polarity
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37589075
REFERENCE   6  (residues 1 to 1612)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (residues 1 to 1612)
  AUTHORS   Murdoch,J.N., Henderson,D.J., Doudney,K., Gaston-Massuet,C.,
            Phillips,H.M., Paternotte,C., Arkell,R., Stanier,P. and Copp,A.J.
  TITLE     Disruption of scribble (Scrb1) causes severe neural tube defects in
            the circletail mouse
  JOURNAL   Hum Mol Genet 12 (2), 87-98 (2003)
   PUBMED   12499390
  REMARK    GeneRIF: Scrb1, encodes a member of the LAP protein family related
            to Drosophila scribble.Disruption of scribble (Scrb1) gene causes
            severe neural tube defects in the circletail mouse
REFERENCE   8  (residues 1 to 1612)
  AUTHORS   Rachel,R.A., Wellington,S.J., Warburton,D., Mason,C.A. and
            Beermann,F.
  TITLE     A new allele of Gli3 and a new mutation, circletail (Crc),
            resulting from a single transgenic experiment
  JOURNAL   Genesis 33 (2), 55-61 (2002)
   PUBMED   12112872
  REMARK    GeneRIF: Heterozygotes are incompletely penetrant for a
            circled-tail phenotype, while homozygotes die at birth of a severe
            neural tube defect.
REFERENCE   9  (residues 1 to 1612)
  AUTHORS   Murdoch,J.N., Rachel,R.A., Shah,S., Beermann,F., Stanier,P.,
            Mason,C.A. and Copp,A.J.
  TITLE     Circletail, a new mouse mutant with severe neural tube defects:
            chromosomal localization and interaction with the loop-tail
            mutation
  JOURNAL   Genomics 78 (1-2), 55-63 (2001)
   PUBMED   11707073
REFERENCE   10 (residues 1 to 1612)
  AUTHORS   Rachel,R.A., Murdoch,J.N., Beermann,F., Copp,A.J. and Mason,C.A.
  TITLE     Retinal axon misrouting at the optic chiasm in mice with neural
            tube closure defects
  JOURNAL   Genesis 27 (1), 32-47 (2000)
   PUBMED   10862153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122211.1 and BC062888.1.
            
            On Jul 14, 2015 this sequence version replaced XP_006520304.1.
            
            Transcript Variant: This variant (3) lacks two in-frame coding
            exons in the 3' region compared to variant 1. The resulting isoform
            (3) is shorter, missing two internal protein segments compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.29 cM"
     Protein         1..1612
                     /product="protein scribble homolog isoform 3"
                     /note="PDZ-domain protein scribble; protein scribble
                     homolog; circletail; scribble homolog 1; scribbled
                     homolog"
                     /calculated_mol_wt=173929
     Region          14..37
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          36..94
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          38..60
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          61..83
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          84..106
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..>396
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          107..129
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          130..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..175
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          176..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..221
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          268..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          291..313
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..336
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..381
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          713..799
                     /region_name="PDZ1_Scribble-like"
                     /note="PDZ domain 1 of Drosophila Scribble, human Scribble
                     homolog, and related domains; cd06704"
                     /db_xref="CDD:467188"
     Site            order(723..729,747,750,779,783,786..787)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467188"
     Region          845..936
                     /region_name="PDZ2_Scribble-like"
                     /note="PDZ domain 2 of Drosophila Scribble, human Scribble
                     homolog, and related domains; cd06703"
                     /db_xref="CDD:467187"
     Site            order(857..863,881,884,914,918,921..922)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467187"
     Region          989..1077
                     /region_name="PDZ3_Scribble-like"
                     /note="PDZ domain 3 of Drosophila Scribble, human Scribble
                     homolog, and related domains; cd06702"
                     /db_xref="CDD:467186"
     Site            order(999..1005,1025,1028,1057,1061,1064..1065)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467186"
     Region          1081..1178
                     /region_name="PDZ4_Scribble-like"
                     /note="PDZ domain 4 of Drosophila Scribble, human Scribble
                     homolog, and related domains; cd06701"
                     /db_xref="CDD:467185"
     Site            order(1096..1102,1123,1126,1156,1160,1163..1164)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467185"
     CDS             1..1612
                     /gene="Scrib"
                     /gene_synonym="Crc; CRIB; mKIAA0147; Scrb1; SCRIB1;
                     vartul"
                     /coded_by="NM_001310543.1:398..5236"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS79381.1"
                     /db_xref="GeneID:105782"
                     /db_xref="MGI:MGI:2145950"
ORIGIN      
        1 mlkciplwrc nrhvesvdkr hcslqvvpee iyrysrslee llldanqlre lpkpffrlln
       61 lrklglsdne iqrlppevan fmqlveldvs rndipeipes ikfckaleia dfsgnplsrl
      121 pdgftqlrsl ahlalndvsl qalpgdvgnl anlvtlelre nllkslpasl sflvkleqld
      181 lggndlevlp dtlgalpnlr elwldrnqls alppelgnlr rlvcldvsen rleelpvelg
      241 glalltdlll sqnllqrlpe gigqlkqlsi lkvdqnrlce vteaigdcen lseliltenl
      301 ltalphslgk ltkltnlnvd rnhlevlppe iggcvalsvl slrdnrlavl ppelahtael
      361 hvldvagnrl rslpfalthl nlkalwlaen qaqpmlrfqt eddaqtgekv ltcyllpqqp
      421 lpsledagqq sspsescsda plsrvsviqf edtlegeeda eeaaaekrgl qrratphpse
      481 lkvmkrgiee rrneafvckp dpsppspsee ekrlsaesal sggsvpsast asegepeilp
      541 aevqglgqhe ampaqeeyte ddyneptvhf aedtlipred geseegqpea awplpsgrqr
      601 lirkdtphyk khfkisklpq peavvallqg vqtdregpta gwhngphtpw apraheeeee
      661 eeeenrdeee geatteeddk eeavasapsv kgvsfdqann lliepariee eeltltivrq
      721 tgglgisiag gkgstpykgd degifisrvs eegpaaragv rvgdkllevn gvalqdaehh
      781 eavealrgag aavqmrvwre rmvepenavt itplrpeddy sprewrgggl rlpllqpetp
      841 vslrqrhaac lvrsekglgf siaggkgstp yragdggifi sriaeggaah ragtlqvgdr
      901 vlsingvdmt earhdhavsl ltaasptisl lleretggty ppsppphssp tpaatvaatv
      961 stavpgepll prlspsllat alegpypvee iclpraggpl glsivggsdh sshpfgvqdp
     1021 gvfiskvlpr glaarcglrv gdrilavngq dvreathqea vsallrpcle lcllvrrdpp
     1081 ppgmrelciq kapgeklgis irggakghag npcdptdegi fiskvsptga agrdgrlrvg
     1141 lrllevnqqs llglthaeav qllrsvgdtl tvlvcdgfdt stttalevsp gvianpfaag
     1201 lghrnslesi ssidrelspe gpgkekelas qalpwesesa ettgrnlepl kldyralaal
     1261 psagslqrgp sattggktte apcspgsqqp pspdelpanv kqayrafaav ptvhppensa
     1321 tqpptpgpaa speqlsfrer qkyfelevrv pqaegppkrv slvgaddlrk mqeeearklq
     1381 qkraqmlree avtsgpdmgl asdrespddq qeaeqpwavp shaggsspss ppplggnapv
     1441 rtakaerrhq erlrmqspel paperalspa erraleaekr alwraarmks leqdalraqm
     1501 vlsksqegrg krgplerlae apspaptpsp tpledfglqt saspgrlspd fveelrtlea
     1561 spspgsqeed gevalvllgr pspgavgped mtlcssrrsv rpgrrglgpv ps
//
