LOCUS       NP_083299                452 aa            linear   ROD 30-APR-2024
DEFINITION  retinoid-inducible serine carboxypeptidase precursor [Mus
            musculus].
ACCESSION   NP_083299
VERSION     NP_083299.3
DBSOURCE    REFSEQ: accession NM_029023.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Bernardo,A.S., Jouneau,A., Marks,H., Kensche,P., Kobolak,J.,
            Freude,K., Hall,V., Feher,A., Polgar,Z., Sartori,C., Bock,I.,
            Louet,C., Faial,T., Kerstens,H.H.D., Bouissou,C., Parsonage,G.,
            Mashayekhi,K., Smith,J.C., Lazzari,G., Hyttel,P., Stunnenberg,H.G.,
            Huynen,M., Pedersen,R.A. and Dinnyes,A.
  TITLE     Mammalian embryo comparison identifies novel pluripotency genes
            associated with the naive or primed state
  JOURNAL   Biol Open 7 (8) (2018)
   PUBMED   30026265
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Pan,X., Wang,Y., Lubke,T., Hinek,A. and Pshezhetsky,A.V.
  TITLE     Mice, double deficient in lysosomal serine carboxypeptidases Scpep1
            and Cathepsin A develop the hyperproliferative vesicular corneal
            dystrophy and hypertrophic skin thickenings
  JOURNAL   PLoS One 12 (2), e0172854 (2017)
   PUBMED   28234994
  REMARK    GeneRIF: in normal tissues the tandem of serine carboxypeptidases,
            Scpep1 and CathA likely constitutes an important part of the
            physiological mechanism responsible for the balanced elimination of
            heightened levels of ET-1 that otherwise would accumulate in
            tissues and consequently contribute to development of the
            hyper-proliferative corneal dystrophy and abnormal skin thickening
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Pan,X., Grigoryeva,L., Seyrantepe,V., Peng,J., Kollmann,K.,
            Tremblay,J., Lavoie,J.L., Hinek,A., Lubke,T. and Pshezhetsky,A.V.
  TITLE     Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary
            roles in regulation of vasoconstriction via inactivation of
            endothelin-1
  JOURNAL   PLoS Genet 10 (2), e1004146 (2014)
   PUBMED   24586188
  REMARK    GeneRIF: our results define the biological role of mammalian serine
            carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together
            participate in the control of ET-1 regulation of vascular tone and
            hemodynamics
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Sebastiani,G., Krzywkowski,P., Dudal,S., Yu,M., Paquette,J.,
            Malo,D., Gervais,F. and Tremblay,P.
  TITLE     Mapping genetic modulators of amyloid plaque deposition in TgCRND8
            transgenic mice
  JOURNAL   Hum Mol Genet 15 (15), 2313-2323 (2006)
   PUBMED   16785251
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Lee,T.H., Streb,J.W., Georger,M.A. and Miano,J.M.
  TITLE     Tissue expression of the novel serine carboxypeptidase Scpep1
  JOURNAL   J Histochem Cytochem 54 (6), 701-711 (2006)
   PUBMED   16461364
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Chen,J., Streb,J.W., Maltby,K.M., Kitchen,C.M. and Miano,J.M.
  TITLE     Cloning of a novel retinoid-inducible serine carboxypeptidase from
            vascular smooth muscle cells
  JOURNAL   J Biol Chem 276 (36), 34175-34181 (2001)
   PUBMED   11447226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014680.1 and BX518946.1.
            
            On Jul 15, 2009 this sequence version replaced NP_083299.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004847.1, AK153225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.34 cM"
     Protein         1..452
                     /product="retinoid-inducible serine carboxypeptidase
                     precursor"
                     /note="retinoid-inducible serine caroboxypetidase;
                     retinoid-inducible serine caroboxypeptidase; serine
                     caroboxypeptidase 1; retinoid-inducible serine
                     carboxypeptidase"
                     /calculated_mol_wt=47817
     sig_peptide     1..28
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
                     /calculated_mol_wt=3166
     mat_peptide     29..452
                     /product="Retinoid-inducible serine carboxypeptidase.
                     /id=PRO_0000004285"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920A5.2)"
                     /calculated_mol_wt=47817
     Region          37..451
                     /region_name="Peptidase_S10"
                     /note="Serine carboxypeptidase; pfam00450"
                     /db_xref="CDD:459815"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
     Site            126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
     Site            192
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
     Site            362
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920A5.2)"
     CDS             1..452
                     /gene="Scpep1"
                     /gene_synonym="2410018F01Rik; 4833411K15Rik; Risc"
                     /coded_by="NM_029023.3:74..1432"
                     /db_xref="CCDS:CCDS25230.1"
                     /db_xref="GeneID:74617"
                     /db_xref="MGI:MGI:1921867"
ORIGIN      
        1 melsrriclv rlwllllsfl lgfsagsaid wrepegkevw dyvtvrkdah mfwwlyyatn
       61 pcknfselpl vmwlqggpgg sstgfgnfee igpldtqlkp rnttwlqwas llfvdnpvgt
      121 gfsyvnttda yakdldtvas dmmvllksff dchkefqtvp fyifsesygg kmaagisvel
      181 ykavqqgtik cnfsgvalgd swispvdsvl swgpylysms lldnqglaev sdiaeqvlda
      241 vnkgfykeat qlwgkaemii ekntdgvnfy niltksspek amessleflr splvrlcqrh
      301 vrhlqgdals qlmngpikkk lkiipedisw gaqasyvfls megdfmkpai dvvdkllaag
      361 vnvtvyngql dlivdtigqe swvqklkwpq lskfnqlkwk alytdpksse taafvksyen
      421 lafywilkag hmvpsdqgem alkmmklvtk qe
//
