LOCUS       NM_011327               2664 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus sterol carrier protein 2, liver (Scp2), mRNA.
ACCESSION   NM_011327 XM_131616
VERSION     NM_011327.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2664)
  AUTHORS   Wang,D., Li,H., Chandel,N.S., Dou,Y. and Yi,R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2664)
  AUTHORS   Parks,C., Rogers,C.M., Prins,P., Williams,R.W., Chen,H.,
            Jones,B.C., Moore,B.M. 2nd and Mulligan,M.K.
  TITLE     Genetic Modulation of Initial Sensitivity to
            Delta9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice
  JOURNAL   Front Genet 12, 659012 (2021)
   PUBMED   34367237
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2664)
  AUTHORS   Martin,G.G., Seeger,D.R., McIntosh,A.L., Milligan,S., Chung,S.,
            Landrock,D., Dangott,L.J., Golovko,M.Y., Murphy,E.J., Kier,A.B. and
            Schroeder,F.
  TITLE     Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid
            Binding Protein-1 Ablation Impacts Response of Brain
            Endocannabinoid to High-Fat Diet
  JOURNAL   Lipids 54 (10), 583-601 (2019)
   PUBMED   31487051
  REMARK    GeneRIF: Both FABP1 and SCP-2 participate in regulating the Brain
            endocannabinoids (EC) system in the brain.
REFERENCE   4  (bases 1 to 2664)
  AUTHORS   Martin,G.G., Seeger,D.R., McIntosh,A.L., Chung,S., Milligan,S.,
            Landrock,D., Dangott,L.J., Golovko,M.Y., Murphy,E.J., Kier,A.B. and
            Schroeder,F.
  TITLE     Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts
            hepatic endocannabinoid level depending on dietary fat
  JOURNAL   Arch Biochem Biophys 650, 93-102 (2018)
   PUBMED   29763591
  REMARK    GeneRIF: These findings suggested that ablation of the Scp-2/Scp-x
            gene in Fabp1 null mice exacerbated hepatic endocannabinoid (EC)
            accumulation and antagonized the impact of high fat diet on hepatic
            EC levels-suggesting both proteins play important roles in
            regulating the hepatic EC system.
REFERENCE   5  (bases 1 to 2664)
  AUTHORS   He,H., Wang,J., Yannie,P.J., Kakiyama,G., Korzun,W.J. and Ghosh,S.
  TITLE     Sterol carrier protein-2 deficiency attenuates diet-induced
            dyslipidemia and atherosclerosis in mice
  JOURNAL   J Biol Chem 293 (24), 9223-9231 (2018)
   PUBMED   29700117
  REMARK    GeneRIF: These results indicate an important regulatory role for
            SCP2 deficiency in attenuating diet-induced atherosclerosis by
            limiting intestinal cholesterol absorption and decreasing hepatic
            triglyceride/VLDL secretion.
REFERENCE   6  (bases 1 to 2664)
  AUTHORS   Myers-Payne,S.C., Fontaine,R.N., Loeffler,A., Pu,L., Rao,A.M.,
            Kier,A.B., Wood,W.G. and Schroeder,F.
  TITLE     Effects of chronic ethanol consumption on sterol transfer proteins
            in mouse brain
  JOURNAL   J Neurochem 66 (1), 313-320 (1996)
   PUBMED   8522969
REFERENCE   7  (bases 1 to 2664)
  AUTHORS   Seedorf,U., Engel,T., Assmann,G., Leenders,F. and Adamski,J.
  TITLE     Intrinsic sterol- and phosphatidylcholine transfer activities of 17
            beta-hydroxysteroid dehydrogenase type IV
  JOURNAL   J Steroid Biochem Mol Biol 55 (5-6), 549-553 (1995)
   PUBMED   8547181
REFERENCE   8  (bases 1 to 2664)
  AUTHORS   Kolodner,R.D., Hall,N.R., Lipford,J., Kane,M.F., Rao,M.R.,
            Morrison,P., Wirth,L., Finan,P.J., Burn,J. and Chapman,P.
  TITLE     Structure of the human MSH2 locus and analysis of two Muir-Torre
            kindreds for msh2 mutations
  JOURNAL   Genomics 24 (3), 516-526 (1994)
   PUBMED   7713503
  REMARK    Erratum:[Genomics 1995 Aug 10;28(3):613]
REFERENCE   9  (bases 1 to 2664)
  AUTHORS   Seedorf,U., Raabe,M. and Assmann,G.
  TITLE     Cloning, expression and sequences of mouse sterol-carrier
            protein-x-encoding cDNAs and a related pseudogene
  JOURNAL   Gene 123 (2), 165-172 (1993)
   PUBMED   8428655
REFERENCE   10 (bases 1 to 2664)
  AUTHORS   Moncecchi,D., Pastuszyn,A. and Scallen,T.J.
  TITLE     cDNA sequence and bacterial expression of mouse liver sterol
            carrier protein-2
  JOURNAL   J Biol Chem 266 (15), 9885-9892 (1991)
   PUBMED   1709640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN176201.1, AK004860.2, M91458.1, CJ238474.1 and BB774576.1.
            
            On Dec 16, 2011 this sequence version replaced NM_011327.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018384.1, AK004860.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DN176201.1         1-70
            71-2044             AK004860.2         1-1974
            2045-2210           M91458.1           1966-2131
            2211-2658           CJ238474.1         24-471
            2659-2664           BB774576.1         423-428
FEATURES             Location/Qualifiers
     source          1..2664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.2 cM"
     gene            1..2664
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /note="sterol carrier protein 2, liver"
                     /db_xref="GeneID:20280"
                     /db_xref="MGI:MGI:98254"
     exon            1..169
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1744
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.176"
                     /EC_number="2.3.1.155"
                     /note="non-specific lipid-transfer protein; SCP-chi;
                     sterol carrier protein X; propanoyl-CoA C-acyltransferase;
                     nonspecific lipid transfer protein; SCP-2/thiolase;
                     SCP-2/3-oxoacyl-CoA thiolase; straight-chain acyl-CoA
                     oxidase; acetyl-CoA C-myristoyltransferase"
                     /codon_start=1
                     /product="sterol carrier protein 2"
                     /protein_id="NP_035457.1"
                     /db_xref="CCDS:CCDS18446.1"
                     /db_xref="GeneID:20280"
                     /db_xref="MGI:MGI:98254"
                     /translation="MPSVALKSPRLRRVFVVGVGMTKFMKPGGENSRDYPDMAKEAGQ
                     KALEDAQIPYSAVEQACVGYVYGDSTSGQRAIYHSLGLTGIPIINVNNNCSTGSTALF
                     MAHQLIQGGLANCVLALGFEKMERGSIGTKFSDRTTPTDKHIEVLIDKYGLSAHPITP
                     QMFGYAGKEHMEKYGTKVEHFAKIGWKNHKHSVNNTYSQFQDEYSLEEVMKSKPVFDF
                     LTILQCCPTSDGAAAAILSSEEFVQQYGLQSKAVEIVAQEMMTDLPSTFEEKSIIKVV
                     GYDMSKEAARRCYEKSGLTPNDVDVIELHDCFSVNELITYEALGLCPEGQGGTLVDRG
                     DNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNL
                     GLGGAVVVTLYRMGFPEAASSFRTHQVSAAPTSSAGDGFKANLVFKEIEKKLEEEGEQ
                     FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDLLALM
                     TGKMNPQSAFFQGKLKIAGNMGLAMKLQNLQLQPGKAKL"
     exon            170..227
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            228..299
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            300..431
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            432..496
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            497..623
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            624..687
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            688..774
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            775..925
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1073
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1181
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1335
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1438
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1568
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1648
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2664
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /note="major polyA site"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /note="hexamer: ATTAAA"
     polyA_site      2656
                     /gene="Scp2"
                     /gene_synonym="ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX"
                     /note="major polyA site"
ORIGIN      
        1 tgcggccccg cccccgacgc ctggggttgg gataatcgga cccgacccgg ctttggttct
       61 gcaaagcctc agtctgtagg agaccttcgc tgctggagcc atgccttctg tcgctttgaa
      121 atctccgcgc ctgcgccggg tgttcgtggt cggcgttggc atgaccaagt tcatgaagcc
      181 tggaggtgag aactcaagag actatcctga tatggcaaag gaagcaggcc agaaggcatt
      241 ggaagatgca cagatccctt actccgcagt ggaacaggca tgcgttggct atgtgtatgg
      301 tgattccacc agtgggcaga gggctatcta tcatagtttg ggactgactg gcattcctat
      361 aattaatgtc aacaataact gttctactgg ttcgactgct ttgtttatgg cccatcaact
      421 gattcaagga ggcttggcaa attgtgtgtt ggctcttggg tttgagaaga tggagagggg
      481 atccattgga acaaaattct cagatcggac cactccaact gataaacata ttgaagtctt
      541 gatcgataag tatggattgt ctgcacatcc gattactcct cagatgtttg ggtatgctgg
      601 gaaagaacat atggaaaaat atggaacaaa agttgaacac tttgcaaaaa ttggatggaa
      661 aaatcataaa cactcagtta ataacacgta ttcccagttc caagatgaat acagcttaga
      721 agaagtaatg aaatcaaaac cagttttcga ttttctgact atcttgcaat gctgccccac
      781 ctcagatggt gccgctgccg cgattctgtc cagcgaggag tttgtgcagc agtacggcct
      841 gcagtccaaa gcggtggaga ttgtggccca ggagatgatg actgacttac ccagtacgtt
      901 tgaagagaaa agtattatta aagtggttgg ctatgatatg agtaaagaag ctgccaggag
      961 atgctatgag aagtccggcc tgacacccaa cgatgtcgac gtgatagagc ttcacgattg
     1021 cttctctgtc aatgaactca tcacttacga agcactgggg ctctgtccag aaggacaagg
     1081 tggaaccctg gtggacagag gggacaacac ttacggagga aagtgggtca tcaaccctag
     1141 tggaggcctc atctcaaagg gacacccact gggcgcaaca ggtctggctc agtgcgcgga
     1201 gctctgctgg cagctgagag gcgaagccgg aaagaggcag gttcccgggg caaaggtggc
     1261 tctgcagcac aatctaggcc tcggaggagc tgtggttgtc accctctaca ggatgggttt
     1321 tcccgaagct gccagctcct tcaggacgca ccaggtttca gctgctccca ccagctctgc
     1381 aggggatgga ttcaaggcaa acctcgtctt taaggagatt gagaagaagc ttgaagagga
     1441 aggggaacag ttcgtgaaga aaatcggtgg catttttgcc ttcaaagtga aagatggccc
     1501 tggaggcaaa gaagctacct gggtggtgga tgtgaagaat ggcaaaggat ctgtgcttcc
     1561 caattcagat aagaaggctg actgcacaat caccatggcc gactcagact tgctggcttt
     1621 gatgactgga aaaatgaacc ctcagtcggc cttctttcaa gggaaactga agattgctgg
     1681 taacatggga ctggccatga aactacagaa ccttcagctt cagccgggca aagctaagct
     1741 gtgaggagtc cctttggcaa cctcaggaca tcaagatgag atgtgtagat aggtagagat
     1801 ccacgtctcg tcgtcagggc ttagactgac acctcccgaa tagcatgaga tagatttgtt
     1861 gctaattggg tgtggtcaat tgtgtttccc cgaagctggg aggtacatag ggcctccctg
     1921 cctgcactgc tgctttgagg acttgcattc tactgtgctt gatgaagcta ctatgtcaat
     1981 gatggtttgg ggtaaacttg agtttcagaa taaaattcag aacagtaaaa tctgaagact
     2041 gagtaaacaa agcccttgtt ttgcttagaa gtatatttga ggatcactgt gttggacact
     2101 cggtgtgaca tttctccttg gggggactag agaagaaaca gatttccata gttgaccagg
     2161 aattagtgcc tcacactcaa ttacctgcat cagtttctca ctaatagttc ttaaaataaa
     2221 attctgtact aaaagtttaa aaaaaaaact ttaaaaatgt tcattttatg ccatcagaaa
     2281 cagttctttt cttcccaaat aaaatacaag aattatggtc agagcttaag agagaattta
     2341 cagctgaaca gaactgtttt aaaatatttt tcaaatgggc atctttttaa aaatcatagt
     2401 atcagagcca tggataccat taataaaaat aactgaataa agttttttcc agagatacgg
     2461 gcttcaaatt atagtttcat attaataagt gtataaactg agtctcacaa atttcctttt
     2521 tcatacactt gattgtctgc atttatcttt cttccaagtt tttctaattc taatgctatt
     2581 tgttataatt taggtttggg ataaaaatat gcttttggaa gatttaaaaa gaaaattaaa
     2641 acagctcttc ctgatttcct tggc
//
