LOCUS       NM_009136                700 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus scrapie responsive gene 1 (Scrg1), mRNA.
ACCESSION   NM_009136
VERSION     NM_009136.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 700)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 700)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 700)
  AUTHORS   Dron M, Bailly Y, Beringue V, Haeberle AM, Griffond B, Risold PY,
            Tovey MG, Laude H and Dandoy-Dron F.
  TITLE     Scrg1 is induced in TSE and brain injuries, and associated with
            autophagy
  JOURNAL   Eur J Neurosci 22 (1), 133-146 (2005)
   PUBMED   16029203
  REMARK    GeneRIF: Taken together, our results indicate that Scrg1 is
            associated with neurodegenerative processes in TSE, but is not
            directly linked to dysregulation of prion protein.
REFERENCE   4  (bases 1 to 700)
  AUTHORS   Dandoy-Dron F, Griffond B, Mishal Z, Tovey MG and Dron M.
  TITLE     Scrg1, a novel protein of the CNS is targeted to the large
            dense-core vesicles in neuronal cells
  JOURNAL   Eur J Neurosci 18 (9), 2449-2459 (2003)
   PUBMED   14622145
  REMARK    GeneRIF: Scrg1 is associated with the secretory pathway of neuronal
            cells.
REFERENCE   5  (bases 1 to 700)
  AUTHORS   Durkin ME, Yuan BZ, Thorgeirsson SS and Popescu NC.
  TITLE     Gene structure, tissue expression, and linkage mapping of the mouse
            DLC-1 gene (Arhgap7)
  JOURNAL   Gene 288 (1-2), 119-127 (2002)
   PUBMED   12034501
REFERENCE   6  (bases 1 to 700)
  AUTHORS   Dron M, Tartare X, Guillo F, Haik S, Barbin G, Maury C, Tovey M and
            Dandoy-Dron F.
  TITLE     Mouse scrapie responsive gene 1 (Scrg1): genomic organization,
            physical linkage to sap30, genetic mapping on chromosome 8, and
            expression in neuronal primary cell cultures
  JOURNAL   Genomics 70 (1), 140-149 (2000)
   PUBMED   11087671
REFERENCE   7  (bases 1 to 700)
  AUTHORS   Dron M, Dandoy-Dron F, Guillo F, Benboudjema L, Hauw JJ, Lebon P,
            Dormont D and Tovey MG.
  TITLE     Characterization of the human analogue of a Scrapie-responsive gene
  JOURNAL   J Biol Chem 273 (29), 18015-18018 (1998)
   PUBMED   9660755
REFERENCE   8  (bases 1 to 700)
  AUTHORS   Dandoy-Dron F, Guillo F, Benboudjema L, Deslys JP, Lasmezas C,
            Dormont D, Tovey MG and Dron M.
  TITLE     Gene expression in scrapie. Cloning of a new scrapie-responsive
            gene and the identification of increased levels of seven other mRNA
            transcripts
  JOURNAL   J Biol Chem 273 (13), 7691-7697 (1998)
   PUBMED   9516475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ223206.1.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_009136.4.
            
            On Dec 9, 2006 this sequence version replaced NM_009136.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223206.1, CX203583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.8 cM"
     gene            1..700
                     /gene="Scrg1"
                     /note="scrapie responsive gene 1"
                     /db_xref="GeneID:20284"
                     /db_xref="MGI:MGI:1328308"
     exon            1..205
                     /gene="Scrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..458
                     /gene="Scrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..513
                     /gene="Scrg1"
                     /note="scrapie-responsive protein 1; scrapie responsive
                     protein one; scRG-1; scrapie-responsive gene 1 protein"
                     /codon_start=1
                     /product="scrapie-responsive protein 1 precursor"
                     /protein_id="NP_033162.1"
                     /db_xref="CCDS:CCDS40342.1"
                     /db_xref="GeneID:20284"
                     /db_xref="MGI:MGI:1328308"
                     /translation="MMKSVVLVILGLTLLLETQAMPSSRLSCYRKLLKDRNCHNLPEG
                     RADLKLIDANVQHHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNH"
     exon            459..700
                     /gene="Scrg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrg1"
     regulatory      681..685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scrg1"
ORIGIN      
        1 caagagaggc agctcctgtc tccttccact ccccttctcc cctcctttct ggctggagca
       61 gagtctgtca atcccaggca gagacaaggc agacaaagct tcacttgtaa ggagcctcct
      121 cgcttctcct ttgcccagac tgccccagtg agctggagca ttgaagaaga gtctcctgcc
      181 aataacactg aaaagaaaga aaaaggagca agagccatga tgaaatctgt ggtacttgtc
      241 atccttgggc taactttgct gttagaaaca caagccatgc cttcaagtcg cctctcctgc
      301 tacagaaagt tgctaaagga tcgcaattgt cacaaccttc cggagggcag agccgacctg
      361 aagctgatag atgcaaatgt ccagcatcat ttctgggatg ggaagggatg cgagatgatc
      421 tgctactgca acttcagcga actgctctgc tgcccaaaag atgtcttctt tggaccaaag
      481 atctcctttg tgatcccctg caacaaccac tgaggatctg ccttgcactc tggagaacat
      541 ggtcctgaag gccttcacgt cccctaattt cccacaaact ctgtcagttc agcgccattt
      601 ctgatatcca tccagtatat ccaatcttgc atagattcta taaagtctta cttgctagag
      661 tatacttggg ctaaagtggt aataaaagtt gtttccattt
//
