LOCUS       NM_019708               1946 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus short coiled-coil protein (Scoc), transcript variant
            2, mRNA.
ACCESSION   NM_019708 XM_985522
VERSION     NM_019708.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY251609.1, BC092071.1 and AU042937.1.
            
            On Oct 26, 2013 this sequence version replaced NM_019708.3.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promotor, differs in the 5' UTR, and initiates translation from a
            downstream start codon compared to variant 1. The resulting protein
            (isoform b) is shorter and has a distinct N-terminus compared to
            isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017629.1, AK076085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BY251609.1         2-198
            198-1941            BC092071.1         1-1744
            1942-1946           AU042937.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..1946
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /note="short coiled-coil protein"
                     /db_xref="GeneID:56367"
                     /db_xref="MGI:MGI:1927654"
     exon            1..241
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /inference="alignment:Splign:2.1.0"
     exon            242..313
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..540
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="short coiled-coil protein isoform b"
                     /protein_id="NP_062682.1"
                     /db_xref="CCDS:CCDS52608.1"
                     /db_xref="GeneID:56367"
                     /db_xref="MGI:MGI:1927654"
                     /translation="MMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAV
                     KEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK"
     exon            314..397
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1946
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /note="hexamer: AATAAA"
     polyA_site      1944
                     /gene="Scoc"
                     /gene_synonym="0610011C06Rik; 2810002J11Rik; SCOCO"
                     /note="major polyA site"
ORIGIN      
        1 gtcaatgccc ttttgttagg gcaaaggtgg accccggtgc tctgccacag gcctgtcgag
       61 gcgtccagca gccagtgcgc aggcgtgcaa tttccagtta ggattggtgg gaggacgcct
      121 cctcgctcgg cgcacgctcc gtgggcggga agggcggggc tgacgctgtc agttggtcgg
      181 agagccgcgc ggcctgaggc ttcctaccca tcccgcctct tcccggcgct tcagacgcaa
      241 gaccattctt taaagagttg gcgttcgagg gctgaaagtc tgctacccaa gatgatgaat
      301 gctgacatgg acgcagttga tgctgaaaat caggtggaac tggaagaaaa gactcgactt
      361 attaatcagg tgttggaact ccaacacaca cttgaagatc tttctgcaag agtagatgca
      421 gttaaggaag aaaatctgaa gctaaagtcg gaaaatcaag ttctcggaca atatatagaa
      481 aacctcatgt ctgcttctag tgtttttcaa acaactgata caaaaagcaa aaggaagtaa
      541 agggctcacc tccctctctt ctatggattg ctgctttttt tcttccccct taaggcttgg
      601 atatgatcca aaagttagag tatctttgtt cttccctgag tatttataaa gagaatgtca
      661 catctaggta acactaatgc tgaacaggag catctctgag ttaacgctat atgtatacgt
      721 tagtctatga aaatgtgcac atgtagagac tttatattag aattacagat atttatgaaa
      781 cttgaagatg aatgttttgc caatttgctt atatatatat aggtttagca ctgtctttta
      841 tcataagcct aactagtaaa atatacaaaa aaataaccat gttgtgaaaa gtgaccaaaa
      901 ccatgtactg aatgcacagc ttctgtacct tgtgcaccgt cttgtgcctc tcccatctcc
      961 ctccctgacg gtaacttcag cagtttctcc tacaagagta acctaaacta gaattgttga
     1021 cacttaacca aaataagaca ctttcttatc taaggcttgc cgtttgtgat atttagtaat
     1081 aagataggat tgctggtttc tctttaatca atcgaaagta gattgaagct atagaaaatg
     1141 aagagttttc tttgaaatgt aaactgccac actgagaagc taaaaactcc ctattgcata
     1201 aaatagttca tttggtgttg aaaagatagg aatgctggtc atatgtgtgt gagaaattaa
     1261 aaaacaacaa acaaacaaaa aacttgagaa aagataggaa taagaaggaa aactggatta
     1321 acagaaataa ccagctcgca gtgttttccc tctaaatgtg tattacctct ggcccacagc
     1381 tgcactttgg ggacatatat gaaagtggac tgagtctaat gtaagtggat taagagagac
     1441 tagttaagag tttggtctca aagtttattt gtacccagga aatgaacttt tgcaaaatta
     1501 attgagagta tattaatatc agaatcatga atataagagt tttgtatatg tgataattat
     1561 taacctcggt attttatctc agttgttttc ccagaatttc tgtaaactca actacttagt
     1621 ttgcagaatt ttagtcattc ttttaacaaa ttttaaaaat ttagtttgta gcttccattt
     1681 gataaggagc tgatatcaga aataatagtg aagtcttata ataggaaaga tccactaatg
     1741 cagctggtgg ctcttaggct gggctgcttt gacttgtgga attatctaat gtattaatgt
     1801 aagccttgat gagtgacgtt agctatatgg atgtgtaatc ctcacattgc agacattttg
     1861 caaccctttt gtgaccttgt tacagatatt taaaattgtg ttcaagttct gctttgctgt
     1921 ttaataaaaa gctgtttcag aggttt
//
