LOCUS       NM_029023               2087 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine carboxypeptidase 1 (Scpep1), mRNA.
ACCESSION   NM_029023
VERSION     NM_029023.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Bernardo,A.S., Jouneau,A., Marks,H., Kensche,P., Kobolak,J.,
            Freude,K., Hall,V., Feher,A., Polgar,Z., Sartori,C., Bock,I.,
            Louet,C., Faial,T., Kerstens,H.H.D., Bouissou,C., Parsonage,G.,
            Mashayekhi,K., Smith,J.C., Lazzari,G., Hyttel,P., Stunnenberg,H.G.,
            Huynen,M., Pedersen,R.A. and Dinnyes,A.
  TITLE     Mammalian embryo comparison identifies novel pluripotency genes
            associated with the naive or primed state
  JOURNAL   Biol Open 7 (8) (2018)
   PUBMED   30026265
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Pan,X., Wang,Y., Lubke,T., Hinek,A. and Pshezhetsky,A.V.
  TITLE     Mice, double deficient in lysosomal serine carboxypeptidases Scpep1
            and Cathepsin A develop the hyperproliferative vesicular corneal
            dystrophy and hypertrophic skin thickenings
  JOURNAL   PLoS One 12 (2), e0172854 (2017)
   PUBMED   28234994
  REMARK    GeneRIF: in normal tissues the tandem of serine carboxypeptidases,
            Scpep1 and CathA likely constitutes an important part of the
            physiological mechanism responsible for the balanced elimination of
            heightened levels of ET-1 that otherwise would accumulate in
            tissues and consequently contribute to development of the
            hyper-proliferative corneal dystrophy and abnormal skin thickening
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Pan,X., Grigoryeva,L., Seyrantepe,V., Peng,J., Kollmann,K.,
            Tremblay,J., Lavoie,J.L., Hinek,A., Lubke,T. and Pshezhetsky,A.V.
  TITLE     Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary
            roles in regulation of vasoconstriction via inactivation of
            endothelin-1
  JOURNAL   PLoS Genet 10 (2), e1004146 (2014)
   PUBMED   24586188
  REMARK    GeneRIF: our results define the biological role of mammalian serine
            carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together
            participate in the control of ET-1 regulation of vascular tone and
            hemodynamics
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Sebastiani,G., Krzywkowski,P., Dudal,S., Yu,M., Paquette,J.,
            Malo,D., Gervais,F. and Tremblay,P.
  TITLE     Mapping genetic modulators of amyloid plaque deposition in TgCRND8
            transgenic mice
  JOURNAL   Hum Mol Genet 15 (15), 2313-2323 (2006)
   PUBMED   16785251
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Lee,T.H., Streb,J.W., Georger,M.A. and Miano,J.M.
  TITLE     Tissue expression of the novel serine carboxypeptidase Scpep1
  JOURNAL   J Histochem Cytochem 54 (6), 701-711 (2006)
   PUBMED   16461364
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Chen,J., Streb,J.W., Maltby,K.M., Kitchen,C.M. and Miano,J.M.
  TITLE     Cloning of a novel retinoid-inducible serine carboxypeptidase from
            vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (36), 34175-34181 (2001)
   PUBMED   11447226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014680.1 and BX518946.1.
            
            On Jul 15, 2009 this sequence version replaced NM_029023.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004847.1, AK153225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1831              AK014680.1         2-1832
            1832-2087           BX518946.1         73-328
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.34 cM"
     gene            1..2087
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /note="serine carboxypeptidase 1"
                     /db_xref="GeneID:74617"
                     /db_xref="MGI:MGI:1921867"
     exon            1..149
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1432
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /note="retinoid-inducible serine caroboxypetidase;
                     retinoid-inducible serine caroboxypeptidase; serine
                     caroboxypeptidase 1; retinoid-inducible serine
                     carboxypeptidase"
                     /codon_start=1
                     /product="retinoid-inducible serine carboxypeptidase
                     precursor"
                     /protein_id="NP_083299.3"
                     /db_xref="CCDS:CCDS25230.1"
                     /db_xref="GeneID:74617"
                     /db_xref="MGI:MGI:1921867"
                     /translation="MELSRRICLVRLWLLLLSFLLGFSAGSAIDWREPEGKEVWDYVT
                     VRKDAHMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDTQLKPRN
                     TTWLQWASLLFVDNPVGTGFSYVNTTDAYAKDLDTVASDMMVLLKSFFDCHKEFQTVP
                     FYIFSESYGGKMAAGISVELYKAVQQGTIKCNFSGVALGDSWISPVDSVLSWGPYLYS
                     MSLLDNQGLAEVSDIAEQVLDAVNKGFYKEATQLWGKAEMIIEKNTDGVNFYNILTKS
                     SPEKAMESSLEFLRSPLVRLCQRHVRHLQGDALSQLMNGPIKKKLKIIPEDISWGAQA
                     SYVFLSMEGDFMKPAIDVVDKLLAAGVNVTVYNGQLDLIVDTIGQESWVQKLKWPQLS
                     KFNQLKWKALYTDPKSSETAAFVKSYENLAFYWILKAGHMVPSDQGEMALKMMKLVTK
                     QE"
     exon            150..298
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            299..388
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            389..544
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            545..619
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            620..692
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            693..730
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            731..859
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            860..953
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1067
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1205
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1369
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2074
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1837
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /note="hexamer: AATAAA"
     polyA_site      2074
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /note="major polyA site"
ORIGIN      
        1 agtccccgcg caagccgtca cgcgatggcc tttggctcct gcctgttgct gatgttgcgg
       61 cggggttttc atcatggagc tctcgcggcg gatctgtctc gtgcgactgt ggctgctgct
      121 cctatcgttc ttactgggct tcagcgcggg atctgccatc gactggcggg aacccgaagg
      181 caaggaagta tgggattatg tgactgtccg aaaggatgcc cacatgttct ggtggctcta
      241 ttatgccacc aacccttgca agaacttttc agagctgccc ctggtcatgt ggcttcaggg
      301 tggtccgggt ggttctagca ctggatttgg aaactttgaa gaaatcggcc ctcttgacac
      361 ccaactcaag cctcgaaata ctacctggct gcagtgggcc agtctcctgt ttgtggataa
      421 tcccgtgggc acgggcttca gctatgtcaa cacaacagat gcctacgcaa aggacctgga
      481 cacggtggct tccgacatga tggttctcct gaaatccttc tttgattgcc ataaagaatt
      541 ccagacggtt ccattctaca ttttctcaga atcctacgga ggaaagatgg ctgctggcat
      601 cagtgtagaa ctttacaagg ctgttcagca agggaccatt aagtgcaact tttctggggt
      661 tgctttgggt gactcctgga tctcccccgt ggattcagtg ctgtcctggg gaccttacct
      721 gtatagtatg tctctccttg ataatcaagg cttggccgag gtgtccgaca ttgcagagca
      781 agtccttgat gctgtaaaca agggcttcta caaggaggcc actcagctgt gggggaaagc
      841 agaaatgatc attgaaaaga acaccgacgg ggtaaacttc tataacatct taactaaaag
      901 cagcccggag aaagctatgg aatcgagcct cgagttcctc cggagcccct tagttcgtct
      961 ctgtcagcgc catgtgagac acctgcaagg agacgcctta agtcaactca tgaacggccc
     1021 catcaaaaag aagctcaaaa ttatccctga ggatatctcc tggggagccc aggcatctta
     1081 tgtcttccta agcatggaag gggacttcat gaagcctgcc atcgacgttg tggataagtt
     1141 gctggcagct ggggtcaatg tgaccgtgta caacggacag ctggatctca ttgtggacac
     1201 cataggtcag gagtcctggg ttcagaagct caagtggcca cagctgtcca aattcaatca
     1261 gctaaaatgg aaggccctgt acaccgatcc taagtcttca gaaacagctg cgttcgtcaa
     1321 gtcctatgag aacctagcct tctactggat cctaaaggcc ggtcacatgg ttccttctga
     1381 ccaaggggag atggccctga agatgatgaa gctggtgacc aagcaggagt agctgagctg
     1441 gctggccctg gaggcgctaa gagcagagcc caggatgcag gtgctaatgt ctatccctgg
     1501 tgctcttctc ccctgctctg ccatgggata tgactctggg agcacctgct ctctcccgta
     1561 ccgaaagact gtggccttct gtgtctactt agaaatcagt tctgcttccc aaagagtatt
     1621 taaaaccaga ctcatttaat caaagtgaag ggttgcaatc gattggtctc ttactacaaa
     1681 agcagttgat agcacatgta aatccaagca cttgagaggt agaagaagca agaggatgga
     1741 tgagaggttc aaacgcatcc gcagctacat cgaaagttca aaagcagcct atgccaaaca
     1801 gggagagtcc ctgtccccca cccccacccc caaaaaagag caaaagcaaa ccacatgatt
     1861 tatagacaaa agcagtggga gagacaaaga aaatacttaa acacccactg agctgccaac
     1921 taggtgtctc tgactacggg tcttttattt gctacatata tatttttaca aaaatgaaat
     1981 ccatattgta cgctattttg ctgtctgctt cgttcccatg tcgacatgac ccgcacttct
     2041 tttcccatca ataaatgtgt tgtgatattt ttaaaaaaaa aaaaaaa
//
