LOCUS       NM_001111288            1225 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001111288
VERSION     NM_001111288.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Hill,S., Deepa,S.S., Sataranatarajan,K., Premkumar,P., Pulliam,D.,
            Liu,Y., Soto,V.Y., Fischer,K.E. and Van Remmen,H.
  TITLE     Sco2 deficient mice develop increased adiposity and insulin
            resistance
  JOURNAL   Mol Cell Endocrinol 455, 103-114 (2017)
   PUBMED   28428045
  REMARK    GeneRIF: Sco2 deficient mice develop increased adiposity, liver
            steatosis, and insulin resistance.
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Du,W., Amarachintha,S., Wilson,A.F. and Pang,Q.
  TITLE     SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative
            Phosphorylation Switch in Hematopoietic Stem Cells
  JOURNAL   Stem Cells 34 (4), 960-971 (2016)
   PUBMED   26676373
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Ishimura,A., Terashima,M., Tange,S. and Suzuki,T.
  TITLE     Jmjd5 functions as a regulator of p53 signaling during mouse
            embryogenesis
  JOURNAL   Cell Tissue Res 363 (3), 723-733 (2016)
   PUBMED   26334721
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Cloonan,S.M., Glass,K., Laucho-Contreras,M.E., Bhashyam,A.R.,
            Cervo,M., Pabon,M.A., Konrad,C., Polverino,F., Siempos,I.I.,
            Perez,E., Mizumura,K., Ghosh,M.C., Parameswaran,H., Williams,N.C.,
            Rooney,K.T., Chen,Z.H., Goldklang,M.P., Yuan,G.C., Moore,S.C.,
            Demeo,D.L., Rouault,T.A., D'Armiento,J.M., Schon,E.A., Manfredi,G.,
            Quackenbush,J., Mahmood,A., Silverman,E.K., Owen,C.A. and Choi,A.M.
  TITLE     Mitochondrial iron chelation ameliorates cigarette smoke-induced
            bronchitis and emphysema in mice
  JOURNAL   Nat Med 22 (2), 163-174 (2016)
   PUBMED   26752519
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Martinez-Morentin,L., Martinez,L., Piloto,S., Yang,H., Schon,E.A.,
            Garesse,R., Bodmer,R., Ocorr,K., Cervera,M. and Arredondo,J.J.
  TITLE     Cardiac deficiency of single cytochrome oxidase assembly factor
            scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy
            model
  JOURNAL   Hum Mol Genet 24 (13), 3608-3622 (2015)
   PUBMED   25792727
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Viscomi,C., Bottani,E., Civiletto,G., Cerutti,R., Moggio,M.,
            Fagiolari,G., Schon,E.A., Lamperti,C. and Zeviani,M.
  TITLE     In vivo correction of COX deficiency by activation of the
            AMPK/PGC-1alpha axis
  JOURNAL   Cell Metab 14 (1), 80-90 (2011)
   PUBMED   21723506
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Qi,Z., He,J., Su,Y., He,Q., Liu,J., Yu,L., Al-Attas,O., Hussain,T.,
            Ding,S., Ji,L. and Qian,M.
  TITLE     Physical exercise regulates p53 activity targeting SCO2 and
            increases mitochondrial COX biogenesis in cardiac muscle with age
  JOURNAL   PLoS One 6 (7), e21140 (2011)
   PUBMED   21750704
  REMARK    GeneRIF: Data suggest that physical exercise attenuates age-related
            changes in mitochondrial COX biogenesis and p53 activity targeting
            SCO2 and mitochondria, and thereby induces antisenescent and
            protective effects in cardiac muscle.
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Brosel,S., Yang,H., Tanji,K., Bonilla,E. and Schon,E.A.
  TITLE     Unexpected vascular enrichment of SCO1 over SCO2 in mammalian
            tissues: implications for human mitochondrial disease
  JOURNAL   Am J Pathol 177 (5), 2541-2548 (2010)
   PUBMED   20864674
  REMARK    GeneRIF: Results describe the tissue distribution of SCO1 and SCO2
            in mouse and human tissues.
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Yang,H., Brosel,S., Acin-Perez,R., Slavkovich,V., Nishino,I.,
            Khan,R., Goldberg,I.J., Graziano,J., Manfredi,G. and Schon,E.A.
  TITLE     Analysis of mouse models of cytochrome c oxidase deficiency owing
            to mutations in Sco2
  JOURNAL   Hum Mol Genet 19 (1), 170-180 (2010)
   PUBMED   19837698
  REMARK    GeneRIF: To understand the biological role of SCO2, mice harboring
            both a Sco2 knock-out (KO) allele and a Sco2 knock-in (KI) E129K
            allele, corresponding to the common E140K mutation in humans, were
            studied.
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Matoba,S., Kang,J.G., Patino,W.D., Wragg,A., Boehm,M.,
            Gavrilova,O., Hurley,P.J., Bunz,F. and Hwang,P.M.
  TITLE     p53 regulates mitochondrial respiration
  JOURNAL   Science 312 (5780), 1650-1653 (2006)
   PUBMED   16728594
  REMARK    GeneRIF: findings show that p53 modulates the balance between the
            utilization of respiratory and glycolytic pathways; identifed
            Synthesis of Cytochrome c Oxidase 2 (SCO2) as the downstream
            mediator of this effect
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113976.13.
            
            On Jul 12, 2018 this sequence version replaced NM_001111288.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019554.1, CV561858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC113976.13        151467-151675       c
            210-389             AC113976.13        151207-151386       c
            390-1225            AC113976.13        149414-150249       c
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.85 cM"
     gene            1..1225
                     /gene="Sco2"
                     /note="SCO2 cytochrome c oxidase assembly protein"
                     /db_xref="GeneID:100126824"
                     /db_xref="MGI:MGI:3818630"
     exon            1..209
                     /gene="Sco2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..389
                     /gene="Sco2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1225
                     /gene="Sco2"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1173
                     /gene="Sco2"
                     /EC_number="2.4.2.4"
                     /note="SCO cytochrome oxidase deficient homolog 2"
                     /codon_start=1
                     /product="protein SCO2 homolog, mitochondrial"
                     /protein_id="NP_001104758.1"
                     /db_xref="CCDS:CCDS49701.1"
                     /db_xref="GeneID:100126824"
                     /db_xref="MGI:MGI:3818630"
                     /translation="MLLALGPKAWPKLSQFKPLLRISGGETLHRNSRHWAGQGQRQGP
                     GLRTRLLITALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQGDFSLLDHKGQP
                     RCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPER
                     DDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIY
                     LLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVLP"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sco2"
                     /note="hexamer: ATTAAA"
     polyA_site      1224
                     /gene="Sco2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcccgat ctttcctggt cctggcacgt gcctccagta ggttctcagt gtccaccctc
       61 tcccttaggc attgttgagt gcgtccgagc gctgccgctg gcccgtgtgc tgcacgacct
      121 cggagccgga cgcagccgag cggggcagcc gatcagaccg ggagtgggtg ccgaggtact
      181 ggtcgacgtg ggccagtgtt tgtcccgagg gacaccctgg ctccgcgtgc acctagacgg
      241 ccctgcgctc agcagtcagc agcgacgcac tctccagggg gcgctcgtgc tatcagatcg
      301 agcacccttc aaggtccctt cacccttcgc tgaacttgtc ctcccaccga ccatcgcaca
      361 gccctaagtc tcgaacccag ctcagccagg agcttcaggt ccacgatgct actggctcta
      421 gggcccaaag cttggcccaa gctctctcag ttcaaacccc tcctcaggat ctcaggaggt
      481 gaaactctgc atagaaattc ccgacactgg gcagggcagg gccagcgcca aggccctggg
      541 ctaagaacta gactgctgat cacagccctg tttggggctg ggctaggctg ggcctggctg
      601 gccgcgaggg ctgagaagga acagtggcgc caacagcagc gtacagaggc cctgcgccag
      661 gctgctgtgg gccagggtga cttcagccta ctagaccaca aaggccagcc tcgatgcaaa
      721 gccgacttcc gaggccagtg ggtgctgatg tacttcggtt ttactcactg ccctgatatt
      781 tgccccgatg agctggaaaa gctagtgcag gtggtgcgga agctagaggc ggagcctgac
      841 ctgcccctgg tgcagcctgt cttcatcact gtggacccag aacgagatga cgtggcagcc
      901 atggcccgct atgtgcaaga attccaccca agactgttag gtctgaccgg ttctacagaa
      961 caggtggccc atgctagtcg caactaccgc gtatactaca gcgctgggcc taaggatgag
     1021 gaccaggact acattgtgga ccactccatt gccatctatc tgctcaaccc tgatggtctt
     1081 ttcaccgatt actatggtcg cagcaggtca gcagagcaga tcgtagagag tatacgtcgg
     1141 cacatagctg ccttccacag tgtcttgccc tgaactatac ctattgccta ggccctgtca
     1201 ttaaatggat gtacttaatc tgtgc
//
